TAT - tyrosine aminotransferase Gene

Homo sapiens

Gene ID: 6898 | Gene type: protein coding

About TAT

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,565,660-71,577,092 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues, 7 paralogues and is associated with 3 phenotypes. Restricted expression toward liver (RPKM 242.2).

Summary

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]

TAT Products(1)

mRNA	Protein	Name
NM_000353.3	NP_000344.1	tyrosine aminotransferase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-tyrosine-2-oxoglutarate transaminase activity	IDA IDA: Inferred from direct assay	7999802	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25502805	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 2-oxoglutarate metabolic process	IDA IDA: Inferred from direct assay	7999802	GOA
involved in glutamate metabolic process	IDA IDA: Inferred from direct assay	7999802	GOA
involved in tyrosine catabolic process	IDA IDA: Inferred from direct assay	7999802	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAT Protein Structure

TAT_ubiq

Aminotran_1_2

0
100
200
300
400
454 a.a.

Protein Preferred Names

Protein Names

tyrosine aminotransferase

L-tyrosine:2-oxoglutarate aminotransferase

TAT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAT	P17735	UBE3A	Homo sapiens	Q05086-3	Validated Y2H	32296183
Intra	TAT	P17735	UBE3A	Homo sapiens	Q05086-3	Y2H Bait-Prey Pool	25910212
Intra	TAT	P17735	UBE3A	Homo sapiens	Q05086-3	Y2H Array	32296183
Intra	TAT	P17735	UBE3A	Homo sapiens	Q05086-3	Validated Y2H	25910212
Intra	TAT	P17735	UBE3A	Homo sapiens	Q05086-3	Y2H Array	25910212
Intra	TAT	P17735	UBE3A	Homo sapiens	Q05086-3	Y2H Prey Pooling	32296183
Intra	TAT	P17735	TAT	Homo sapiens	P17735	Y2H Array	32296183
Intra	TAT	P17735	TAT	Homo sapiens	P17735	Y2H Prey Pooling	32296183
Intra	TAT	P17735	TAT	Homo sapiens	P17735	Y2H Array	31515488
Intra	TAT	P17735	TAT	Homo sapiens	P17735	Y2H Array	25502805
Intra	TAT	P17735	TAT	Homo sapiens	P17735	Validated Y2H	32296183
Intra	TAT	P17735	GLUL	Homo sapiens	P15104	Y2H Array	25910212
Intra	TAT	P17735	GLUL	Homo sapiens	P15104	Y2H Bait-Prey Pool	25910212
Intra	TAT	P17735	GLUL	Homo sapiens	P15104	Validated Y2H	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tyrosinemia, Type Ii

Tyrosinemia Type Ii	Oculocutaneous Tyrosinemia
Richner-Hanhart Syndrome	Tyrosine Aminotransferase Deficiency
Tat Deficiency	Tyrosine Transaminase Deficiency
Keratosis Palmoplantaris With Corneal Dystrophy	TYRSN2
Oregon Type Tyrosinemia	Tyrosinemia Type 2
Tyrosinosis Oculocutaneous Type	Tyrosinosis, Oculocutaneous Type
Richner Hanhart Syndrome	Keratosis Palmoplantaris-Corneal Dystrophy Syndrome
Tyrosinemia Due To Tat Deficiency	Tyrosinemia Due To Tyrosine Aminotransferase Deficiency
Tyrosinemia 2	Tyrosinemia Oregon Type
Tyrosine Transaminase Deficiency Disease

Tyrosinemia

Hypertyrosinemia	Tyrosinemias
Hereditary Tyrosinemia	Hypertyrosinaemia
Tyrosinaemia	Hereditary Hypertyrosinemia

Tyrosinemia, Type Iii

Tyrosinemia Type Iii	4-Hydroxyphenylpyruvate Dioxygenase Deficiency
TYRSN3	4-Hydroxyphenylpyruvic Acid Oxidase Deficiency
Tyrosinemia Type 3	4-Alpha Hydroxyphenylpyruvate Dioxygenase Deficiency
4-Alpha Hydroxyphenylpyruvic Acid Oxidase Deficiency	Tyrosinemia Due To 4-Hydroxyphenylpyruvate Dioxygenase Deficiency
Tyrosinemia Due To 4-Hydroxyphenylpyruvic Acid Oxidase Deficiency	Tyrosinemia Due To Hpd Deficiency
Tyrosinemia 3

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Palmoplantar Keratosis

Palmoplantar Keratoderma	Keratosis Palmaris Et Plantaris
Palmo-Plantar Keratodermas	Keratoderma, Palmoplantar
Keratoderma Palmoplantar	Keratoderma, Palmoplantar, Diffuse
Hyperkeratosis Of Palms And Soles	Palmoplantar Hyperkeratosis

Disseminated Intravascular Coagulation

Defibrination Syndrome	Dic
Diffuse Or Disseminated Intravascular Coagulation	Fibrinolytic Purpura
Consumption Coagulopathy	Diffuse Intravascular Coagulation
Dic - [Disseminated Intravascular Coagulation]	Disseminated Intravascular Coagulopathy
Fibrinolysis Nos	Thrombolytic Purpura

Herpes Simplex Virus Keratitis

Dendritic Keratitis	Keratitis, Dendritic
Keratitis, Herpetic

Alkaptonuria

Homogentisic Acid Oxidase Deficiency	Alcaptonuria
AKU	Deficiency Of Homogentisicase
Homogentisate 1,2-Dioxygenase Deficiency	Alkaptonuric Ochronosis
Homogentisic Acidura	Ochronosis, Hereditary
Hereditary Ochronosis	Ochronosis
Homogentisicaciduria	Deficiency Of Homogentisate Oxygenase

Hawkinsinuria

4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency	4-Hppd Deficiency
4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency	HWKS
HAWK

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Tyrosinemia, Type I

Tyrosinemia Type I	Hepatorenal Tyrosinemia
Fumarylacetoacetase Deficiency	Fah Deficiency
TYRSN1	Fumarylacetoacetate Hydrolase Deficiency
Tyrosinemia Type 1	Tyrosinemia 1
Fumarylacetoacetase

Keratitis, Hereditary

Keratitis	Autosomal Dominant Keratitis
Hereditary Keratitis	Dominantly Inherited Keratitis
Keratitis Hereditary	KERH

Glutaric Aciduria Iii

Glutaryl-Coa Oxidase Deficiency	Ga Iii
Glutaric Acidemia Type 3	GA3
Glutaric Aciduria Type 3	Glutaric Aciduria 3
Glutaric Acidemia Type Iii	Glutaric Aciduria Type Iii

Corneal Dystrophy

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Amino Acid Metabolic Disorder

Amino Acid Metabolism, Inborn Errors	Inborn Errors Of Amino Acid Metabolism
Disorder Of Amino Acid Metabolism	Amino Acid Metabolism Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2224	Thiamine disulfide	Inhibitor	98.05%	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0117	Tat-NR2B9c	Inhibitor	99.97%	Phase 3
HY-142118	Trabedersen	Inhibitor	90.45%	Phase 3
HY-P4056	CIGB-300	Antagonist	/	Phase 3
HY-19149	Ro24-7429		99.89%	Phase 2
HY-148130	Rugonersen	Activator	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (88)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4108	TAT-HA2 Fusion Peptide		99.93%	Unkown
HY-P2260	Tat-beclin 1		99.93%	Unkown
HY-P1136B	TAT-Gap19		99.47%	Unkown
HY-P2262	TAT-DEF-Elk-1	Inhibitor	99.98%	Unkown
HY-P5307	Peptide A5K		99.08%	Unkown
HY-P1136C	TAT-Gap19 TFA		99.38%	Unkown
HY-P1420	TAT-cyclo-CLLFVY	Inhibitor	98.06%	Unkown
HY-P0282A	TAT peptide TFA		99.49%	Unkown
HY-P0281A	TAT TFA		98.40%	Unkown
HY-P5381	gp91 ds-tat	Inhibitor	98.27%	Unkown
HY-P1575	TAT (48-57)		98.65%	Unkown
HY-126428	ZL0580		99.26%	Unkown
HY-P1491	HIV-1 TAT (48-60)		99.80%	Unkown
HY-P2260C	Tat-beclin 1 scrambled TFA		98.54%	Unkown
HY-109042	Relacorilant	Antagonist	99.37%	Yes
HY-P0117A	Tat-NR2B9c TFA	Inhibitor	99.67%	Unkown
HY-P1328	TAT-14	Activator	99.66%	Unkown
HY-P1801A	Cys-TAT(47-57) TFA		98.04%	Unkown
HY-P2259	TAT-GluA2 3Y	Inhibitor	99.95%	Unkown
HY-P3429A	SAMβA TFA	Inhibitor	98.91%	Unkown
HY-P2280	TAT-P110	Inhibitor	99.26%	Unkown
HY-P2262A	TAT-DEF-Elk-1 TFA	Inhibitor	/	Unkown
HY-P2307	Tat-NR2Baa		96.89%	Unkown
HY-P4106A	Tat-GluR23Y, scrambled TFA		99.47%	Unkown
HY-W104477	3-Fluoro-L-tyrosine		99.73%	Unkown
HY-P2467	Biotin-TAT (47-57)		99.35%	Unkown
HY-111605	Macropa-NCS		/	Unkown
HY-P0282	TAT peptide		/	Unkown
HY-P10638	TAT-CN21	Inhibitor	99.90%	Unkown
HY-P2260B	Tat-beclin 1 scrambled		99.01%	Unkown
HY-P4114	TAT-NSF700scr		/	Unkown
HY-P5117	TAT-CIRP	Inhibitor	98.32%	Unkown
HY-P5320	TAT-BH4 (Bcl-xL)	Inhibitor	/	Unkown
HY-P5754B	TAT-NEP1-40 acetate	Inhibitor	94.33%	Unkown
HY-P10438	Tat-braftide	Inhibitor	/	Unkown
HY-148412	Monarsen	Inhibitor	/	Unkown
HY-156372	AChE-IN-44	Inhibitor	/	Unkown
HY-P10049	TAT-TCL1-Akt-in	Inhibitor	/	Unkown
HY-P10074	TAT-MEK1	Inhibitor	/	Unkown
HY-P10076	TAT-JBD20	Inhibitor	/	Unkown
HY-P10106	TAT-PAK18 inhibitory peptide	Inhibitor	/	Unkown
HY-P10110	retro-inverso TAT-Beclin 1 (D-amino acid)	Inducer	/	Unkown
HY-P10255	K90-114TAT	Inhibitor	/	Unkown
HY-P10275	Tat-NTS peptide	Inhibitor	/	Unkown
HY-P10357	TAT-CBD3	Inhibitor	/	Unkown
HY-P10358	TAT-CBD3A6K		/	Unkown
HY-P10360	Tat-βsyn-degron	Degrader	/	Unkown
HY-P10436	Braftide	Inhibitor	99.68%	Unkown
HY-P10445	TAT-PiET	Inhibitor	/	Unkown
HY-P10446	TAT-PiET-PROTAC	Inhibitor	/	Unkown
HY-P10464	Tat-AKAP79 (326-336)	Inhibitor	/	Unkown
HY-P10465	TRPV1-Tat	Antagonist	/	Unkown
HY-P1328A	TAT-14 TFA	Activator	/	Unkown
HY-P1420A	TAT-cyclo-CLLFVY TFA	Inhibitor	/	Unkown
HY-P1575A	TAT (48-57) (TFA)		/	Unkown
HY-P1801	Cys-TAT(47-57)		/	Unkown
HY-P2260A	Tat-beclin 1 TFA		/	Unkown
HY-P2307A	Tat-NR2Baa TFA		/	Unkown
HY-P2493	(Cys47)-HIV-1 tat Protein (47-57)		/	Unkown
HY-P3429	SAMβA	Inhibitor	/	Unkown
HY-P3730	Cdk2/Cyclin Inhibitory Peptide I	Inhibitor	/	Unkown
HY-P3731	Cdk2/Cyclin Inhibitory Peptide II	Inhibitor	/	Unkown
HY-P4101	Cys(Npys)-TAT (47-57)		/	Unkown
HY-P4103	Cys(Npys)-TAT (47-57), FAM-labeled		/	Unkown
HY-P4105	TAT (47-57), TAMRA-labeled		/	Unkown
HY-P4106	Tat-GluR23Y, scrambled		/	Unkown
HY-P4122	TAT (47-57), FAM-labeled		/	Unkown
HY-P4123	TAT (47-57) GGG-Cys(Npys)		/	Unkown
HY-P4125	FITC-LC-TAT (47-57)		/	Unkown
HY-P5277	TAT-GluN2BCTM	Degrader	/	Unkown
HY-P5320A	TAT-BH4 (Bcl-xL) (TFA)	Inhibitor	/	Unkown
HY-P5395	TAT-GluR23A Fusion Peptide	Inhibitor	/	Unkown
HY-P5754	TAT-NEP1-40	Inhibitor	/	Unkown
HY-P5754A	TAT-NEP1-40 TFA	Inhibitor	/	Unkown
HY-P5874	Myr-TAT-CBD3	Inhibitor	/	Unkown
HY-P5883	TAT-M2NX	Inhibitor	/	Unkown
HY-P5891	TAT-SAMβA	Antagonist	/	Unkown
HY-P5947	Tat-HA-NR2B9c		/	Unkown
HY-RS14225	TAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-10281	YM-60828 methanesulfonate	Inhibitor	/	Unkown
HY-115828	APA-APA-MPO dihydrochloride		/	Unkown
HY-115829	APA-H-MPO hydrochloride		/	Unkown
HY-119120	JTK-101	Inhibitor	/	Unkown
HY-P10401	TAT-GluR6-9c	Antagonist	/	Unkown
HY-P10405	TAT-D1 peptide	Antagonist	/	Unkown
HY-P3431	VSGLNPSLWSIFGLQFILLWLVSGSRHYLW	Antagonist	/	Unkown
HY-P3431A	VSGLNPSLWSIFGLQFILLWLVSGSRHYLW TFA	Antagonist	/	Unkown
HY-P0281	TAT		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAT	VGNC	VGNC:53455
Bos taurus	TAT	VGNC	VGNC:35616
Felis catus	TAT	VGNC	VGNC:65965
Mus musculus	TAT	MGD	MGI:98487
Macaca mulatta	TAT	VGNC	VGNC:78100
Rattus norvegicus	TAT	RGD	RGD:3820
Macaca fascicularis	TAT	NCBI	NCBI:102144775
Susscrofa domestica	TAT	NCBI
Others	TAT	NCBI

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