2. Gene
  3. SMIM1 - small integral membrane protein 1 (Vel blood group) Gene

SMIM1 - small integral membrane protein 1 (Vel blood group) Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Vel

Gene ID: 388588 | Gene type: protein coding

About SMIM1

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:3,772,749-3,775,956 (from NCBI)

This gene has 4 transcripts (splice variants), 103 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 6.7), bone marrow (RPKM 6.0) and 14 other tissues.

Summary

This gene encodes a small, conserved protein that participates in red blood cell formation. The encoded protein is localized to the cell membrane and is the antigen for the Vel blood group. Alternative splicing results in different transcript variants that encode the same protein. [provided by RefSeq, Dec 2013]

SMIM1 Products(4)

mRNA Protein Name
NM_001163724.3 NP_001157196.1 small integral membrane protein 1
NM_001288583.2 NP_001275512.1 small integral membrane protein 1
NM_001379690.1 NP_001366619.1 small integral membrane protein 1
NM_001379691.1 NP_001366620.1 small integral membrane protein 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
23563606 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
23505126 GOA
located in cell surface IMP
IMP: Inferred from mutant phenotype
23563606 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23563606 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
26452714 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

small integral membrane protein 1

bloodgroup VEL protein

SMIM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SMIM1 B2RUZ4 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SDC3 Homo sapiens A0A0S2Z4U3
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SDC3 Homo sapiens A0A0S2Z4U3
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 RELL2 Homo sapiens Q8NC24
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 RELL2 Homo sapiens Q8NC24
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 CD74 Homo sapiens P04233-2
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 ASZ1 Homo sapiens Q8WWH4
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 ASZ1 Homo sapiens Q8WWH4
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 ASZ1 Homo sapiens Q8WWH4
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMPRSS2 Homo sapiens O15393-2
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMEM154 Homo sapiens Q6P9G4
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMEM154 Homo sapiens Q6P9G4
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 TMEM154 Homo sapiens Q6P9G4
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 MUC1 Homo sapiens P15941-11
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 GJA8 Homo sapiens P48165
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SLC18A1 Homo sapiens P54219-3
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 SLC26A11 Homo sapiens Q86WA9
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 SLC26A11 Homo sapiens Q86WA9
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SLC26A11 Homo sapiens Q86WA9
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 NDUFAF2 Homo sapiens Q8N183
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 NDUFAF2 Homo sapiens Q8N183
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 NDUFAF2 Homo sapiens Q8N183
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 STING1 Homo sapiens Q86WV6
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 STING1 Homo sapiens Q86WV6
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 STING1 Homo sapiens Q86WV6
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 SIGLEC7 Homo sapiens Q9Y286
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SIGLEC7 Homo sapiens Q9Y286
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 SIGLEC7 Homo sapiens Q9Y286
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 LRP10 Homo sapiens Q7Z4F1
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 LRP10 Homo sapiens Q7Z4F1
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 LRP10 Homo sapiens Q7Z4F1
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 FFAR2 Homo sapiens O15552
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 MFSD6 Homo sapiens Q6ZSS7
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 MFSD6 Homo sapiens Q6ZSS7
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 MFSD6 Homo sapiens Q6ZSS7
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 NAALAD2 Homo sapiens Q9Y3Q0
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 NAALAD2 Homo sapiens Q9Y3Q0
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 NAALAD2 Homo sapiens Q9Y3Q0
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 COMT Homo sapiens P21964
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 COMT Homo sapiens P21964
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 COMT Homo sapiens P21964
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 GJB5 Homo sapiens O95377
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 PVR Homo sapiens P15151
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 HACD2 Homo sapiens Q6Y1H2
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 HACD2 Homo sapiens Q6Y1H2
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 HACD2 Homo sapiens Q6Y1H2
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 BIK Homo sapiens Q13323
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 ANKS6 Homo sapiens Q68DC2
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 ANKS6 Homo sapiens Q68DC2
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 ANKS6 Homo sapiens Q68DC2
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 ICAM3 Homo sapiens P32942
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 ICAM3 Homo sapiens P32942
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 ICAM3 Homo sapiens P32942
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
Intra
SMIM1 B2RUZ4 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
SMIM1 B2RUZ4 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
SMIM1 B2RUZ4 CYB561 Homo sapiens P49447
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Blood Group, Vel System

VEL
Tungiasis

Tunga Penetrans Infestation

Chigger Flea

S Penetrans

Sarcopsylla Penetrans

T Penetrans

Tunga Penetrans

Sand-Flea Infestation

Jiggers Infestation

Chigoe Infestation

Jigger Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13436 SMIM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SMIM1 VGNC VGNC:106497
Mus musculus SMIM1 MGD MGI:1916109
Canis familiaris SMIM1 VGNC VGNC:53448
Rattus norvegicus SMIM1 RGD RGD:1564257