PCBP1 - poly(rC) binding protein 1 Gene

Homo sapiens

Also known as HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1

Gene ID: 5093 | Gene type: protein coding

About PCBP1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,087,477-70,089,203 (from NCBI)

This gene has 1 transcript (splice variant), 99 orthologues, 12 paralogues and is associated with 43 phenotypes.

Summary

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

PCBP1 Products(1)

mRNA	Protein	Name
NM_006196.4	NP_006187.2	poly(rC)-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	7556077	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	14722620	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	8152927	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in viral RNA genome replication	IDA IDA: Inferred from direct assay	12414943	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCBP1 Protein Structure

KH_1

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

poly(rC)-binding protein 1

alpha-CP1

PCBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PCBP1	Q15365	PUF60	Homo sapiens	Q9UHX1	Pull Down	16713569
Intra	PCBP1	Q15365	IGF2BP3	Homo sapiens	O00425	Y2H Prey Pooling	32296183
Intra	PCBP1	Q15365	IGF2BP3	Homo sapiens	O00425	Y2H Array	32296183
Intra	PCBP1	Q15365	RBM39	Homo sapiens	Q14498-2	Pull Down	17389360
Intra	PCBP1	Q15365	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	PCBP1	Q15365	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	PCBP1	Q15365	RBFOX2	Homo sapiens	O43251-10	Y2H Array	32296183
Intra	PCBP1	Q15365	RBFOX2	Homo sapiens	O43251-10	Y2H Prey Pooling	32296183
Intra	PCBP1	Q15365	RBPMS2	Homo sapiens	Q6ZRY4	Validated Y2H	32296183
Intra	PCBP1	Q15365	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Array	32296183
Intra	PCBP1	Q15365	RBPMS2	Homo sapiens	Q6ZRY4	Complementation	32296183
Intra	PCBP1	Q15365	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Prey Pooling	32296183
Intra	PCBP1	Q15365	PAK1	Homo sapiens	Q13153	Anti Bait CoIP	17389360
Intra	PCBP1	Q15365	PAK1	Homo sapiens	Q13153	Anti Tag CoIP	17389360
Intra	PCBP1	Q15365	PAK1	Homo sapiens	Q13153-1	Protein Kinase Assay	17389360
Intra	PCBP1	Q15365	THAP11	Homo sapiens	Q96EK4	Anti Bait CoIP	22673507
Intra	PCBP1	Q15365	THAP11	Homo sapiens	Q96EK4	IF	22673507
Intra	PCBP1	Q15365	THAP11	Homo sapiens	Q96EK4	Anti Tag CoIP	22673507
Intra	PCBP1	Q15365	RBM3	Homo sapiens	P98179	Y2H Array	32296183
Intra	PCBP1	Q15365	RBM3	Homo sapiens	P98179	Y2H Prey Pooling	32296183
Intra	PCBP1	Q15365	PTBP1	Homo sapiens	P26599	Pull Down	16713569
Intra	PCBP1	Q15365	PTBP1	Homo sapiens	P26599	Y2H Array	16713569
Intra	PCBP1	Q15365	RBM39	Homo sapiens	Q14498	Anti Bait CoIP	17389360
Intra	PCBP1	Q15365	PPIG	Homo sapiens	Q13427	Y2H	22365833
Intra	PCBP1	Q15365	PRPF8	Homo sapiens	Q6P2Q9	Y2H	22365833
Intra	PCBP1	Q15365	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	22365833
Intra	PCBP1	Q15365	SNRPA	Homo sapiens	P09012	Y2H Array	25416956
Intra	PCBP1	Q15365	SNRPA	Homo sapiens	P09012	Y2H Array	32296183
Intra	PCBP1	Q15365	SNRPA	Homo sapiens	P09012	Y2H Array	31515488
Intra	PCBP1	Q15365	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	32296183
Intra	PCBP1	Q15365	WBP11	Homo sapiens	Q9Y2W2	Pull Down	16713569
Intra	PCBP1	Q15365	WBP11	Homo sapiens	Q9Y2W2	Y2H	16713569
Intra	PCBP1	Q15365	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H	16713569
Intra	PCBP1	Q15365	TSC22D4	Homo sapiens	Q9Y3Q8	Pull Down	16713569
Intra	PCBP1	Q15365	KLF1	Homo sapiens	Q13351	Y2H Array	32296183
Intra	PCBP1	Q15365	KLF1	Homo sapiens	Q13351	Y2H Prey Pooling	32296183
Intra	PCBP1	Q15365	QKI	Homo sapiens	Q96PU8	Pull Down	16713569
Intra	PCBP1	Q15365	PCBP2	Homo sapiens	Q15366	Y2H	16713569
Intra	PCBP1	Q15365	PCBP2	Homo sapiens	Q15366	Pull Down	16713569
Cross	PCBP1	Q15365	PA	Influenza A virus	Q67020	BiFC	21994455
Cross	PCBP1	Q15365	GAMMAHV.ORF34	Murid herpesvirus 4	O41951	Pull Down	22028648
Cross	PCBP1	Q15365	GAMMAHV.ORF34	Murid herpesvirus 4	O41951	Anti Tag CoIP	22028648
Cross	PCBP1	Q15365	GAMMAHV.ORF34	Murid herpesvirus 4	O41951	IF	22028648
Cross	PCBP1	Q15365	GAMMAHV.ORF34	Murid herpesvirus 4	O41951	Y2H Array	22028648

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PCBP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74649	PCBP1 Protein, Human (His)	Q15365 (D2-C356)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 17

DFNB17	Autosomal Recessive Nonsyndromic Deafness 17
Autosomal Recessive Deafness 17

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10115	PCBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCBP1	RGD	RGD:1561319
Macaca mulatta	PCBP1	VGNC	VGNC:106194
Felis catus	PCBP1	VGNC	VGNC:81140
Mus musculus	PCBP1	MGD	MGI:1345635
Others	PCBP1	NCBI

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