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Isoforms Recommended:	PI3Kδ

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PI3K-δ

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By Targets:	PI3K (143) Akt (4) Apoptosis (29) ATM/ATR (1) Autophagy (10) Bcr-Abl (1) Casein Kinase (5) CDK (1) Cytochrome P450 (1) DNA-PK (4) EGFR (1) Epigenetic Reader Domain (1) G Protein-coupled Receptor Kinase (GRK) (1) HDAC (4) Isotope-Labeled Compounds (3) Kinesin (1) Lipase (1) MEK (2) Mitophagy (7) mTOR (17) PARP (1) PERK (2) PI4K (2) PPAR (1) Reactive Oxygen Species (6)
By Research Areas:	Cancer (118) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (32) Metabolic Disease (1) Neurological Disease (1)

144

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: PI3K

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101921

PI3Kδ-IN-1	PI3K	Inflammation/Immunology
PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC₅₀ of 1.7 nM.

HY-108418

PI3Kδ-IN-15 1 Publications Verification	PI3K	Cancer
PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC₅₀ of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα .

HY-144993

PI3Kδ/γ-IN-1	PI3K	Cancer
PI3Kδ/γ-IN-1 is a potent, selective *PI3K-δ/γ* inhibitor for research of hematological malignancies.

HY-122593

PI3Kδ-IN-5	PI3K	Cancer
PI3Kδ-IN-5 (compound 7n) is a highly potent and selective inhibitor of PI3Kδ with an IC₅₀ of 0.9 nM .

HY-155232

PI3Kδ-IN-16	PI3K Apoptosis	Cancer
PI3Kδ-IN-16 is a potent and selective inhibitor of PI3Kδ. PI3Kδ-IN-16 has a strong anti-proliferative effect on cells, causing cell cycle arrest and inducing apoptosis .

HY-15288

PI3kδ inhibitor 1	PI3K	Cancer
PI3kδ inhibitor 1 is a potent and selective PI3Kδ inhibitor with an IC₅₀ of 3.8 nM.

HY-142646

PI3Kδ-IN-9	PI3K	Cancer
PI3Kδ-IN-9 is a selective PI3Kδ inhibitor with an IC₅₀ value of 3.8 nM.

HY-157128

PI3Kδ-IN-18	PI3K	Inflammation/Immunology
Se15 is a selective inhibitor of **PI3Kδ with an IC₅₀ value less than 0.1nM. Se15 can be used in research on autoimmune .**

HY-134472

PI3Kδ-IN-8	PI3K	Cancer
PI3Kδ-IN-8 is a potent, selective and orally active PI3Kδ inhibitor, with an IC₅₀ of 3.3 nM. PI3Kδ-IN-8 shows selectivity for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ (IC₅₀=377.2, 241.6, 17.9 nM, respectively). PI3Kδ-IN-8 has anti-tumor activity .

HY-155975

PI3Kδ-IN-14	PI3K	Inflammation/Immunology
PI3Kδ-IN-14 (Compound (S)-29) is a selective PI3Kδ inhibitor (IC₅₀: 0.8 nM, K_d: 84.8 nM). PI3Kδ-IN-14 binds to the ATP-binding site of the kinase domain of PI3Kδ. PI3Kδ-IN-14 has anti-inflammatory activity by inhibiting the PI3K/AKT pathway. PI3Kδ-IN-14 ameliorates acute lung injury (ALI) .

HY-144254

PI3Kδ-IN-10	PI3K Akt Apoptosis	Cancer
PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor with IC₅₀ of 2 nM. PI3Kδ-IN-10 robustly suppresses the downstream AKT pathway to induce subsequent apoptosis in hepatocellular carcinoma models .

HY-155833

PI3Kδ-IN-13	PI3K	Infection Inflammation/Immunology Cancer
PI3Kδ-IN-13 (compound 89) is a PI3Kδ inhibitor (IC₅₀=2.6 nM). PI3Kδ-IN-13 can be used in the research of cell proliferation diseases such as cancer, infection, inflammation and autoimmune diseases .

HY-125376

PI3Kδ-IN-3	PI3K	Cancer
PI3Kδ-IN-3 (Compound 11) is a **PI3Kδ inhibitor (IC₅₀*: 9 nM). PI3Kδ-IN-3 inhibits B cell function. PI3Kδ-IN-3 has good pharmacokinetic properties .***

HY-149634

PI3Kδ-IN-17	PI3K	Cancer
PI3Kδ-IN-17 (Compound S5) is a potent inhibitor of *PI3Kδ, with IC₅₀* of 2.82?nM. PI3Kδ-IN-17 shows strong inhibitory activity of proliferation in SU-DHL-6 cells (IC₅₀ = 0.035 μM) .

HY-150638

PI3Kδ/γ-IN-3	PI3K Apoptosis	Cancer
PI3Kδ/γ-IN-3 (Compound 58) is a potent and orally active PI3Kδ and PI3Kγ dual inhibitor with IC₅₀s of 1 nM and 16 nM, respectively. PI3Kδ/γ-IN-3 induces tumor cell apoptosis and can be used for B-cell malignancies research .

HY-158147

PI3Kδ-IN-20	PI3K	Cancer
PI3Kδ-IN-20 (compound (S)-36) is a potent inhibitor of PI3Kδ, with the IC₅₀ of 6.4 nM. PI3Kδ-IN-20 has oral bioactivity. PI3Kδ-IN-20 shows significant suppression of cell proliferation and remarkable induction of apoptosis both in vitro and in vivo .

HY-143472

PI3Kδ-IN-11	PI3K Akt Apoptosis	Cancer
PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC₅₀ value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of *PI3K/Akt* pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies .

HY-146789

PI3Kδ/γ-IN-2	PI3K	Cancer
PI3Kδ/γ-IN-2 is a potent PI3Kδ and PI3Kγ dual inhibitor with IC₅₀s of 1 nM and 4.3 nM, respectively. PI3Kδ/γ-IN-2 has favorable oral bioavailability. PI3Kδ/γ-IN-2 has potential for battling B-cell malignancies .

HY-162647

PI3Kδ-IN-22	PI3K	Inflammation/Immunology
PI3Kδ-IN-22 (Compound 26) is a selective inhibitor for PI3Kδ with pK_i of 9.3. PI3Kδ-IN-22 inhibits PI3Kδ-AKT signaling pathway in THP-1 cells, with pIC₅₀ of 9.4. PI3Kδ-IN-22 exhibits good pharmacokinetic characters in rats .

HY-149235

PI3Kδ-IN-12	PI3K	Inflammation/Immunology
PI3Kδ-IN-12 (compound 13) is a PI3Kδ inhibitor (pIC₅₀ = 5.8), with pKi values of 8.0/6.5/6.4/6.7 for PI3Kδ/γ/β/α, respectively. PI3Kδ-IN-12 can be used in the study of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) .

HY-158688

PI3Kδ-IN-21	PI3K	Inflammation/Immunology
PI3Kδ-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases δ (PI3Kδ), with an IC₅₀ of 13.6 nM. PI3Kδ-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kδ-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model .

HY-11080

PKI-179	PI3K mTOR	Cancer
PKI-179 is a potent and orally active dual *PI3K/mTOR* inhibitor, with IC₅₀s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for *PI3K-α, PI3K-β, PI3K-γ, PI3K-δ* and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC₅₀s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo .

HY-11080A

PKI-179 hydrochloride	PI3K mTOR	Cancer
PKI-179 hydrochloride is a potent and orally active dual *PI3K/mTOR* inhibitor, with IC₅₀s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for *PI3K-α, PI3K-β, PI3K-γ, PI3K-δ* and mTOR, respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R, with IC₅₀s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo .

HY-12644

Acalisib 1 Publications Verification GS-9820; CAL-120	PI3K	Cancer
Acalisib is a potent and selective PI3Kδ inhibitor with an IC₅₀ of 12.7 nM.

HY-12948

AMG319	PI3K	Cancer
AMG319 is a potent and selective PI3Kδ kinase inhibitor with IC₅₀ of 18 nM.

HY-16754

Seletalisib 1 Publications Verification UCB5857	PI3K	Inflammation/Immunology
Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor with an IC₅₀ of 12 nM.

HY-19535B

Nemiralisib succinate GSK2269557 succinate	PI3K	Cancer
Nemiralisib Succinate is a potent and highly selective PI3Kδ inhibitor with a pK_i of 9.9.

HY-19535

Nemiralisib hydrochloride GSK2269557	PI3K	Cancer
Nemiralisib hydrochloride (GSK2269557) is a potent and highly selective PI3Kδ inhibitor with a pK_i of 9.9.

HY-147898

PI3K-IN-33	PI3K Apoptosis	Cancer
PI3K-IN-33 (Compound 6e) is a highly selective *PI3K* inhibitor with IC₅₀ values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-33 can be used in leukemia research .

HY-147900

PI3K-IN-35	PI3K Apoptosis	Cancer
PI3K-IN-35 (Compound 6l) is a highly selective *PI3K* inhibitor with IC₅₀ values of 13.98, 7.22 and 10.94 μM for PI3K-α、PI3K-β and PI3K-δ, respectively. PI3K-IN-35 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-35 can be used in leukemia research .

HY-147899

PI3K-IN-34	PI3K Apoptosis	Cancer
PI3K-IN-34 (Compound 6g) is a highly selective *PI3K* inhibitor with IC₅₀ values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research .

HY-10110

IC-87114 2 Publications Verification	PI3K	Cancer
IC-87114 is a potent and selective PI3Kδ inhibitor with IC₅₀ of 0.5 μM.

HY-16122

CAL-130 Racemate	PI3K	Cancer
CAL-130 Racemate is the racemate of CAL-130. CAL-130 Racemate is a PI3Kδ inhibitor.

HY-19535A

Nemiralisib GSK2269557 free base	PI3K	Cancer
Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pK_i of 9.9.

HY-17635

Leniolisib 1 Publications Verification CDZ173	PI3K	Inflammation/Immunology
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

HY-132880

GSK251	PI3K	Cancer
GSK251 is a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode.

HY-17635A

Leniolisib phosphate 1 Publications Verification CDZ173 phosphate	PI3K	Inflammation/Immunology
Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.

HY-12279F

Umbralisib R-enantiomer TGR-1202 R-enantiomer; RP5264 R-enantiomer	PI3K	Cancer
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.

HY-101114

LAS191954	PI3K	Inflammation/Immunology
LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC₅₀ of 2.6 nM .

HY-162292

Anticancer agent 190	PI3K Kinesin	Cancer
Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ with activity against breast cancer .

HY-106006

RV-1729	PI3K	Others Inflammation/Immunology
RV-1729 is an inhibitor of the phosphatidylinositol 3-kinase-δ (PI3Kδ). RV-1729 identifies inhibition of the PI3K isotype by quantifying the release of phosphatidylinositol 3,4, 5-triphosphate (PIP3) (IC₅₀=12 nM), showing twice the selectivity for PI3Kδ relative to PI3Kγ. RV-1729 is also 16 times more selective to PI3Kα. RV-1729 regulates immune and inflammatory responses by inhibiting PI3Kδ. RV-1729 can be used in studies of asthma and chronic obstructive pulmonary disease (COPD) .

HY-100694

GS-9901	PI3K	Inflammation/Immunology
GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC₅₀ of 1 nM. Has potential to treat rheumatoid arthritis .

HY-162878

CHF-6523	PI3K	Inflammation/Immunology
CHF-6523 is an orally active PI3Kδ inhibitor that can be used in research related to chronic obstructive pulmonary disease (COPD) .

HY-16122A

CAL-130	PI3K	Cancer
CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC₅₀s of 1.3 and 6.1 nM, respectively.

HY-16122B

CAL-130 Hydrochloride	PI3K	Cancer
CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC₅₀s of 1.3 and 6.1 nM, respectively.

HY-17645

Tenalisib 1 Publications Verification RP6530	PI3K	Cancer
Tenalisib (RP6530) is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC₅₀ values of 25 and 33 nM, respectively.

HY-12340

ETP-46321	PI3K	Cancer
ETP-46321 is a potent and orally bioavailable PI3Kα and PI3Kδ inhibitor with K_iapps of 2.3 and 14.2 nM, respectively.

HY-12869

AZD-8835 1 Publications Verification	PI3K	Cancer
AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC₅₀s of 6.2 and 5.7 nM, respectively.

HY-112439

PI3Kdelta inhibitor 1	PI3K	Inflammation/Immunology Cancer
PI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3Kδ inhibitor with an IC₅₀ of 1.3 nM .

HY-123790

AS2541019	PI3K	Inflammation/Immunology
AS2541019 is a PI3Kδ (p110δ) inhibitor. AS2541019 inhibits B cell activation and proliferation, and suppresses xenograft antibody production .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18085

Quercetin Maximum Cited Publications 81 Publications Verification	Flavonols Structural Classification Classification of Application Fields Anti-aging Source classification Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Sunscreen Disease markers Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Reactive Oxygen Species PI3K Autophagy Mitophagy Apoptosis
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0146

Quercetin dihydrate Maximum Cited Publications 81 Publications Verification	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	PI3K Apoptosis
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a *PI3K* inhibitor with *IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .*

HY-18085A

Quercetin hydrate	Structural Classification Flavonols Flavonoids other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species
Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085R

Quercetin (Standard)	Flavonols Structural Classification Source classification Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Disease markers Glycyrrhiza uralensis Fisch.	Reactive Oxygen Species PI3K Autophagy Mitophagy Apoptosis
Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0146R

Quercetin dihydrate (Standard)	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	PI3K Apoptosis
Quercetin (dihydrate) (Standard) is the analytical standard of Quercetin (dihydrate). This product is intended for research and analytical applications. Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

Cat. No.	Product Name	Chemical Structure

HY-17635S

Leniolisib-d5
Leniolisib-d5 is a deuterated labeled Leniolisib . Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

HY-18085AS

Quercetin-d3 hydrate
Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085S1

Quercetin-d3
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-18085S

Quercetin-d5
Quercetin-d₅ is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-18085S2

Quercetin-13C3
Quercetin- ¹³C₃ is the ¹³C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81872

	PI3 Kinase p110 delta Antibody (YA1617) PIK3CD; Phosphatidylinositol 4; 5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; Phosphatidylinositol 4; 5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta	WB, ICC/IF	Human, Mouse, Rat
	PI3 Kinase p110 delta Antibody (YA1617) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1617), targeting PI3 Kinase p110 delta, with a predicted molecular weight of 119 kDa (observed band size: 119 kDa). PI3 Kinase p110 delta Antibody (YA1617) can be used for WB, ICC/IF experiment in human, mouse, rat background.

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PI3K-δ

Inhibitors & Agonists

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