Search Result
Results for "
Ionizable lipid
" in MedChemExpress (MCE) Product Catalog:
53
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-160439
-
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Liposome
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Others
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Ionizable lipid-2 (compound 1) is an ionizable lipid used for nucleic acid delivery and construct lipid nanoparticles (LNPs) .
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-
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- HY-156630
-
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Liposome
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Others
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Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
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-
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- HY-148648
-
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Liposome
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Others
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Lipid 29 is an ionizable amino lipid. Lipid 29 can be used to form lipid nanoparticles .
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-
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- HY-159708
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Liposome
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Others
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Ionizable lipid Az1is an ionizable lipid which can react with a variety of terminal alkynes under the CuAAC standard condition .
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-
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- HY-156630A
-
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Liposome
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Others
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Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
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-
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- HY-W440753
-
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Liposome
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Others
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BP Lipid 114 is an ethanolamine ionizable lipid (CN113387825A) .
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-
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- HY-W440779
-
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Liposome
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Metabolic Disease
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BP Lipid 135 is a cationieally ionizable lipid. BP Lipid 135 can be used to prepare lipid nanoparticles (LNP) (WO2022218503A1) .
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-
-
- HY-159717
-
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Liposome
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Others
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Lipid 331 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 331 is a carrier for both siRNA and mRNA .
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-
-
- HY-159714
-
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Liposome
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Others
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Lipid HTO12 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid HTO12 is a carrier for both siRNA and mRNA .
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-
-
- HY-159715
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Liposome
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Others
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Lipid DIM1 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid DIM1 is a carrier for both siRNA and mRNA .
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-
-
- HY-159716
-
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Liposome
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Others
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Lipid 50 (compound 50) is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 50 is a carrier for both siRNA and mRNA .
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-
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- HY-142995
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Liposome
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Others
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DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .
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-
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- HY-159726
-
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Liposome
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Others
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C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .
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-
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- HY-159709
-
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Liposome
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Others
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VL-422 is an ionizable cationic lipid that can be used for lipid nanoparticle (LNP) and drug delivery research .
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-
-
- HY-160553
-
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Liposome
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Others
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9322-O16B, an ionizable cationic lipid, is used for LNP generation .
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-
-
- HY-151507
-
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Liposome
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Others
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306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
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-
-
- HY-167003
-
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Liposome
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Others
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L16 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. L16 can be used in the preparation of liposomes .
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-
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- HY-167004
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Liposome
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Others
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IAJD93 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD93 can be used in the preparation of liposomes .
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- HY-167004A
-
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Liposome
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Others
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IAJD249 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD249 can be used in the preparation of liposomes .
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- HY-167002
-
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Liposome
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Others
|
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RM 137-15 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. RM 137-15 can be used in the preparation of liposomes .
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-
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- HY-167011
-
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Liposome
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Others
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Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes .
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-
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- HY-167015
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Liposome
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Others
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1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes .
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-
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- HY-167012
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Liposome
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Others
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306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes .
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- HY-148842
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Liposome
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Others
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C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .
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- HY-154974
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Liposome
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Cancer
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LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model .
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- HY-160552
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Liposome
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Others
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244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
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- HY-159700
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Liposome
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Infection
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AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .
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- HY-145405
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Liposome
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Others
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C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
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- HY-147332
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Liposome
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Neurological Disease
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TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .
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- HY-150116
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Liposome
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Others
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Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
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- HY-150115
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Liposome
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Others
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Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
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- HY-153378
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Liposome
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Others
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Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
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- HY-150117
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Liposome
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Others
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Lipid 6 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
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- HY-150118
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Liposome
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Others
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Lipid 8 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
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- HY-153377
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- HY-160908
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Liposome
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Others
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Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA .
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- HY-134782
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Liposome
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Others
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OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
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- HY-153186
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Liposome
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Others
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LNP Lipid-3 is an ionizable lipid extracted from patent WO2021113777A, and can be used for the generation of Lipid nanoparticles (LNPs).
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- HY-153375
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Liposome
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Others
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LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles (LNP) .
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- HY-153376
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Liposome
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Others
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LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP) .
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- HY-W440752
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Liposome
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Cancer
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BP Lipid 113 is an ionizable lipid analogous to SM-102. It can be used to prepare liposome or lipid nanoparticles.
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- HY-160512
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Liposome
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Others
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Lipid 9 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
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- HY-153373
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Liposome
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Others
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4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).
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- HY-W440743
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Liposome
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Cancer
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BP Lipid 103 is an amine ionizable lipid analogous to SM-102. It can be used to prepare liposome or lipid nanoparticles.
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- HY-W440800
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Liposome
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Cancer
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BP Lipid 226 is an amino ionizable lipid analogous to ALC-0315. It can be used to prepare liposome or lipid nanoparticles.
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- HY-145739
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- HY-159735
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Liposome
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Others
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Lipid 23 is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNP). Lipid 23 can be used for mRNA delivery .
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- HY-160705
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Liposome
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Cancer
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PNI 132, an ionizable lipid derived from the patent WO2020252589A, is useful in the formulation of lipid nanoparticles.
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- HY-145796
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Liposome
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Others
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503O13 is a degradable ionizable lipid for siRNA delivery.
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- HY-112757
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DLinDMA
1 Publications Verification
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Liposome
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Others
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DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
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- HY-W440803
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Liposome
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Cancer
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BP Lipid 218 is an ionizable amine lipid with two identical ester tails adjacent to C6 position relative to amine.
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- HY-W590532
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Liposome
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Others
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306-O12B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs).
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- HY-149156
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Liposome
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Cancer
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Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids .
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- HY-156985
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Isotope-Labeled Compounds
Liposome
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Others
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Lipid AX4 is an ionizable cationic lipid with the pKa of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .
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- HY-46759
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Liposome
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Infection
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Genevant CL1 is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery [1][2].
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- HY-153372
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Liposome
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Others
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93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
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- HY-159725
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Liposome
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Others
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BAmP-O16B is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNPs) .
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- HY-158862
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Liposome
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Others
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BP Lipid 376 features a unique piperidine ionizable head group with a carbamate linkage to the lipid scaffold comprised of a linoleate ester and aliphatic acetal ester. This lipid may be used in the development of lipid nanoparticles for drug delivery.
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- HY-46759A
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Liposome
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Infection
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Genevant CL1 monohydrochloride is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery .
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- HY-W590548
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Liposome
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Others
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ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .
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- HY-158861
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G1-nPr-C14E
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Liposome
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Others
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C3-K2-E14 is a multi-ionizable amino-lipid featuring a central tertiary amine with two identical branches and an n-propyl group. Each branch features a propanamide linking to a branched amine, each with two C14 arms and a hydroxyl. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug discovery.
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- HY-W800802
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Liposome
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Cancer
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BP Lipid 227 is an ionizable lipid. It has primary esters at C5 position relative to the amine nitrogen. The primary lipid tail has an 8 carbon tail. BP Lipid 227 can be used in the generation of liposomes.
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- HY-149167
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- HY-W590531
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- HY-W800827
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Liposome
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Cancer
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BP Lipid 229 is an amino ionizable lipid. It has primary esters at C7 position relative to the amine nitrogen. The primary lipid tail has 8 carbon tail. BP Lipid 229 can be used in the generation of liposomes.
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- HY-156857
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-
- HY-W800841
-
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Liposome
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Cancer
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BP Lipid 314 is an ionizable amino lipid featuring a dimethylamino head group, a carbamate linking to a central tertiary carbon with two other branches, a linoleate ester, and an aliphatic acetal ester.
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- HY-151511
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Liposome
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Cancer
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A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
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- HY-158864
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Liposome
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Others
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BP Lipid 378 is derived from patent WO2020219876A1 (Example 8). BP Lipid 378 is an ionizable amino lipid that features a unique pyrrolidine head group with a carbamate linkage to the lipid tails. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA delivery.
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- HY-W590678
-
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Liposome
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Others
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SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for drug delivery.
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- HY-112251
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D-Lin-MC3-DMA
Maximum Cited Publications
65 Publications Verification
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Liposome
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Cancer
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D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
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- HY-145795
-
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Liposome
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Others
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OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.
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- HY-148049
-
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Liposome
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Others
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TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
|
-
- HY-112251A
-
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Liposome
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Cancer
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D-Lin-MC3-DMA Excipient, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
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- HY-134781
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CKK-E12
1 Publications Verification
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Liposome
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Others
|
|
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
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- HY-158863
-
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Liposome
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Others
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BP Lipid 377 is derived from patent WO2018062413A1. BP Lipid 377 is an ionizable amino lipid comprised of three linoleic acid tails and an N,N-dimethylamine head group four carbon atoms in length. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA and drug delivery.
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- HY-W800778
-
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Liposome
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Cancer
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Bis(2-butyloctyl) 10-oxononadecanedioate is an ionizable lipid-like compound containing four hydrophobic tails bound by esters. It can be used to build lipids for mRNA encapsulation and delivery.
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- HY-160580
-
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Liposome
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Others
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G1-OC2-K3-E10 is an ionizable lipid, and can be used for delivery of mRNA in lipid nanoparticles (LNPs) .
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- HY-158865
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Liposome
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Others
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BP Lipid 399 is derived from patent WO2020219876A1 (Example 3).BP Lipid 399 is an ionizable amino lipid analog of LP01 featuring a novel pyrrolidine head group three carbon atoms in length. This compound can be useful for the building or modification of lipid nanoparticles.
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- HY-W800777
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Liposome
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Cancer
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6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.
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- HY-156936
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Liposome
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Others
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RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
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- HY-W440802
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Liposome
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Others
|
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BP Lipid 217 is derived from patent WO2023178065A2 (B32). BP Lipid 217 is an ethanolamine ionizable lipid with both ester bonds located adjacent to C8 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315.
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- HY-W598178
-
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Liposome
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Others
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93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .
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- HY-153737
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Liposome
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Others
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113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
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- HY-112772A
-
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Liposome
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Others
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98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.
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- HY-148855
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Liposome
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Others
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OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
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- HY-W800737
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Liposome
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Cancer
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BP Lipid 126 is an amino ionizable lipid (Compound 143) from patent WO2017201333A1 with ester bonds located at C8 and C7 position relative to nitrogen. The ester linkages are introduced to improve tissue clearance. The ethanolamine head can effectively enhance mRNA encapsulation. BP Lipid 126 can be used in the generation of liposomes.
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- HY-W440787
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Liposome
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Others
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BP Lipid 142 is derived from patent WO2018170306A1 (Example 102). BP Lipid 142 is an ionizable amine lipid analogous to SM-102. The propanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 and C8 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The primary ester located at C6 is attached with a long (11-carbon) lipid tail. The lipid can be used for mRNA-based therapies.
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- HY-142654
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Liposome
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Others
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ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
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- HY-W800849
-
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Liposome
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Cancer
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BP Lipid 315 is a cationic ionizable lipid ALC-0315 analogue featuring a Boc-protected primary amine, a central tertiary amine, and two ester tails located at the C8 position relative to the amine. One of these esters features a symmetrical branched C17 tail, while the other is an asymmetric C11 tail.
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- HY-W590681
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Liposome
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Others
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113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
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- HY-W590679
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Liposome
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Others
|
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113-O16B is a disulfide bond-containing ionizable cationic lipidoid. 113-O16B has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
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-
- HY-151512
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-
- HY-160852
-
|
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Liposome
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Inflammation/Immunology
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YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .
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- HY-157252
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Liposome
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Cancer
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CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .
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- HY-112251S
-
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Isotope-Labeled Compounds
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Others
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D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].
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- HY-145799
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5A2-SC8
1 Publications Verification
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Liposome
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Cancer
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5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
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- HY-145798
-
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Liposome
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Others
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N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
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- HY-130751
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Liposome
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Inflammation/Immunology
|
|
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-156630
-
|
|
Drug Delivery
|
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
|
-
- HY-148648
-
|
|
Drug Delivery
|
|
Lipid 29 is an ionizable amino lipid. Lipid 29 can be used to form lipid nanoparticles .
|
-
- HY-151507
-
|
|
Drug Delivery
|
|
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
|
-
- HY-156630A
-
|
|
Drug Delivery
|
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
|
-
- HY-W440753
-
|
|
Drug Delivery
|
|
BP Lipid 114 is an ethanolamine ionizable lipid (CN113387825A) .
|
-
- HY-W440779
-
|
|
Drug Delivery
|
|
BP Lipid 135 is a cationieally ionizable lipid. BP Lipid 135 can be used to prepare lipid nanoparticles (LNP) (WO2022218503A1) .
|
-
- HY-142995
-
|
|
Drug Delivery
|
|
DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .
|
-
- HY-167003
-
|
|
Drug Delivery
|
|
L16 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. L16 can be used in the preparation of liposomes .
|
-
- HY-167004
-
|
|
Drug Delivery
|
|
IAJD93 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD93 can be used in the preparation of liposomes .
|
-
- HY-167004A
-
|
|
Drug Delivery
|
|
IAJD249 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD249 can be used in the preparation of liposomes .
|
-
- HY-167002
-
|
|
Drug Delivery
|
|
RM 137-15 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. RM 137-15 can be used in the preparation of liposomes .
|
-
- HY-167011
-
|
|
Drug Delivery
|
|
Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes .
|
-
- HY-167015
-
|
|
Drug Delivery
|
|
1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes .
|
-
- HY-167012
-
|
|
Drug Delivery
|
|
306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes .
|
-
- HY-148842
-
|
|
Drug Delivery
|
|
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .
|
-
- HY-145405
-
|
|
Drug Delivery
|
|
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
-
- HY-147332
-
|
|
Drug Delivery
|
|
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .
|
-
- HY-150116
-
|
|
Drug Delivery
|
|
Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150115
-
|
|
Drug Delivery
|
|
Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153378
-
|
|
Drug Delivery
|
|
Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150117
-
|
|
Drug Delivery
|
|
Lipid 6 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150118
-
|
|
Drug Delivery
|
|
Lipid 8 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153377
-
|
|
Drug Delivery
|
|
Lipid 14 is a potent ionizable lipid and can be used to synthesize lipid nanoparticles (LNPs) .
|
-
- HY-134782
-
|
|
Drug Delivery
|
|
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153186
-
|
|
Drug Delivery
|
|
LNP Lipid-3 is an ionizable lipid extracted from patent WO2021113777A, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153375
-
|
|
Drug Delivery
|
|
LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles (LNP) .
|
-
- HY-153376
-
|
|
Drug Delivery
|
|
LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP) .
|
-
- HY-153373
-
|
|
Drug Delivery
|
|
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).
|
-
- HY-145739
-
-
- HY-145796
-
|
|
Drug Delivery
|
|
503O13 is a degradable ionizable lipid for siRNA delivery.
|
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
Drug Delivery
|
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
- HY-W590532
-
|
|
Drug Delivery
|
|
306-O12B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs).
|
-
- HY-149156
-
|
|
Drug Delivery
|
|
Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids .
|
-
- HY-46759
-
|
|
Drug Delivery
|
|
Genevant CL1 is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery [1][2].
|
-
- HY-153372
-
|
|
Drug Delivery
|
|
93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
|
-
- HY-46759A
-
|
|
Drug Delivery
|
|
Genevant CL1 monohydrochloride is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery .
|
-
- HY-149167
-
|
ATX 100
|
Drug Delivery
|
|
ATX-0126 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. ATX-0126 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .
|
-
- HY-156857
-
|
|
Drug Delivery
|
|
PPZ-A10 is a ionizable lipid that delivered mRNA preferentially to liver and spleen immune cells.
|
-
- HY-151511
-
|
|
Drug Delivery
|
|
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
|
-
- HY-W590678
-
|
|
Drug Delivery
|
|
SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for drug delivery.
|
-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
65 Publications Verification
|
Drug Delivery
|
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
- HY-145795
-
|
|
Drug Delivery
|
|
OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.
|
-
- HY-148049
-
|
|
Drug Delivery
|
|
TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
|
-
- HY-134781
-
CKK-E12
1 Publications Verification
|
Drug Delivery
|
|
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
|
-
- HY-153737
-
|
|
Drug Delivery
|
|
113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
|
-
- HY-112772A
-
|
|
Drug Delivery
|
|
98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.
|
-
- HY-148855
-
|
|
Drug Delivery
|
|
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
|
-
- HY-142654
-
|
|
Drug Delivery
|
|
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
|
-
- HY-151512
-
|
|
Drug Delivery
|
|
A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .
|
-
- HY-157252
-
|
|
Drug Delivery
|
|
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .
|
- HY-145799
-
5A2-SC8
1 Publications Verification
|
Drug Delivery
|
|
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
|
- HY-145798
-
|
|
Drug Delivery
|
|
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
|
- HY-130751
-
|
|
Drug Delivery
|
|
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-W141932
-
|
Stearoylglycine; N-Octadecanoylglycine
|
Peptides
|
Others
|
|
N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films .
|
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-112251S
-
|
|
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-159708
-
|
|
|
Azide
|
|
Ionizable lipid Az1is an ionizable lipid which can react with a variety of terminal alkynes under the CuAAC standard condition .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-160439
-
|
|
|
Cationic Lipids
|
|
Ionizable lipid-2 (compound 1) is an ionizable lipid used for nucleic acid delivery and construct lipid nanoparticles (LNPs) .
|
-
- HY-156630
-
|
|
|
Cationic Lipids
|
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
|
-
- HY-148648
-
|
|
|
Cationic Lipids
|
|
Lipid 29 is an ionizable amino lipid. Lipid 29 can be used to form lipid nanoparticles .
|
-
- HY-159708
-
|
|
|
Cationic Lipids
|
|
Ionizable lipid Az1is an ionizable lipid which can react with a variety of terminal alkynes under the CuAAC standard condition .
|
-
- HY-156630A
-
|
|
|
Cationic Lipids
|
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
|
-
- HY-W440753
-
|
|
|
Cationic Lipids
|
|
BP Lipid 114 is an ethanolamine ionizable lipid (CN113387825A) .
|
-
- HY-W440779
-
|
|
|
Cationic Lipids
|
|
BP Lipid 135 is a cationieally ionizable lipid. BP Lipid 135 can be used to prepare lipid nanoparticles (LNP) (WO2022218503A1) .
|
-
- HY-159717
-
|
|
|
Cationic Lipids
|
|
Lipid 331 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 331 is a carrier for both siRNA and mRNA .
|
-
- HY-159714
-
|
|
|
Cationic Lipids
|
|
Lipid HTO12 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid HTO12 is a carrier for both siRNA and mRNA .
|
-
- HY-159715
-
|
|
|
Cationic Lipids
|
|
Lipid DIM1 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid DIM1 is a carrier for both siRNA and mRNA .
|
-
- HY-159716
-
|
|
|
Cationic Lipids
|
|
Lipid 50 (compound 50) is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 50 is a carrier for both siRNA and mRNA .
|
-
- HY-142995
-
|
|
|
Cationic Lipids
|
|
DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .
|
-
- HY-159726
-
|
|
|
Cationic Lipids
|
|
C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .
|
-
- HY-159709
-
|
|
|
Cationic Lipids
|
|
VL-422 is an ionizable cationic lipid that can be used for lipid nanoparticle (LNP) and drug delivery research .
|
-
- HY-160553
-
|
|
|
Cationic Lipids
|
9322-O16B, an ionizable cationic lipid, is used for LNP generation .
|
-
- HY-151507
-
|
|
|
Cationic Lipids
|
|
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
|
-
- HY-167011
-
|
|
|
Cationic Lipids
|
|
Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes .
|
-
- HY-167015
-
|
|
|
Cationic Lipids
|
|
1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes .
|
-
- HY-167012
-
|
|
|
Cationic Lipids
|
|
306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes .
|
-
- HY-148842
-
|
|
|
Cationic Lipids
|
|
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .
|
-
- HY-154974
-
|
|
|
Cationic Lipids
|
|
LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model .
|
-
- HY-160552
-
|
|
|
Cationic Lipids
|
|
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
|
-
- HY-159700
-
|
|
|
Cationic Lipids
|
|
AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .
|
-
- HY-145405
-
|
|
|
Cationic Lipids
|
|
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
-
- HY-147332
-
|
|
|
Cationic Lipids
|
|
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .
|
-
- HY-150116
-
|
|
|
Cationic Lipids
|
|
Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150115
-
|
|
|
Cationic Lipids
|
|
Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153378
-
|
|
|
Cationic Lipids
|
|
Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150117
-
|
|
|
Cationic Lipids
|
|
Lipid 6 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150118
-
|
|
|
Cationic Lipids
|
|
Lipid 8 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153377
-
|
|
|
Cationic Lipids
|
|
Lipid 14 is a potent ionizable lipid and can be used to synthesize lipid nanoparticles (LNPs) .
|
-
- HY-160908
-
|
|
|
Cationic Lipids
|
Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA .
|
-
- HY-134782
-
|
|
|
Cationic Lipids
|
|
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153186
-
|
|
|
Cationic Lipids
|
|
LNP Lipid-3 is an ionizable lipid extracted from patent WO2021113777A, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153375
-
|
|
|
Cationic Lipids
|
|
LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles (LNP) .
|
-
- HY-153376
-
|
|
|
Cationic Lipids
|
|
LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP) .
|
-
- HY-W440752
-
|
|
|
Cationic Lipids
|
|
BP Lipid 113 is an ionizable lipid analogous to SM-102. It can be used to prepare liposome or lipid nanoparticles.
|
-
- HY-153373
-
|
|
|
Cationic Lipids
|
|
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).
|
-
- HY-W440743
-
|
|
|
Cationic Lipids
|
|
BP Lipid 103 is an amine ionizable lipid analogous to SM-102. It can be used to prepare liposome or lipid nanoparticles.
|
-
- HY-W440800
-
|
|
|
Cationic Lipids
|
|
BP Lipid 226 is an amino ionizable lipid analogous to ALC-0315. It can be used to prepare liposome or lipid nanoparticles.
|
-
- HY-145739
-
-
- HY-160705
-
|
|
|
Cationic Lipids
|
|
PNI 132, an ionizable lipid derived from the patent WO2020252589A, is useful in the formulation of lipid nanoparticles.
|
-
- HY-145796
-
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
|
Cationic Lipids
|
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
- HY-W440803
-
|
|
|
Cationic Lipids
|
|
BP Lipid 218 is an ionizable amine lipid with two identical ester tails adjacent to C6 position relative to amine.
|
-
- HY-W590532
-
|
|
|
Cationic Lipids
|
|
306-O12B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs).
|
-
- HY-149156
-
|
|
|
Cationic Lipids
|
|
Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids .
|
-
- HY-156985
-
|
|
|
Cationic Lipids
|
|
Lipid AX4 is an ionizable cationic lipid with the pKa of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .
|
-
- HY-46759
-
|
|
|
Cationic Lipids
|
|
Genevant CL1 is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery [1][2].
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- HY-153372
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Cationic Lipids
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93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
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- HY-159725
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Cationic Lipids
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BAmP-O16B is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNPs) .
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- HY-158862
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Cationic Lipids
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BP Lipid 376 features a unique piperidine ionizable head group with a carbamate linkage to the lipid scaffold comprised of a linoleate ester and aliphatic acetal ester. This lipid may be used in the development of lipid nanoparticles for drug delivery.
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- HY-46759A
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Cationic Lipids
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Genevant CL1 monohydrochloride is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery .
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- HY-W590548
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Cationic Lipids
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ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .
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- HY-158861
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G1-nPr-C14E
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Cationic Lipids
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C3-K2-E14 is a multi-ionizable amino-lipid featuring a central tertiary amine with two identical branches and an n-propyl group. Each branch features a propanamide linking to a branched amine, each with two C14 arms and a hydroxyl. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug discovery.
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- HY-W800802
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Cationic Lipids
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BP Lipid 227 is an ionizable lipid. It has primary esters at C5 position relative to the amine nitrogen. The primary lipid tail has an 8 carbon tail. BP Lipid 227 can be used in the generation of liposomes.
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- HY-149167
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ATX 100
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Cationic Lipids
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ATX-0126 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. ATX-0126 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .
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- HY-W590531
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Cationic Lipids
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80-O16B is an ionizable cationic lipid containing disulfide bonds that can be used to prepare lipid nanoparticles (LNP) .
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- HY-W800827
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Cationic Lipids
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BP Lipid 229 is an amino ionizable lipid. It has primary esters at C7 position relative to the amine nitrogen. The primary lipid tail has 8 carbon tail. BP Lipid 229 can be used in the generation of liposomes.
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- HY-156857
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Cationic Lipids
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PPZ-A10 is a ionizable lipid that delivered mRNA preferentially to liver and spleen immune cells.
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- HY-W800841
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Cationic Lipids
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BP Lipid 314 is an ionizable amino lipid featuring a dimethylamino head group, a carbamate linking to a central tertiary carbon with two other branches, a linoleate ester, and an aliphatic acetal ester.
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- HY-151511
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Cationic Lipids
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A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
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- HY-158864
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Cationic Lipids
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BP Lipid 378 is derived from patent WO2020219876A1 (Example 8). BP Lipid 378 is an ionizable amino lipid that features a unique pyrrolidine head group with a carbamate linkage to the lipid tails. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA delivery.
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- HY-W590678
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Cationic Lipids
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SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for drug delivery.
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- HY-112251
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D-Lin-MC3-DMA
Maximum Cited Publications
65 Publications Verification
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Cationic Lipids
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D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
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- HY-145795
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Cationic Lipids
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OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.
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- HY-148049
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Cationic Lipids
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TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
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- HY-112251A
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- HY-134781
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CKK-E12
1 Publications Verification
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Cationic Lipids
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CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
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- HY-158863
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Cationic Lipids
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BP Lipid 377 is derived from patent WO2018062413A1. BP Lipid 377 is an ionizable amino lipid comprised of three linoleic acid tails and an N,N-dimethylamine head group four carbon atoms in length. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA and drug delivery.
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- HY-W800778
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Cationic Lipids
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Bis(2-butyloctyl) 10-oxononadecanedioate is an ionizable lipid-like compound containing four hydrophobic tails bound by esters. It can be used to build lipids for mRNA encapsulation and delivery.
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- HY-160580
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Cationic Lipids
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G1-OC2-K3-E10 is an ionizable lipid, and can be used for delivery of mRNA in lipid nanoparticles (LNPs) .
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- HY-158865
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Cationic Lipids
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BP Lipid 399 is derived from patent WO2020219876A1 (Example 3).BP Lipid 399 is an ionizable amino lipid analog of LP01 featuring a novel pyrrolidine head group three carbon atoms in length. This compound can be useful for the building or modification of lipid nanoparticles.
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- HY-W800777
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Cationic Lipids
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6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.
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- HY-156936
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Cationic Lipids
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RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
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- HY-W440802
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Cationic Lipids
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BP Lipid 217 is derived from patent WO2023178065A2 (B32). BP Lipid 217 is an ethanolamine ionizable lipid with both ester bonds located adjacent to C8 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315.
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- HY-153737
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Cationic Lipids
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113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
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- HY-112772A
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Cationic Lipids
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98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.
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- HY-148855
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Cationic Lipids
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OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
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- HY-W800737
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Cationic Lipids
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BP Lipid 126 is an amino ionizable lipid (Compound 143) from patent WO2017201333A1 with ester bonds located at C8 and C7 position relative to nitrogen. The ester linkages are introduced to improve tissue clearance. The ethanolamine head can effectively enhance mRNA encapsulation. BP Lipid 126 can be used in the generation of liposomes.
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- HY-W440787
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Cationic Lipids
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BP Lipid 142 is derived from patent WO2018170306A1 (Example 102). BP Lipid 142 is an ionizable amine lipid analogous to SM-102. The propanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 and C8 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The primary ester located at C6 is attached with a long (11-carbon) lipid tail. The lipid can be used for mRNA-based therapies.
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- HY-142654
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Cationic Lipids
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ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
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- HY-W800849
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Cationic Lipids
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BP Lipid 315 is a cationic ionizable lipid ALC-0315 analogue featuring a Boc-protected primary amine, a central tertiary amine, and two ester tails located at the C8 position relative to the amine. One of these esters features a symmetrical branched C17 tail, while the other is an asymmetric C11 tail.
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- HY-W590679
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Cationic Lipids
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113-O16B is a disulfide bond-containing ionizable cationic lipidoid. 113-O16B has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
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- HY-151512
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Cationic Lipids
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A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .
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- HY-157252
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Cationic Lipids
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CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .
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- HY-145799
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5A2-SC8
1 Publications Verification
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Cationic Lipids
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5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
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- HY-145798
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Cationic Lipids
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N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
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- HY-130751
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Cationic Lipids
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DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
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