Search Result

Results for "

10A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (1) Apoptosis (4) Bacterial (1) CRISPR/Cas9 (1) DNA/RNA Synthesis (1) EGFR (1) Estrogen Receptor/ERR (1) FXR (1) G Protein-coupled Receptor Kinase (GRK) (1) Glutaminase (1) Histone Methyltransferase (1) HSP (2) iGluR (2) Interleukin Related (1) Isotope-Labeled Compounds (3) mAChR (1) MDM-2/p53 (1) MicroRNA (8) Microtubule/Tubulin (2) PD-1/PD-L1 (1) PDK-1 (1) Phosphodiesterase (PDE) (16) PI3K (1) Potassium Channel (2) Pyruvate Kinase (1) Reactive Oxygen Species (1) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (23)
By Research Areas:	Cancer (29) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (15)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) Pre-designed siRNA Sets (23) miRNA inhibitors (2) siRNAs (23)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135848

N-Methylbenzamide	Phosphodiesterase (PDE)	Cancer
N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity .

HY-144666

GLS-1-IN-1	Glutaminase	Cancer
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor. GLS-1-IN-1 shows inhibitory effect against Hep G2, MCF 7, and MCF 10A cells .

HY-18078

PQ-10	Phosphodiesterase (PDE)	Neurological Disease
PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC₅₀ andED₅₀ of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia .

HY-123743

JNJ-42314415	Phosphodiesterase (PDE)	Neurological Disease
JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with K_i values of 35 nM and 64 nM for human recombinant PDE10A and rPDE10A, respectively .

HY-158237

PDE10A-IN-3	Phosphodiesterase (PDE)	Neurological Disease
PDE10A-IN-3 (Compound 8a) is an inhibitor of phosphodiesterase 10A (PDE10A). PDE10A-IN-3 can be used in schizophrenia research .

HY-R00058

*hsa-miR-10a-3p mimic*	MicroRNA	Cancer
hsa-miR-10a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-10a-3p mimic hsa-miR-10a-3p mimic

HY-R00059

*hsa-miR-10a-5p mimic*	MicroRNA	Cancer
hsa-miR-10a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-10a-5p mimic hsa-miR-10a-5p mimic

HY-128349

MT-3014	Phosphodiesterase (PDE)	Neurological Disease
MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC₅₀s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively .

HY-160111

PDM-042	Phosphodiesterase (PDE)	Neurological Disease
PDM-042 is a potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. PDM-042 shows potent inhibitory activities for human and rat PDE10A with IC₅₀ values of less than 1 nM and more than 1000-fold selectivity against other phosphodiesterases. PDM-042 can be used for the research of schizophrenia .

HY-W654262

10α-Methoxy-9,10-dihydrolysergol-d3 ((6aR,9R,10AS)-10A-Methoxy-7-methyl-4,6,6a,7,8,9,10,10A-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity)-d₃	Isotope-Labeled Compounds	Others
10α-Methoxy-9,10-dihydrolysergol-d₃ is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .

HY-RI00058

*hsa-miR-10a-3p inhibitor*	MicroRNA	Cancer
hsa-miR-10a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-10a-3p inhibitor hsa-miR-10a-3p inhibitor

HY-RI00059

*hsa-miR-10a-5p inhibitor*	MicroRNA	Cancer
hsa-miR-10a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-10a-5p inhibitor hsa-miR-10a-5p inhibitor

HY-131973

PDE10A-IN-2 hydrochloride	Phosphodiesterase (PDE)	Cardiovascular Disease Metabolic Disease
PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC₅₀ of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can be used for pulmonary arterial hypertension (PAH) research .

HY-12913

AMG 579	Phosphodiesterase (PDE)	Neurological Disease
AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC₅₀ of 0.1 nM.

HY-R00058A

*hsa-miR-10a-3p agomir*	MicroRNA	Cancer
hsa-miR-10a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-10a-3p agomir hsa-miR-10a-3p agomir

HY-R00059A

*hsa-miR-10a-5p agomir*	MicroRNA	Cancer
hsa-miR-10a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-10a-5p agomir hsa-miR-10a-5p agomir

HY-152838

Gemlapodect RO554965	Phosphodiesterase (PDE)	Neurological Disease
Gemlapodect (RO554965) is an inhibitor of phosphodiesterase 10A (PDE10A). Gemlapodect can be used for researching schizophrenia .

HY-163558

Anticancer agent 212	Others	Cancer
Anticancer agent 212 (compound 10a) is a potent anticancer agent. Anticancer agent 212 shows cytotoxicity ^[1]

HY-166876S

Nicergoline impurity 18-d4	Isotope-Labeled Compounds	Others
Nicergoline impurity 18-d₄ is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .

HY-W743954

Nicergoline impurity 11-d3	Isotope-Labeled Compounds	Others
Nicergoline impurity 11-d₃ is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .

HY-147028

M4 mAChR agonist-1	mAChR	Neurological Disease
M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC₅₀ >10 μM for human M4 .

HY-168064

EGFR-IN-124	EGFR	Cancer
EGFR-IN-124 (compound 10A) is an EGFR inhibitor, with IC₅₀ of 0.54 μM. EGFR-IN-124 can be used in anti-cancer research .

HY-RI00058A

*hsa-miR-10a-3p antagomir*	MicroRNA	Cancer
hsa-miR-10a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-10a-3p antagomir hsa-miR-10a-3p antagomir

HY-RI00059A

*hsa-miR-10a-5p antagomir*	MicroRNA	Cancer
hsa-miR-10a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-10a-5p antagomir hsa-miR-10a-5p antagomir

HY-146652

UGM-IN-3	Bacterial	Infection
UGM-IN-3 (compound 10a) is a UDP-galactopyranose mutase (UGM) inhibitor with a K_d of 66 μM. UGM-IN-3 inhibits the growth of *Mycobacterium tuberculosis* with a MIC value of 6.2 μg/mL .

HY-18037

AMG-7980	Phosphodiesterase (PDE)	Others
AMG-7980 exhibits high affinity to phosphodiesterase 10A (PDE10A), with a K_D of 0.94 nM. AMG-7980 can be used as a tracer of PDE10A, when labeled with radioactive isotope .

HY-117838

Phosphodiesterase 10-IN-2	Phosphodiesterase (PDE)	Neurological Disease
Phosphodiesterase 10-IN-2 (THPP-4) is an oral active phosphodiesterase 10A (PDE10A) inhibitor with the K_i of 4.5 nM. Phosphodiesterase 10-IN-2 can be used for study of schizophrenia .

HY-153168

Bemoradan	Phosphodiesterase (PDE)	Cardiovascular Disease
Bemoradan (compound 10a) is an orally active and selective canine Phosphodiesterase (PDE) fraction III inhibitor. Bemoradan is a long-acting, potent, inotropic vasodilator and a novel cardiotonic agent, and can be used in congestive heart failure research .

HY-162758

ALR2-IN-5	Aldose Reductase	Metabolic Disease
ALR2-IN-5 (Compound 10a) is an inhibitor of ALR2 with an IC₅₀ value of 99.29 nM. ALR2-IN-5 exhibits hypoglycemic effects and can be utilized in research related to diabetes .

HY-N10922

*(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone*	Others	Cancer
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

HY-155185

NMDA receptor antagonist 7	iGluR	Neurological Disease
NMDA receptor antagonist 7 (Compound (S)-10a) is GluN2B subunit-selective NMDA Receptor antagonist, with an K_i of 93 nM and an IC₅₀ of 72 nM. NMDA receptor antagonist 7 can be used for research of neurodegenerative diseases .

HY-155185A

NMDA receptor antagonist 8	iGluR	Neurological Disease
NMDA receptor antagonist 8 (Compound (R)-10a) is GluN2B subunit-selective NMDA Receptor antagonist, with an K_i of 265 nM and an IC₅₀ of 62 nM. NMDA receptor antagonist 8 can be used for research of neurodegenerative diseases .

HY-117604

THPP-1	Phosphodiesterase (PDE)	Neurological Disease
THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with K_i values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species .

HY-10030

Mardepodect succinate PF-2545920 succinate	Phosphodiesterase (PDE)	Neurological Disease
Mardepodect succinate (PF-2545920 succinate) is a potent and specific phosphodiesterase 10A (PDE10A) inhibitor with potential activity in the treatment of schizophrenia. Mardepodect succinate has been further optimized to improve brain penetration and compound-like properties for use in schizophrenia research .

HY-W003486

5,7-Dichloropyrazolo[1,5-a]pyrimidine	Phosphodiesterase (PDE)	Neurological Disease
5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is a pyrazolopyrimidine phosphodiesterase 10A (PDE10A) inhibitor (K_i=24 μM). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used in the study of schizophrenia .

HY-131194

JAK2/STAT3-IN-1	Interleukin Related	Cancer
JAK2/STAT3-IN-1 (compound (S)-10a) is a potent GP130 inhibitor with an IC₅₀ of 3.04 µM. JAK2/STAT3-IN-1 shows anti-tumor activity .

HY-142817

GRK6-IN-2 1 Publications Verification	G Protein-coupled Receptor Kinase (GRK)	Cancer
GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC₅₀ of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma .

HY-151959

FXR agonist 4	FXR	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC₅₀ value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD) .

HY-161663

Phosphodiesterase-IN-2	Phosphodiesterase (PDE)	Cardiovascular Disease
Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC₅₀ of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline (HY-108353)-induced cardiac hypertrophic in mouse models .

HY-119467

MDK0734	Ser/Thr Protease	Cancer
MDK0734 is a selective inhibitor that inhibits feline hepsin B endopeptidase and exopeptidase activities. MDK0734 demonstrated efficacy in a cell-based in vitro tumor invasion model, significantly attenuating the invasive ability of MCF-10A neoT cells. MDK0734 provides new potential inhibitors for the development of clinically useful compounds targeting the deleterious effects of feline hepsin B in cancer progression .

HY-159515

PBE-AMF	Apoptosis DNA/RNA Synthesis Reactive Oxygen Species	Cancer
PBE-AMF is a prodrug that activates H₂O₂ with anticancer activity. PBE-AMF impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBE-AMF potently and selectively inhibits the proliferation of MDA-MB-231 cells (IC₅₀=6.4 μM) while sparing non-cancerous MCF-10A cells .

HY-149431

NDNA4	HSP Potassium Channel	Cancer
NDNA4 (compound 17) is a selective inhibitor of Hsp90α (IC₅₀: 0.34 μM). NDNA4 is a permanently charged analog with low membrane permeability and low cytotoxicity against Ovcar-8 and MCF-10A ((IC₅₀ >100 μM)). NDNA4 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins .

HY-155956

GM-90257	Microtubule/Tubulin Apoptosis	Cancer
GM-90257 is a microtubule acetylation inhibitor that binds directly to α-tubulin. GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes the apoptosis of MDA-MB-231 cells with weaker effects on MCF-10A or MCF-7 cells, which have a relatively low level of microtubule acetylation .

HY-149432

NDNA3	HSP Potassium Channel	Cancer
NDNA3 (compound 14) is a selective inhibitor of Hsp90α (IC₅₀: 0.51 μM). NDNA3 is a permanently charged analog with low membrane permeability and low toxicity to Ovcar-8 (IC₅₀: 12.66 μM) and MCF-10A (IC₅₀: 11.72 μM) cells. NDNA3 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins .

HY-116264

CatB-IN-1	Ser/Thr Protease	Cancer
CatB-IN-1 is an enzyme inhibitor with significant inhibitory activity against tumor invasion. CatB-IN-1 may reduce the invasiveness of tumor cells by regulating intracellular protein metabolism. CatB-IN-1 demonstrates effective anti-invasive ability in cell models and can significantly reduce the invasive ability of MCF-10A neoT cells. The structure-activity relationship study of CatB-IN-1 shows that its design can target multiple functions of cat hepsin B .

HY-156375

PKM2 activator 6	Pyruvate Kinase PDK-1	Cancer
PKM2 activator 6 (Compound Z10) is a PKM2 activator and PDK1 inhibitor (K_D: 121 and 19.6 μM respectively). PKM2 activator 6 induces colorectal cell apoptosis, and inhibits cell proliferation and migration . PKM2 activator 6 inhibits glycolysis. PKM2 activator 6 inhibits proliferation of DLD-1, HCT-8, HT-29, MCF-10A cells (IC₅₀: 10.04, 2.16, 3.57, 66.39 μM) .

HY-123446

JNJ-42259152	Others	Neurological Disease
JNJ-42259152 is a phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer that is specific for PDE10A activity. JNJ-42259152 can be dynamically scanned in healthy volunteers to assess its kinetic properties in the brain. The half-life of JNJ-42259152 in the blood is an average of 90 minutes. JNJ-42259152 has demonstrated reliable binding potential (BPND) in different target areas (such as the lentiform nucleus, caudate nucleus, ventral striatum, etc.), providing an important tool for studying neuropsychiatric diseases .

HY-144638

JMX0293	Apoptosis	Cancer
JMX0293 is an O-alkylamino-tethered salicylamide derivative compound. JMX0293 maintains good potency against MDA-MB-231 cell line (IC₅₀ = 3.38 μM) while exhibiting very low toxicity against human non-tumorigenic breast epithelial cell line MCF-10A (IC₅₀> 60 μM). JMX0293 inhibits STAT3 phosphorylation and contribute to apoptosis in TNBC MDA-MB-231 cells. JMX0293 significantly suppresses MDA-MB-231 xenograft tumor growth in vivo without significant toxicity .

HY-155197

ER degrader 7	Microtubule/Tubulin Estrogen Receptor/ERR	Cancer
ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC₅₀s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth .

HY-145432

PI3K-IN-28	PI3K	Cancer
PI3K-IN-28 (Compound 6c) is a potent inhibitor of PI3K. PI3K-IN-28 displays the most potent activity with lower toxic effects on MCF-10a. PI3K-IN-28 displays half-maximal inhibitory concentration (IC₅₀, μM) values of 5.8, 2.3, and 7.9. PI3K-IN-28 is the most potent one with a selectivity index (SI) of 39 and is considered as a latent lead for further optimization of anticancer agents .

Cat. No.	Product Name	Target	Research Area

HY-P99265

Mapatumumab HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody	Inhibitory Antibodies	Cancer
Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer .

HY-P99619

Finotonlimab SCT-I10A	PD-1/PD-L1	Cancer
Finotonlimab (SCT-I10A) is a recombinant humanised IgG PD-1 antibody. Finotonlimab has the potential for solid tumors or lymphomas research .

HY-P99147

*Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)*	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse TCR V gamma 2 Antibody is an anti-mouse TCR V gamma 2 IgG antibody inhibitor derived from host Armenian Hamster.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10922

*(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone*	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Celastrus Plants	Others
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

Species:	Human (11) Virus (2) Mouse (2) Cynomolgus (1) Canine (1)
Tag:	His (11) Strep (1) Tag Free (2) Avi (4) Fc (3) Flag (1)
Source:	HEK293 (14) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P72440

	TRAIL R1/TNFRSF10A Protein, Human (216a.a, HEK293, His) Tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; CD261; TNFRSF10A; APO2; DR4	Human	HEK293
	TRAIL R1/TNFRSF10A protein is a receptor for TNFSF10/TRAIL, which recruits caspase-8 through FADD to initiate cell apoptosis and form a death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in the monomeric state. TRAIL R1/TNFRSF10A Protein, Human (216a.a, HEK293, His) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (216a.a, HEK293, His) is 216 a.a., with molecular weight of 19-30 kDa.

HY-P78219

	TRAIL R1/TNFRSF10A Protein, Human (Biotinylated, HEK293, His-Avi) DR4; CD261; TNFRSF10A; TRAIL-R; APO2; TRAIL R1; MGC9365	Human	HEK293
	TRAIL R1/TNFRSF10A protein is a receptor for TNFSF10/TRAIL, which recruits caspase-8 through FADD to initiate cell apoptosis and form a death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in the monomeric state. TRAIL R1/TNFRSF10A Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (Biotinylated, HEK293, His-Avi) is 206 a.a., with molecular weight of 25-30 kDa.

HY-P72689

	CLEC10A/CD301 Protein, Human (HEK293, His) C-type lectin domain family 10 member A; CD301; CLEC10A; CLECSF13; CLECSF14; HML	Human	HEK293
	CLEC10A/CD301 Protein, implicated in probable immune response regulation, binds Tn-Ag sugar moieties in a calcium-dependent manner. Recognizing these structures on carcinoma cells, CLEC10A/CD301 suggests a role in immune surveillance. Further exploration of its molecular interactions and downstream signaling pathways will enhance understanding of its contributions to immune modulation, especially in the context of cancer immunity. CLEC10A/CD301 Protein, Human (HEK293, His) is the recombinant human-derived CLEC10A/CD301 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CLEC10A/CD301 Protein, Human (HEK293, His) is 256 a.a., with molecular weight of ~40 kDa.

HY-P75676

	CLEC10A/CD301 Protein, Human (HEK293, Fc) C-type lectin domain family 10 member A; CD301; CLEC10A; CLECSF13; CLECSF14; HML	Human	HEK293
	CLEC10A/CD301 Protein, implicated in probable immune response regulation, binds Tn-Ag sugar moieties in a calcium-dependent manner. Recognizing these structures on carcinoma cells, CLEC10A/CD301 suggests a role in immune surveillance. Further exploration of its molecular interactions and downstream signaling pathways will enhance understanding of its contributions to immune modulation, especially in the context of cancer immunity. CLEC10A/CD301 Protein, Human (HEK293, Fc) is the recombinant human-derived CLEC10A/CD301 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC10A/CD301 Protein, Human (HEK293, Fc) is 232 a.a., with molecular weight of ~58 kDa.

HY-P76265

	CLEC10A/CD301 Protein, Mouse (HEK293, Fc) C-type lectin domain family 10 member A; CD301; CLEC10A; CLECSF13; CLECSF14; HML	Mouse	HEK293
	CLEC10A/CD301 has predicted carbohydrate-binding activity and plays an upstream role in connective tissue replacement in inflammatory responses and wound healing. This protein is expected to be located on the membrane and be an integral part of the membrane structure, being active on the outside of the plasma membrane. CLEC10A/CD301 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC10A/CD301 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P76266

	CLEC10A/CD301 Protein, Mouse (HEK293, His) C-type lectin domain family 10 member A; CD301; CLEC10A; CLECSF13; CLECSF14; HML	Mouse	HEK293
	The CLEC10A/CD301 protein is a receptor that recognizes terminal galactose and N-acetylgalactosamine units and is involved in a variety of biological processes.It may play a crucial role by promoting interactions between tumor-killing macrophages and tumor cells.CLEC10A/CD301 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CLEC10A/CD301 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74500

	TRAIL R1/TNFRSF10A Protein, Human (HEK293, hFc) Tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; CD261; APO2; DR4	Human	HEK293
	TRAIL R1/TNFRSF10A protein is a receptor for TNFSF10/TRAIL, which recruits caspase-8 through FADD to initiate cell apoptosis and form a death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in the monomeric state. TRAIL R1/TNFRSF10A Protein, Human (HEK293, hFc) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (HEK293, hFc) is 216 a.a., with molecular weight of ~47 kDa.

HY-P78529

	TRAIL R1/TNFRSF10A Protein, Human (HEK293, His-Avi) DR4; CD261; TNFRSF10A; TRAIL-R; APO2; TRAIL R1; MGC9365	Human	HEK293
	TRAIL R1/TNFRSF10A protein is a receptor for TNFSF10/TRAIL, which recruits caspase-8 through FADD to initiate cell apoptosis and form a death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in the monomeric state. TRAIL R1/TNFRSF10A Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (HEK293, His-Avi) is 206 a.a., with molecular weight of 25-30 kDa.

HY-P700740

	IL-10 Protein, Cynomolgus (HEK293, His) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Cynomolgus	HEK293
	IL-10 Protein, a key immune regulatory cytokine, centrally modulates immune responses. IL-10 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-10 protein, expressed by HEK293 , with N-His labeled tag. The total length of IL-10 Protein, Cynomolgus (HEK293, His) is 160 a.a., with molecular weight of 20-22 kDa.

HY-P78460

	IL-10 Protein, Human (HEK293, His-Avi) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-10 Protein, Human (HEK293, His-Avi) is 160 a.a., with molecular weight of 23-25 kDa.

HY-P78144

	IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) is 160 a.a., with molecular weight of 23-25 kDa.

HY-P703191

	SCN10A Protein, Human (HEK293, Flag, Strep) Sodium channel protein type 10 subunit alpha; Peripheral nerve sodium channel 3; PN3; hPN3; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8; SCN10A; Homo sapiens; Human; PN3; Ion channel; Sodium channel; Voltage-gated channel	Human	HEK293
	SCN10A Protein, Human (HEK293, Flag, Strep) is the recombinant human-derived SCN10A, expressed by HEK293 , with Strep, Flag labeled tag. ,

HY-P79268

	IL-10 Protein, Canine IL10; CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; IL10A; IL-10MGC126451; interleukin-10; TGIF; Interleukin 10	Canine	E. coli
	IL-10 is the most important cytokine that inhibits pro-inflammatory responses and limits excessive immune responses in various autoimmune diseases. It belongs to the type 2 cytokine superfamily. IL-10 plays an important role in transmitting information, activating and regulating immune cells, mediating T and B cell activation, proliferation and differentiation, and in inflammatory responses. IL-10 can promote the proliferation and activation of CD8T⁺ cells, enhancing anti-tumor capabilities. IL-10 Protein, Canine is the recombinant canine-derived IL-10 protein, expressed by E. coli , with tag free. The total length of IL-10 Protein, Canine is 160 a.a..

HY-P700073AF

	Animal-Free Galectin-10 Protein, Human (His) GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN; Charcot-Leyden crystal protein (CLC); Eosinophil lysophospholipase; Lysolecithin acylhydrolase	Human	E. coli
	Galectin-10 Protein, pivotal in immune regulation, recognizes cell-surface glycans, inducing anergy and suppressing CD25-positive regulatory T-cells (Treg). Interacting with CEL, it modulates immune responses, highlighting its significance in orchestrating immunoregulatory cellular processes. Animal-Free Galectin-10 Protein, Human (His) is the recombinant human-derived animal-FreeGalectin-10 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free Galectin-10 Protein, Human (His) is 141 a.a., with molecular weight of ~36.7 kDa.

HY-P77024

	HA1/Hemagglutinin Protein, H17N10 (AFC35418, HEK293, His) Influenza A H17N10 (A/little yellow-shouldered bat/Guatemala/164/2009) Hemagglutinin Protein (His)	Virus	HEK293
	The hemagglutinin (HA) protein is essential for viral attachment to host cells, binding to sialic acid receptors, and initiating virion internalization through clathrin-dependent or -independent pathways. As a class I viral fusion protein, HA determines host range and virulence, mediating viral penetration into the cytoplasm. Hemagglutinin/HA Protein, H17N10 (AFC35418, HEK293, His) is the recombinant Virus-derived Hemagglutinin/HA protein, expressed by HEK293 , with C-His labeled tag.

HY-P70751

	IL-10 Protein, Human (HEK293) Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10; RP11-262N9.1; IL10A; MGC126450; MGC126451; TGIF	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with tag free. The total length of IL-10 Protein, Human (HEK293) is 160 a.a., with molecular weight of 16-20 kDa.

HY-P77023

	HA/Hemagglutinin Protein, H17N10 (AFC35418, sf9, His) Influenza A H17N10 (A/little yellow-shouldered bat/Guatemala/164/2009) Hemagglutinin / HA Protein (His)	Virus	Sf9 insect cells
	The hemagglutinin (HA) protein is essential for viral attachment to host cells, binding to sialic acid receptors, and initiating virion internalization through clathrin-dependent or -independent pathways. As a class I viral fusion protein, HA determines host range and virulence, mediating viral penetration into the cytoplasm. Hemagglutinin/HA Protein, H17N10 (AFC35418, sf9, His) is the recombinant Virus-derived Hemagglutinin/HA protein, expressed by Sf9 insect cells , with C-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W654262

10α-Methoxy-9,10-dihydrolysergol-d3
10α-Methoxy-9,10-dihydrolysergol-d₃ is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .

HY-166876S

Nicergoline impurity 18-d4
Nicergoline impurity 18-d₄ is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .

HY-W743954

Nicergoline impurity 11-d3
Nicergoline impurity 11-d₃ is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81102

	Collagen X Antibody COAA1_HUMAN antibody; Col10A 1 antibody; COL10A1 antibody; Collagen alpha 1(X) chain antibody; Collagen alpha-1(X) chain antibody; Collagen type X alpha 1 (Schmid metaphyseal chondrodysplasia) antibody; Collagen type X alpha 1 antibody; Collagen X alpha 1 polypeptide antibody; CollagenX antibody; fa66d11 antibody; fb10c08 antibody; OTTHUMP00000040411 antibody; Procollagen type X alpha 1 antibody; Schmid metaphyseal chondrodysplasia antibody; wu:fa66d11 antibody; wu:fb10c08 antibody;	WB	Human, Mouse, Rat
	Collagen X Antibody is an unconjugated, approximately 66 kDa, rabbit-derived, anti-Collagen X monoclonal antibody. Collagen X Antibody can be used for: WB expriments in mouse, rat, human background without labeling.

HY-P81113

	IL-10 Antibody Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. 白介素10	WB, ICC/IF, FC	Human
	IL-10 Antibody is an unconjugated, approximately 18 kDa, rabbit-derived, anti-IL-10 monoclonal antibody. IL-10 Antibody can be used for: WB, ICC, FC expriments in human background without labeling.

HY-P80317

	S100A4 Antibody 18A2 antibody; 42A antibody; calcium Placental protein antibody; Calvasculin antibody; CAPL antibody; Fibroblast specific protein 1 (FSP1) antibody; Fibroblast specific protein 1 antibody; Fibroblast specific protein antibody; FSP1 antibody; Leukemia multidrug resistance associated protein antibody; Malignant transformation suppression 1 (MTS1) antibody; Malignant transformation suppression 1 antibody; Metastasin antibody; MTS1 antibody; OTTHUMP00000015467 antibody; OTTHUMP00000015468 antibody; P9KA antibody; PEL98 antibody; Placental calcium-binding protein antibody; Protein Mts1 antibody; Protein S100 A4 antibody; Protein S100-A4 antibody; S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) antibody; S100 calcium binding protein A4 antibody; S100 calcium-binding protein A4 antibody; S100a4 antibody; S10A4_HUMAN antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	S100A4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 12 kDa, targeting to S100A4. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P81237

	Wnt10a Antibody FLJ14301; OODD; Protein Wnt-10A ; SSPS; STHAG4; Wingless type MMTV integration site family member 10A antibody; WN10A_HUMAN; wnt10A;	WB, IHC-P	Human, Mouse
	Wnt10a Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Wnt10a, with a predicted molecular weight of 46 kDa. Wnt10a Antibody can be used for WB, IHC-P experiments in human, mouse backgrounds.

HY-P82135

	RPL10A Antibody (YA1880) RPL10A; NEDD6; 60S ribosomal protein L10A; CSA-19; Neural precursor cell expressed developmentally down-regulated protein 6; NEDD-6	WB	Human, Mouse, Rat
	RPL10A Antibody (YA1880) is a biotin-conjugated non-conjugated IgG antibody, targeting RPL10A, with a predicted molecular weight of 25 kDa (observed band size: 25 kDa). RPL10A Antibody (YA1880) can be used for WB experiment in human, mouse, rat background.

HY-P81993

	Hsc70 Interacting Protein HIP Antibody (YA1738) HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; ST13	WB, IHC-P, ICC/IF, FC	Human, Mouse
	Hsc70 Interacting Protein HIP Antibody (YA1738) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1738), targeting Hsc70 Interacting Protein HIP, with a predicted molecular weight of 41 kDa (observed band size: 47 kDa). Hsc70 Interacting Protein HIP Antibody (YA1738) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse background.

HY-P82437

	RHOQ Antibody (YA2182) ARHQ; RASL7A; Rho related GTP binding protein RhoQ; Rhoq; TC10A	WB, ICC/IF	Human, Rat
	RHOQ Antibody (YA2182) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2182), targeting RHOQ, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). RHOQ Antibody (YA2182) can be used for WB, ICC/IF experiment in human, rat background.

HY-P82837

	Collagen X alpha 1 Antibody (YA2582) CollagenX; COL10A1; COAA1; Collagen type X alpha 1	WB	Human, Mouse, Rat
	Collagen X alpha 1 Antibody (YA2582) is a biotin-conjugated non-conjugated IgG antibody, targeting Collagen X alpha 1, with a predicted molecular weight of 66 kDa (observed band size: 66 kDa). Collagen X alpha 1 Antibody (YA2582) can be used for WB experiment in human, mouse, rat background.

HY-P82241

	TNPO3 Antibody (YA1986) TNPO 3; Imp12; Importin 12; IPO12; MTR10A; TNPO3; Transportin 3; Transportin SR; TRN-SR2; TRNSR	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	TNPO3 Antibody (YA1986) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1986), targeting TNPO3, with a predicted molecular weight of 104 kDa (observed band size: 100 kDa). TNPO3 Antibody (YA1986) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P81425

	S100A8 Antibody (YA1170) Calgranulin-A antibody; Calprotectin L1L subunit antibody; CFAG antibody; Cystic fibrosis antigen antibody; Leukocyte L1 complex light chain antibody; Migration inhibitory factor-related protein 8 antibody; MRP-8 antibody; N-terminally processed antibody; p8 antibody; Protein S100-A8 antibody; S100 calcium-binding protein A8 antibody; S100A8 antibody; S10A8_HUMAN antibody; Urinary stone protein band A antibody	WB, IHC-P, ICC/IF, IP, FC	Human
	S100A8 Antibody (YA1170) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1170), targeting S100A8. S100A8 Antibody (YA1170) can be used for WB, IHC-P, IF-Cell, FC, IF-Tissue, IP experiment in human background.

HY-P83734

	S100A9 Antibody(YA3464) Leukocyte L1 complex heavy chain antibody; 60B8AG antibody; CAGB antibody; Calgranulin B antibody; Calgranulin-B antibody; Calprotectin L1H subunit antibody; CFAG antibody; CGLB antibody; Cystic fibrosis antigen B antibody; L1AG antibody; Leukocyte L1 complex heavy chain antibody; LIAG antibody; MAC387 antibody; MIF antibody; Migration inhibitory factor related protein 14 antibody; Migration inhibitory factor-related protein 14 antibody; MRP 14 antibody; MRP-14 antibody; MRP14 antibody; Myeloid-related protein 14 antibody; NIF antibody; OTTHUMP00000015331 antibody; p14 antibody; Protein S100-A9 antibody; S100 A9 antibody; S100 calcium binding protein A9 antibody; S100 calcium binding protein A9 calgranulin B antibody; S100 calcium-binding protein A9 antibody; S100A9 antibody; S10A9_HUMAN antibody	WB, IHC-P, ICC/IF	Human
	S100A9 Antibody(YA3464) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3464), targeting S100A8. S100A9 Antibody (YA1170) can be used for WB, IHC-P, IF-Cell, FC, IF-Tissue, IP experiment in human background.

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Clonality
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Appearance
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SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-R00058

*hsa-miR-10a-3p mimic*		MicroRNAs miRNA mimics
hsa-miR-10a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R00059

*hsa-miR-10a-5p mimic*		MicroRNAs miRNA mimics
hsa-miR-10a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI00058

*hsa-miR-10a-3p inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-10a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI00059

*hsa-miR-10a-5p inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-10a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R00058A

*hsa-miR-10a-3p agomir*		MicroRNAs miRNA agomirs
hsa-miR-10a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R00059A

*hsa-miR-10a-5p agomir*		MicroRNAs miRNA agomirs
hsa-miR-10a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00058A

*hsa-miR-10a-3p antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-10a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00059A

*hsa-miR-10a-5p antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-10a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RS02779

CLEC10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CLEC10A Human Pre-designed siRNA Set A contains three designed siRNAs for CLEC10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10199

PDE10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PDE10A Human Pre-designed siRNA Set A contains three designed siRNAs for PDE10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10200

Pde10a Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Pde10a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pde10a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10201

Pde10a Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Pde10a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde10a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03036

COQ10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
COQ10A Human Pre-designed siRNA Set A contains three designed siRNAs for COQ10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12161

RPL10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RPL10A Human Pre-designed siRNA Set A contains three designed siRNAs for RPL10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12519

SCN10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SCN10A Human Pre-designed siRNA Set A contains three designed siRNAs for SCN10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12520

Scn10a Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Scn10a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Scn10a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12521

Scn10a Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Scn10a Rat Pre-designed siRNA Set A contains three designed siRNAs for Scn10a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01171

ATP10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ATP10A Human Pre-designed siRNA Set A contains three designed siRNAs for ATP10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14795

TNFRSF10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TNFRSF10A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15087

TRMT10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TRMT10A Human Pre-designed siRNA Set A contains three designed siRNAs for TRMT10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15828

WNT10A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
WNT10A Human Pre-designed siRNA Set A contains three designed siRNAs for WNT10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02959

COL10A1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
COL10A1 Human Pre-designed siRNA Set A contains three designed siRNAs for COL10A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12985

SLC10A1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SLC10A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12986

SLC10A2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SLC10A2 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12987

Slc10a2 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Slc10a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc10a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12988

Slc10a2 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Slc10a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc10a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12989

SLC10A3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SLC10A3 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12990

SLC10A4 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SLC10A4 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12991

SLC10A5 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SLC10A5 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12992

SLC10A6 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SLC10A6 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12993

SLC10A7 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SLC10A7 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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