1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. PDGFs & PDGFRs
  4. PDGF

Platelet-derived growth factors (PDGFs) are potent mitogenic factors (mitogens) that regulate cell growth and division, in connective tissue and the developing nervous system. PDGFs are secreted from many cell types including platelets, endothelial, epithelial, glial and inflammatory cells. PDGFs target a broad spectrum of mesoderm-derived cells, like fibroblasts, pericytes, smooth muscle cells, glial cells or mesangial cells. Four PDGF genes (PDGFA, PDGFB, PDGFC and PDGFD) edit 5 biologically active PDGF proteins which consist of a homodimer (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) or heterodimer (PDGF-AB) of two chains. PDGFs are characterized by a highly conserved eight-cysteine residues domain termed the PDGF/VEGF homology domain. There are two cognate transmembrane receptors, PDGFRα and PDGFRβ, two distinct class III receptor tyrosine kinases. PDGFRα binds PDGF-A, -B and -C, while PDGFRβ can only be activated by PDGF-B and -D. The receptors dimerize upon ligand binding and cross-phosphorylate intracellular tyrosine residues. These phosphorylated residues serve as binding sites for downstream signaling components and activate, among others, phospholipase C γ (PLCγ), phosphatidyl inositol 3-kinase (PI3K), and JAK-STAT signaling. Overall, PDGFs exert their cellular effects by inducing homo- or heterodimeric complexes of α- and β-tyrosine kinase receptors, resulting in cell growth, chemotaxis, actin reorganization, and prevention of apoptosis.

Cat. No. Product Name / Synonyms Species Source
  • HY-P7279
    PDGF-CC Protein, Human (HEK293)

    rHuPDGF-CC; PDGF-C; SCDGF

    Human HEK293
    PDGF-CC Protein, Human (HEK293) is a member of the PDGF family, binds to PDGFR-α and PDGFR-β and acts as potent angiogenic factor.
  • HY-P7055G
    GMP PDGF-BB Protein, Human

    PDGFBB; PDGF-BB

    Human E. coli
    The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. GMP PDGF-BB Protein, Human is the recombinant human-derived PDGF-BB protein, expressed by E. coli , with tag free. The total length of GMP PDGF-BB Protein, Human is 109 a.a., with molecular weight of ~14.0 kDa.
  • HY-P73352
    PDGF-BB Protein, Mouse (P.pastoris, His)

    Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS

    Mouse P. pastoris
    PDGF-BB, a crucial growth factor, regulates diverse cellular processes, including development, proliferation, migration, survival, and chemotaxis. It is vital for tissue proliferation, blood vessel development, and kidney glomeruli formation. PDGF-BB interacts with PDGFRA, PDGFRB, XLKD1, LRP1, and SORL1, highlighting its versatile cellular involvement. PDGF-BB Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag.
  • HY-P7087
    PDGF-BB Protein, Mouse

    rMuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Mouse E. coli
    PDGF-BB Protein, Mouse is an active PDGF isoform, used in cell culture applications.
  • HY-P7055
    PDGF-BB Protein, Human

    rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Human E. coli
    PDGF-BB Protein, Human is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect.
  • HY-P7277
    PDGF-AA Protein, Mouse

    rMuPDGF-AA; PDGF-1; Pdgfa

    Mouse E. coli
    PDGF-AA Protein, Mouse is a member of PDGF family, binds to FDGFR, and may has the potential to enhance wound healing.
  • HY-P70825
    PDGF-AA Protein, Human (His)

    PDGFAA; PDGF-AA

    Human E. coli
    PDGF-AA Protein, Human (His) is a member of PDGF family, binds to FDGFR, and may has the potential to enhance wound healing.
  • HY-P73351
    PDGF-BB Protein, Human (P.pastoris, His)

    Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS

    Human P. pastoris
    The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. PDGF-BB Protein, Human (P.pastoris, His) is the recombinant human-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Human (P.pastoris, His) is 109 a.a., with molecular weight of ~14.3 kDa.
  • HY-P7055A
    PDGF-BB Protein, Human (P.pastoris)

    rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Human P. pastoris
    PDGF-BB Protein, Human (P.pastoris) is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect.
  • HY-P70598
    PDGF-AA Protein, Human

    PDGFAA; PDGF-AA

    Human E. coli
    PDGF-A protein is a key growth factor that regulates embryonic development, cell proliferation, migration, survival, and chemotaxis, and exerts potent mitogenic effects on mesenchymal cells. It is essential for alveolar septal formation, gastrointestinal tract development, interstitial cell maturation, spermatogenesis, and oligodendrocyte development, and contributes to spinal cord and cerebellar myelination. PDGF-AA Protein, Human is the recombinant human-derived PDGF-AA protein, expressed by E. coli , with tag free.
  • HY-P73354
    PDGF-CC Protein, Mouse (HEK293, Fc)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Mouse HEK293
    The PDGF-CC protein is a key growth factor that plays crucial roles in a variety of cellular processes, including embryonic development, cell proliferation, migration, survival, and chemotaxis. It has potent mitogenic and chemoattractant properties and is essential during embryonic skeletal formation, craniofacial development, palate development, skin morphogenesis and wound healing stages. PDGF-CC Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PDGF-CC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of PDGF-CC Protein, Mouse (HEK293, Fc) is 111 a.a., with molecular weight of ~46 kDa.
  • HY-P74640
    PDGF-CC Protein, Cynomolgus (HEK293, hFc)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Cynomolgus HEK293
    Platelet derived growth factor C (PDGF-CC) is a growth factor that plays an essential role in the regulation of cell proliferation, cell migration, survival and chemotaxis. PDGF-CC is a potent mitogen and chemoattractant for cells of mesenchymal origin which plays an important roll in normal skeleton formation and normal skin morphogenesis during embryonic development, wound healing, angiogenesis and blood vessel development as well as being involved in fibrotic processes. PDGF-CC Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived PDGF-CC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of PDGF-CC Protein, Cynomolgus (HEK293, hFc) is 111 a.a., with molecular weight of ~45 kDa.
  • HY-P74643
    PDGF-AA Protein, Human (P.pastoris, His)

    Platelet-derived growth factor subunit A; PDGF-1; PDGFA

    Human P. pastoris
    PDGF-A protein is a key growth factor that regulates embryonic development, cell proliferation, migration, survival, and chemotaxis, and exerts potent mitogenic effects on mesenchymal cells. It is essential for alveolar septal formation, gastrointestinal tract development, interstitial cell maturation, spermatogenesis, and oligodendrocyte development, and contributes to spinal cord and cerebellar myelination. PDGF-AA Protein, Human (P.pastoris, His) is the recombinant human-derived PDGF-AA protein, expressed by P. pastoris , with N-His labeled tag.
  • HY-P75966
    PDGF-BB Protein, Cynomolgus (HEK293, Fc)

    Platelet-derived growth factor subunit B; PDGF-2; PDGFB

    Cynomolgus HEK293
    PDGF-BB is a growth factor frequently overexpressed in cancers, are novel potent lymphangiogenic factors. PDGF-BB Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived PDGF-BB protein, expressed by HEK293 , with N-mFc labeled tag. The total length of PDGF-BB Protein, Cynomolgus (HEK293, Fc) is 109 a.a., with molecular weight of ~43 & 32 kDa, respectively.
  • HY-P7055B
    PDGF-BB Protein, Human (His)

    rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Human E. coli
    The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. PDGF-BB Protein, Human (His) is the recombinant human-derived PDGF-BB protein, expressed by E. coli , with N-6*His labeled tag. The total length of PDGF-BB Protein, Human (His) is 109 a.a., with molecular weight of approximately 15 kDa.
  • HY-P7278
    PDGF-BB Protein, Rat

    rRtPDGF-BB; PDGF-2; Pdgfb

    Rat E. coli
    PDGF-BB Protein, Rat is a member of PDGF family, which promotes cell proliferation, survival and migration, through binding to the tyrosine kinase PDGF receptor.
  • HY-P7280
    PDGF-DD Protein, Human (CHO)

    rHuPDGF-DD; Platelet-derived growth factor D; SCDGFB

    Human CHO
    PDGF-DD Protein, Human (CHO) is a member of the PDGF family, specifically binds to and activates its cognate receptor PDGFR-β, and participates in regulating cancer proliferation, transformation, and invasion through activating multiple downstream oncogenic pathways, resulting in tumor development and progression.
  • HY-P70699
    PDGF-BB Protein, Mouse (His)

    PDGFBB; PDGF-BB

    Mouse E. coli
    PDGF-BB protein is an important member of the PDGF/VEGF growth factor family and plays a vital role in cell signaling and tissue development, contributing to cell growth, angiogenesis and blood vessel development.Its membership emphasizes the importance of fundamental physiological processes that coordinate tissue homeostasis.PDGF-BB Protein, Mouse (His) is the recombinant mouse-derived PDGF-BB protein, expressed by E.coli , with C-6*His labeled tag.
  • HY-P73719
    PDGF-CC Protein, Mouse (P.pastoris, His)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Mouse P. pastoris
    The PDGF-CC protein is a key growth factor that plays crucial roles in a variety of cellular processes, including embryonic development, cell proliferation, migration, survival, and chemotaxis. It has potent mitogenic and chemoattractant properties and is essential during embryonic skeletal formation, craniofacial development, palate development, skin morphogenesis and wound healing stages. PDGF-CC Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PDGF-CC protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-CC Protein, Mouse (P.pastoris, His) is 111 a.a., with molecular weight of ~14.4 kDa.
  • HY-P71615
    PDGF-DD Protein, Mouse (His-SUMO)

    Pdgfd; Scdgfb; Platelet-derived growth factor D; PDGF-D; Spinal cord-derived growth factor B; SCDGF-B

    Mouse E. coli
    PDGF-DD protein is an important growth factor that controls embryonic development, cell proliferation, migration, survival and chemotaxis, and has a potent mitogenic effect on mesenchymal cells. It plays a key role in wound healing and has carcinogenic potential, contributing to tumor formation. PDGF-DD Protein, Mouse (His-SUMO) is the recombinant mouse-derived PDGF-DD protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
Cat. No. Product Name Effect Purity