S100P - S100 calcium binding protein P Gene

Homo sapiens

Also known as MIG9

Gene ID: 6286 | Gene type: protein coding

About S100P

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:6,693,878-6,697,170 (from NCBI)

This gene has 2 transcripts (splice variants), 131 orthologues and 21 paralogues. Biased expression in stomach (RPKM 580.8), bone marrow (RPKM 258.6) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate Cancer. [provided by RefSeq, Jul 2008]

S100P Products(1)

mRNA	Protein	Name
NM_005980.3	NP_005971.1	protein S100-P

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	15632002	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11747429	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11747429	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	15313892	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15632002	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100P Protein Structure

S_100

0
95 a.a.

Protein Preferred Names

Protein Names

protein S100-P

migration-inducing gene 9 protein

S100P Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	S100P	P25815	TGFBI	Homo sapiens	Q15582	Validated Y2H	32296183
Intra	S100P	P25815	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	S100P	P25815	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	S100P	P25815	S100A1	Homo sapiens	Q5T7Y6	BFG-2H	27107012
Intra	S100P	P25815	S100A1	Homo sapiens	Q5T7Y6	SLC	27107012
Intra	S100P	P25815	S100Z	Homo sapiens	Q8WXG8	Validated Y2H	32296183
Intra	S100P	P25815	S100Z	Homo sapiens	Q8WXG8	Y2H Prey Pooling	32296183
Intra	S100P	P25815	S100Z	Homo sapiens	Q8WXG8	Y2H Array	32296183
Intra	S100P	P25815	AGER	Homo sapiens	Q15109	Anti Bait CoIP	16061848
Intra	S100P	P25815	MYH9	Homo sapiens	P35579	FPS	31837246
Intra	S100P	P25815	CAPZA1	Homo sapiens	P52907	FPS	31837246
Intra	S100P	P25815	TP53	Homo sapiens	P04637	FPS	31837246
Intra	S100P	P25815	S100B	Homo sapiens	P04271	Y2H Prey Pooling	32296183
Intra	S100P	P25815	S100B	Homo sapiens	P04271	Y2H Array	25416956
Intra	S100P	P25815	S100B	Homo sapiens	P04271	Y2H Array	32296183
Intra	S100P	P25815	S100B	Homo sapiens	P04271	Y2H Prey Pooling	25416956
Intra	S100P	P25815	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	S100P	P25815	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	S100P	P25815	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	S100P	P25815	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	S100P	P25815	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	S100P	P25815	NEFL	Homo sapiens	P07196	Anti Tag CoIP	33961781
Intra	S100P	P25815	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	S100P	P25815	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	S100P	P25815	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	S100P	P25815	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	S100P	P25815	S100A1	Homo sapiens	P23297	FRET	15171681
Intra	S100P	P25815	S100A1	Homo sapiens	P23297	MAPPIT	25416956
Intra	S100P	P25815	S100A1	Homo sapiens	P23297	Confocal	15171681
Intra	S100P	P25815	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	S100P	P25815	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	S100P	P25815	ARC	Homo sapiens	Q7LC44	Validated Y2H	32296183
Intra	S100P	P25815	ARC	Homo sapiens	Q7LC44	Y2H Array	32296183
Intra	S100P	P25815	ARC	Homo sapiens	Q7LC44	Y2H Prey Pooling	32296183
Cross	S100P	P25815	Cacybp	Mus musculus	Q9CXW3	Affinity Chrom	12042313

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100P Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71138	S100P Protein, Human (His)	P25815 (M1-K95)	≥95%
HY-P71138A	S100P Protein, Human (N-His)	P25815 (T2-K95)	≥95%

S100P Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83465	S100P Antibody (YA3210)	WB, IHC-P, ICC/IF, IP	Human

Related Diseases

Diseases

Alias

Classic Pulmonary Blastoma

Biphasic Pulmonary Blastoma

Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium	Adenosquamous Carcinoma Of The Endometrium
Endometrial Adenosquamous Cancer	Endometrial Adenosquamous Cell Carcinoma

Smarca4-Deficient Sarcoma Of Thorax

Smarca4-Dts

Smarca4-Deficient Thoracic Sarcoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2268	RAGE antagonist peptide	Antagonist	98.81%	Unkown
HY-P2268A	RAGE antagonist peptide TFA	Antagonist	99.71%	Unkown
HY-146695	S100P-IN-1	Inhibitor	99.74%	Unkown
HY-RS12389	S100P Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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