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PTP-1B inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (1) Aldose Reductase (2) Amylases (2) Amyloid-β (1) Antibiotic (1) Apoptosis (3) Autophagy (1) Bacterial (2) Beta-secretase (1) Dipeptidyl Peptidase (1) Enterovirus (1) Fungal (1) Glucosidase (7) HIV (1) IKK (1) Insulin Receptor (1) Monoamine Oxidase (1) Parasite (2) Phosphatase (81) PPAR (2) PTEN (2) SHP2 (8) Tie (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (2) Endocrinology (5) Infection (6) Inflammation/Immunology (7) Metabolic Disease (55) Neurological Disease (6)
Oligonucleotides:	Antisense Oligonucleotides (2)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10704

PTP1B-IN-1 5 Publications Verification PTP1B inhibitor	Phosphatase	Metabolic Disease
PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of *PTP1B* with an IC₅₀ value of 1.6 mM. It is often used as the mother core for derivatives of analogues .

HY-15133

PTP1B-IN-3	Phosphatase	Metabolic Disease Cancer
PTP1B-IN-3 is a potent and orally active *PTP1B* inhibitor with IC₅₀s of 120 nM for both *PTP1B* and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects .

HY-15133A

PTP1B-IN-3 diammonium	Phosphatase	Metabolic Disease Cancer
PTP1B-IN-3 diammonium is a potent and orally active *PTP1B* inhibitor with IC₅₀s of 120 nM for both *PTP1B* and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects .

HY-153018

PTP1B-IN-22	Phosphatase	Metabolic Disease
PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes .

HY-15756

PTP1B-IN-4	Phosphatase	Metabolic Disease
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase *PTP1B, with an IC₅₀* of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes .

HY-108196

PTP1B-IN-15	Phosphatase	Endocrinology
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity .

HY-159694A

IONIS PTP1BRx sodium ISIS 404173 sodium	Phosphatase	Metabolic Disease
IONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

HY-159694

IONIS PTP1BRx ISIS 404173	Phosphatase	Metabolic Disease
IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

HY-162479

PTP1B-IN-26	Phosphatase Amyloid-β	Metabolic Disease
PTP1B-IN-26 (Compound 7a) is a derivative of phenylthiosemicarbazide‐phenoxy‐1,2,3‐triazole‐N‐phenylacetamide. PTP1B-IN-26 is an inhibitor of protein tyrosine phosphatase 1B (PTP-1B). PTP1B-IN-26 is a competitive inhibitor. PTP1B-IN-26 can be used to research in type 2 diabetes .

HY-161321

PTP1B-IN-24	Phosphatase Insulin Receptor Akt	Metabolic Disease
PTP1B-IN-24 (Compound 9) is a reversible *PTP1B* inhibitor with an IC₅₀ value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of *PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1* and AKT .

HY-100462

PTP1B-IN-2 3 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 50 nM.

HY-139641

PTP1B-IN-14	Phosphatase	Others
PTP1B-IN-14 is a selective *PTP1B* inhibitor (IC₅₀ = 0.72 μM) targeting the allosteric site.

HY-139640

PTP1B-IN-13	Phosphatase	Others
PTP1B-IN-13 is a selective *PTP1B* inhibitor targeting the allosteric site with an IC₅₀ value of 1.59 μM.

HY-144717

PTP1B-IN-18	Phosphatase	Metabolic Disease
PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research .

HY-163463

PTP1B-IN-25	Phosphatase Fungal HIV Bacterial	Infection Metabolic Disease
PTP1B-IN-25 (Compound 19) is a *PTP1B* inhibitor with remarkable antiviral, antibacterial, and antidiabetic activities. PTP1B-IN-25 has IC₅₀ values of 0.37 μM, 8.6 μM, 3.7 μM, and 29 μM against *PTP1B, HIV, α-Glucosidase, and methicillin-resistant Staphylococcus aureus* (MRSA) respectively .

HY-144718

PTP1B-IN-17	Phosphatase	Metabolic Disease
PTP1B-IN-17 (Compound 45), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 30.2 μM. PTP1B-IN-17 can be used for the research of type 2 diabetes.

HY-144716

PTP1B-IN-19	Phosphatase	Metabolic Disease
PTP1B-IN-19 (Compound 43), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 23.3 μM. PTP1B-IN-19 can be used for the research of type 2 diabetes.

HY-144713

PTP1B-IN-16	Phosphatase	Metabolic Disease
PTP1B-IN-16 (Compound 46), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 12.6 μM. PTP1B-IN-16 can be used for the research of type 2 diabetes.

HY-168185

α-glucosidase/PTP1B-IN-1	Glucosidase Phosphatase Amylases	Metabolic Disease
α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and *PTP1B* inhibitor with an IC₅₀ value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC₅₀ of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus .

HY-N9326

Uralenol	Phosphatase	Metabolic Disease
Uralenol is a natural *PTP1B* inhibitor (IC₅₀=21. 5 μM) from Broussonetia papyrifera. PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor in many cellular and biochemical studies .

HY-19383

Ertiprotafib PTP 112	Phosphatase IKK PPAR	Metabolic Disease
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC₅₀ of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC₅₀ of ~1 μM for PPARα/PPARβ.

HY-12312

TCS 401 2 Publications Verification	Phosphatase	Metabolic Disease
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

HY-121515

DPM-1001	Phosphatase	Metabolic Disease
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property .

HY-121515A

DPM-1001 trihydrochloride	Phosphatase	Metabolic Disease
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property .

HY-162480

PTP1B-IN-27	Glucosidase Phosphatase	Endocrinology
PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC₅₀=8.2 µM). PTP1B-IN-27 also inhibits α-Glucosidase (IC₅₀=120 µM) and shows competitive inhibition (K_i=118 µM) .

HY-149255

PTP1B/AKR1B1-IN-2	Phosphatase Aldose Reductase	Metabolic Disease
PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual *PTP1B/AKR1B1* inhibitor (IC₅₀s: 3.2 and 2.1 μM, K_is: 4.0 and 0.9μM). PTP1B/AKR1B1-IN-2 is an insulin-mimetic agent. PTP1B/AKR1B1-IN-2 improves glucose uptake in murine C2C12 myoblasts. PTP1B/AKR1B1-IN-2 can be used for research of Type 2 diabetes mellitus (T2DM) .

HY-19779

JTT 551	Phosphatase	Metabolic Disease
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

HY-W002314

2-Bromo-4'-hydroxyacetophenone	Phosphatase	Others
2-Bromo-4'-hydroxyacetophenone a *PTP1B* inhibitor, with a K_i of 42 μM .

HY-12312A

TCS 401 free base	Phosphatase	Metabolic Disease
TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

HY-149254

PTP1B/AKR1B1-IN-1	Phosphatase Aldose Reductase	Metabolic Disease
PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC₅₀s of 0.06 μM and 4.3 μM, respectively. PTP1B/AKR1B1-IN-1 also inhibits TC-PTP with an IC₅₀ value of 9 μM. PTP1B/AKR1B1-IN-1 serves as an insulin-mimetic agent in murine myoblasts, and reduces AKR1B1-dependent sorbitol accumulation. PTP1B/AKR1B1-IN-1 inhibits development of type 2 diabetes mellitus (T2DM) to control blood glucose levels .

HY-156607

Anticancer agent 143	Phosphatase	Cancer
Anticancer agent 143 (compound 369) is a dual *PTPN2/PTP1B* inhibitor with IC₅₀ values <2.5 nM. Anticancer agent 143 can be used in cancer research .

HY-156608

Anticancer agent 144	Phosphatase	Cancer
Anticancer agent 144 (compound 444) is a dual *PTPN2/PTP1B* inhibitor with IC₅₀ values <2.5 nM. Anticancer agent 144 can be used in cancer research .

HY-162499

MY17	Phosphatase	Metabolic Disease
MY17 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC₅₀=0.41±0.05 μM). MY17 alleviates palmitic acid (PA) -induced insulin resistance by up-regulating the expression of phosphorylated insulin receptor substrate (IRS1) and protein kinase B (AKT). By binding with *PTP1B, MY17 can inhibit* the activity of *PTP1B*, thereby improving insulin signaling and having anti-diabetic activity. MY17 can be used in the study of type 2 diabetes .

HY-125108

PHPS1 sodium 2 Publications Verification	SHP2 Phosphatase	Cardiovascular Disease Cancer
PHPS1 sodium is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively .

HY-112368

PHPS1 2 Publications Verification	SHP2 Phosphatase	Cardiovascular Disease Cancer
PHPS1 is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively .

HY-N1789

Kaempferol-7,4'-dimethyl ether	Phosphatase Others	Others
Kaempferol-7,4'-dimethyl ether is a *PTP1B* inhibitor, and also can inhibit the production of NO. Kaempferol-7,4'-dimethyl ether shows the inhibition rate of 46.1% at 100 μM. Kaempferol-7,4'-dimethyl ether inhibits *PTP1B* activity with IC50 value of 16.92 μM .

HY-N10649

PTP1B-IN-21	Phosphatase	Metabolic Disease
PTP1B-IN-21 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC₅₀=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC₅₀>100 μM), which is a key target for type 2 diabetes inhibition .

HY-N10648

PTP1B-IN-20	Phosphatase	Metabolic Disease
PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC₅₀=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC₅₀=78.0 μM), which is a key target for type 2 diabetes inhibition .

HY-117830

CX08005	Phosphatase	Endocrinology
CX08005 is a competitive *PTP1B* inhibitor. CX08005 can directly enhance the action of insulin in vivo and in vitro and improve insulin resistance .

HY-N13199

3-O-Dihydro-p-coumaroyltohogenol	Phosphatase	Metabolic Disease
3-O-Dihydro-p-coumaroyltohogenol is a *PTP1B* inhibitor (IC₅₀=6.27 μM) with antidiabetic and antiobesity activities .

HY-111469

CPT-157633 1 Publications Verification	Phosphatase	Metabolic Disease
CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a *PTP1B* inhibitor. CPT-157633 prevents binge drinking-induced glucose intolerance .

HY-N3267

Methyl pseudolarate B	Phosphatase	Metabolic Disease
Methyl pseudolarate B, a natural diterpenoid, is a protein tyrosine phosphatase 1B (PTP1B) (Phosphatase) inhibitor with an IC₅₀ value of 10.9 μM .

HY-N1783

(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid	Phosphatase	Cancer
(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent *PTP1B* inhibitor, with an IC₅₀ of 0.4 μM. (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid exhibits potent *PTP1B* inhibitory activity without cytotoxicity .

HY-N4185

Licoflavone A 1 Publications Verification	Phosphatase	Neurological Disease
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-N12736

Dehydrodanshenol A	Phosphatase	Metabolic Disease
Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research .

HY-N6650

Isotanshinone IIA	Phosphatase	Metabolic Disease
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC₅₀ 0f 11.4 μM.

HY-N0374

Licochalcone C 2 Publications Verification	Glucosidase	Metabolic Disease
Licochalcone C could inhibit α-glucosidase, with IC₅₀s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

HY-N10002

Caffeoyltryptophan	Phosphatase Glucosidase	Metabolic Disease
Caffeoyltryptophan is a competitive *PTP1B* inhibitor, with an IC₅₀ of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase, linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes .

HY-155961

Antidiabetic agent 2	Dipeptidyl Peptidase Phosphatase Amylases Glucosidase	Metabolic Disease
Antidiabetic agent 2 (Compound 56) is a glucose-uptake promoter. Antidiabetic agent 2 inhibits DPP-4, *PTP-1B, α-amylase, and α-glucosidase* with IC₅₀s of 0.036, 0.042, 0.241, 0.185 μM. Antidiabetic agent 2 decreases blood glucose levels .

HY-128978

(E,E)-RAMB4	Phosphatase	Metabolic Disease
(E,E)-RAMB4 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1 .

Cat. No.	Product Name		Classification

HY-159694A

IONIS PTP1BRx sodium ISIS 404173 sodium		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

HY-159694

IONIS PTP1BRx ISIS 404173		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

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PTP-1B inhibitor

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