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Acute toxicity

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72

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Peptides

1

Inhibitory Antibodies

18

Natural
Products

1

Isotope-Labeled Compounds

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W040269
    Dehydrothio-p-toluidine
    1 Publications Verification

    DHPT

    		 Fluorescent Dye Others
    Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions .
    Dehydrothio-p-toluidine
  • HY-120395
    UC-514321

    		STAT Apoptosis TET Protein Inflammation/Immunology Cancer
    UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity .
    UC-514321
  • HY-153219A
    P-CAB agent 2

    		Potassium Channel Endocrinology
    P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H +/K +-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion .
    P-CAB agent 2
  • HY-153219
    P-CAB agent 2 hydrochloride

    		Potassium Channel Endocrinology
    P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H +/K +-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion .
    P-CAB agent 2 hydrochloride
  • HY-W011108
    Obidoxime dichloride

    		Cholinesterase (ChE) Neurological Disease
    Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated .
    Obidoxime dichloride
  • HY-146371
    COX-2-IN-13

    		COX Inflammation/Immunology
    COX-2-IN-13 (compound 13e) is a potent and selective inhibitor of COX-2 with an IC50 of 0.98 μM. COX-2-IN-13 is an anti-inflammatory agent. COX-2-IN-13 shows safety in-vivo acute toxicity study .
    COX-2-IN-13
  • HY-146370
    COX-2-IN-12

    		COX Inflammation/Immunology
    COX-2-IN-12 (compound 3b) is a potent and selective inhibitor of COX-2 with an IC50 of 19.98 μM. COX-2-IN-12 is an anti-inflammatory agent. COX-2-IN-12 shows safety in-vivo acute toxicity study .
    COX-2-IN-12
  • HY-146025
    Antitumor agent-F10

    		Others Cancer
    Antitumor agent-F10 (Compound F10) is a camptothecin derivative. Antitumor agent-F10 is an orally–bioavailable and potent antitumor agent. Antitumor agent-F10 displays lower acute toxicity than SN-38 does and the solubility of F10 reached 9.86 μg/mL .
    Antitumor agent-F10
  • HY-147841
    HIV-1 inhibitor-41

    		HIV Reverse Transcriptase Infection
    HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC50 values of 20.8 nM and 50 nM against HIV-1 WT and mutant E138K strain, respectively. HIV-1 inhibitor-41 shows low hERG, no apparent CYP enzymatic inhibition and no acute toxicity .
    HIV-1 inhibitor-41
  • HY-147807
    HIV-1 inhibitor-40

    		HIV Cytochrome P450 Infection
    HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC50 values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity .
    HIV-1 inhibitor-40
  • HY-W795264
    FR900098

    		Parasite Infection
    FR900098 is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 has no effect on bone marrow red blood cells in NMRI mice .
    FR900098
  • HY-155998
    NF-κB-IN-11

    		NF-κB Inflammation/Immunology
    NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay .
    NF-κB-IN-11
  • HY-122817
    FR900098 sodium

    		Antibiotic Parasite Infection
    FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .
    FR900098 sodium
  • HY-116653
    Flurtamone

    		Stearoyl-CoA Desaturase (SCD) Others
    Flurtamone is a chiral herbicide with acute toxicity levels to Selenastrum capricornutum .
    Flurtamone
  • HY-131551
    Drometrizole

    		Biochemical Assay Reagents Others
    Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies .
    Drometrizole
  • HY-N1436
    L-(+)-Abrine

    L-Abrine; L-N-Methyltryptophan; N-α-Methyl-L-tryptophan

    		 Others Inflammation/Immunology
    L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.
    L-(+)-Abrine
  • HY-Y0069
    N-Acetylglycine

    Aceturic acid; Acetamidoacetic acid

    		 Endogenous Metabolite Others
    N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
    N-Acetylglycine
  • HY-N2542
    Tubeimoside III

    		Others Inflammation/Immunology Cancer
    Tubeimoside III, a triterpenoid saponin, shows anti-inflammatory, anti-tumor, anti-tumorigenic activities, and acute toxicity in vivo .
    Tubeimoside III
  • HY-131551R
    Drometrizole (Standard)

    		Biochemical Assay Reagents Others
    Drometrizole (Standard) is the analytical standard of Drometrizole. This product is intended for research and analytical applications. Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies .
    Drometrizole (Standard)
  • HY-116653R
    Flurtamone (Standard)

    		Stearoyl-CoA Desaturase (SCD) Others
    Flurtamone (Standard) is the analytical standard of Flurtamone. This product is intended for research and analytical applications. Flurtamone is a chiral herbicide with acute toxicity levels to Selenastrum capricornutum .
    Flurtamone (Standard)
  • HY-B1812
    Veratrole

    		Antibiotic Apoptosis NF-κB Others
    Veratrole is a key compound found widely in plants that attracts pollinators. Veratrole can be used as a safe fragrance ingredient with low acute and administration toxicity .
    Veratrole
  • HY-P2047
    Lavendomycin

    Antibiotic FR-900201

    		 Antibiotic Bacterial Infection
    Lavendomycin is a peptide antibiotic from Streptomyces. Lavendomycin inhibits Gram-positive bacteria .
    Lavendomycin
  • HY-W099757
    (±)-Coniine hydrochloride

    2-Propylpiperidine hydrochloride

    		 nAChR Neurological Disease
    (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg .
    (±)-Coniine hydrochloride
  • HY-120407
    Looplure

    ENT-33266

    		 Insecticide Others
    Looplure (ENT-33266) is an insect attractant with acute toxicity studies in different animal models showing activity at oral and dermal median lethal doses (LD50) and median lethal concentrations (LC50) for fish with some values, and low toxicity in most cases except for some cases.
    Looplure
  • HY-149240
    Anticancer agent 108

    		P-glycoprotein Cancer
    Anticancer agent 108 (Compound 3.10) is a potent P-gp inhibitor with significant antitumor activity and less toxicity to normal and pseudonormal cells. Anticancer agent 108 (Compound 3.10) had no acute toxic effect on С57BL/6 mice .
    Anticancer agent 108
  • HY-138100
    Hyalodendrin

    (+)-Hyalodendrin

    		 Fungal Infection
    Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .
    Hyalodendrin
  • HY-119034
    AD-20

    		Others Cancer
    AD-20 is an o-methoxyphenylacetyl dehydroalanine derivative. AD-20 can not only reduce the acute and subchronic toxicity of Doxorubicin (HY-15142A), but also enhance its anti-tumor effect .
    AD-20
  • HY-Y0069R
    N-Acetylglycine (Standard)

    		Endogenous Metabolite Others
    N-Acetylglycine (Standard) is the analytical standard of N-Acetylglycine. This product is intended for research and analytical applications. N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
    N-Acetylglycine (Standard)
  • HY-N2542R
    Tubeimoside III (Standard)

    		Others Inflammation/Immunology Cancer
    Tubeimoside III (Standard) is the analytical standard of Tubeimoside III. This product is intended for research and analytical applications. Tubeimoside III, a triterpenoid saponin, shows anti-inflammatory, anti-tumor, anti-tumorigenic activities, and acute toxicity in vivo .
    Tubeimoside III (Standard)
  • HY-103447
    Zearalenone
    5+ Cited Publications

    Mycotoxin F2; Toxin F2

    		 Estrogen Receptor/ERR Others
    Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
    Zearalenone
  • HY-W012683
    Iminodiacetic acid

    		Others Cancer
    Iminodiacetic acid (IDA) is a chelating agent that strongly binds transition metals . Iminodiacetic acid can be used for removal of toxic metal ions from water . Iminodiacetic acid can serve as a biomarker to potentially predict the severity of ARDS (acute respiratory distress syndrome) .
    Iminodiacetic acid
  • HY-D0261
    Tiron

    		Biochemical Assay Reagents Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals .
    Tiron
  • HY-127165
    Velnacrine

    HP 029 free base; Hydroxytacrine

    		 Cholinesterase (ChE) Neurological Disease
    Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC50 of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD50 of 65 mg/kg .
    Velnacrine
  • HY-129406
    AF 698

    		Others Cardiovascular Disease
    AF 698 is a phthalate derivative of Apovincamine (HY-135743) that can be used as a peripheral vasodilator with selective vasomotor effects on cerebral microvascular circulation. AF 698 has better vasodilator effect than Vincamine (HY-B1021), but there is no significant difference in the protective effect of the two drugs against hypobaric hypoxia-induced lethality in mice .
    AF 698
  • HY-163003
    Antitrypanosomal agent 19

    		Parasite Infection
    Antitrypanosomal agent 19 (compound 10) is an orally available antitrypanosomal agent. Antitrypanosomal agent 19 effectively inhibits the growth of trypanosomatids T. b. brucei, T. b. gambiense and T. b. rhodesiense, mitigating the Human trypanosomiasis (HAT)-induced acute infectious toxicity in mice .
    Antitrypanosomal agent 19
  • HY-D1005A16
    Poloxamer 235 (P85)

    PEG-PPG-PEG, 4600 (Averag)

    		 Biochemical Assay Reagents Others
    Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral LD50 of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .
    Poloxamer 235 (P85)
  • HY-119048
    Adechlorin

    2'-Chloropentostatin

    		 Others Others
    Adechlorin (2'-Chloropentostatin) is an adenosine deaminase inhibitor isolated from actinomycete culture, with potent inhibitory activity against calf intestinal adenosine deaminase, a Ki value that is comparable to other known inhibitors, and can enhance the antiviral activity of Ara-A, and has lower acute toxicity in mice than other analogs.
    Adechlorin
  • HY-N6678
    Zearalanone
    1 Publications Verification

    		 Estrogen Receptor/ERR Endocrinology
    Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
    Zearalanone
  • HY-P99264
    Inotuzumab

    Humanized Anti-CD22 Recombinant Antibody

    		 ADC Antibody CD22 Cancer
    Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4, κ antibody that targets human CD22. Inotuzumab can be linked to a toxic agent ozogamicin as an antibody-drug conjugate (ADC). Inotuzumab can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma .
    Inotuzumab
  • HY-152927
    Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)

    		Biochemical Assay Reagents Others
    Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg .
    Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)
  • HY-103447R
    Zearalenone (Standard)

    Mycotoxin F2(Standard); Toxin F2 (Standard)

    		 Estrogen Receptor/ERR Others
    Zearalenone (Standard) is the analytical standard of Zearalenone. This product is intended for research and analytical applications. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
    Zearalenone (Standard)
  • HY-156135
    NSC194598

    		RET Others
    NSC194598 is a p53 DNA-binding inhibitor with IC50 value of 180 nM and 2-40 μM for in vitro and in vivo, respectively. NSC194598 interferes with transcriptional activation of mutated RET gene in human medullary thyroid carcinoma TT cells. NSC194598 can be used for acute toxicity to normal tissues by radiation and chemotherapy research .
    NSC194598
  • HY-125923
    Djenkolic acid

    		Others Metabolic Disease
    Djenkolic acid is a sulfur-containing non-protein amino acid naturally found in the djenkol beans of the Southeast Asian plant Archidendron jiringa. Djenkolic Acid often causes renal injury, including hypersensitivity to or a direct toxic effect of a djenkol bean metabolite, resulting in acute kidney injury and/or urinary tract obstruction by djenkolic acid crystals, sludge, and/or possible ureteral spasms .
    Djenkolic acid
  • HY-146495
    Antitubercular agent-19

    		Bacterial Infection
    Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice .
    Antitubercular agent-19
  • HY-111125
    AMRI-59

    		Parasite Reactive Oxygen Species Apoptosis Infection Cancer
    AMRI-59 is a potent inhibitor of PrxI used for parasitic infections. AMRI-59 can increase cellular ROS, leading to activation of signaling pathways mediated by mitochondria and apoptosis signal-regulated kinase 1, thereby leading to apoptosis in A549 human lung adenocarcinoma. AMRI-59 exhibits significant antitumor activity without apparent acute toxicity .
    AMRI-59
  • HY-117082
    UTL-5g

    GBL-5g

    		 TNF Receptor Inflammation/Immunology
    UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors .
    UTL-5g
  • HY-147925
    hCAI/II-IN-4

    		Carbonic Anhydrase Others
    hCAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with Ki values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. hCAI/II-IN-4 has anti-hypoxia activities and low toxicity. hCAI/II-IN-4 can be used for acute mountain sickness (AMS) research .
    hCAI/II-IN-4
  • HY-129278
    Lunarine

    		Parasite Infection Cardiovascular Disease Neurological Disease
    Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD50 of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with Ki of 304 μM .
    Lunarine
  • HY-N6678R
    Zearalanone (Standard)

    		Estrogen Receptor/ERR Endocrinology
    Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
    Zearalanone (Standard)
  • HY-151933
    HIV-1 inhibitor-49

    		HIV Reverse Transcriptase Infection
    HIV-1 inhibitor-49 is an orally active HIV-1 inhibitor, is a HEPT analog. HIV-1 inhibitor-49 possesses great pharmacokinetics profiles and potent non-nucleoside reverse transcriptase inhibitory activity (IC50=30 nM). HIV-1 inhibitor-49 exerts potential safety without acute toxicity in mouse model .
    HIV-1 inhibitor-49

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