2. Gene
  3. FZD7 - frizzled class receptor 7 Gene

FZD7 - frizzled class receptor 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FzE3

Gene ID: 8324 | Gene type: protein coding

About FZD7

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:202,033,855-202,038,441 (from NCBI)

This gene has 1 transcript (splice variant), 265 orthologues and 15 paralogues.

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

FZD7 Products(1)

mRNA Protein Name
NM_003507.2 NP_003498.1 frizzled-7 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
18256285 GOA
enables Wnt receptor activity IDA
IDA: Inferred from direct assay
28733458 GOA
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
18313787 GOA
enables frizzled binding IPI
IPI: Inferred from physical interaction
19188438 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
27386966 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18215320 GOA
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18313787 GOA
involved in mesenchymal to epithelial transition IMP
IMP: Inferred from mutant phenotype
17016432 GOA
involved in negative regulation of cardiac muscle cell differentiation IGI
IGI: Inferred from genetic interaction
23939491 GOA
involved in negative regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
18156211 GOA
involved in negative regulation of ectodermal cell fate specification IMP
IMP: Inferred from mutant phenotype
18681827 GOA
involved in non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19773752 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18215320 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19773752 GOA
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
19773752 GOA
involved in positive regulation of epithelial cell proliferation involved in wound healing IMP
IMP: Inferred from mutant phenotype
18313787 GOA
involved in positive regulation of phosphorylation IDA
IDA: Inferred from direct assay
18256285 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18681827 GOA
involved in regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
9707618 GOA
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
18681827 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
18256285 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
27386966 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD7 Protein Structure

Fz

Fz: Fz domain (49 - 160)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (243 - 565)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
Protein Preferred Names Protein Names

frizzled-7

Frizzled, drosophila, homolog of, 7

FZD7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FZD7 O75084 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
FZD7 O75084 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
FZD7 O75084 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 SLC6A15 Homo sapiens Q9H2J7
Validated Y2H
32296183
Intra
FZD7 O75084 SLC6A15 Homo sapiens Q9H2J7
Y2H Array
32296183
Intra
FZD7 O75084 SLC6A15 Homo sapiens Q9H2J7
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
FZD7 O75084 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
FZD7 O75084 SLC30A4 Homo sapiens O14863
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 SLC30A4 Homo sapiens O14863
Y2H Array
32296183
Intra
FZD7 O75084 AQP9 Homo sapiens O43315
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 AQP9 Homo sapiens O43315
Y2H Array
32296183
Intra
FZD7 O75084 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
FZD7 O75084 MGST1 Homo sapiens P10620
Validated Y2H
32296183
Intra
FZD7 O75084 MGST1 Homo sapiens P10620
Y2H Array
32296183
Intra
FZD7 O75084 MGST1 Homo sapiens P10620
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
FZD7 O75084 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
FZD7 O75084 WNT3 Homo sapiens P56703
Pull Down
21314951
Intra
FZD7 O75084 WNT3 Homo sapiens P56703
Anti Tag CoIP
18313787
Intra
FZD7 O75084 SDCBP Homo sapiens O00560
Anti Bait CoIP
18256285
Intra
FZD7 O75084 SDCBP Homo sapiens O00560
Far-WB
18256285
Intra
FZD7 O75084 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
FZD7 O75084 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
16189514
Intra
FZD7 O75084 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
FZD7 O75084 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
FZD7 O75084 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
FZD7 O75084 NCS1 Homo sapiens P62166
Validated Y2H
32296183
Intra
FZD7 O75084 NCS1 Homo sapiens P62166
Y2H Array
32296183
Intra
FZD7 O75084 NCS1 Homo sapiens P62166
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
FZD7 O75084 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
32296183
Intra
FZD7 O75084 HPCAL1 Homo sapiens P37235
Y2H Array
32296183
Intra
FZD7 O75084 HPCAL1 Homo sapiens P37235
Validated Y2H
32296183
Intra
FZD7 O75084 HPCAL1 Homo sapiens P37235
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 NCALD Homo sapiens P61601
Y2H Array
32296183
Intra
FZD7 O75084 NCALD Homo sapiens P61601
Validated Y2H
32296183
Intra
FZD7 O75084 NCALD Homo sapiens P61601
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
FZD7 O75084 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
FZD7 O75084 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD7 Proteins

Cat. No. Product Name Accession Purity
HY-P78730 Frizzled-7 Protein, Human (HEK293, His) O75084 (Q33-L185) ≥95%
HY-P79214 Frizzled-7 Protein, Human (CHO, hFc) O75084/NP_003498 (Q33-L185) ≥95%

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P1454 Fz7-21 Antagonist 99.59% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1454A Fz7-21 TFA Antagonist 99.35% Unkown
HY-117002 SRI 37892 Inhibitor 98.92% Unkown
HY-P1454B Fz7-21S 98.91% Unkown
HY-156095 F7H Inhibitor 99.42% Unkown
HY-P10204 FZD7 antagonist 1 / Unkown
HY-RS05183 FZD7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990418 Anti-FZD7 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FZD7 VGNC VGNC:99364
Felis catus FZD7 VGNC VGNC:80213
Bos taurus FZD7 VGNC VGNC:29171
Mus musculus FZD7 MGD MGI:108570
Canis familiaris FZD7 VGNC VGNC:57384
Rattus norvegicus FZD7 RGD RGD:2321905
Others FZD7 NCBI