App - amyloid beta precursor protein Gene

Rattus norvegicus

Also known as Abeta

Gene ID: 54226 | Gene type: protein coding

About App

Primary_assembly 11: 24,019,778-24,236,561 reverse strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 280 orthologues, 2 paralogues and is associated with 50 phenotypes. Biased expression in Kidney (RPKM 196.2), Lung (RPKM 1647.7) and 9 other tissues.

Summary

Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to metal ion; defense response to Other organism; and positive regulation of MAPK cascade. Located in several cellular components, including astrocyte projection; axon; and rough endoplasmic reticulum. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

App Products(1)

mRNA	Protein	Name
NM_019288.2	NP_062161.1	amyloid-beta precursor protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor receptor binding	IPI IPI: Inferred from physical interaction	19334058	RGD
enables peptidase activator activity	IDA IDA: Inferred from direct assay	12493564	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9461550	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	20209079	RGD
involved in antifungal humoral response	IDA IDA: Inferred from direct assay	20209079	RGD
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	20209079	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	9144253	RGD
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	18583042	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	18583042	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	10821917	RGD
involved in cellular response to norepinephrine stimulus	IMP IMP: Inferred from mutant phenotype	9144253	RGD
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	20209079	RGD
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	20209079	RGD
involved in innate immune response	IDA IDA: Inferred from direct assay	20209079	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11404397	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	11404397	RGD
involved in positive regulation of protein metabolic process	IDA IDA: Inferred from direct assay	11404397	RGD
involved in regulation of response to calcium ion	IGI IGI: Inferred from genetic interaction	11404397	RGD
involved in response to interleukin-1	IDA IDA: Inferred from direct assay	20395292	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	16230335	RGD
involved in response to yeast	IDA IDA: Inferred from direct assay	20209079	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in astrocyte projection	IDA IDA: Inferred from direct assay	8097074	RGD
located in axon	IDA IDA: Inferred from direct assay	8987743	RGD
located in cell surface	IDA IDA: Inferred from direct assay	8987743	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	14615045	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12843239	RGD
located in growth cone filopodium	IDA IDA: Inferred from direct assay	12843239	RGD
located in growth cone lamellipodium	IDA IDA: Inferred from direct assay	12843239	RGD
located in main axon	IDA IDA: Inferred from direct assay	12843239	RGD
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	29577889	RGD
NOT located in synaptic vesicle	IDA IDA: Inferred from direct assay	8987743	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

App Protein Structure

A4_EXTRA

Kunitz_ABPP-like

APP_E2

JMTM_Notch_APP

0
200
400
600
770 a.a.

Protein Preferred Names

Protein Names

amyloid-beta precursor protein

amyloid-beta A4 protein

ABPP	AG
alzheimer disease amyloid A4 protein homolog	alzheimer disease amyloid protein
amyloid A4	amyloid beta (A4) precursor protein
amyloid beta A4 protein	amyloid precursor protein
amyloidogenic glycoprotein	beta-amyloid precursor protein

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0192	Arbutin	Inhibitor	99.76%	Unkown
HY-14537	Latrepirdine dihydrochloride		99.65%	Yes
HY-14862	Latrepirdine		/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-103374	Phenserine	Inhibitor	99.55%	Phase 3
HY-10254	Mirdametinib		99.95%	Phase 2
HY-50759	Ispinesib		99.62%	Phase 2
HY-106005	MMV390048	Inhibitor	99.17%	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99185	Bapineuzumab		96.62%	Phase 3
HY-P990078	Remternetug	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (74)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103490	Takinib		98.92%	Unkown
HY-139214	IXA4	Inhibitor	98.83%	Unkown
HY-N1472	Levistolide A		99.26%	Unkown
HY-19369	L-685458		99.37%	Unkown
HY-16009	Buntanetap	Inhibitor	99.71%	Unkown
HY-12856	GSK503	Inhibitor	99.52%	Unkown
HY-135699	TD52		≥95.0%	Unkown
HY-114174	Fmoc-Ala-Glu-Asn-Lys-NH2		99.13%	Unkown
HY-124322	NB-360	Inhibitor	99.22%	Unkown
HY-108643	CMPD1	Inhibitor	99.86%	Unkown
HY-129096	IDT307		99.76%	Unkown
HY-123960A	Raphin1 acetate	Inhibitor	99.93%	Unkown
HY-124832	δ-Secretase inhibitor 11	Inhibitor	99.06%	Unkown
HY-18010	PCI 29732	Inhibitor	99.86%	Unkown
HY-123960	Raphin1	Inhibitor	99.75%	Unkown
HY-12989	LDN-91946	Inhibitor	98.70%	Unkown
HY-15294	CZC24832	Inhibitor	99.07%	Unkown
HY-18292	ARN2966	Inhibitor	99.87%	Unkown
HY-136499	DI-82		98.76%	Unkown
HY-50883	BMS 299897	Inhibitor	99.64%	Unkown
HY-153986	AEP-IN-2		99.13%	Unkown
HY-126242S	Tyk2-IN-7	Inhibitor	99.62%	Unkown
HY-120597	SAK3	Activator	99.44%	Unkown
HY-50882	ELN318463	Inhibitor	99.45%	Unkown
HY-135699A	TD52 dihydrochloride		99.90%	Unkown
HY-139973	OAB-14		98.72%	Unkown
HY-145286	IMPDH2-IN-2		99.73%	Unkown
HY-161110	APP degrader-1	Degrader	98.35%	Unkown
HY-117924	AUTEN-67	Inducer	≥92.0%	Unkown
HY-19918A	Anatabine dicitrate		99.03%	Unkown
HY-16009B	Buntanetap L-Tartrate		98.93%	Unkown
HY-131068	BACE-1 inhibitor 2	Inhibitor	/	Unkown
HY-128585	GNE684	Inhibitor	/	Unkown
HY-P2551	Biotin-β-Amyloid (17-40)		/	Unkown
HY-103374A	Phenserine tartrate	Inhibitor	/	Unkown
HY-103538	JLK-6	Inhibitor	/	Unkown
HY-105940	IQB-782		/	Unkown
HY-107164	Thiomarinol A	Inhibitor	/	Unkown
HY-108966	Kushenol C	Inhibitor	/	Unkown
HY-118243	KMS88009	Inhibitor	/	Unkown
HY-118245	APP-FUBINACA	Agonist	/	Unkown
HY-126047B	(R)-(+)-Anatabine		/	Unkown
HY-128464	LL320		/	Unkown
HY-135618	DHODH-IN-3	Inhibitor	/	Unkown
HY-136733	Ac-DNLD-CHO	Inhibitor	/	Unkown
HY-144739	BACE1-IN-8	Inhibitor	/	Unkown
HY-144741	BACE1-IN-9	Inhibitor	/	Unkown
HY-147672	IleRS-IN-1	Inhibitor	/	Unkown
HY-147674	Isoleucyl tRNA synthetase-IN-2	Inhibitor	/	Unkown
HY-149396	FXIIa-IN-1	Inhibitor	/	Unkown
HY-161109	Aβ42-IN-4		/	Unkown
HY-161953	O-GlcNAcase-IN-2	Inhibitor	/	Unkown
HY-168241	Flucopride		/	Unkown
HY-N12249	7-Deoxy-trans-dihydronarciclasine	Inhibitor	/	Unkown
HY-P10163	α-Secretase Substrate II, Fluorogenic		/	Unkown
HY-P10180	β-Amyloid/A4 Protein Precusor (319-335)		/	Unkown
HY-P10247	Amyloid precursor C-terminal peptide		/	Unkown
HY-P10487	APP669-711		/	Unkown
HY-P1378	β-Amyloid (1-43)(human)		/	Unkown
HY-P1378A	β-Amyloid (1-43)(human) TFA		/	Unkown
HY-P1729	M-2420		/	Unkown
HY-P1894	β-Amyloid Protein Precursor 770 (135-155)		/	Unkown
HY-P3779	Amyloid 17-42	Inducer	/	Unkown
HY-P4553	H-Met-Pro-OH		/	Unkown
HY-P4919	Mca-SEVNLDAEFK(Dnp)		/	Unkown
HY-P6365B	APP-018		/	Unkown
HY-RS00863	APP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00864	App Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00865	App Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-128090	Apstatin	Inhibitor	/	Unkown
HY-149397	FXIIa-IN-2	Inhibitor	/	Unkown
HY-19846	VRX-03011		/	Unkown
HY-50882A	ELN318463 racemate	Inhibitor	/	Unkown
HY-P4885	Glp-amyloid-β (3-40) peptide (human)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	App	NCBI	NCBI:351
Mus musculus	App	NCBI	NCBI:11820

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