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Results for "

LH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Apoptosis (3) Cannabinoid Receptor (1) Casein Kinase (1) CDK (1) CRFR (1) Cuproptosis (1) Dengue virus (2) DNA/RNA Synthesis (3) Dopamine Transporter (1) ERK (1) Estrogen Receptor/ERR (7) Flavivirus (2) GABA Receptor (1) GnRH Receptor (34) Histamine Receptor (1) Histone Methyltransferase (1) Keap1-Nrf2 (1) Kisspeptin Receptor (3) Monoamine Oxidase (2) Neurokinin Receptor (1) Neuropeptide Y Receptor (3) PD-1/PD-L1 (2) PERK (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (1) Endocrinology (45) Infection (2) Inflammation/Immunology (4) Metabolic Disease (11) Neurological Disease (7)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121827

LH21	Cannabinoid Receptor	Metabolic Disease
LH-21 is a potent in vivo neutral cannabinoid CB1 receptor antagonist. LH-21 reduces food intake and body weight gain in obese Zucker rats. , and displays efficacy as a feeding inhibitor .

HY-161723

LH2-051	Dopamine Transporter CDK	Neurological Disease
LH2-051 is a lysosome-enhancing lead compound, which promotes the lysosome biogenesis and the Aβ aggregate clearance through dopamine transporter-cyclin-dependent kinase 9-transcription factor EB (DAT-CDK9-TFEB) pathway. LH2-051 exhibits good pharmacokinetic characteristics in mouse models. LH2-051 is potential for ameliorating Aleheimer’s Disease .

HY-161716

LH1753	Others	Others
LH1753 is an orally active L-cystine crystallization inhibitor with an EC₅₀ of 29.5 nM. LH1753 can be used for Cystinuria research .

HY-161715

LH708	Others	Others
LH708 is an orally active L-cystine crystallization inhibitor with an EC₅₀ of 59.8 nM. LH708 can be used for Cystinuria research .

HY-119218

LH 1	Others	Inflammation/Immunology
LH 1 is a potent immunostimulant used for the anti-PVP (polyvinylpyrrolidone) response in athymic mice .

HY-132223

LH1306	PD-1/PD-L1	Inflammation/Immunology Cancer
LH1306 is a C2-symmetric inhibitor of PD-₁/PD-L₁ protein-protein interaction (PPI), with an IC₅₀ value of 25 nM. LH1306 can be used in anti-tumor research .

HY-138271

LH65.3	Others	Others
LH65.3 is a compound with the potential to modulate bacterial infection that was identified through integrated small interfering RNA and small molecule screening to control bacterial infection, involving the regulation of multiple kinases and phosphatases.

HY-P3675

LH-RH (4-10)	GnRH Receptor	Endocrinology
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes .

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .

HY-P3604

LH-RH II (chicken)	Androgen Receptor	Endocrinology
LH-RH II (chicken) is one of the two forms of luteinizing hormone-releasing hormone (LHRH) the hypothalamus of the domestic hen, which are structural variants of mammalian LHRH. LH-RH II (chicken) enhances gonadotrophin release in the domestic chicken .

HY-15704

LH846 1 Publications Verification	Casein Kinase	Cancer
LH846 is a selective inhibitor of CKIδ, with an IC₅₀ of 290 nM, and less potently inhibits CKIα and CKIε, with IC₅₀s of 2.5 μM and 1.3 μM, respectively.

HY-132212

LH1307	PD-1/PD-L1	Inflammation/Immunology Cancer
LH1307 is a C2-symmetric inhibitor of PD-1/PD-L1 protein-protein interactions with a IC₅₀ value of 3.0 μM and can be used in cancer studies .

HY-110258

ML334 5+ Cited Publications LH601A	Keap1-Nrf2	Cancer
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity .

HY-P3664

[D-Phe2,D-Ala6]-LH-RH Wy 18185	GnRH Receptor	Endocrinology
[D-Phe2,D-Ala6]-LH-RH is a potent *LH-RH* antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities .

HY-P3666

[D-Phe2,6, Pro3]-LH-RH	GnRH Receptor	Endocrinology
[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist .

HY-138638

Cross-linked dextran LH 20	Others	Others
Cross-linked dextran LH 20 could be used for the isolation and purification of natural compounds and foods, such as red wine, pigments, and flavonoids .

HY-P3668

[D-Lys6]-LH-RH	GnRH Receptor	Endocrinology Cancer
[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist .

HY-P3672

[D-Ala6]-LH-RH	GnRH Receptor	Endocrinology
[D-Ala6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Ala6]-LH-RH acts as a GnRH receptor agonist .

HY-P3673

Lamprey LH-RH I	GnRH Receptor	Endocrinology
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models .

HY-P3670

[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide	GnRH Receptor	Endocrinology
[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide is a LHRH peptide analogue.

HY-P3671

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH	GnRH Receptor	Endocrinology
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist .

HY-P0243

Luteinizing Hormone Releasing Hormone (LH-RH), salmon Salmon GnRH; Salmon gonadotropin-releasing hormone; sGnRH	GnRH Receptor	Metabolic Disease
Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

HY-P2357

MI-1544	GnRH Receptor	Metabolic Disease
MI-1544 is a powerful GnRH antagonist. MI-1544 induces inhibitory effects on the pituitary LH release and on gonads. MI-1544 can be used for the research of antifertility effect .

HY-139303

LUF5771	Others	Endocrinology
LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy .

HY-P1628

Ganirelix	GnRH Receptor	Metabolic Disease
Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea .

HY-105173

Teverelix EP 24332	GnRH Receptor Histamine Receptor	Endocrinology Cancer
Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer .

HY-P0056

Histrelin	GnRH Receptor	Cancer
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis .

HY-P0056A

Histrelin acetate	GnRH Receptor	Cancer
Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis .

HY-P1174

GnRH Associated Peptide (GAP) (1-13), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-13), human is an amino acid peptide fragment derived from GnRH. GAP can increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in rat anterior pituitary cells. GAP also inhibit the secretion of prolactin .

HY-151247

GnRH-R antagonist 1	GnRH Receptor	Cancer
GnRH-R antagonist 1 (compound 21a) is an orally safe and membrane-permeable GnRH-R antagonist with high binding affinity (IC₅₀=0.57 nM) and potent in vitro antagonistic activity (IC₅₀=2.18 nM). GnRH-R antagonist 1 can be used in studies of advanced prostate cancer and premature LH peaks preventing .

HY-149597

Lysyl hydroxylase 2-IN-1	Monoamine Oxidase	Cancer
Lysyl hydroxylase 2-IN-1 (compound 12) is a selective lysyl hydroxylase 2 (LH2) Inhibitor with an IC₅₀ of ~300 nM. Lysyl hydroxylase 2-IN-1 demonstrates selectivity for LH2 over LH1 and LH3 .

HY-130249

BAY-298	GnRH Receptor	Endocrinology
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC₅₀s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels .

HY-130248

BAY-899	GnRH Receptor	Endocrinology
BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC₅₀s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels .

HY-130248B

(R)-BAY-899	GnRH Receptor	Others
(R)-BAY-899 is the R-enantiomer of BAY-899. BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively .

HY-19464

Org 43553	Others	Endocrinology
Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor *(LH-R)* agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC₅₀ values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine .

HY-149611

Lysyl hydroxylase 2-IN-2	Monoamine Oxidase	Cancer
Lysyl hydroxylase 2-IN-2 (compound 13) is a potent Lysyl hydroxylase 2 (LH2) inhibitor, with the IC₅₀ of approximately 500 nM. Lysyl hydroxylase 2-IN-2 inhibits the migration in 344SQ WT cells, but not impedes the migration of the same cell line with an LH2 knockout cells .

HY-P0053

Fertirelin	GnRH Receptor	Endocrinology
Fertirelin is a GnRH and LH-RH analogue. Fertirelin can be used of the study for reversing cow follicular cysts .

HY-12096A

WAY-207024 dihydrochloride	GnRH Receptor	Cardiovascular Disease
WAY-207024 (dihydrochloride) is a potent and orally active GnRH antagonist that reduces leuteinizing hormone (LH) levels in plasma .

HY-P0053A

Fertirelin acetate	GnRH Receptor	Endocrinology
Fertirelin acetate is a GnRH and LH-RH analogue. Fertirelin acetate can be used of the study for reversing cow follicular cysts .

HY-N2274

23-Hydroxylongispinogenin 12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol	Others	Cancer
23-Hydroxylongispinogenin (12-Oleanene-3β,16β,23,28-tetrol) is extracted from Lysimachia heterogenea Klatt. Lysimachia heterogenea Klatt is a perennial herb, which is used as a folk medicine in subduing swelling and detoxicating in China. The effective fraction LH-1 of L. heterogene has antitumor activity .

HY-125611

Fluorogestone acetate	GnRH Receptor	Endocrinology
Fluorogestone acetate is a progesterone compound. Fluorogestone acetate inhibits ovulation and synchronizes the estrous cycle in cattle by inhibiting the release of luteinizing hormone (LH) from the pituitary gland .

HY-B1617

Zuclomiphene	Estrogen Receptor/ERR	Metabolic Disease
Zuclomiphene (compound 23) is a potent inhibitor of 17β-Estradiol (HY-B0141) and can inhibit the secretion of luteinizing hormone (LH) .

HY-163200

Cu(I) chelator 1	Cuproptosis	Neurological Disease
Cu(I) chelator 1 (Compound LH2) is a chelator which targets the Cu(I) redox state. Cu(I) chelator 1 prevents ROS production .

HY-110258B

(R,S,R)-ML334 (R,S,R)-LH601A	Others	Cancer
(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity .

HY-E70001

Recombinant Human Luteinizing Hormone	Others	Endocrinology
Recombinant Human Luteinizing Hormone is a recombinant form of Luteinizing hormone (human) (HY-P2293). Luteinizing hormone (human), a heterodimeric glycoprotein hormone produced by the pituitary gland (LH), plays key roles in human reproduction .

HY-B1617A

Zuclomiphene citrate	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

HY-P3606

GnRH Associated Peptide (1-24), human GAP (1-24), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-B1617AS

Zuclomiphene-d4 citrate	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene-d₄ (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].

HY-164764

ADX61623	Estrogen Receptor/ERR	Endocrinology
ADX61623 is a potent follicle stimulating hormone (FSH) receptor (FSHR) negative allosteric modulator (NAM). ADX61623 shows luteinizing hormone receptor (LH-R) activity and is not active on thyroid-stimulating hormone (TSH) receptors. ADX61623 can be used for the study of estrogen dependent disease .

HY-100812

2-Hydroxysaclofen	GABA Receptor	Neurological Disease Endocrinology
2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABA_B) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats .

Cat. No.	Product Name	Type

HY-131946

Menotropin Menotrophin	Cell Assay Reagents
Menotropin (Menotrophin) is a hormone that can be extracted from the urine of postmenopausal women and has both follicle stimulating hormone (FSH) and luteinizing hormone (LH) activity .

Cat. No.	Product Name	Target	Research Area

HY-P1905

[Gln8]-C517 (LH-RH), chicken	Peptides	Endocrinology
[Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.

HY-P3675

LH-RH (4-10)	GnRH Receptor	Endocrinology
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes .

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .

HY-P3604

LH-RH II (chicken)	Androgen Receptor	Endocrinology
LH-RH II (chicken) is one of the two forms of luteinizing hormone-releasing hormone (LHRH) the hypothalamus of the domestic hen, which are structural variants of mammalian LHRH. LH-RH II (chicken) enhances gonadotrophin release in the domestic chicken .

HY-P3663

[Lys8] LH-RH	Peptides	Others
[Lys8] LH-RH is a analogue of LH-RH. [Lys8] LH-RH stimulates LH and FSH release .

HY-P3664

[D-Phe2,D-Ala6]-LH-RH Wy 18185	GnRH Receptor	Endocrinology
[D-Phe2,D-Ala6]-LH-RH is a potent *LH-RH* antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities .

HY-P3666

[D-Phe2,6, Pro3]-LH-RH	GnRH Receptor	Endocrinology
[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist .

HY-P3668

[D-Lys6]-LH-RH	GnRH Receptor	Endocrinology Cancer
[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist .

HY-P3672

[D-Ala6]-LH-RH	GnRH Receptor	Endocrinology
[D-Ala6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Ala6]-LH-RH acts as a GnRH receptor agonist .

HY-P3673

Lamprey LH-RH I	GnRH Receptor	Endocrinology
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models .

HY-P3670

[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide	GnRH Receptor	Endocrinology
[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide is a LHRH peptide analogue.

HY-P3671

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH	GnRH Receptor	Endocrinology
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist .

HY-P0243

Luteinizing Hormone Releasing Hormone (LH-RH), salmon Salmon GnRH; Salmon gonadotropin-releasing hormone; sGnRH	GnRH Receptor	Metabolic Disease
Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

HY-P2357

MI-1544	GnRH Receptor	Metabolic Disease
MI-1544 is a powerful GnRH antagonist. MI-1544 induces inhibitory effects on the pituitary LH release and on gonads. MI-1544 can be used for the research of antifertility effect .

HY-P3084

Human follicular gonadotropin releasing peptide hF-GRP	Peptides	Endocrinology
Human follicular gonadotropin releasing peptide (hF-GRP) is a hormone peptide. Human follicular gonadotropin releasing peptide can stimulate pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in vitro .

HY-P4689

Prolactin-Releasing Peptide (1-31) (rat)	Peptides	Metabolic Disease
Prolactin-Releasing Peptide (1-31) (rat) is a UHR-1/GRP10 receptor ligand. Prolactin-Releasing Peptide (1-31) (rat) reduces fasting-induced food intake, increases plasma levels of LH, FSH, and testosterone in rats .

HY-P1628

Ganirelix	GnRH Receptor	Metabolic Disease
Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea .

HY-105173

Teverelix EP 24332	GnRH Receptor Histamine Receptor	Endocrinology Cancer
Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer .

HY-P0056

Histrelin	GnRH Receptor	Cancer
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis .

HY-P0056A

Histrelin acetate	GnRH Receptor	Cancer
Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis .

HY-P1174

GnRH Associated Peptide (GAP) (1-13), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-13), human is an amino acid peptide fragment derived from GnRH. GAP can increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in rat anterior pituitary cells. GAP also inhibit the secretion of prolactin .

HY-P10594

Myr-Arf1(2–17)	Peptides	Endocrinology
Myr-Arf1(2–17) is a sarcosinated peptide that mimics the localization and function of Arf1 protein on the cell membrane. Myr-Arf1(2–17) can be used to study the desensitization mechanism of luteinizing hormone/chorionic gonadotropin receptor (LH/CGR) .

HY-P0053

Fertirelin	GnRH Receptor	Endocrinology
Fertirelin is a GnRH and LH-RH analogue. Fertirelin can be used of the study for reversing cow follicular cysts .

HY-P0053A

Fertirelin acetate	GnRH Receptor	Endocrinology
Fertirelin acetate is a GnRH and LH-RH analogue. Fertirelin acetate can be used of the study for reversing cow follicular cysts .

HY-P2293

Luteinizing hormone (human)	Peptides	Endocrinology
Luteinizing hormone (human), a heterodimeric glycoprotein hormone produced by the pituitary gland (LH), plays key roles in human reproduction .

HY-P2110

RS-18286	Peptides	Others
RS-18286 is a potent LHRH antagonist studied for its effects on pituitary hormone secretion in sexually active rams. Injection of RS-18286 resulted in an immediate suppression of pulsatile LH secretion, accompanied by a decrease in testosterone levels, while FSH and PRL levels remained unchanged. The duration of LH suppression was dose-related, lasting approximately 4.3 to 31.8 hours for low to high doses, respectively. During the recovery phase, a compensatory increase in LH pulse frequency was observed, suggesting a response to diminished testosterone feedback. Even at the lowest dose, RS-18286 transiently reduced testosterone levels, demonstrating an effect on acute hypothalamic sensitivity to changes in hormonal feedback .

HY-P3606

GnRH Associated Peptide (1-24), human GAP (1-24), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P3975

Glp-His-Pro-Gly-NH2 pGlu-His-Pro-Gly-NH2	Peptides	Endocrinology
Glp-His-Pro-Gly-NH2 (pGlu-His-Pro-Gly-NH2) is a peptide containing 4 amino acids. Glp-His-Pro-Gly-NH2 stimulates gonadotrophin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) release .

HY-P4568

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) .

HY-P4577

(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) .

HY-P4564

(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) .

HY-P1250

RFRP-3(human) Neuropeptide VF(124-131)(human)	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca ²⁺?mobilization. RFRP-3(human) is a NPFF1?receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM .

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

HY-P3605

GnRH Associated Peptide (25-53), human GAP (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P4542

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)	CRFR	Endocrinology
(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition .

HY-P0262A

Galantide TFA	Neuropeptide Y Receptor	Neurological Disease Metabolic Disease
Galantide TFA is a reversible and non-specific galanin (GAL) receptor antagonist. Galantide TFA dose-dependently shows antagonism to galanin-induced K ⁺ conductance with an IC₅₀ value of 4 nM. Galantide TFA can be used for the research of neurological disease and hormone metabolism research .

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor	Metabolic Disease
Spexin TFA is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC₅₀ values are 45.7 and 112.2 nM, respectively). Spexin TFA exhibits no significant activity at galanin receptor 1. Spexin TFA is an endogenous satiety-inducing peptide; Spexin TFA inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Spexin TFA attenuates LH secretion in goldfish. Spexin TFA exhibits anxiolytic effects in vivo.

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P2161B

TAK-683 acetate 1 Publications Verification	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P2446

ORG 30276 APTAA-LHRH	Peptides	Endocrinology
ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2274

23-Hydroxylongispinogenin 12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Asclepiadaceae Lysimachia heterogenea Klatt Plants Primulaceae Disease Research Fields Gymnema sylvestre (Retz.) Schult. Cancer	Others
23-Hydroxylongispinogenin (12-Oleanene-3β,16β,23,28-tetrol) is extracted from Lysimachia heterogenea Klatt. Lysimachia heterogenea Klatt is a perennial herb, which is used as a folk medicine in subduing swelling and detoxicating in China. The effective fraction LH-1 of L. heterogene has antitumor activity .

HY-18572

2,4-D 2,4-Dichlorophenoxyacetic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research	DNA/RNA Synthesis Apoptosis
2,4-D (2, 4-dichlorophenoxyacetic acid) is a selective herbicide that can be orally active for the control of broad-leaved weeds. 2,4-D can induce apoptosis. 2,4-D inhibits DNA and protein synthesis, thereby preventing normal plant growth and development .

HY-18572R

2,4-D (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	DNA/RNA Synthesis Apoptosis
2,4-D (Standard) is the analytical standard of 2,4-D. This product is intended for research and analytical applications. 2,4-D (2, 4-dichlorophenoxyacetic acid) is a selective herbicide that can be orally active for the control of broad-leaved weeds. 2,4-D can induce apoptosis. 2,4-D inhibits DNA and protein synthesis, thereby preventing normal plant growth and development .

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HY-P70205

	Progonadoliberin-2/GNRH II Protein, Human (HEK293, His) rHuProgonadoliberin-2/GnRH II, His; Progonadoliberin-2; Progonadoliberin II; Gonadoliberin-2; Gonadoliberin II; Gonadotropin-Releasing Hormone II; GnRH II; Luliberin II; Luteinizing Hormone-Releasing Hormone II; LH-RH II; GnRH-Associated Peptide 2; GnRH-Associated Peptide II; GNRH2	Human	HEK293
	Progonadoliberin-2/GNRH II Proteinas, a pivotal player in the endocrine system, potently stimulates gonadotropin secretion, promoting both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. Its capacity to orchestrate the secretion of these hormones underscores its significance in governing reproductive functions within the intricate endocrine signaling network that regulates the reproductive axis. Progonadoliberin-2/GNRH II Protein, Human (HEK293, His) is the recombinant human-derived Progonadoliberin-2/GNRH II protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-B1617AS

Zuclomiphene-d4 citrate
Zuclomiphene-d₄ (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].

HY-B1617AS1

Zuclomiphene-d5 citrate
Zuclomiphene-d₅ (citrate) is the deuterium labeled Zuclomiphene citrate[1]. Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[2][3][4][5].

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HY-P82228

	LHX2 Antibody (YA1973) LHX2; LH2; LIM/homeobox protein LHx2; Homeobox protein LH-2; LIM homeobox protein 2	WB	Human, Mouse, Rat
	LHX2 Antibody (YA1973) is a biotin-conjugated non-conjugated IgG antibody, targeting LHX2, with a predicted molecular weight of 44 kDa (observed band size: 44 kDa). LHX2 Antibody (YA1973) can be used for WB experiment in human, mouse, rat background.

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HY-U00334

LH secretion antagonist 1		Alkynes
LH secretion antagonist 1 is an antagonist of luteinising hormone secretion, and may be used as an analgesic. LH secretion antagonist 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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