KPNB1 - karyopherin subunit beta 1 Gene

Homo sapiens

Also known as IMB1; IPO1; IPOB; Impnb; NTF97

Gene ID: 3837 | Gene type: protein coding

About KPNB1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,649,919-47,685,505 (from NCBI)

This gene has 16 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 74.8), appendix (RPKM 47.4) and 25 other tissues.

Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

KPNB1 Products(2)

mRNA	Protein	Name
NM_001276453.2	NP_001263382.1	importin subunit beta-1 isoform 2
NM_002265.6	NP_002256.2	importin subunit beta-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	22701565	GOA
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	14645851	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9405152	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11984006	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NLS-bearing protein import into nucleus	IDA IDA: Inferred from direct assay	14645851	GOA
involved in RNA import into nucleus	IDA IDA: Inferred from direct assay	9670026	GOA
involved in astral microtubule organization	IMP IMP: Inferred from mutant phenotype	23783028	GOA
involved in establishment of mitotic spindle localization	IMP IMP: Inferred from mutant phenotype	23783028	GOA
involved in mitotic chromosome movement towards spindle pole	IMP IMP: Inferred from mutant phenotype	23783028	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	23783028	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	23783028	GOA
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	15964792	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	7615630	GOA
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	17209048	GOA
involved in ribosomal protein import into nucleus	IDA IDA: Inferred from direct assay	9687515	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLS-dependent protein nuclear import complex	IPI IPI: Inferred from physical interaction	10353244	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	11891849	GOA
located in endoplasmic reticulum tubular network	IDA IDA: Inferred from direct assay	22701565	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	22701565	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	9670026	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNB1 Protein Structure

IBN_N

HEAT_EZ

0
200
400
600
800
876 a.a.

Protein Preferred Names

Protein Names

importin subunit beta-1

PTAC97

Recombinant KPNB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70837	KPNB1 Protein, Human (His)	Q14974-1 (M1-A876)	≥95%

Related Diseases

Diseases

Alias

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Campomelic Dysplasia

Acampomelic Campomelic Dysplasia	Camptomelic Dysplasia
Campomelic Dysplasia With Autosomal Sex Reversal	Cmpd
CMD1	Cmpd1
Cmpd1/Sra1	Acampomelic Campomelic Dysplasia With Autosomal Sex Reversal
Campomelic Dwarfism	Campomelic Syndrome
Dysplasia, Campomelic	Chronic Myeloproliferative Disorder
Familial Dilated Cardiomyopathy

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07422	KPNB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KPNB1	VGNC	VGNC:42506
Bos taurus	KPNB1	VGNC	VGNC:30707
Mus musculus	KPNB1	MGD	MGI:107532
Macaca mulatta	KPNB1	VGNC	VGNC:74203
Felis catus	KPNB1	VGNC	VGNC:67979
Rattus norvegicus	KPNB1	RGD	RGD:2909
Others	KPNB1	NCBI

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