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Glycosylation

" in MedChemExpress (MCE) Product Catalog:

51

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12

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5

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15

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3

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W040294

    Methyl α-D-glucopyranoside

    Biochemical Assay Reagents Others
    Methyl α-D-glucoside (Methyl α-D-glucopyranoside) can be used for protein glycosylation modification. Methyl α-D-glucoside is a kind of biological materials or organic compounds that are widely used in life science research .
    Methyl α-D-glucoside
  • HY-113230B

    Endogenous Metabolite Metabolic Disease
    Galactosylhydroxylysine hydrochloride is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine hydrochloride is released during bone resorption and has been shown to be elevated in metabolic bone loss .
    Galactosylhydroxylysine hydrochloride
  • HY-P0095

    Angiotensin-converting Enzyme (ACE) Others
    Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .
    Acetyl tetrapeptide-5
  • HY-138802
    ML089
    1 Publications Verification

    Others Metabolic Disease
    ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC50 of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia .
    ML089
  • HY-125732

    Others Infection
    Decarestrictine D exhibits inhibitory activity against cholesterol levels. Decarestrictine D is utilized as receptor for glycosylation reactions to synthesize novel hybrid antibiotics .
    Decarestrictine D
  • HY-113230

    Endogenous Metabolite Metabolic Disease
    Galactosylhydroxylysine is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine is released during bone resorption and has been shown to be elevated in metabolic bone loss .
    Galactosylhydroxylysine
  • HY-116392E

    Glucosylceramide Synthase (GCS) Neurological Disease Metabolic Disease
    D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth .
    D-threo-PDMP
  • HY-157461

    Others Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Glycation-IN-1 (Compound 3) is an inhibitor of glycosylation reactions, which has a strong inhibitory effect on the synthesis of initial, intermediate, and final products of glycosylation reactions. Glycion-IN-1 can be used in the research of various chronic diseases, such as diabetes, immune inflammation, cardiovascular diseases and neurodegenerative diseases .
    Glycation-IN-1
  • HY-164390

    Neu5Acα2-6Galβ1-4GlcNAc

    Endogenous Metabolite Infection Cancer
    6′SLN is a cancer-related extracellular vesicle (EVs) surface glycan that serves as a key form of protein glycosylation in EVs. 6′SLN is also a sialic acid derivative that can interact with hemagglutinins (HAs) from human and avian influenza virus strains, making it useful for research into anti-influenza drugs .
    6′SLN
  • HY-W415798

    Endogenous Metabolite Others
    Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .
    Ac4GalNAlk
  • HY-W009783

    HIV Influenza Virus Infection
    1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity .
    1-Deoxymannojirimycin hydrochloride
  • HY-N1347

    3,3',4',5',7-Pentahydroxyflavone

    Fungal HIV Integrase Bacterial Infection
    Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation .
    Robinetin
  • HY-N1347R

    Fungal HIV Integrase Bacterial Infection
    Robinetin (Standard) is the analytical standard of Robinetin. This product is intended for research and analytical applications. Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation .
    Robinetin (Standard)
  • HY-137042

    Alkyne-Cy5

    Oxidative Phosphorylation Mitochondrial Metabolism Cancer
    Cyanine5 alkyne (Alkyne-Cy5) is a fluorescent dye used to label azide proteins and can be used to analyse post-translational modifications of proteins, glycosylation etc. Cyanine5 alkyne can also be used as a mitochondrial OXPHOS inhibitor to inhibit the growth of cancer stem cells (CSC) . Cyanine5 alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Cyanine5 alkyne
  • HY-E70292

    GALNT11

    Notch Endogenous Metabolite Cardiovascular Disease
    N-Acetylgalactosaminyltransferase 11 (GALNT11) is a glycosylation transferase capable of activating the Notch signal .
    N-Acetylgalactosaminyltransferase 11
  • HY-156862

    Others Others
    (+)-Chloroquine is a aminoquinoline drug impairs in vitro the terminal glycosylation of angiotensin-converting enzyme 2 (ACE-2) .
    (+)-Chloroquine
  • HY-125849

    Chrysin 7-O-β-gentiobioside

    Others Cancer
    Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) is the glycosylation product of Chrysin .
    Chrysin 7-O-beta-gentiobioside
  • HY-160109

    Mucin Cancer
    Ac5GalNTGc is a analog of hexosamine. Ac5GalNTGc inhibits mucin-type O-linked glycosylation biosynthesis .
    Ac5GalNTGc
  • HY-41588

    Biochemical Assay Reagents Others
    2,3,4,6-Tetra-O-acetyl-D-glucopyranose, 96% can be used in simulated glycosylation experiments.
    2,3,4,6-Tetra-O-acetyl-D-glucopyranose, 96%
  • HY-W039855A

    Biochemical Assay Reagents Others
    1,2,3,4-Tetra-O-benzyl-β-D-glucopyranoside is a substrate for enzymatic glycosylation reactions and glycosyltransferase assays.
    1,2,3,4-Tetra-O-benzyl-β-D-glucopyranoside, 98%
  • HY-W674039

    Biochemical Assay Reagents Others
    6-Azido-6-deoxy-D-glucose, 95% is used for visualizing protein-specific glycosylation in living cells.
    6-Azido-6-deoxy-D-glucose, 95%
  • HY-E70290

    GALNT1

    Endogenous Metabolite β-catenin Wnt Cancer
    N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .
    N-Acetylgalactosaminyltransferase 1
  • HY-E70104

    α-L-Rhamnosidase

    Others Others
    α-Rhamnosidase is a glycoside hydrolase. α-Rhamnosidase is able to finish the enzymatic de-glycosylation of many nature flavone glycosides .
    α-Rhamnosidase
  • HY-W661016

    1-Azido-1-deoxy-beta-D-galactopyranoside, 97%

    Biochemical Assay Reagents Others
    1-Azido-1-deoxy-β-D-galactopyranoside, 97% is extensively used in research on glycosylation processes and enzyme mechanisms.
    1-Azido-1-deoxy-β-D-galactopyranoside, 97%
  • HY-W039939

    2-ADG, 98%

    Biochemical Assay Reagents Others
    2-Azido-2-deoxy-D-glucose, 98% is a glycosylation inhibitor, which can be used to study the mechanisms of glycosylating enzymes.
    2-Azido-2-deoxy-D-glucose, 98%
  • HY-W378863

    Biochemical Assay Reagents
    Methyl 2,3,5-tri-O-benzyl-β-D-ribofuranoside is a glycosylation reagent that can be used in the synthesis of oligosaccharides and polysaccharides .
    Methyl 2,3,5-tri-O-benzyl-β-D-ribofuranoside
  • HY-129389
    Benzyl-α-GalNAc
    1 Publications Verification

    Others Cancer
    Benzyl-α-GalNAc is a potent O-glycosylation inhibitor. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, which has good potential for investigation in liver fibrosis. Benzyl-α-GalNAc also significantly enhances the anti-tumour activity of 5-FU (HY-90006) (e.g. pancreatic cancer) by inhibiting O-glycosylation .
    Benzyl-α-GalNAc
  • HY-W047324

    4-Aminophenylmannoside, 98%

    Biochemical Assay Reagents Others
    4-Aminophenyl-α-D-mannopyranoside, 98% is a synthetic glycoside primarily used as a molecular tool in biochemical research for studying glycosylation processes and enzyme-substrate interactions.
    4-Aminophenyl-α-D-mannopyranoside, 98%
  • HY-W718137

    Biochemical Assay Reagents Others
    6-Azido-6-deoxy-D-galactose, 95% can be used as a substrate in enzymology to study the activity and specificity of galactosyltransferases and other glycosylation enzymes.
    6-Azido-6-deoxy-D-galactose,95%
  • HY-160109A

    Mucin Cancer
    Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc inhibits mucin-type O-linked glycosylation biosynthesis .
    Ac5GalNTGc epimer
  • HY-W008125

    Acetobromo-alpha-D-glucuronic acid methyl ester, 98%

    Biochemical Assay Reagents Others
    Acetobromo-α-D-glucuronic acid methyl ester, 98% (Acetobromo-alpha-D-glucuronic acid methyl ester, 98%) can be used in glycobiology research and can undergo glycosylation reactions with suitable glycoside receptors.
    Acetobromo-α-D-glucuronic acid methyl ester, 98%
  • HY-W013707

    Cytidine triphosphate disodium dihydrate; 5'-CTP disodium dihydrate

    Endogenous Metabolite Metabolic Disease
    Cytidine-5'-triphosphate disodium dihydrate (5'-CTP disodium dihydrate) is a molecule of high energy, and acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation .
    Cytidine-5'-triphosphate disodium dihydrate
  • HY-156905

    Others Cancer
    6-Azido-N-acetylgalactosamine-UDP (compound 5) is an active sugar donor in the beta-1, 3-N-Acetylhexaminyltransferase (LgtA)-catalyzed glycosylation of lactose .
    6-Azido-N-acetylgalactosamine-UDP
  • HY-N7603

    Monoamine Oxidase Neurological Disease
    Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC50 of 85.5 μM .
    Rubrofusarin triglucoside
  • HY-P99322

    LFG316; Anti-Human C5 Recombinant Antibody

    Complement System Inflammation/Immunology
    Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex .
    Tesidolumab
  • HY-W039854

    1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranose, 96%

    Biochemical Assay Reagents Others
    1,2,3,4-Tetra-O-acetyl-β-D-glucopyranose, 96% (1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranose, 96%) can be used in glycobiology research to study glycosylation mechanisms, glycosidic bond formation, and stereochemistry.
    1,2,3,4-Tetra-O-acetyl-β-D-glucopyranose, 96%
  • HY-E70295

    GALNT14

    Endogenous Metabolite Cancer
    N-Acetylgalactosaminyltransferase 14 (GALNT14) is a mucin-type glycosylating enzyme polypeptide that promotes the migration of ovarian cancer by modifying mucin 13 (MUC13). GALNT14 can regulate the O-glycosylation and stability of MUC13, thereby mediating the malignant behavior of ovarian cancer cells .
    N-Acetylgalactosaminyltransferase 14
  • HY-161424

    Others Cancer
    ZJ-101 is a structurally simplified analog derived from the marine natural product superstolide A. ZJ-101 exhibits potent antiproliferative activity. ZJ-101 can target and inhibit O-glycosylation, thereby modulating the endomembrane system. ZJ-101 can inhibit cell-cell adhesion .
    ZJ-101
  • HY-129099

    PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite Cancer
    N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .
    N-Desmethyltamoxifen
  • HY-129099A

    PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite Cancer
    N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .
    N-Desmethyltamoxifen hydrochloride
  • HY-P4027

    HCV Infection
    HCV-1 e2 Protein (554-569) is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) contains a putative n-glycosylation site, which was previously thought to influence the immune recognition of e2 .
    HCV-1 e2 Protein (554-569)
  • HY-P4027A

    HCV Infection
    HCV-1 e2 Protein (554-569) TFA is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) TFA contains a putative N-glycosylation site, which was previously thought to influence the immune recognition of e2 .
    HCV-1 e2 Protein (554-569) (TFA)
  • HY-P99324

    Anti-Human EGFR Recombinant Antibody

    EGFR Apoptosis Cancer
    Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects .
    Tomuzotuximab
  • HY-E70120

    Fungal Infection
    Phosphomannose isomerase is the first enzyme involved in the biosynthesis pathway of GDP-Man. Phosphomannose isomerase catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P). Phosphomannose isomerase is important for cell wall synthesis and protein glycosylation. Phosphomannose isomerase is a potent antifungal target to curb the threats posed by A. flavus .
    Phosphomannose isomerase
  • HY-A0098
    Tunicamycin
    Maximum Cited Publications
    92 Publications Verification

    Bacterial Fungal Influenza Virus Antibiotic Infection Inflammation/Immunology Cancer
    Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity .Tunicamycin increases exosome release in cervical cancer cells .
    Tunicamycin
  • HY-135646

    Influenza Virus Infection Inflammation/Immunology
    Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities .
    Eleutheroside B1
  • HY-124890

    Others Metabolic Disease
    Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .
    Thr101
  • HY-P2232

    Ovotransferrin

    Others Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Conalbumin (Ovotransferrin), also known as ovotransferrin, is a monomeric glycoprotein consisting of 686 amino acids, encoded by the avian transferrin gene in the oviduct, and a prominent component of chicken egg white. Exhibiting a unique glycosylation pattern that differentiates it from serum transferrin, Conalbumin is a potent iron binder that plays a crucial role in iron transport to developing embryos. Additionally, it possesses a range of biological activities, including antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory properties, making it valuable in numerous applications such as infant formula ingredients, food additives, and agents for enhancing animal health.
    Conalbumin
  • HY-135785

    OGT Acyltransferase Metabolic Disease
    OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells .
    OSMI-3
  • HY-163958

    PD-1/PD-L1 Cancer
    PD-L1-IN-7 (compound CB31) is an inhibitor of PD-L1, which can induce PD-L1 internalization and PD-L1 retention in cells. PD-L1-IN-7 can inhibit the interaction of PD-1/PD-L1 (IC50: 0.2 nM), change the glycosylation pattern, and promote PD-L1 degradation. PD-L1-IN-7 can also enhance T cell infiltration, amplify T cell function and the ability to kill tumor cells .
    PD-L1-IN-7

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