Search Result

Results for "

Crosslinker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (9) ADC Linker (19) Amino Acid Derivatives (1) Bacterial (1) Biochemical Assay Reagents (19) Casein Kinase (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (2) E3 Ligase Ligand-Linker Conjugates (2) Endogenous Metabolite (1) Fluorescent Dye (1) Isotope-Labeled Compounds (5) Microtubule/Tubulin (1) Parasite (1) PROTAC Linkers (4)
By Research Areas:	Cancer (37) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (5) Metabolic Disease (1)
Click Chemistry:	ADC Synthesis (1) DBCO (1) PROTAC Synthesis (2) Azide (5) Alkynes (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: DNA Alkylator/Crosslinker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120937

DC4 Crosslinker	Others	Others
DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons .

HY-118759

DSP Crosslinker 1 Publications Verification	ADC Linker	Inflammation/Immunology
DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs) .

HY-144337

*DNA crosslinker* 4 dihydrochloride**	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer .

HY-144335

*DNA crosslinker* 2 dihydrochloride**	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer .

HY-144336

*DNA crosslinker* 3 dihydrochloride**	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer .

HY-144333

*DNA crosslinker* 1 dihydrochloride**	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 1 dihydrochloride (Compound 4) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.1 °C. DNA crosslinker 1 dihydrochloride can be used for researching anticancer .

HY-168619

*DNA crosslinker* 6**	Parasite	Infection Cancer
DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC₅₀=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC₅₀ value of 0.83 µM for the inhibition of T. brucei .

HY-W096122

*DTSSP Crosslinker* disodium**	Others	Others
DTSSP Crosslinker disodium is a protein cross-linker containing a disulfide bond. DTSSP Crosslinker disodium can react with sidechains of amino acids that are within close proximity .

HY-W264744

3-Maleimidobenzoic acid	Biochemical Assay Reagents	Others
3-Maleimidobenzoic acid is a protein crosslinker .

HY-124318

SMPH Crosslinker	PROTAC Linkers	Cancer
SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-126349

DTSSP Crosslinker	ADC Linker	Cancer
DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W019543

DSS Crosslinker 4 Publications Verification	ADC Linker	Cancer
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-118759S

*DSP Crosslinker-d8*	Isotope-Labeled Compounds	Others
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-W705390

*DSS Crosslinker-d4*	Isotope-Labeled Compounds	Others
DSS Crosslinker-d₄ is the deuterium labeled DSS Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-157414

Azide-A-DSBSO crosslinker	Others	Others
Azide-A-DSBSO crosslinker is a mass spectrometry (MS)-cleavable, membrane-permeable, homobifunctional, azide-labeled, acid-cleavable cross-linked peptide. Azide-A-DSBSO crosslinker enables the study of protein-protein interactions via cross-linking mass spectrometry (XL-MS) .

HY-124329

BS3 Crosslinker	ADC Linker	Cancer
BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-114697

DSG Crosslinker Disuccinimidyl glutarate	ADC Linker	Inflammation/Immunology
DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-124329AS

*BS3 Crosslinker-d4 disodium*	Isotope-Labeled Compounds	Others
BS3 Crosslinker-d₄ (disodium) is the deuterium labeled BS3 Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-124329A

*BS3 Crosslinker* disodium**	ADC Linker	Cancer
BS3 Crosslinker disodium is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W332335

Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium	Biochemical Assay Reagents	Others
Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium is a protein crosslinker, and is a biotinylation reagentcan for labeling cell surface proteins .

HY-130547S

*BS2G Crosslinker-d4 disodium*	Isotope-Labeled Compounds	Others
BS2G Crosslinker-d₄ (disodium) is the deuterium labeled BS2G Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-100216

SPDP 5 Publications Verification SPDP Crosslinker; Py-ds-Prp-OSu	ADC Linker	Cancer
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-130547

*BS2G Crosslinker* disodium**	ADC Linker	Cancer
BS2G Crosslinker (disodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-114697S

*DSG Crosslinker-d4* Disuccinimidyl glutarate-d₄	Isotope-Labeled Compounds	Others
DSG Crosslinker-d₄ is the deuterium labeled DSG Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-W011541

SIA Crosslinker Iodoacetic acid N-hydroxysuccinimide ester; N-Succinimidyl Iodoacetate	ADC Linker	Cancer
SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W319374

2-(Methylsulfonyl)ethyl n-succinimidyl carbonate	Biochemical Assay Reagents	Others
2-(Methylsulfonyl)ethyl n-succinimidyl carbonate is a protein crosslinker. 2-(Methylsulfonyl)ethyl n-succinimidyl carbonate has amino protective function .

HY-142740

Rha-PEG3-SMCC	Drug-Linker Conjugates for ADC	Cancer
Rha-PEG3-SMCC (compound 13) is a agent-linker conjugate for ADC with potent antitumor activity by using SMCC (a protein crosslinker), linked via the noncleavable ADC linker Rha-PEG3.

HY-140051

N-Boc-aminoxy-PEG3-propargyl t-Boc-aminooxy-PEG3-Propargyl	ADC Linker	Cancer
N-Boc-aminoxy-PEG3-propargyl is a crosslinker containing a propargyl group and a t-Boc-aminooxy group. N-Boc-aminoxy-PEG3-propargyl can be used in the synthesis of ADC .

HY-145485

HS-PEG-SH (MW 3400)	Biochemical Assay Reagents	Others
HS-PEG-SH (MW 3400), a linear homobifunctional PEG, is a cross-linker. HS-PEG-SH can be used for drug delivery and preparation of PEG hydrogels .

HY-150014

AMT-NHS	Others	Others
AMT-NHS is an RNA-protein crosslinker. AMT-NHS is composed of a psoralen derivative and an N-hydroxysuccinimide ester group which react with RNA bases and primary amines of protein, respectively. AMT-NHS can penetrate into living yeast cells and crosslink Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different crosslinking patterns and targets both single- and double-stranded regions of RNA. AMT-NHS can be used for capturing diverse RNA-protein interactions in cells .

HY-103700A

Azide-phenylalanine hydrochloride UAA Crosslinker 2	Amino Acid Derivatives	Others
Azide-phenylalanine hydrochloride is a phenylalanine derivative. Azide-phenylalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-135066

Triallyl pentaerythritol Pentaerythritol triallyl ether	Others	Others
Triallyl pentaerythritol (PEATA), a crosslinker, decreases the protein rejection compared to membranes functionalized with MBAA or without any crosslinker .

HY-130458

EGNHS 2 Publications Verification EGS Crosslinker	PROTAC Linkers	Cancer
EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-W123009

Sulfo-KMUS sodium salt 11-Maleimidoundecanoic acid sulfo-N-succinimidyl ester sodium salt	Biochemical Assay Reagents	Others
Sulfo-KMUS (sodium salt) acts as a crosslinker .

HY-130547A

BS2G Crosslinker	DNA Alkylator/Crosslinker

HY-107783

Sulfo-GMBS	Others	Cancer
Sulfo-GMBS is a cross-linker. Among the amine-sulfhydryl cross-linkers, Sulfo-GMBS generated the largest number of cross-links and covered most of the cross-links that were identified with AMAS and GMBS .

HY-129377

Sulfo-SPP	ADC Linker	Cancer
Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.

HY-129377A

Sulfo-SPP sodium	ADC Linker	Cancer
Sulfo-SPP sodium a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.

HY-136772

Pomalidomide-PEG1-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Others
Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand .

HY-126495

Sulfo-LC-SPDP	ADC Linker	Cancer
Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.

HY-126503

trans-Sulfo-SMCC	ADC Linker	Cancer
trans-Sulfo-SMCC is a non-cleavable and membrane permeable ADC crosslinker.

HY-137383

Sulfo-SANPAH	Others	Cardiovascular Disease
Sulfo-SANPAH is a primary amine-nitrobenzene azide cross-linker .

HY-119523

Disuccinimidyl sebacate 1 Publications Verification DSSeb; Sebacic acid bis N-succinimidyl ester	Biochemical Assay Reagents	Others
Disuccinimidyl sebacate (DSSeb) is a cross-linker that can be used in the synthesis of the intermolecular cross-linked peptides .

HY-128925

AMAS 1 Publications Verification	ADC Linker	Cancer
AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.

HY-W104848

4-Maleimidobenzoic acid	Biochemical Assay Reagents	Others
4-Maleimidobenzoic acid is a protein crosslinker. 4-Maleimidobenzoic acid can be used to synthesis maleimidobenzoyl spacers .

HY-W123005

Dimethyl pimelimidate dihydrochloride	Biochemical Assay Reagents	Others
Dimethyl pimelimidate dihydrochloride (DMP) is a protein crosslinker that can be used in chromatin immunoprecipitation experiments (ChIP) to enhance signal .

HY-42360

SMCC	ADC Linker	Cancer
SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses .

HY-134853

2-(Boc-amino)ethanethiol	Others	Cancer
2-(Boc-amino)ethanethiol (compound 35) is a bifunctional cross-linker that can be used in the synthesis of bifunctional azobenzene glycoconjugates .

HY-D0975

Sulfo-SMCC sodium 4 Publications Verification	ADC Linker	Cancer
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

HY-P3159

VPM peptide	Biochemical Assay Reagents	Others
VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel .

Cat. No.	Product Name	Type

HY-D2396

Sulfo SMCC R-phycoerythrin Sulfo SMCC R-PE	Dyes
Sulfo SMCC R-phycoerythrin is a conjugate composed of the protein crosslinker SMCC (HY-42360) and R-PE (R-Phycoerythrin) (HY-D0988) that can be used to label proteins to make them carry red fluorescence. Among them, SMCC is able to engage antigen-coupled spleen cells to induce antigen-specific immune responses .

Cat. No.	Product Name	Type

HY-D0975

Sulfo-SMCC sodium 4 Publications Verification	Biochemical Assay Reagents
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

HY-W068119A

N-(2-Aminoethyl)maleimide hydrochloride 2-Maleimidoethylamine hydrochloride	Biochemical Assay Reagents
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a cross-linker. N-(2-Aminoethyl)maleimide hydrochloride can be used to prepare MMP-2 sensitive nanosystem, and for cancer research .

HY-125865

Casein

Native Proteins

Casein is a phosphoprotein that can be separated into various electrophoretic components, such as α₂-Casein, κ-Casein, β-casein, and γ-casein. Casein has also been blended and grafted with other polymers, cross-linkers, or monomers to improve its functional properties, including mechanical properties, water resistance, thermal stability, and barrier properties. Casein has various applications in the paper, leather, textile, and food industries, serving as coatings, adhesives, and packaging materials .

HY-W123009

Sulfo-KMUS sodium salt 11-Maleimidoundecanoic acid sulfo-N-succinimidyl ester sodium salt	Biochemical Assay Reagents
Sulfo-KMUS (sodium salt) acts as a crosslinker .

HY-W017588

N-(2-Hydroxyethyl)maleimide	Biochemical Assay Reagents
N-(2-Hydroxyethyl)maleimide is a cross-linker. N-(2-Hydroxyethyl)maleimide is used for chemical synthesis .

Cat. No.	Product Name	Target	Research Area

HY-P3159

VPM peptide	Biochemical Assay Reagents	Others
VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-P3159A

VPM peptide TFA	Biochemical Assay Reagents	Others
VPM peptide TFA is a dithiol protease-cleavable peptide cross-linker. VPM peptide TFA can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel .

Cat. No.	Product Name	Chemical Structure

HY-118759S

*DSP Crosslinker-d8*
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-W705390

*DSS Crosslinker-d4*
DSS Crosslinker-d₄ is the deuterium labeled DSS Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-124329AS

*BS3 Crosslinker-d4 disodium*
BS3 Crosslinker-d₄ (disodium) is the deuterium labeled BS3 Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-130547S

*BS2G Crosslinker-d4 disodium*
BS2G Crosslinker-d₄ (disodium) is the deuterium labeled BS2G Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-114697S

*DSG Crosslinker-d4*
DSG Crosslinker-d₄ is the deuterium labeled DSG Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

Cat. No.	Product Name		Classification

HY-111434

*UAA crosslinker* 1**		Azide
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-111434A

*UAA crosslinker* 1 hydrochloride**		Azide
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140051

N-Boc-aminoxy-PEG3-propargyl t-Boc-aminooxy-PEG3-Propargyl		Alkynes
N-Boc-aminoxy-PEG3-propargyl is a crosslinker containing a propargyl group and a t-Boc-aminooxy group. N-Boc-aminoxy-PEG3-propargyl can be used in the synthesis of ADC .

HY-103700A

Azide-phenylalanine hydrochloride UAA Crosslinker 2		Azide
Azide-phenylalanine hydrochloride is a phenylalanine derivative. Azide-phenylalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130435

DBCO-PEG4-amine		PROTAC Synthesis DBCO ADC Synthesis
DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker) . DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		Azide PROTAC Synthesis
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: