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Pathways Recommended:	PI3K/Akt/mTOR

Results for "

Peptide K

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Peptide-Drug Conjugates (PDCs) (1) Adrenergic Receptor (1) Akt (4) Antibiotic (1) APC (1) Apoptosis (5) Bacterial (14) Biochemical Assay Reagents (3) Calcium Channel (2) Cathepsin (2) Complement System (1) CXCR (1) Dipeptidyl Peptidase (1) Drug Intermediate (1) Endogenous Metabolite (2) Epigenetic Reader Domain (3) ERK (1) Estrogen Receptor/ERR (1) Fungal (3) GABA Receptor (2) GCGR (2) GLP Receptor (3) Histone Demethylase (4) Histone Methyltransferase (5) HIV (1) HSP (1) Insulin Receptor (2) Integrin (1) MHC (1) MMP (2) Na+/K+ ATPase (3) Neurokinin Receptor (3) NF-κB (1) Opioid Receptor (1) p38 MAPK (1) PDK-1 (1) PI3K (5) Potassium Channel (12) Protease Activated Receptor (PAR) (1) Protein Arginine Deiminase (1) Proton Pump (2) Ras (2) Reactive Oxygen Species (1) Secretin Receptor (2) Ser/Thr Protease (3) Sodium Channel (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (5) Endocrinology (3) Infection (16) Inflammation/Immunology (11) Metabolic Disease (11) Neurological Disease (16)

By Targets:

Amyloid-β (1)

Peptide-Drug Conjugates (PDCs) (1)

Adrenergic Receptor (1)

Akt (4)

Antibiotic (1)

APC (1)

Apoptosis (5)

Bacterial (14)

Biochemical Assay Reagents (3)

Calcium Channel (2)

Cathepsin (2)

Complement System (1)

CXCR (1)

Dipeptidyl Peptidase (1)

Drug Intermediate (1)

Endogenous Metabolite (2)

Epigenetic Reader Domain (3)

ERK (1)

Estrogen Receptor/ERR (1)

Fungal (3)

GABA Receptor (2)

GCGR (2)

GLP Receptor (3)

Histone Demethylase (4)

Histone Methyltransferase (5)

HIV (1)

HSP (1)

Insulin Receptor (2)

Integrin (1)

MHC (1)

MMP (2)

Na+/K+ ATPase (3)

Neurokinin Receptor (3)

NF-κB (1)

Opioid Receptor (1)

p38 MAPK (1)

PDK-1 (1)

PI3K (5)

Potassium Channel (12)

Protease Activated Receptor (PAR) (1)

Protein Arginine Deiminase (1)

Proton Pump (2)

Ras (2)

Reactive Oxygen Species (1)

Secretin Receptor (2)

Ser/Thr Protease (3)

Sodium Channel (1)

By Research Areas:

Cancer (22)

Cardiovascular Disease (5)

Endocrinology (3)

Infection (16)

Inflammation/Immunology (11)

Metabolic Disease (11)

Neurological Disease (16)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Formyl Peptide Receptor (FPR) Peptide-Drug Conjugates (PDCs) Natriuretic Peptide Receptor (NPR) CGRP Receptor Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5964A

*K1 peptide* TFA**	GABA Receptor	Neurological Disease
K1 peptide TFA is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP) .

HY-P5307

Peptide A5K INF7-A5K-TAT	Biochemical Assay Reagents	Others
Peptide A5K (INF7-A5K-TAT) is an RNP delivery peptide that delivers CRISPR RNPs to T cells. Peptide A5K effectively edits T cells without substantial impact on T cell viability .

HY-103433

K579	Dipeptidyl Peptidase	Metabolic Disease
K579 is a potent and orally active dipeptidyl peptidase IV inhibitor. K579 inhibits the blood glucose elevation. K579 increases the plasma insulin and active forms of glucagon-like peptide-1 (GLP-1). K579 has the potential for the research of diabetic .

HY-14533

K 01-162 K162	Amyloid-β	Neurological Disease
K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ₄₂ peptide with an EC₅₀ value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease .

HY-P10675

Peptide K	Biochemical Assay Reagents	Metabolic Disease
Peptide K is a self-assembling peptide fiber that can be used to prepare fibrous nanocomposite hydrogels. The fibrous nanocomposite hydrogels have a dynamic network that adapts to cells and enhances cell-matrix and cell-cell interactions, thus significantly promoting the mechanotransduction, metabolic energy, and osteogenesis of encapsulated stem cells .

HY-P5964

K1 peptide	GABA Receptor	Neurological Disease
K1 peptide is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP) .

HY-P5600

The K4 peptide	Bacterial	Infection
The K4 peptide is an antimicrobial peptide with strong activity against Gram-positive and Gram-negative bacteria, including human pathogenic bacteria, such as Staphylococcus aureus and Marine Vibrio bacteria .

HY-P5307A

Peptide A5K acetate INF7-A5K-TAT acetate	Biochemical Assay Reagents	Cancer
Peptide A5K (INF7-A5K-TAT acetate) acetate is a INF7-TAT derivative and is used for CRISPR RNP delivery into T cells. Peptide A5K acetate effectively promotes the delivery of Cas9 RNP to natural killer (NK) cells .

HY-111214

K-14585	Protease Activated Receptor (PAR) NF-κB p38 MAPK	Inflammation/Immunology
K-14585 is a peptide competitive PAR2 antagonist. K-14585 inhibits PAR2-dependent IL-8 production, NF-κB phosphorylation, and p38 signaling. K-14585 reduces SLIGKV (PAR2 agonist peptide)-induced Ca ²⁺ mobilisation in primary human keratinocytes .

HY-P10556

(KFF)3K	Bacterial	Infection
(KFF)3K is a cell penetrating peptide that can promote the absorption of other antibiotics by disrupting the outer membrane of bacteria. (KFF)3K can be introduced into a hydrocarbon scaffold to induce its antibacterial properties, making it an effective antimicrobial peptide. (KFF)3K can be used in the development of new antimicrobial agents .

HY-120286

K-13	Drug Intermediate	Others
K-13 is a cyclic peptide compound synthesized by a specific organozinc reagent. Its synthesis process involves intermolecular and intramolecular Negishi cross-coupling reactions and is one of the shortest routes reported for the synthesis of such cyclic peptides.

HY-P5599

Temporin K	Bacterial	Infection
Temporin K is an antimicrobial peptide against Legionella pneumophila .

HY-P2064

Lariatin A	Bacterial	Infection
Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171 .

HY-P5923

E70K	CXCR	Inflammation/Immunology
E70K is a CXCL8 C-terminal peptide with a substitution of glutamic acid (E) 70 with lysine (K). E70K can reduce neutrophil adhesion and migration during inflammation .

HY-P0191

Charybdotoxin	Potassium Channel	Inflammation/Immunology
Charybdotoxin, a 37-amino acid peptide, is a K ⁺ channel blocker .

HY-P0191A

Charybdotoxin TFA	Potassium Channel	Inflammation/Immunology
Charybdotoxin TFA, a 37-amino acid peptide, is a K ⁺ channel blocker .

HY-P5887

Tertiapin-RQ	Potassium Channel	Neurological Disease
Tertiapin-RQ is an inward rectifier K ⁺ channel blocker peptide with antidepressive effect .

HY-P10090

Apoptin-derived peptide	Akt PI3K Apoptosis	Cancer
Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating *PI3K/AKT/ARNT* signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the *PI3K/AKT* pathway involved in the development of gastric cancer .

HY-P0141

Akt/SKG Substrate Peptide	Akt	Others
Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

HY-P5203

Enterocin K1 EntK1	Bacterial	Infection
Enterocin K1 (EntK1) is a bacteriocin. Enterocin K1 is a ribosomal synthetic peptide. Enterocin K1 specifically targets *Enterococcus faecalis* via the Eep protein on the bacterial membrane. Enterocin K1 displays a potent antibacterial activity against VRE. Enterocin K1 can be used for related studies of VRE infections .

HY-P0141A

*Akt/SKG Substrate Peptide* TFA**	Akt	Others
Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

HY-P10320

T3 Peptide Tumstatin (69-88), human	PI3K Akt	Cardiovascular Disease
T3 Peptide is an active fragment of tumstatin. T3 Peptide binds integrin α_vβ₃/α_vβ₅, activates the PI3K/Akt/p70S6K signaling pathway, and thus stimulates the proliferation and migration of rat cardiac fibroblasts .

HY-P2255

H3K4(Me) (1-20)	Histone Demethylase	Others
H3K4(Me) (1-20), a histone peptide. H3K4me is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci .

HY-P10093

Penetratin-PI3Kγ(126-150)	PI3K	Others
Penetratin-PI3Kγ(126-150) is a peptide inhibitor of ΡI3Κγ that plays an important role in respiratory system diseases .

HY-P2257

H3K4(Me3) (1-20)	Histone Demethylase	Others
H3K4(Me3) (1-20) is a histone peptide. Trimethylation of histone H3 on lysine 4 (H3K4 me3) is found in active euchromatin but not in silent heterochromatin .

HY-P2253

H3K27(Me2) (15-34)	Histone Demethylase	Cancer
H3K27(Me2) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me) .

HY-P3150

Recombinant Proteinase K	Ser/Thr Protease	Others
Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations .

HY-P5704

K11	Bacterial	Infection
K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability .

HY-P10843

R4K1	Estrogen Receptor/ERR	Cancer
R4K1 is a cell-permeable stapled peptide. R4K1 binds to the estrogen receptor (ER) α with high affinity and inhibits its interaction with coactivators. R4K1 can enter breast cancer cells to regulate gene transcription and inhibit cell proliferation. R4K1 can be used in the study of cancer .

HY-P1565

*Transdermal Peptide* Disulfide** TD 1 Disulfide(Peptide)	Na+/K+ ATPase	Inflammation/Immunology
Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide can enhance the transdermal delivery of many macromolecules .

HY-P1885

*HIV gag peptide* (197-205)**	HIV	Infection
HIV gag peptide (197-205) is a H-2K ^d-restricted epitope derived from the p24 portion of the HIV-1 gag protein, consists of amino acids 197-205 (AMQMLKETI) .

HY-P5155

Stromatoxin 1	Potassium Channel	Neurological Disease
Stromatoxin 1 is an inhibitor of Potassium Channel, a peptide which can be isolated from tarantulas. Stromatoxin 1 selectively inhibits *K(V)2.1, K(V)2.2, K(V)4.2*, and K(V)2.1/9.3 channels. K(V)2.1 and K(V)2.2, but not K(V)4.2, channel subunits play a key role in opposing both myogenic and neurogenic urinary bladder smooth muscle (UBSM) contractions in rats .

HY-P3711

SPAI-1	Na+/K+ ATPase	Others
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na ⁺, K ⁺-ATPase and H ⁺, K ⁺-ATPase in vitro, stimulates Mg ²⁺-ATPase .

HY-P1565A

*Transdermal Peptide* Disulfide TFA** TD 1 Disulfide(Peptide) TFA	Na+/K+ ATPase	Others
Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules .

HY-P5377

Abz-HPGGPQ-EDDnp Cathepsin K substrate	Ser/Thr Protease	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

HY-P10358

TAT-CBD3A6K	Calcium Channel	Neurological Disease
TAT-CBD3A6K, is a modified TAT-CBD3 peptide. TAT-CBD3A6K reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function .

HY-P1244

Secretin (33-59), rat Secretin (rat)	Secretin Receptor	Neurological Disease
Secretin (33-59), rat is a 27-aa peptide, acts on secretin receptor, enhances the secretion of bicarbonate, enzymes, and K ⁺ from the pancreas.

HY-P2576

Polistes mastoparan	Bacterial	Infection
Polistes mastoparan is an antimicrobial peptide. Polistes mastoparan increases S. aureus cell K ⁺ efflux and inhibits cell viability with EC₅₀ of 5 μM .

HY-P0197

Neurokinin A 2 Publications Verification Substance K; Neurokinin α; Neuromedin L	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-P1918A

Activated Protein C (390-404), human TFA	APC	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-P1244A

Secretin (33-59), rat TFA Secretin (rat) (TFA)	Secretin Receptor	Neurological Disease
Secretin (33-59), rat (TFA) is a 27-aa peptide, which acts on secretin receptor, and enhances the secretion of bicarbonate, enzymes, and K ⁺ from the pancreas .

HY-P1602

Apidaecin IB	Bacterial	Infection
Apidaecin IB is a insect antimicrobial peptide, with minimum inhibitory concentration (MIC) values of 8 μM for E. coli (ML35, O18K1H7 and ATCC 25922).

HY-P0197A

Neurokinin A TFA 2 Publications Verification Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-121459

Neoantimycin	HSP Ras
Neoantimycin is a GRP78/BiP and *K-Ras* regulator with anticancer activity. Its biosynthesis is catalyzed by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) system .

HY-P5632

Bovine tracheal antimicrobial peptide	Bacterial	Infection
Bovine tracheal antimicrobial peptide is a kind of comes from the tracheal mucosa of antimicrobial peptides. Bovine tracheal antimicrobial peptide has activity against E.coli D31, K.pneumoniae 13883, S.aureus 25923, P.aeruginosa 27853 and C.albicans 14053, MIC value 12-25, 12-25, 25-50, 25-50, 6-12 μg/ml, respectively .

HY-P3278

Caloxin 2A1 1 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular plasma membrane Ca ²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-P5691

P1	Bacterial	Infection Cancer
P1 is a broad-spectrum antimicrobial peptide. P1 shows antibacterial activity against Gram-positive and Gram-negative bacteria,such as B. anthracis spores and Carbapenem-resistant A. baumannii and K. pneumoniae .

HY-P5701

EP2	Bacterial Fungal	Infection
EP2 is an antimicrobial peptide. EP2 has antibacterial and antifungal activities. EP2 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 11.4 μg/mL .

HY-162371

NRPSs-IN-1	Others	Infection
NRPSs-IN-1 (Compound 7) is a cell-penetrating inhibitor of *non-ribosomal peptide* synthetase (NRPSs). NRPSs-IN-1 K inhibits gramicidin S synthetase A (GrsA) with a K_d** value of 16.6 nM .

HY-149205

CXJ-2	PI3K ERK	Inflammation/Immunology
CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the *PI3K/ERK* pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-120286

K-13	Structural Classification Natural Products Microorganisms Source classification	Drug Intermediate
K-13 is a cyclic peptide compound synthesized by a specific organozinc reagent. Its synthesis process involves intermolecular and intramolecular Negishi cross-coupling reactions and is one of the shortest routes reported for the synthesis of such cyclic peptides.

HY-P5701

EP2	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial Fungal
EP2 is an antimicrobial peptide. EP2 has antibacterial and antifungal activities. EP2 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 11.4 μg/mL .

HY-P5702

EP3	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial Apoptosis Fungal
EP3 is an antimicrobial peptide. EP3 has antibacterial and antifungal activities. EP3 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 12.85 μg/mL. EP3 also shows antitumor activity against cancer cells, and induces cell apoptosis .

HY-113513

5-HEPE	Microorganisms Source classification	Others
5(S)-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.

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