Igf1 - insulin-like growth factor 1 Gene

Rattus norvegicus

Also known as IGF

Gene ID: 24482 | Gene type: protein coding

About Igf1

Summary

Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (Insulin like growth factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Igf1 Products(4)

mRNA	Protein	Name
NM_001082477.2	NP_001075946.2	insulin-like growth factor I isoform a preproprotein
NM_001082478.1	NP_001075947.1	insulin-like growth factor I isoform c preproprotein
NM_001082479.1	NP_001075948.1	insulin-like growth factor I isoform d preproprotein
NM_178866.4	NP_849197.3	insulin-like growth factor I isoform b preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	16083987	RGD
enables insulin-like growth factor receptor binding	IDA IDA: Inferred from direct assay	16083987	RGD
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	17023532	RGD
enables steroid binding	IDA IDA: Inferred from direct assay	16083987	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone development	IEP IEP: Inferred from expression pattern	24735836	RGD
involved in cardiac atrium development	IEP IEP: Inferred from expression pattern	15486038	RGD
involved in cellular response to Thyroglobulin triiodothyronine	IEP IEP: Inferred from expression pattern	8674839	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	19853640	RGD
involved in cellular response to electrical stimulus	IEP IEP: Inferred from expression pattern	18661273	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	17531559	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	20013160	RGD
involved in cellular response to nicotine	IEP IEP: Inferred from expression pattern	23454400	RGD
involved in cellular response to progesterone stimulus	IEP IEP: Inferred from expression pattern	19853640	RGD
involved in cellular response to zinc ion starvation	IEP IEP: Inferred from expression pattern	21893222	RGD
involved in cranial suture morphogenesis	IEP IEP: Inferred from expression pattern	10597685	RGD
involved in detection of mechanical stimulus involved in sensory perception	IMP IMP: Inferred from mutant phenotype	21037532	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	17123939	RGD
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	16083987	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	16650607	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	17103039	RGD
involved in negative regulation of cholangiocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	17531559	RGD
involved in negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17023532	RGD
involved in negative regulation of immune system process	IMP IMP: Inferred from mutant phenotype	8575560	RGD
involved in negative regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16699953	RGD
involved in negative regulation of oligodendrocyte apoptotic process	IDA IDA: Inferred from direct assay	17577243	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20724525	RGD
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	20724525	RGD
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	28315330	RGD
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	15544842	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16869890	RGD
involved in positive regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	16897348	RGD
involved in positive regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	24262632	RGD
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	16897348	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	17023532	RGD
involved in positive regulation of steroid hormone biosynthetic process	IDA IDA: Inferred from direct assay	17023532	RGD
involved in positive regulation of vascular endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	28315330	RGD
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	16763033	RGD
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16083987	RGD
involved in regulation of translation	IMP IMP: Inferred from mutant phenotype	15544842	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19382144	RGD
involved in response to caffeine	IEP IEP: Inferred from expression pattern	22995397	RGD
involved in response to epidermal growth factor	IEP IEP: Inferred from expression pattern	2003595	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	11201330	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	17645580	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	24239160	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	19359918	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	21750148	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	19766709	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19180987	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	11834488	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	23454400	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	2383530	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	17626604	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19327374	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	7524339	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	15917159	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	8532765	RGD
involved in retinal cell apoptotic process	IDA IDA: Inferred from direct assay	10973501	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15990634	RGD
located in interstitial matrix	IDA IDA: Inferred from direct assay	15544842	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21037532	RGD
located in platelet alpha granule	IDA IDA: Inferred from direct assay	9449625	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin-like growth factor I

IGF-I

somatomedin

Recombinant Igf1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7203	IGF-I/IGF-1 Protein, Rat	P08025 (G49-A118)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15656	Ceritinib	Inhibitor	99.98%	Yes
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.57%	Yes
HY-B0025	Voglibose	Inhibitor	≥98.0%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99165	Teprotumumab	Inhibitor	99.46%	Unkown

Clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10191	Linsitinib	Inhibitor	99.84%	Phase 3
HY-109155	Paltusotine	Agonist	99.52%	Phase 3
HY-15494	Picropodophyllin		99.85%	Phase 2
HY-10200	BMS-754807	Inhibitor	99.41%	Phase 2
HY-153485	Cimdelirsen	Inhibitor	/	Phase 2
HY-153485A	Cimdelirsen sodium	Inhibitor	/	Phase 2
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-B0794B	AZ7550 Mesylate	Inhibitor	99.24%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-B0794	AZ7550	Inhibitor	/	Phase 1
HY-B0794A	AZ7550 hydrochloride	Inhibitor	98.66%	Phase 1
HY-135749	BN201	Activator	/	Phase 1
HY-114913	Fenarimol	Inhibitor	/	Phase 1

Inhibitory Antibodies (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99294	Ganitumab	Inhibitor	96.00%	Phase 3
HY-P99197	Figitumumab	Inhibitor	96.89%	Phase 3
HY-P99274	Xentuzumab	Antagonist	99.71%	Phase 2
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99189	Cixutumumab	Inhibitor	99.63%	Phase 2
HY-P99218	Robatumumab	Inhibitor	99.90%	Phase 2
HY-P99712	Lonigutamab	Inhibitor	95.00%	Phase 2
HY-P99867	Dusigitumab		96.37%	Phase 2
HY-P99672	Istiratumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (47)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108477	TMPyP4 tosylate	Inhibitor	≥98.0%	Unkown
HY-116624	MAZ51		99.96%	Unkown
HY-50866	NVP-AEW541		99.92%	Unkown
HY-10262	BMS-536924		99.83%	Unkown
HY-15609	AZD-3463		99.58%	Unkown
HY-10252	NVP-ADW742		99.54%	Unkown
HY-N0908	Ginsenoside Rg5		99.87%	Unkown
HY-10253	AG1024		98.86%	Unkown
HY-13203	NVP-TAE 226		99.77%	Unkown
HY-10524	GSK1904529A		98.89%	Unkown
HY-W074890	Palmitoylglycine	Modulator	99.74%	Unkown
HY-P5438	Srctide	Substrate	99.93%	Unkown
HY-100349	SU4312	Inhibitor	99.76%	Unkown
HY-18785	Indirubin Derivative E804	Inhibitor	98.54%	Unkown
HY-P2090A	Angiopeptin TFA		99.01%	Unkown
HY-145110	IGF-1R inhibitor-2	Inhibitor	98.36%	Unkown
HY-135680	I-OMe-Tyrphostin AG 538	Inhibitor	98.03%	Unkown
HY-RS06614	IGF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-139783	3-Campholenyl-2-butanol	Inhibitor	≥98.0%	Unkown
HY-135436	AG 538	Inhibitor	99.80%	Unkown
HY-125102	AZ12253801	Inhibitor	/	Unkown
HY-50866B	NVP-AEW541 dihydrochloride		/	Unkown
HY-108230	ALK-IN-12	Inhibitor	/	Unkown
HY-118046	GSK2163632A	Inhibitor	/	Unkown
HY-15494S1	Picropodophyllin-d6		/	Unkown
HY-156914	IGF-1R/SRC-IN-1	Inhibitor	99.86%	Unkown
HY-162506	IGF-1R inhibitor-3	Inhibitor	/	Unkown
HY-167854	KW-2450 free base	Inhibitor	/	Unkown
HY-169572	IGF-1R inhibitor-5	Inhibitor	/	Unkown
HY-169600	IGF-1R inhibitor-4	Inhibitor	/	Unkown
HY-402309	IGF-1R modulator 1	Modulator	/	Unkown
HY-B0794S	AZ7550-d5	Inhibitor	/	Unkown
HY-P10044	IGF1Rtide		/	Unkown
HY-P2090	Angiopeptin		/	Unkown
HY-RS06615	IGF1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06616	Igf1r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06617	Igf1r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-100349A	cis-SU4312	Inhibitor	/	Unkown
HY-109155A	Paltusotine hydrochloride	Agonist	/	Unkown
HY-117885	PF-5177624	Inhibitor	/	Unkown
HY-119112A	LY 379196	Inhibitor	/	Unkown
HY-138257A	(R)-Indeloxazine benzenesulfonate	Inhibitor	/	Unkown
HY-14357	BMS 695735	Inhibitor	/	Unkown
HY-168616	CL-A3-7	Inhibitor	/	Unkown
HY-21291	SU-4313	Modulator	99.31%	Unkown
HY-N6611	Chimaphilin	Inhibitor	/	Unkown
HY-P3226	JB-1	Antagonist	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990084	Veligrotug	Inhibitor	99.25%	Unkown
HY-P991042	Anti-IGFBP2 Antibody (M14)	Antagonist	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igf1	NCBI	NCBI:3479
Macaca fascicularis	Igf1	NCBI	NCBI:102128018
Mus musculus	Igf1	NCBI	NCBI:16000

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