1. Gene
  2. PSMA3 - proteasome 20S subunit alpha 3 Gene

PSMA3 - proteasome 20S subunit alpha 3 Gene

Homo sapiens

Also known as HC8; PSC3

Gene ID: 5684 | Gene type: protein coding

About PSMA3

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:58,244,843-58,272,004 (from NCBI)

This gene has 13 transcripts (splice variants), 245 orthologues and 18 paralogues. Ubiquitous expression in appendix (RPKM 46.2), lymph node (RPKM 44.1) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PSMA3 Products(2)

mRNA Protein Name
NM_002788.4 NP_002779.1 proteasome subunit alpha type-3 isoform 1
NM_152132.3 NP_687033.1 proteasome subunit alpha type-3 isoform 2

PSMA3 Protein Structure

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (8 - 30)

Proteasome

Proteasome: Proteasome subunit (31 - 217)

  • 0
  • 100
  • 200
  • 255 a.a.
Protein Preferred Names Protein Names

proteasome subunit alpha type-3

macropain subunit C8

PSMA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PSMA3 P25788 LINC02913 Homo sapiens Q8NAJ2 25416956
Intra
PSMA3 P25788 LINC02913 Homo sapiens Q8NAJ2 25416956
Intra
PSMA3 P25788 b2r550_human Homo sapiens B2R550 25416956
Intra
PSMA3 P25788 b2r550_human Homo sapiens B2R550 25416956
Intra
PSMA3 P25788 b2r550_human Homo sapiens B2R550 25416956
Intra
PSMA3 P25788 C1orf105 Homo sapiens O95561 25416956
Intra
PSMA3 P25788 C1orf105 Homo sapiens O95561 25416956
Intra
PSMA3 P25788 PRR10 Homo sapiens Q14CW7 25416956
Intra
PSMA3 P25788 PRR10 Homo sapiens Q14CW7 25416956
Intra
PSMA3 P25788 PRR10 Homo sapiens Q14CW7 25416956
Intra
PSMA3 P25788 PCOTH Homo sapiens Q58A44 25416956
Intra
PSMA3 P25788 q5jpt6_human Homo sapiens Q5JPT6 25416956
Intra
PSMA3 P25788 q5jpt6_human Homo sapiens Q5JPT6 25416956
Intra
PSMA3 P25788 q5jpt6_human Homo sapiens Q5JPT6 25416956
Intra
PSMA3 P25788 SNRPC Homo sapiens Q5TAL4 25416956
Intra
PSMA3 P25788 SNRPC Homo sapiens Q5TAL4 25416956
Intra
PSMA3 P25788 SNRPC Homo sapiens Q5TAL4 25416956
Intra
PSMA3 P25788 yt011_human Homo sapiens Q5W150 25416956
Intra
PSMA3 P25788 yt011_human Homo sapiens Q5W150 25416956
Intra
PSMA3 P25788 RUSC1-AS1 Homo sapiens Q66K80 25416956
Intra
PSMA3 P25788 RUSC1-AS1 Homo sapiens Q66K80 25416956
Intra
PSMA3 P25788 PWWP2B Homo sapiens Q6NUJ5 25416956
Intra
PSMA3 P25788 PWWP2B Homo sapiens Q6NUJ5 25416956
Intra
PSMA3 P25788 KIRREL2 Homo sapiens Q6UWL6 25416956
Intra
PSMA3 P25788 SLC22A23 Homo sapiens Q7L9D0 25416956
Intra
PSMA3 P25788 FAM171A2 Homo sapiens Q8N0U1 25416956
Intra
PSMA3 P25788 FAM171A2 Homo sapiens Q8N0U1 25416956
Intra
PSMA3 P25788 q8n779_human Homo sapiens Q8N779 25416956
Intra
PSMA3 P25788 q8n779_human Homo sapiens Q8N779 25416956
Intra
PSMA3 P25788 KIRREL3-AS3 Homo sapiens Q8N7Y1 25416956
Intra
PSMA3 P25788 KIRREL3-AS3 Homo sapiens Q8N7Y1 25416956
Intra
PSMA3 P25788 SLAIN1 Homo sapiens Q8ND83 25416956
Intra
PSMA3 P25788 SLAIN1 Homo sapiens Q8ND83 25416956
Intra
PSMA3 P25788 URB1-AS1 Homo sapiens Q96HZ7 25416956
Intra
PSMA3 P25788 URB1-AS1 Homo sapiens Q96HZ7 25416956
Intra
PSMA3 P25788 FAM218A Homo sapiens Q96MZ4 25416956
Intra
PSMA3 P25788 q9h8e5_human Homo sapiens Q9H8E5 25416956
Intra
PSMA3 P25788 q9h8e5_human Homo sapiens Q9H8E5 25416956
Intra
PSMA3 P25788 q9nwl9_human Homo sapiens Q9NWL9 25416956
Intra
PSMA3 P25788 q9nwl9_human Homo sapiens Q9NWL9 25416956
Intra
PSMA3 P25788 KRTAP19-5 Homo sapiens Q3LI72 25416956
Intra
PSMA3 P25788 KRTAP19-5 Homo sapiens Q3LI72 25416956
Intra
PSMA3 P25788 MIA2 Homo sapiens Q96PC5 25416956
Intra
PSMA3 P25788 LETM1 Homo sapiens O95202 25416956
Intra
PSMA3 P25788 FAM83A Homo sapiens Q86UY5 32296183
Intra
PSMA3 P25788 VPS37C Homo sapiens A5D8V6 25416956
Intra
PSMA3 P25788 PATL1 Homo sapiens Q86TB9 25416956
Intra
PSMA3 P25788 STX6 Homo sapiens O43752 25416956
Intra
PSMA3 P25788 STX6 Homo sapiens O43752 25416956
Intra
PSMA3 P25788 PRR3 Homo sapiens P79522 25416956
Intra
PSMA3 P25788 PRR3 Homo sapiens P79522 25416956
Intra
PSMA3 P25788 GATA2 Homo sapiens P23769 31515488
Intra
PSMA3 P25788 GATA2 Homo sapiens P23769 25416956
Intra
PSMA3 P25788 GATA2 Homo sapiens P23769 25416956
Intra
PSMA3 P25788 DGLUCY Homo sapiens Q7Z3D6 25416956
Intra
PSMA3 P25788 DGLUCY Homo sapiens Q7Z3D6 25416956
Intra
PSMA3 P25788 ZNF366 Homo sapiens Q8N895 25416956
Intra
PSMA3 P25788 ZNF366 Homo sapiens Q8N895 25416956
Intra
PSMA3 P25788 ZNF366 Homo sapiens Q8N895 29892012
Intra
PSMA3 P25788 ZNF366 Homo sapiens Q8N895 31515488
Intra
PSMA3 P25788 ZNF366 Homo sapiens Q8N895 25416956
Intra
PSMA3 P25788 PML Homo sapiens P29590
Y2H
21988832
Intra
PSMA3 P25788 PSMA6 Homo sapiens P60900 25416956
Intra
PSMA3 P25788 PSMA6 Homo sapiens P60900 16169070
Intra
PSMA3 P25788 PSMA6 Homo sapiens P60900 32296183
Intra
PSMA3 P25788 PSMA6 Homo sapiens P60900 25416956
Intra
PSMA3 P25788 PSMA4 Homo sapiens P25789
Y2H
14733938
Intra
PSMA3 P25788 PSMA1 Homo sapiens P25786 25416956
Intra
PSMA3 P25788 PSMA1 Homo sapiens P25786
Y2H
21988832
Intra
PSMA3 P25788 SNRPB Homo sapiens P14678-2 25416956
Intra
PSMA3 P25788 SNRPB Homo sapiens P14678-2 25416956
Intra
PSMA3 P25788 MDM2 Homo sapiens Q00987 22659184
Intra
PSMA3 P25788 KRTAP26-1 Homo sapiens Q6PEX3 25416956
Intra
PSMA3 P25788 KRTAP26-1 Homo sapiens Q6PEX3 25416956
Intra
PSMA3 P25788 KRTAP26-1 Homo sapiens Q6PEX3 25416956
Intra
PSMA3 P25788 OSR2 Homo sapiens Q8N2R0 25416956
Intra
PSMA3 P25788 PSMA2 Homo sapiens P25787
Y2H
14733938
Intra
PSMA3 P25788 PSMA2 Homo sapiens P25787 35271311
Intra
PSMA3 P25788 PSMA7 Homo sapiens O14818 15225636
Intra
PSMA3 P25788 PSMA7 Homo sapiens O14818
Y2H
21988832
Intra
PSMA3 P25788 PSMB4 Homo sapiens P28070 25416956
Intra
PSMA3 P25788 GATA3 Homo sapiens P23771 25416956
Intra
PSMA3 P25788 ATP6V0C Homo sapiens P27449 25416956
Intra
PSMA3 P25788 PTPN23 Homo sapiens Q9H3S7 25416956
Intra
PSMA3 P25788 PTPN23 Homo sapiens Q9H3S7 25416956
Intra
PSMA3 P25788 GORASP2 Homo sapiens Q9H8Y8 25416956
Intra
PSMA3 P25788 GORASP2 Homo sapiens Q9H8Y8 25416956
Intra
PSMA3 P25788 PRR13 Homo sapiens Q9NZ81 25416956
Intra
PSMA3 P25788 LASP1 Homo sapiens Q14847 25416956
Intra
PSMA3 P25788 LASP1 Homo sapiens Q14847 25416956
Intra
PSMA3 P25788 RAMAC Homo sapiens Q9BTL3 25416956
Intra
PSMA3 P25788 FBXL18 Homo sapiens Q96D16 25416956
Intra
PSMA3 P25788 FBXL18 Homo sapiens Q96D16 25416956
Intra
PSMA3 P25788 SF1 Homo sapiens Q15637 25416956
Intra
PSMA3 P25788 STX4 Homo sapiens Q12846 25416956
Intra
PSMA3 P25788 RBFOX2 Homo sapiens O43251 25416956
Intra
PSMA3 P25788 RBFOX2 Homo sapiens O43251 25416956
Intra
PSMA3 P25788 RBM42 Homo sapiens Q9BTD8 25416956
Intra
PSMA3 P25788 RBM42 Homo sapiens Q9BTD8 25416956
Intra
PSMA3 P25788 NPPB Homo sapiens P16860 25416956
Intra
PSMA3 P25788 NPPB Homo sapiens P16860 25416956
Intra
PSMA3 P25788 C4orf42 Homo sapiens Q96CW7 25416956
Intra
PSMA3 P25788 CCL28 Homo sapiens Q9NRJ3 25416956
Intra
PSMA3 P25788 SPATA8 Homo sapiens Q6RVD6 25416956
Intra
PSMA3 P25788 BTN2A2 Homo sapiens Q8WVV5 25416956
Intra
PSMA3 P25788 ZNF385C Homo sapiens Q66K41 25416956
Intra
PSMA3 P25788 CST2 Homo sapiens P09228 25416956
Intra
PSMA3 P25788 DMC1 Homo sapiens Q14565 25416956
Intra
PSMA3 P25788 DMC1 Homo sapiens Q14565 25416956
Intra
PSMA3 P25788 DMC1 Homo sapiens Q14565 31515488
Intra
PSMA3 P25788 RAD54L2 Homo sapiens Q9Y4B4 25416956
Intra
PSMA3 P25788 DMRT3 Homo sapiens Q9NQL9 25416956
Intra
PSMA3 P25788 DMRT3 Homo sapiens Q9NQL9 25416956
Intra
PSMA3 P25788 CRB3 Homo sapiens Q9BUF7 25416956
Intra
PSMA3 P25788 CRB3 Homo sapiens Q9BUF7 25416956
Intra
PSMA3 P25788 CRB3 Homo sapiens Q9BUF7 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PSMA3 Proteins

Cat. No. Product Name Accession Purity
HY-P75988 PSMA3 Protein, Human (His) P25788-1 (M1-M255) ≥95%

PSMA3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82641 PSMA3 Antibody (YA2386) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Familial Cold Autoinflammatory Syndrome 4

FCAS4

Nlrc4-Related Familial Cold Autoinflammatory Syndrome

Nlrc4-Related Familial Cold Urticaria

Autoinflammatory, Cold, Familial, Syndrome, Type 4

Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor

Nonanaplastic Renal Wilm'S Tumour

Nonanaplastic Renal Wilms Tumor

Renal Wilms' Tumour

Atrophoderma Vermiculata

Atrophoderma Vermiculatum

Folliculitis Ulerythematosa Reticulata

Atrophodermia Vermiculata

Honeycomb Atrophy

Atrophodermia Reticulata Symmetrica Faciei

AVA

Atrophodermia Reticulata

Folliculitis Ulerythematosa

Folliculitis Ulerythematosa Reticulate

Burnett Schwartz Berberian Syndrome

Basal Ganglia Calcification

Fahr'S Syndrome

Fahr'S Disease

Fahr Disease

Basal Ganglia Disease

Basal Ganglia Diseases

Basal Ganglia Disorders

Abnormality Of The Basal Ganglia

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PSMA3 RGD RGD:61844
Mus musculus PSMA3 MGD MGI:104883
Canis familiaris PSMA3 VGNC VGNC:45090
Felis catus PSMA3 VGNC VGNC:69106
Bos taurus PSMA3 VGNC VGNC:33438
Others PSMA3 NCBI