Search Result
Results for "
Lactic acid
" in MedChemExpress (MCE) Product Catalog:
5
Biochemical Assay Reagents
9
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-B2227
-
Lactic acid
|
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .
|
-
-
- HY-B2227C
-
Lactic acid potassium
|
Bacterial
|
Infection
Others
Cancer
|
Lactate (Lactic acid) potassium is used as a sodium chloride substitute in the elaboration of dry meat products. Lactate potassium (56%) and sodium diacetate (4%) mixture inhibit the development of L. sake and L. monocytogenes bacteria at 4℃ to extend the shelf life of food .
|
-
-
- HY-B2227B
-
Lactic acid sodium
|
Bacterial
|
Metabolic Disease
Cancer
|
Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis . Lactate (Lactic acid) sodium is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection . Lactate sodium also has antimicrobial activity, which can be used as a food preservative .
|
-
-
- HY-B2227BS2
-
Lactic acid-13C sodium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Lactate- 13C (sodium) is the 13C labeled Lactate sodium[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].
|
-
-
- HY-B2227A
-
Lactic acid calcium
|
Bacterial
|
Cancer
|
Lactate (Lactic acid) calcium is used by the beverage industry as a source of calcium to fortify fruit juice. Lactate calcium facilitates the growth and phytic acid degradation of soybean sprouts .
|
-
-
- HY-141540
-
|
Others
|
Others
|
Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers .
|
-
-
- HY-Y0479
-
-
-
- HY-113099
-
Indole-3-Lactic acid
|
Endogenous Metabolite
|
Inflammation/Immunology
|
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity .
|
-
-
- HY-B2227BS3
-
Lactic acid-13C-1 sodium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Lactate- 13C-1 (sodium) is the 13C labeled Lactate (sodium)[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].
|
-
-
- HY-Y0479R
-
|
Bacterial
Endogenous Metabolite
Antibiotic
|
Infection
|
L-Lactic acid (Standard) is the analytical standard of L-Lactic acid. This product is intended for research and analytical applications. L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid.
|
-
-
- HY-Y0479S3
-
-
-
- HY-111095S2
-
(R)-2-Hydroxypropionic acid-13C-1; D-Lactic acid-13C-1
|
Endogenous Metabolite
|
Others
|
D-(-)-Lactic acid- 13C-1 is the 13C labeled D-(-)-Lactic acid. D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants .
|
-
-
- HY-10058
-
|
JAK
Aurora Kinase
Bcr-Abl
FLT3
Apoptosis
Autophagy
|
Cancer
|
AT9283 lactic acid is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 lactic acid inhibits growth and survival of multiple solid tumors in vitro and in vivo .
|
-
-
- HY-111095B
-
-
-
- HY-141941S
-
-
-
- HY-111095S1
-
(R)-2-Hydroxypropionic acid-13C; D-Lactic acid-13C
|
Isotope-Labeled Compounds
|
Others
|
D-(-)-Lactic acid-13C ((R)-2-Hydroxypropionic acid-13C) is a 13C-labeled D-Lactic acid. D-(-)-Lactic acid-13C can be used as an internal standard and can also be used in studies such as metabolic tracing.
|
-
-
- HY-Y0479S
-
-
-
- HY-111095S3A
-
(R)-2-Hydroxypropionic acid-13C-2 sodium; D-Lactic acid-13C-2 sodium
|
Isotope-Labeled Compounds
|
Others
|
D-(-)-Lactic acid-13C-2 (sodium) is a sodium. D-(-)-Lactic acid-13C-2 (sodium) can be used for a variety of biochemical studies.
|
-
-
- HY-D0884
-
(S)-2-Hydroxypropanoic acid lithium
|
Biochemical Assay Reagents
|
Others
|
L-Lactic acid (lithium) is a chemical compound belonging to the class of lithium salts. It is commonly used in the pharmaceutical industry as a mood stabilizer and antipsychotic for the improvement of bipolar disorder and schizophrenia. L-Lactic acid (lithium) works by affecting the balance of certain chemicals in the brain, which can help reduce symptoms such as mood swings, aggression, and hallucinations.
|
-
-
- HY-B2247
-
PLGA (50:50)
Maximum Cited Publications
16 Publications Verification
poly(Lactic-co-glycolic acid) (50:50)
|
Biochemical Assay Reagents
|
Others
|
PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
|
-
-
- HY-Y0479AS
-
-
-
- HY-P2807A
-
LDH, Lactic Dehydrogenase
|
Others
|
Others
|
Lactate Dehydrogenase (LDH), Porcine Heart (LDH, Lactic Dehydrogenase) is a biological material or organic compound that can be used in life science research .
|
-
-
- HY-N9274
-
|
Others
|
Others
|
3-Hydroxy-3-(4-hydroxyphenyl)-lactic acid is a key metabolite in the P. roqueforti fermentation approach, with quantitative data of 10.2 ± 1.1 µM in Tyr 1 (presence of L-tyrosine) of .
|
-
-
- HY-107727
-
|
Neuropeptide Y Receptor
|
Neurological Disease
|
BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition .
|
-
-
- HY-Y0445A
-
|
PDHK
Reactive Oxygen Species
NKCC
Apoptosis
|
Cancer
|
Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. Sodium dichloroacetate also works as NKCC inhibitor .
|
-
-
- HY-N8139
-
|
Others
|
Metabolic Disease
|
2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria .
|
-
-
- HY-P10352
-
|
Bacterial
|
Infection
|
Pediocin PA-1 is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 can be used as a food biopreservative .
|
-
-
- HY-P10352A
-
|
Bacterial
|
Infection
|
Pediocin PA-1 TFA is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 TFA can be used as a food biopreservative .
|
-
-
- HY-113133
-
|
Glycosidase
|
Infection
Metabolic Disease
Inflammation/Immunology
|
Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo .
|
-
-
- HY-B2247A
-
poly(Lactic-co-glycolic acid) (75:25)
|
Biochemical Assay Reagents
|
Others
|
PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides .
|
-
-
- HY-P2807B
-
LDH-1, LD1 isoenzyme, 4H isoenzyme, Lactic Dehydrogenase
|
Others
|
Others
|
Lactate Dehydrogenase 1 (LDH-1), Human Erythrocytes (LDH-1, LD1 isoenzyme, 4H isoenzyme, Lactic Dehydrogenase) is a biological material or organic compound that can be used in life science research .
|
-
-
- HY-B1530
-
(±)-Ammonium lactate
|
Bacterial
|
Infection
|
Ammonium lactate is the ammonium salt of lactic acid, with mild anti-bacterial properties. Ammonium lactate can be used for the research of xerosis .
|
-
-
- HY-W040233
-
Sodium L-lactate
|
Others
|
Others
Cancer
|
Sodium (S)-2-hydroxypropanoate (Sodium L-lactate) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid .
|
-
-
- HY-129563
-
|
HIV
HIV Protease
|
Infection
|
CGP 57813 is a peptidomimetic inhibitor of HIV protease that can be encapsulated by nanoparticles composed of poly(D,L-lactic acid) (PLA) and pH-sensitive methacrylic acid copolymers and delivered into the body .
|
-
-
- HY-W040233B
-
Sodium L-lactate (purity≥90%)
|
Others
|
Others
|
Sodium (S)-2-hydroxypropanoate (Sodium L-lactate) (purity≥90%) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid .
|
-
-
- HY-D2418
-
|
Fluorescent Dye
|
Metabolic Disease
|
PS-SCOTfluor-12 (compound 10) is a fluorescent probe for imaging Lactic acid (HY-B2227) metabolism in live cells. λex/λem= 485/605 nm .
|
-
-
- HY-W010625
-
|
Biochemical Assay Reagents
|
Others
|
Lithium 2-hydroxypropanoate is a biochemical reagent used for the determination of lactic acid. Lithium 2-hydroxypropanoate is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
-
- HY-158255A
-
|
Biochemical Assay Reagents
|
Others
|
mPEG-PLGA (22500-26500) is a biodegradable polymer composed of methyl polyethylene glycol (mPEG) and poly(lactic-co-glycolic acid) (PLGA). mPEG-PLGA (22500-26500) can be used in drug delivery systems .
|
-
-
- HY-148775A
-
|
Biochemical Assay Reagents
|
Others
|
mPEG-PLGA (21500-26500) is a biodegradable polymer composed of methyl polyethylene glycol (mPEG) and poly(lactic-co-glycolic acid) (PLGA). mPEG-PLGA (21500-26500) can be used in drug delivery systems .
|
-
-
- HY-B1773A
-
|
Biochemical Assay Reagents
|
Others
|
Sodium Propionate is used as a food preservative, bakery product and as a mold inhibitor in insect cell cultures. It is also used as a preservative in pharmaceuticals, cosmetics, agriculture and animal feed. It is used as a food additive. In addition, it inhibits the growth of lactic acid bacteria.
|
-
-
- HY-136593
-
(S)-3-(4-Hydroxyphenyl)Lactic acid
|
Others
|
Others
|
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid (compound 1) is a metabolite isolated from the culture medium of Leuconostoc mesenteroides. (S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid has high DPPH radical-scavenging activities and antioxidative activities .
|
-
-
- HY-B2227BR
-
|
Bacterial
|
Metabolic Disease
Cancer
|
Lactate (sodium) (Standard) is the analytical standard of Lactate (sodium). This product is intended for research and analytical applications. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis . Lactate (Lactic acid) sodium is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection [4] . Lactate sodium also has antimicrobial activity, which can be used as a food preservative .
|
-
-
- HY-130117
-
|
Reactive Oxygen Species
Apoptosis
|
Cancer
|
AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A (AlbA) to a dichloroacetate acid (DCA) subunit. AlbA-DCA can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in tumor microenvironment (TME), and also selectively kills cancer cells and induce apoptosis .
|
-
-
- HY-W002299
-
Boc-D-Leu-OH hydrate
|
Amino Acid Derivatives
|
Neurological Disease
|
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .
|
-
-
- HY-W005288
-
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .
|
-
-
- HY-W040233R
-
|
Others
|
Others
Cancer
|
Sodium (S)-2-hydroxypropanoate (Standard) is the analytical standard of Sodium (S)-2-hydroxypropanoate. This product is intended for research and analytical applications. Sodium (S)-2-hydroxypropanoate (Sodium L-lactate) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid .
|
-
-
- HY-B1773AR
-
|
Biochemical Assay Reagents
|
Others
|
Sodium propionate (Standard) is the analytical standard of Sodium propionate. This product is intended for research and analytical applications. Sodium Propionate is used as a food preservative, bakery product and as a mold inhibitor in insect cell cultures. It is also used as a preservative in pharmaceuticals, cosmetics, agriculture and animal feed. It is used as a food additive. In addition, it inhibits the growth of lactic acid bacteria.
|
-
-
- HY-158089
-
|
Biochemical Assay Reagents
|
Others
|
PLGA-COOH (MW 80000) (LA/GA 50:50) is a copolymer, which consist of lactic acid (LA)-glycolic acid (GA) with a molar ratio of 50:50, and a carboxyl terminal groups. PLGA-COOH (MW 80000) (LA/GA 50:50) is utilized in drug delivery system for its biocompatibility and biodegradability .
|
-
-
- HY-16397
-
Phenethylbiguanide
|
Mitochondrial Metabolism
AMPK
Apoptosis
|
Metabolic Disease
Cancer
|
Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis .
|
-
-
- HY-151243
-
|
Lactate Dehydrogenase
|
Cancer
|
NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC50=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells. NCATS-SM1441 can be used to study cancer metabolism .
|
-
- HY-B2227R
-
|
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Lactate (Standard) is the analytical standard of Lactate. This product is intended for research and analytical applications. Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .
|
-
- HY-167924
-
|
Others
|
Inflammation/Immunology
|
Ono 3307 Free base is a novel synthetic protease inhibitor that exhibits protective effects against acute pancreatitis by preventing hyperamylasemia and pancreatic edema. Ono 3307 Free base also inhibits the redistribution of lysosomal enzymes in acinar cells and mitigates lactic dehydrogenase discharge. Ono 3307 Free base effectively reduces cathepsin B leakage from lysosomes in a dose-dependent manner.
|
-
- HY-Y0335
-
Dihydroxyacetone
|
Endogenous Metabolite
|
Others
|
1,3-Dihydroxyacetone (DHA), the main active ingredient in sunless tanning skin-care preparations and an important precursor for the synthesis of various fine chemicals, is produced on an industrial scale by microbial fermentation of glycerol (HY-B1659) in Gluconobacter oxydans. 1,3-Dihydroxyacetone is also used for synthesis of new biodegradable polymers by combining with lactic acid (HY-B2227) .
|
-
- HY-D0153
-
|
Fluorescent Dye
|
Cancer
|
Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles .
|
-
- HY-129101
-
Eseroline fumarate
|
5-HT Receptor
|
Neurological Disease
|
(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum .
|
-
- HY-156829
-
|
Others
|
Cancer
|
PLGA-PEG-PLGA (1500-1500-1500) (LA/GA 1:1) is a matrix materia, with lactic acid (LA):glycolic acid (GA) = 1:1, that acts as anti-cancer drug delivery. PLGA-PEG-PLGA (1500-1500-1500) (LA/GA 1:1) can improve a drug's bioavailability, efficacy, water solubility, drug encapsulation efficiency, sustained drug release, and to minimize undesirable toxicity .
|
-
- HY-156829A
-
|
Others
|
Cancer
|
PLGA-PEG-PLGA (1500-1500-1500) (LA/GA 15:1) is a matrix materia, with lactic acid (LA):glycolic acid (GA) = 15:1, that acts as anti-cancer drug delivery. PLGA-PEG-PLGA (1500-1500-1500) (LA/GA 15:1) can improve a drug's bioavailability, efficacy, water solubility, drug encapsulation efficiency, sustained drug release, and to minimize undesirable toxicity .
|
-
- HY-148775
-
|
Biochemical Assay Reagents
|
Others
|
PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) has a molecular weight of 60kDA to 3.4kDA and contains a 75:25 ratio of lactic acid (LA) to glycolic acid (GA) molecules .
|
-
- HY-148775B
-
|
Biochemical Assay Reagents
|
Others
|
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) has a molecular weight of 60kDA to 3.4kDA and contains a 75:25 ratio of lactic acid (LA) to glycolic acid (GA) molecules .
|
-
- HY-163726
-
|
GLUT
EGFR
Apoptosis
|
Cancer
|
GLUT1/EGFR-IN-1 (compound H) is a potent inhibitor of GLUT1 and EGFR. GLUT1/EGFR-IN-1 can simultaneously act on the EGFR tyrosine kinase ATP-binding site and inhibit GLUT1-mediated energy metabolism, resulting in reductions in ATP, MMP, intra-cellular lactic acid, and EGFR nuclear transfer. GLUT1/EGFR-IN-1 can be used for nasopharyngeal carcinoma (NPC) and triple-negative breast cancer (TNBC) research .
|
-
- HY-Y0335R
-
|
Endogenous Metabolite
|
Others
|
1,3-Dihydroxyacetone (Standard) is the analytical standard of 1,3-Dihydroxyacetone. This product is intended for research and analytical applications. 1,3-Dihydroxyacetone (DHA), the main active ingredient in sunless tanning skin-care preparations and an important precursor for the synthesis of various fine chemicals, is produced on an industrial scale by microbial fermentation of glycerol (HY-B1659) in Gluconobacter oxydans. 1,3-Dihydroxyacetone is also used for synthesis of new biodegradable polymers by combining with lactic acid (HY-B2227) .
|
-
- HY-148776
-
|
Biochemical Assay Reagents
|
Others
|
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) has a molecular weight of 20kDA to 5.0kDA and contains a 50:50 ratio of lactic acid (LA) to glycolic acid (GA) molecules. The molecular ratio of LA to GA determines the rate of matrix degradation and protein re-release .
|
-
- HY-117247
-
|
DNA/RNA Synthesis
|
Infection
|
5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase .
|
-
-
-
HY-L204
-
|
359 compounds
|
Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism.
MCE contains 359 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.
|
Cat. No. |
Product Name |
Type |
-
- HY-D2418
-
|
Fluorescent Dyes/Probes
|
PS-SCOTfluor-12 (compound 10) is a fluorescent probe for imaging Lactic acid (HY-B2227) metabolism in live cells. λex/λem= 485/605 nm .
|
-
- HY-D0153
-
|
Fluorescent Dyes/Probes
|
Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles .
|
Cat. No. |
Product Name |
Type |
-
- HY-D0884
-
(S)-2-Hydroxypropanoic acid lithium
|
Biochemical Assay Reagents
|
L-Lactic acid (lithium) is a chemical compound belonging to the class of lithium salts. It is commonly used in the pharmaceutical industry as a mood stabilizer and antipsychotic for the improvement of bipolar disorder and schizophrenia. L-Lactic acid (lithium) works by affecting the balance of certain chemicals in the brain, which can help reduce symptoms such as mood swings, aggression, and hallucinations.
|
-
- HY-B2247
-
PLGA (50:50)
Maximum Cited Publications
16 Publications Verification
poly(Lactic-co-glycolic acid) (50:50)
|
Drug Delivery
|
PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
|
-
- HY-B1773A
-
|
Biochemical Assay Reagents
|
Sodium Propionate is used as a food preservative, bakery product and as a mold inhibitor in insect cell cultures. It is also used as a preservative in pharmaceuticals, cosmetics, agriculture and animal feed. It is used as a food additive. In addition, it inhibits the growth of lactic acid bacteria.
|
-
- HY-W010625
-
|
Biochemical Assay Reagents
|
Lithium 2-hydroxypropanoate is a biochemical reagent used for the determination of lactic acid. Lithium 2-hydroxypropanoate is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-B1773AR
-
|
Biochemical Assay Reagents
|
Sodium propionate (Standard) is the analytical standard of Sodium propionate. This product is intended for research and analytical applications. Sodium Propionate is used as a food preservative, bakery product and as a mold inhibitor in insect cell cultures. It is also used as a preservative in pharmaceuticals, cosmetics, agriculture and animal feed. It is used as a food additive. In addition, it inhibits the growth of lactic acid bacteria.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10352A
-
|
Bacterial
|
Infection
|
Pediocin PA-1 TFA is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 TFA can be used as a food biopreservative .
|
-
- HY-P4519
-
|
Peptides
|
Others
|
Ac-Lys(Ac)-D-Ala-D-Lactic acid is a depsipeptide substrate for penicillin-sensitive D-alanine carboxypeptidases (DD-carboxypeptidases) .
|
-
- HY-P4837
-
|
Peptides
|
Others
|
Ac-Lys-D-Ala-D-lactic acid is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
-
- HY-P10352
-
|
Bacterial
|
Infection
|
Pediocin PA-1 is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 can be used as a food biopreservative .
|
-
- HY-W002299
-
Boc-D-Leu-OH hydrate
|
Amino Acid Derivatives
|
Neurological Disease
|
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B2227BS2
-
|
Lactate- 13C (sodium) is the 13C labeled Lactate sodium[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].
|
-
-
- HY-Y0479S
-
|
L-Lactic acid- 13C3 is a 13C-labeled L-Lactic acid (HY-Y0479). L-Lactic acid- 13C3 can be used for lactate metabolism research .
|
-
-
- HY-Y0479AS
-
|
L-Lactic acid- 13C3 (sodium) is the 13C labeled L-Lactic acid. L-Lactic acid- 13C3 sodium can be used for lactate metabolism research[1].
|
-
-
- HY-B2227BS3
-
|
Lactate- 13C-1 (sodium) is the 13C labeled Lactate (sodium)[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].
|
-
-
- HY-Y0479S3
-
|
L-Lactic acid-2- 13C1 is the 13C-labeled L-Lactic acid (HY-Y0479). L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid .
|
-
-
- HY-111095S2
-
|
D-(-)-Lactic acid- 13C-1 is the 13C labeled D-(-)-Lactic acid. D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants .
|
-
-
- HY-141941S
-
|
Triazole Lactic Acid- 13C2, 15N3 is the 13C and 15N labeled Triazole Lactic Acid[1].
|
-
-
- HY-111095S1
-
|
D-(-)-Lactic acid-13C ((R)-2-Hydroxypropionic acid-13C) is a 13C-labeled D-Lactic acid. D-(-)-Lactic acid-13C can be used as an internal standard and can also be used in studies such as metabolic tracing.
|
-
-
- HY-111095S3A
-
|
D-(-)-Lactic acid-13C-2 (sodium) is a sodium. D-(-)-Lactic acid-13C-2 (sodium) can be used for a variety of biochemical studies.
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-B2247
-
poly(Lactic-co-glycolic acid) (50:50)
|
|
Polymers
|
PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
|
-
- HY-B2247A
-
poly(Lactic-co-glycolic acid) (75:25)
|
|
Polymers
|
PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides .
|
-
- HY-158089
-
|
|
Polymers
|
PLGA-COOH (MW 80000) (LA/GA 50:50) is a copolymer, which consist of lactic acid (LA)-glycolic acid (GA) with a molar ratio of 50:50, and a carboxyl terminal groups. PLGA-COOH (MW 80000) (LA/GA 50:50) is utilized in drug delivery system for its biocompatibility and biodegradability .
|
-
- HY-148775
-
|
|
Polymers
|
PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) has a molecular weight of 60kDA to 3.4kDA and contains a 75:25 ratio of lactic acid (LA) to glycolic acid (GA) molecules .
|
-
- HY-148776
-
|
|
Polymers
|
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) has a molecular weight of 20kDA to 5.0kDA and contains a 50:50 ratio of lactic acid (LA) to glycolic acid (GA) molecules. The molecular ratio of LA to GA determines the rate of matrix degradation and protein re-release .
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent: