2. Gene
  3. C1QBP - complement C1q binding protein Gene

C1QBP - complement C1q binding protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p32; HABP1; gC1qR; GC1QBP; SF2p32; gC1Q-R; COXPD33; SF2AP32

Gene ID: 708 | Gene type: protein coding

About C1QBP

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,432,777-5,439,155 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 56.9), kidney (RPKM 48.1) and 25 other tissues.

Summary

The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum Complement System. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]

C1QBP Products(1)

mRNA Protein Name
NM_001212.4 NP_001203.1 complement component 1 Q subcomponent-binding protein, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables complement component C1q complex binding IDA
IDA: Inferred from direct assay
8195709 GOA
enables deoxyribonuclease inhibitor activity IDA
IDA: Inferred from direct assay
31353207 GOA
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
31353207 GOA
enables hyaluronic acid binding IDA
IDA: Inferred from direct assay
8567680 GOA
enables kininogen binding IDA
IDA: Inferred from direct assay
8662673 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8710908 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
15243141 GOA
enables transcription factor binding IDA
IDA: Inferred from direct assay
15243141 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cytosolic ribosome assembly IMP
IMP: Inferred from mutant phenotype
21536856 GOA
involved in negative regulation of MDA-5 signaling pathway IDA
IDA: Inferred from direct assay
19164550 GOA
involved in negative regulation of RIG-I signaling pathway IDA
IDA: Inferred from direct assay
19164550 GOA
involved in negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
19164550 GOA
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
31353207 GOA
involved in negative regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
16177118 GOA
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
10022843 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15243141 GOA
involved in negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
17881511 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16177118 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15031724 GOA
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
20810993 GOA
involved in positive regulation of dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
16140380 GOA
involved in positive regulation of neutrophil chemotaxis IDA
IDA: Inferred from direct assay
9461517 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16177118 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
11859136 GOA
involved in positive regulation of trophoblast cell migration IMP
IMP: Inferred from mutant phenotype
20810993 GOA
involved in regulation of complement activation IDA
IDA: Inferred from direct assay
8195709 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
17881511 GOA
located in cytosol IDA
IDA: Inferred from direct assay
15243141 GOA
located in membrane IDA
IDA: Inferred from direct assay
8662673 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
9305894 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
11083468 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15243141 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QBP Protein Structure

MAM33

MAM33: Mitochondrial glycoprotein (86 - 279)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

complement component 1 Q subcomponent-binding protein, mitochondrial

ASF/SF2-associated protein p32

C1QBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
C1QBP Q07021 VTN Homo sapiens P04004
Pull Down
8900153
Intra
C1QBP Q07021 VTN Homo sapiens P04004
ELISA
8900153
Intra
C1QBP Q07021 LBR Homo sapiens Q14739
Anti Tag CoIP
28565870
Intra
C1QBP Q07021 FOXC1 Homo sapiens Q12948
Anti Tag CoIP
18676636
Intra
C1QBP Q07021 FOXC1 Homo sapiens Q12948
Pull Down
18676636
Intra
C1QBP Q07021 PRKD1 Homo sapiens Q15139
Anti Bait CoIP
10831594
Intra
C1QBP Q07021 PRKD1 Homo sapiens Q15139
Confocal
10831594
Intra
C1QBP Q07021 PRKD1 Homo sapiens Q15139
Protein Kinase Assay
10831594
Intra
C1QBP Q07021 PRKD1 Homo sapiens Q15139
Pull Down
10831594
Intra
C1QBP Q07021 PRKD1 Homo sapiens Q15139
Y2H
10831594
Cross
C1QBP Q07021 Cdkn2a Mus musculus Q64364
Anti Bait CoIP
17486078
Cross
C1QBP Q07021 Cdkn2a Mus musculus Q64364
Anti Tag CoIP
17486078
Cross
C1QBP Q07021 Cdkn2a Mus musculus Q64364
IF
17486078
Intra
C1QBP Q07021 PRKCZ Homo sapiens Q05513
Anti Bait CoIP
10831594
Intra
C1QBP Q07021 YBX1 Homo sapiens P67809
Anti Bait CoIP
25497084
Intra
C1QBP Q07021 YBX1 Homo sapiens P67809
BN-PAGE
26184334
Intra
C1QBP Q07021 YBX1 Homo sapiens P67809
Y2H Pooling
21653829
Intra
C1QBP Q07021 CDKN2A Homo sapiens Q8N726
Pull Down
17486078
Intra
C1QBP Q07021 CDK13 Homo sapiens Q14004-2
Anti Bait CoIP
16721827
Intra
C1QBP Q07021 CDK13 Homo sapiens Q14004-2
Y2H
16721827
Intra
C1QBP Q07021 KNG1 Homo sapiens P01042
Affinity Chrom
8710908
Intra
C1QBP Q07021 KNG1 Homo sapiens P01042
Filter Binding
8710908
Intra
C1QBP Q07021 F12 Homo sapiens P00748
Filter Binding
8710908
Intra
C1QBP Q07021 HRK Homo sapiens O00198
IF
15031724
Intra
C1QBP Q07021 HRK Homo sapiens O00198
Anti Tag CoIP
15031724
Intra
C1QBP Q07021 HRK Homo sapiens O00198
Pull Down
15031724
Intra
C1QBP Q07021 APOA1 Homo sapiens P02647
Anti Tag CoIP
28565870
Intra
C1QBP Q07021 APOA1 Homo sapiens P02647
Anti Bait CoIP
28565870
Intra
C1QBP Q07021 KLF1 Homo sapiens Q13351
Y2H Prey Pooling
32296183
Intra
C1QBP Q07021 KLF1 Homo sapiens Q13351
Validated Y2H
32296183
Intra
C1QBP Q07021 KLF1 Homo sapiens Q13351
Y2H Array
32296183
Intra
C1QBP Q07021 MAVS Homo sapiens Q7Z434
Anti Bait CoIP
19164550
Intra
C1QBP Q07021 MAVS Homo sapiens Q7Z434
FRET
19164550
Cross
C1QBP Q07021 P08563-PRO_0000041302 Rubella virus P08563-PRO_0000041302
IF
24955142
Cross
C1QBP Q07021 P08563-PRO_0000041302 Rubella virus P08563-PRO_0000041302
Pull Down
24955142
Cross
C1QBP Q07021 P27958-PRO_0000037566 Hepatitis C virus P27958-PRO_0000037566
Y2H
11086025
Cross
C1QBP Q07021 P27958-PRO_0000037566 Hepatitis C virus P27958-PRO_0000037566
Pull Down
11086025
Cross
C1QBP Q07021 P07566-PRO_0000041308 Rubella virus P07566-PRO_0000041308
Y2H
12034482
Cross
C1QBP Q07021 O40955-PRO_0000240177 Rubella virus O40955-PRO_0000240177
Pull Down
22238231
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C1QBP Proteins

Cat. No. Product Name Accession Purity
HY-P7692 HABP1/C1QBP Protein, Human (His) Q07021 (L74-Q282) ≥95%

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 33

COXPD33
Rubella

German Measles

Three Day Measles

Rubella Nos
Hantavirus Hemorrhagic Fever With Renal Syndrome

Hemorrhagic Fever, Russian

Hemorrhagic Nephrosonephritis

Hfrs

Puumala Virus Nephropathy

Hemorrhagic Fever With Renal Syndrome
Cryoglobulinemia

Cryoimmunoglobulinaemia
Korean Hemorrhagic Fever

Hemorrhagic Fever With Renal Syndrome
Angioedema

Angioneurotic Oedema

Quincke'S Edema

Angioneurotic Edema

Giant Urticaria
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis

ECTD14

Ectodermal Dysplasia 14

Ectn14
Myopathy

Muscular Diseases

Myopathies
Hantavirus Pulmonary Syndrome

Hps

Four Corners Hantavirus

Hards

Hantavirus

Hantavirus-Associated Respiratory Distress Syndrome

Hanta Virus

Hantavirus Cardiopulmonary Syndrome

Hps - [Hantavirus Pulmonary Syndrome]

Hcps - [Hantavirus Cardiopulmonary Syndrome]
Hereditary Angioedema

Hereditary Angioneurotic Edema

Hereditary Angioedema Type 1

Hane

Angioedema, Hereditary

Hae

Angioedemas, Hereditary

Deficiency Of C1 Esterase Inhibitor

C1 Esterase Inhibitor Deficiency

C1 Inhibitor Deficiency

Familial Angioneurotic Edema

Hereditary Bradykinine-Induced Angioedema

Hereditary Non Histamine-Induced Angioedema

Hae 1

Hae-I

Hereditary Angioneurotic Edema Type 1

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii

Hereditary Angioneurotic Oedema

Familial Angioedema

Hae - [Hereditary Angioneurotic Oedema]

Bannister Disease, Hereditary

Quincke Disease Or Oedema

Hereditary Quincke Oedema
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01720 C1QBP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus C1QBP RGD RGD:2230
Felis catus C1QBP VGNC VGNC:98772
Canis familiaris C1QBP VGNC VGNC:38578
Mus musculus C1QBP MGD MGI:1194505
Bos taurus C1QBP VGNC VGNC:26618
Macaca mulatta C1QBP VGNC VGNC:97742
Others C1QBP NCBI