2. Gene
  3. PRKAA1 - protein kinase AMP-activated catalytic subunit alpha 1 Gene

PRKAA1 - protein kinase AMP-activated catalytic subunit alpha 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AMPK; AMPKa1; AMPK alpha 1

Gene ID: 5562 | Gene type: protein coding

About PRKAA1

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,759,389-40,798,374 (from NCBI)

This gene has 9 transcripts (splice variants), 229 orthologues and 17 paralogues. Ubiquitous expression in gall bladder (RPKM 18.4), thyroid (RPKM 16.3) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic Enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PRKAA1 Products(8)

mRNA Protein Name
NM_001355028.2 NP_001341957.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 3
NM_001355029.2 NP_001341958.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 4
NM_001355034.2 NP_001341963.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 5
NM_001355035.2 NP_001341964.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_001355036.2 NP_001341965.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_001355037.2 NP_001341966.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_006251.6 NP_006242.5 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1
NM_206907.4 NP_996790.3 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables AMP-activated protein kinase activity IDA
IDA: Inferred from direct assay
14651849 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16306228 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
17028174 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18439900 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CAMKK-AMPK signaling cascade IMP
IMP: Inferred from mutant phenotype
26103054 GOA
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
14651849 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
25412657 GOA
involved in cellular response to stress IDA
IDA: Inferred from direct assay
37079666 GOA
acts upstream of positive effect lipid droplet disassembly IDA
IDA: Inferred from direct assay
34077757 GOA
involved in motor behavior IGI
IGI: Inferred from genetic interaction
21768291 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
14651849 GOA
involved in negative regulation of hepatocyte apoptotic process IDA
IDA: Inferred from direct assay
32029622 GOA
involved in neuron cellular homeostasis IGI
IGI: Inferred from genetic interaction
21768291 GOA
involved in positive regulation of T cell activation IDA
IDA: Inferred from direct assay
38377992 GOA
involved in positive regulation of T cell mediated immune response to tumor cell IDA
IDA: Inferred from direct assay
38377992 GOA
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
22012985 GOA
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
26103054 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
17028174 GOA
involved in protein localization to lipid droplet IDA
IDA: Inferred from direct assay
34077757 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17028174 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
18381428 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21768291 GOA
part of nucleotide-activated protein kinase complex IPI
IPI: Inferred from physical interaction
25412657 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAA1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (28 - 279)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

5'-AMP-activated protein kinase catalytic subunit alpha-1

5'-AMP-activated protein kinase, catalytic alpha-1 chain

PRKAA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PRKAA1 Q13131 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
Intra
PRKAA1 Q13131 PNMA5 Homo sapiens Q96PV4
Y2H Array
31515488
Intra
PRKAA1 Q13131 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
PRKAA1 Q13131 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
PRKAA1 Q13131 CDX4 Homo sapiens O14627
Validated Y2H
25416956
Intra
PRKAA1 Q13131 CDX4 Homo sapiens O14627
Y2H Array
25416956
Intra
PRKAA1 Q13131 CDX4 Homo sapiens O14627
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 RIMBP3 Homo sapiens Q9UFD9
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
25416956
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Y2H Array
25416956
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Anti Tag CoIP
20562859
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
TAP
16306228
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Anti Tag CoIP
25852190
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
TAP
23455922
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Anti Bait CoIP
22363791
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Y2H Array
21988832
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Pull Down
32707033
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Anti Tag CoIP
35271311
Intra
PRKAA1 Q13131 FSBP Homo sapiens O95073
Y2H Array
25416956
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
TAP
23455922
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Y2H Array
25416956
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
TAP
16306228
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
25852190
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
33961781
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Bait CoIP
22363791
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Pull Down
32707033
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
35271311
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Y2H Array
31515488
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
20562859
Intra
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Validated Y2H
25416956
Intra
PRKAA1 Q13131 ROPN1 Homo sapiens Q9HAT0
Y2H Array
31515488
Intra
PRKAA1 Q13131 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
25416956
Intra
PRKAA1 Q13131 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
Intra
PRKAA1 Q13131 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra
PRKAA1 Q13131 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
Intra
PRKAA1 Q13131 HMBOX1 Homo sapiens Q6NT76
Y2H Array
25416956
Intra
PRKAA1 Q13131 L3MBTL3 Homo sapiens Q96JM7
Validated Y2H
25416956
Intra
PRKAA1 Q13131 L3MBTL3 Homo sapiens Q96JM7
Y2H Array
25416956
Intra
PRKAA1 Q13131 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra
PRKAA1 Q13131 HSP90AB1 Homo sapiens P08238
TAP
23455922
Intra
PRKAA1 Q13131 VPS37B Homo sapiens Q9H9H4
Y2H Array
25416956
Intra
PRKAA1 Q13131 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
PRKAA1 Q13131 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
PRKAA1 Q13131 BHLHE40 Homo sapiens O14503
Validated Y2H
25416956
Intra
PRKAA1 Q13131 BHLHE40 Homo sapiens O14503
Y2H Array
25416956
Intra
PRKAA1 Q13131 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra
PRKAA1 Q13131 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
TAP
23455922
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
18480843
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
TAP
16306228
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Bait CoIP
22363791
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Pull Down
32707033
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
35271311
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
20562859
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
33961781
Intra
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
25852190
Intra
PRKAA1 Q13131 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
25416956
Intra
PRKAA1 Q13131 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
25416956
Intra
PRKAA1 Q13131 ZBED1 Homo sapiens O96006
Y2H Array
25416956
Intra
PRKAA1 Q13131 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra
PRKAA1 Q13131 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 ABI2 Homo sapiens Q9NYB9
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
Intra
PRKAA1 Q13131 ABI2 Homo sapiens Q9NYB9
Y2H Array
25416956
Intra
PRKAA1 Q13131 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra
PRKAA1 Q13131 UBXN11 Homo sapiens Q5T124
Validated Y2H
25416956
Intra
PRKAA1 Q13131 RFX6 Homo sapiens Q8HWS3
Y2H Prey Pooling
25416956
Intra
PRKAA1 Q13131 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
PRKAA1 Q13131 INO80E Homo sapiens Q8NBZ0
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKAA1 Proteins

Cat. No. Product Name Accession Purity
HY-P76141 AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&Q9Y478 (M1-I270)&Q13131 (M1-Q559) ≥95%
HY-P76143 AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&O43741 (M1-I272)&Q13131 (M1-Q559) ≥95%

Related Diseases

Diseases Alias
Wolff-Parkinson-White Syndrome

Wolff-Parkinson-White Pattern

Wpw Syndrome

Anomalous Atrioventricular Excitation

Anomalous A-V Excitation

Ventricular Pre-Excitation With Arrhythmia

WPWS

Ventricular Familial Preexcitation Syndrome

Preexcitation Syndrome

Ventricular Preexcitation

Wpw - [Wolff-Parkinson- White] Syndrome

Pre-Excitation Syndrome
Myotonia
Cardia Cancer

Ca Cardia - Stomach

Malignant Neoplasm Of Cardia Of Stomach
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diabetes Mellitus

Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148065 FMF-06-098-1 / Unkown
HY-RS11100 PRKAA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRKAA1 MGD MGI:2145955
Macaca mulatta PRKAA1 VGNC VGNC:76399
Rattus norvegicus PRKAA1 RGD RGD:3387
Felis catus PRKAA1 VGNC VGNC:69045
Bos taurus PRKAA1 VGNC VGNC:50248
Canis familiaris PRKAA1 VGNC VGNC:51914