Cdk1 - cyclin-dependent kinase 1 Gene

Rattus norvegicus

Also known as Cdc2; Cdc2a

Gene ID: 54237 | Gene type: protein coding

About Cdk1

Biased expression in Thymus (RPKM 28.3), Spleen (RPKM 193.1) and 8 other tissues.

Summary

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone kinase activity. Involved in several processes, including Golgi disassembly; positive regulation of protein import into nucleus; and ventricular cardiac muscle cell development. Acts upstream of or within negative regulation of gene expression. Located in cytoplasm and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder Cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk1 Products(1)

mRNA	Protein	Name
NM_019296.2	NP_062169.1	cyclin-dependent kinase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclin binding	IPI IPI: Inferred from physical interaction	15696186	RGD
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9753325	RGD
enables histone kinase activity	IDA IDA: Inferred from direct assay	19821535	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9753325	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi disassembly	IDA IDA: Inferred from direct assay	9753325	RGD
involved in animal organ regeneration	IMP IMP: Inferred from mutant phenotype	15696186	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16179908	RGD
involved in cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	15695611	RGD
involved in chromosome condensation	IMP IMP: Inferred from mutant phenotype	15695611	RGD
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28350193	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	9753325	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	19821535	RGD
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15253691	RGD
acts upstream of positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28350193	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18356527	RGD
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15696186	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	18356527	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	19136513	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	16826023	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	16155410	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	17200138	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	16730872	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	19497425	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	18181150	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16963227	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16427046	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	19237604	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16427046	RGD
involved in ventricular cardiac muscle cell development	IEP IEP: Inferred from expression pattern	15253691	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk1 Protein Structure

STKc_CDK1_euk

0
100
200
297 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 1

Cell division cycle control protein 2	cell division control protein 2 homolog
cell division cycle 2 homolog A	cell division cycle 2, G1 to S and G2 to M
cell division protein kinase 1	p34 protein kinase

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-10492	Dinaciclib	Inhibitor	99.64%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes
HY-B0263	Thiabendazole	Inhibitor	99.77%	Unkown

Clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10580	GSK 3 Inhibitor IX	Inhibitor	99.74%	Phase 4
HY-112272	Lerociclib	Inhibitor	98.35%	Phase 3
HY-10005	Flavopiridol	Inhibitor	99.73%	Phase 2
HY-30237	(R)-Roscovitine	Inhibitor	99.53%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-50940	AT7519	Inhibitor	99.76%	Phase 2
HY-10006	Flavopiridol Hydrochloride	Inhibitor	99.73%	Phase 2
HY-10424	Milciclib	Inhibitor	99.90%	Phase 2
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.11%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.08%	Phase 2
HY-137432	Avotaciclib	Inhibitor	99.72%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.42%	Phase 2
HY-137432A	Avotaciclib trihydrochloride	Inhibitor	99.75%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	98.53%	Phase 2
HY-103712	Samuraciclib	Inhibitor	/	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-10008	SNS-032	Inhibitor	99.54%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.80%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-12422	Voruciclib	Inhibitor	99.77%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1
HY-12422A	Voruciclib hydrochloride	Inhibitor	99.23%	Phase 1

Pre-clinical Phase

Bioactive Molecules (91)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12529	Ro-3306	Inhibitor	99.83%	Unkown
HY-12302	Kenpaullone	Inhibitor	98.20%	Unkown
HY-124719	hSMG-1 inhibitor 11j	Inhibitor	99.82%	Unkown
HY-10329	JNJ-7706621	Inhibitor	99.91%	Unkown
HY-15339	CVT-313	Inhibitor	99.90%	Unkown
HY-15154	NG 52	Inhibitor	99.88%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.61%	Unkown
HY-11009	CGP60474	Inhibitor	99.23%	Unkown
HY-124760	hSMG-1 inhibitor 11e	Inhibitor	99.81%	Unkown
HY-N0417	Cucurbitacin E	Inhibitor	99.92%	Unkown
HY-10032	PF 477736	Inhibitor	99.21%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	99.49%	Unkown
HY-13914	Roniciclib	Inhibitor	98.09%	Unkown
HY-15275	BMS-265246	Inhibitor	98.92%	Unkown
HY-15878	LDC000067	Inhibitor	99.00%	Unkown
HY-18299A	Purvalanol A	Inhibitor	98.30%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-117535	CDK2-IN-4	Inhibitor	96.71%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	98.95%	Unkown
HY-18629	SU9516	Inhibitor	99.81%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.80%	Unkown
HY-18299	Purvalanol B	Inhibitor	≥97.0%	Unkown
HY-129478	TC11	Activator	99.55%	Unkown
HY-X0150	JSH-150	Inhibitor	98.66%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-16559	Riviciclib hydrochloride		98.89%	Unkown
HY-108359	Alsterpaullone	Inhibitor	99.85%	Unkown
HY-15569	NU6102	Inhibitor	99.23%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-15889	AMG 925	Inhibitor	98.20%	Unkown
HY-107419	NU6140	Inhibitor	99.07%	Unkown
HY-103647	K00546	Inhibitor	98.08%	Unkown
HY-103221	MeBIO	Inhibitor	≥98.0%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.81%	Unkown
HY-139980	CDK9-IN-13	Inhibitor	99.94%	Unkown
HY-112463	CDK1-IN-2	Inhibitor	97.17%	Unkown
HY-19316	NU2058	Inhibitor	99.66%	Unkown
HY-N5072	Desmethylglycitein	Inhibitor	98.98%	Unkown
HY-111237	Butyrolactone I	Inhibitor	98.03%	Unkown
HY-100429	CAN508	Inhibitor	99.59%	Unkown
HY-153556	GW297361	Inhibitor	98.13%	Unkown
HY-13816	NU6027	Inhibitor	99.04%	Unkown
HY-115924	CDK1-IN-1	Inhibitor	99.33%	Unkown
HY-112462	Cdk1/2 Inhibitor III	Inhibitor	99.69%	Unkown
HY-111930	5-Iodo-indirubin-3'-monoxime	Inhibitor	99.50%	Unkown
HY-N12625	(R)-(+)-O-Demethylbuchenavianine	Inhibitor	98.67%	Unkown
HY-103383	(R)-DRF053 dihydrochloride	Inhibitor	99.30%	Unkown
HY-14372	BS-194	Inhibitor	99.36%	Unkown
HY-112346	RGB-286147	Inhibitor	98.60%	Unkown
HY-103381	NSC693868	Inhibitor	≥99.0%	Unkown
HY-168673	CDK1-IN-6	Inhibitor	/	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-13461	PHA-767491	Inhibitor	99.85%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	Unkown
HY-114903	(E/Z)-BIO-acetoxime	Inhibitor	/	Unkown
HY-147646	CDK1/Cyc B-IN-1	Inhibitor	98.47%	Unkown
HY-15889A	AMG 925 (HCl)	Inhibitor	/	Unkown
HY-151409	CDK1-IN-5	Inhibitor	/	Unkown
HY-151407	CDK1-IN-3	Inhibitor	/	Unkown
HY-126244	CDK4/6-IN-3	Inhibitor	/	Unkown
HY-151408	CDK1-IN-4	Inhibitor	/	Unkown
HY-170965	Anticancer agent 264	Inhibitor	/	Unkown
HY-111932	Indirubin-5-sulfonate	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-155787	SHR5428	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-112363	Aloisine A	Inhibitor	/	Unkown
HY-161826	Antitumor agent-174	Inhibitor	/	Unkown
HY-151071	TMX-3013	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-151069	TMX-2039	Inhibitor	/	Unkown
HY-123369	BMI-1026	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-112336	Aloisine RP106	Inhibitor	/	Unkown
HY-170306	LZ9	Inhibitor	/	Unkown
HY-115942	Anticancer agent 29	Inhibitor	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-147901	KDM1/CDK1-IN-1	Inhibitor	/	Unkown
HY-146253	CDK1/2/4-IN-1	Inhibitor	/	Unkown
HY-111931	Indirubin-3'-monoxime-5-sulphonic acid	Inhibitor	/	Unkown
HY-170651	CDK4/6/HDAC-IN-1	Inhibitor	/	Unkown
HY-164906	TMX-2138	Degrader	/	Unkown
HY-141685	3-Methylthienyl-carbonyl-JNJ-7706621	Inhibitor	/	Unkown
HY-112450	Olomoucine II	Inhibitor	/	Unkown
HY-123045	PNU-292137	Inhibitor	/	Unkown
HY-112394	2-Cyanoethylalsterpaullone	Inhibitor	/	Unkown
HY-160643	CDK2-IN-27	Inhibitor	/	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk1	NCBI	NCBI:983
Mus musculus	Cdk1	NCBI	NCBI:12534

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