PRKAA1 - protein kinase AMP-activated catalytic subunit alpha 1 Gene

Homo sapiens

Also known as AMPK; AMPKa1; AMPK alpha 1

Gene ID: 5562 | Gene type: protein coding

About PRKAA1

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,759,389-40,798,374 (from NCBI)

This gene has 9 transcripts (splice variants), 229 orthologues and 17 paralogues. Ubiquitous expression in gall bladder (RPKM 18.4), thyroid (RPKM 16.3) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic Enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PRKAA1 Products(8)

mRNA	Protein	Name
NM_001355028.2	NP_001341957.1	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 3
NM_001355029.2	NP_001341958.1	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 4
NM_001355034.2	NP_001341963.1	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 5
NM_001355035.2	NP_001341964.1	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_001355036.2	NP_001341965.1	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_001355037.2	NP_001341966.1	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_006251.6	NP_006242.5	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1
NM_206907.4	NP_996790.3	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AMP-activated protein kinase activity	IDA IDA: Inferred from direct assay	14651849	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16306228	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	17028174	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18439900	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CAMKK-AMPK signaling cascade	IMP IMP: Inferred from mutant phenotype	26103054	GOA
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	14651849	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	25412657	GOA
involved in cellular response to stress	IDA IDA: Inferred from direct assay	37079666	GOA
acts upstream of positive effect lipid droplet disassembly	IDA IDA: Inferred from direct assay	34077757	GOA
involved in motor behavior	IGI IGI: Inferred from genetic interaction	21768291	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	14651849	GOA
involved in negative regulation of hepatocyte apoptotic process	IDA IDA: Inferred from direct assay	32029622	GOA
involved in neuron cellular homeostasis	IGI IGI: Inferred from genetic interaction	21768291	GOA
involved in positive regulation of T cell activation	IDA IDA: Inferred from direct assay	38377992	GOA
involved in positive regulation of T cell mediated immune response to tumor cell	IDA IDA: Inferred from direct assay	38377992	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	22012985	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	26103054	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	17028174	GOA
involved in protein localization to lipid droplet	IDA IDA: Inferred from direct assay	34077757	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17028174	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	18381428	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21768291	GOA
part of nucleotide-activated protein kinase complex	IPI IPI: Inferred from physical interaction	25412657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAA1 Protein Structure

Pkinase

0
100
200
300
400
500
559 a.a.

Protein Preferred Names

Protein Names

5'-AMP-activated protein kinase catalytic subunit alpha-1

5'-AMP-activated protein kinase, catalytic alpha-1 chain

Recombinant PRKAA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76141	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&Q9Y478 (M1-I270)&Q13131 (M1-Q559)	≥95%
HY-P76143	AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&O43741 (M1-I272)&Q13131 (M1-Q559)	≥95%

Related Diseases

Diseases

Alias

Wolff-Parkinson-White Syndrome

Wolff-Parkinson-White Pattern	Wpw Syndrome
Anomalous Atrioventricular Excitation	Anomalous A-V Excitation
Ventricular Pre-Excitation With Arrhythmia	WPWS
Ventricular Familial Preexcitation Syndrome	Preexcitation Syndrome
Ventricular Preexcitation	Wpw - [Wolff-Parkinson- White] Syndrome
Pre-Excitation Syndrome

Myotonia

Cardia Cancer

Ca Cardia - Stomach

Malignant Neoplasm Of Cardia Of Stomach

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148065	FMF-06-098-1		/	Unkown
HY-RS11100	PRKAA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKAA1	MGD	MGI:2145955
Macaca mulatta	PRKAA1	VGNC	VGNC:76399
Rattus norvegicus	PRKAA1	RGD	RGD:3387
Felis catus	PRKAA1	VGNC	VGNC:69045
Bos taurus	PRKAA1	VGNC	VGNC:50248
Canis familiaris	PRKAA1	VGNC	VGNC:51914

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