Search Result
Results for "
Protecting group
" in MedChemExpress (MCE) Product Catalog:
7
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W046355
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- HY-W048673
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Amino Acid Derivatives
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Others
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Boc-Dap(Boc)-OH is an amino acid derivative with a Boc protecting group and can be used in the synthesis of primary amides .
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- HY-W005561
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Amino Acid Derivatives
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Others
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H-Dab(Boc)-OMe hydrochloride is an N-terminally protected diaminobutyric acid containing two protecting groups: methoxy (OMe) and tert-butyloxycarbonyl (Boc). H-Dab(Boc)-OMe hydrochloride can be used to synthesize the bifunctional chelator H3Dpaa that can rapidly complex 68Ga under physiological conditions .
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- HY-W013154
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Amino Acid Derivatives
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Others
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Fmoc-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as the biotinylated derivative of the opioid receptor antagonist TIPP .
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- HY-W048722
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Fmoc-D-2-Thienylalanine
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Amino Acid Derivatives
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Others
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Fmoc-D-Thi-OH (Fmoc-D-2-Thienylalanine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize AS-Z-P with thrombin inhibitory activity .
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- HY-W047799
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Amino Acid Derivatives
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Others
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Fmoc-Phe(4-CONH2)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a small-sized HTLV-I protease inhibitor with hydrophilicity .
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- HY-W048730
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Amino Acid Derivatives
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Others
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Fmoc-Phe(4-tBu)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize rOicPaPhe(p-Me)-NH(2) with platelet aggregation activation inhibitory activity .
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- HY-W013153
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Amino Acid Derivatives
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Others
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Fmoc-D-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg 10]HOE 140, which has bradykinin B1 antagonist activity .
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- HY-W048718
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Fmoc-D-α-t-butylglycine
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Amino Acid Derivatives
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Others
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Fmoc-D-Tle-OH (Fmoc-D-α-t-butylglycine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize chelating agents that can form a single stereoisomer-enriched form after coordination with metal centers .
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- HY-W048739
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Amino Acid Derivatives
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Others
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Fmoc-α-Me-Leu-OH is a leucine derivative with an Fmoc protecting group, which can be used to synthesize peptides with oxytocin receptor agonist activity .
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- HY-W008919
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N-Alpha,N-epsilon-di-Boc-L-lysine 4-nitrophenyl ester
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Amino Acid Derivatives
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Others
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Boc-Lys(Boc)-Onp (N-Alpha,N-epsilon-di-Boc-L-lysine 4-nitrophenyl ester) is a lysine with a Boc protecting group. Boc-Lys(Boc)-Onp was used as a substrate for a catalyst model to study its enzymatic hydrolysis reaction catalyzed by a copper(II) complex .
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- HY-W097054
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Amino Acid Derivatives
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Others
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Fmoc-L-cysteic acid is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize triarylsulfonium compounds for radiolabeling of peptides .
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- HY-W019032
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Amino Acid Derivatives
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Others
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Fmoc-D-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with antibacterial activity .
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- HY-W011156
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Amino Acid Derivatives
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Others
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Mpa(Trt) is a 3-mercaptopropionic acid derivative containing a trityl protecting group (Trt) and can be used to synthesize compounds with anti-leukemia activity .
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- HY-78927
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Amino Acid Derivatives
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Others
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N-Boc-L-Prolinal is a proline with a Boc protecting group, which can be used to synthesize biologically active peptide mimetics, such as the synthesis of Dolastatin 10 (HY-15580) analogs with anti-colon cancer activity .
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- HY-W010922
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Amino Acid Derivatives
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Others
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Fmoc-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bicyclic peptide tachykinin NK2 antagonists .
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- HY-W047788
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Amino Acid Derivatives
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Others
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H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities .
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- HY-W008876
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Amino Acid Derivatives
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Others
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Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II .
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- HY-W106325
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Amino Acid Derivatives
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Others
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Fmoc-N-Me-D-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize somatostatin-dopamine chimeric analogs .
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- HY-W077219
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Boc-Arg(Mtr)-OH
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Amino Acid Derivatives
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Others
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Boc-L-Arg(Mtr)-OH (Boc-Arg(Mtr)-OH) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antithrombotic activity .
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- HY-W548477
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Amino Acid Derivatives
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Others
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H-Lys(Fmoc)-OH hydrochloride is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize diacylated GLP-1 derivatives with antidiabetic activity .
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- HY-W101889
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N-Boc-N'-xanthyl-L-glutamine
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Amino Acid Derivatives
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Others
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Boc-Gln(Xan)-OH (N-Boc-N'-xanthyl-L-glutamine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antigenic activity .
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- HY-W091365
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N-Boc-N'-xanthyl-L-asparagine
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Amino Acid Derivatives
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Others
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Boc-Asn(Xan)-OH (N-Boc-N'-xanthyl-L-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize locust fat growth hormone .
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- HY-W101305
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Amino Acid Derivatives
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Others
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Fmoc-Pen(Acm)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize chemically modified cyclic peptides containing cell adhesion recognition (CAR) sequences .
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- HY-137002
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Amino Acid Derivatives
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Others
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Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .
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- HY-W008064
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Fmoc-L-Citrulline
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Amino Acid Derivatives
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Cancer
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Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif .
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- HY-W048697
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Amino Acid Derivatives
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Others
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Fmoc-D-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize analogs of cyclic lanthionine enkephalin, a δ-opioid receptor selective ligand .
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- HY-W101935
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N-Boc-D-arginine hydrochloride
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Amino Acid Derivatives
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Others
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N-Boc-D-Arg hydrochloride (N-Boc-D-arginine hydrochloride) is an amino acid derivative with a Boc protecting group, which can be used to synthesize desmopressin with the effects of improving nocturia, urinary incontinence and enuresis .
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- HY-W009118
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Amino Acid Derivatives
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Others
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Fmoc-5-Ava-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize fatty acid-based dimeric peptides with PSD-95 inhibitory activity .
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- HY-W010835
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Boc-S-trityl-D-cysteine
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Amino Acid Derivatives
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Others
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Boc-D-Cys(Trt)-OH (Boc-S-trityl-D-cysteine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize the bicyclic depsipeptide histone deacetylase inhibitor spirocysteine .
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- HY-W089230
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N,N'-Di-tert-butoxycarbonyl-L-histidine
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Amino Acid Derivatives
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Others
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Boc-His(Boc)-OH (N,N'-Di-tert-butoxycarbonyl-L-histidine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize the dodecapeptide α-mating factor of Saccharomyces cerevisiae .
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- HY-W101495
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N-Boc-L-leucine monohydrate
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Amino Acid Derivatives
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Others
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Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .
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- HY-W041989
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Amino Acid Derivatives
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Others
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Fmoc-Oic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg 10]HOE 140, which has bradykinin B1 antagonist activity .
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- HY-34738
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3-(Boc-amino)-1-propanol
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Amino Acid Derivatives
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Others
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Boc-β-Ala-ol (3-(Boc-amino)-1-propanol) is an alanine derivative with a Boc protecting group at the N-terminus, which can be used to synthesize bioactive peptide mimics, such as Nα-Benzoyl-α-azaornithine phenyl ester, which has trypsin inhibitory activity .
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- HY-W089233
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N-Boc-D-glutaMic acid 1-tert-butyl ester
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Amino Acid Derivatives
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Others
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Boc-D-Glu-OtBu (N-Boc-D-glutaMic acid 1-tert-butyl ester) is an amino acid derivative with a Boc protecting group, which can be used to synthesize Adamant-1-yl tripeptide with immunostimulatory activity .
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- HY-W088100
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N-Boc-N'-trityl-D-asparagine; Boc-D-Asn(Trt)-OH
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Amino Acid Derivatives
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Cancer
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Boc-N-gamma-trityl-D-asparagin (N-Boc-N'-trityl-D-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize metastasis-inhibiting or tumor growth-inhibiting metastasis-inhibiting MS derivatives .
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- HY-W014692
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N-t-Boc-amino-D-alanine; Boc-D-Dap-OH
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Amino Acid Derivatives
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Others
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Boc-D-2,3-diaminopropionic acid (N-t-Boc-amino-D-alanine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize a potent NMDA receptor glycine site agonist with GluN2 subunit-specific activity .
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- HY-W044285
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Amino Acid Derivatives
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Others
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Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity .
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- HY-Y1169
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4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate; Fmoc-L-Asp(OtBu)-OH
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Amino Acid Derivatives
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Others
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Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
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- HY-78933
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Microtubule/Tubulin
ADC Cytotoxin
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Cancer
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Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC .
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- HY-20841
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(S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid; Boc-4-Pyranoyl-Gly-OH
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Amino Acid Derivatives
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Others
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Boc-(2S)-Gly-4-pyranoyl ((S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid) is an amino-terminally protected glycine derivative that can be used to synthesize dipeptidyl peptidase IV with antidiabetic activity .
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- HY-W088805
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Fmoc-3-carboxypiperidine
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Amino Acid Derivatives
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Others
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Fmoc-NIP-OH (Fmoc-3-carboxypiperidine) is a Fmoc-protected amino acid derivative commonly used in peptide synthesis .
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- HY-41062
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- HY-164253
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DNA/RNA Synthesis
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Others
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TBS-rG(Ac)Is with TBSProtecting Group (Protect OHHydroxyl), acetylated guanosine ribonucleotide.
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- HY-41063
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ADC Linker
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Cancer
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N-Boc-N-methyl-D-Valinol is an ADC linker with BOC protecting group.
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- HY-41064
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ADC Linker
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Cancer
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N-Boc-N-methyl-D-Valaldehyde is an ADC linker with a BOC protecting group.
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- HY-W009229
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- HY-Y1080
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- HY-164249
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DNA/RNA Synthesis
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Others
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DMT-rG(Ac)Is with DMTProtecting Group (Protect 5'end), acetylated guanosine ribonucleotide.
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- HY-W010712
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Amino Acid Derivatives
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Others
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Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation .
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- HY-W338516
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Amino Acid Derivatives
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Others
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Fmoc-L-Homoarginine hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Homoarginine hydrochloride can be used for synthesis of homoarginine containing peptide .
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- HY-W419374
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Amino Acid Derivatives
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Others
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ivDde-Lys(Fmoc)-OH is a derivative of amino acid with protecting groups. ivDde-Lys(Fmoc)-OH can be used for peptide synthesis .
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- HY-W109214
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Amino Acid Derivatives
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Others
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Fmoc-L-Dap(Boc,Me)-OH is a derivative of amino acid with protecting groups. Fmoc-L-Dap(Boc,Me)-OH can be used for synthesis of diaminopropionic acid containing peptide .
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- HY-135233
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SATA
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Biochemical Assay Reagents
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Others
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N-Succinimidyl S-acetylthioacetate (SATA), a protein modification agent, introduces thiol-groups into protein molecules. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form .
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- HY-W010712S1
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Isotope-Labeled Compounds
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Others
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Fmoc-His(Trt)-OH- 15N3 is the 15N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].
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- HY-W025723A
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N-(Benzyloxycarbonyl)-D-homoserine
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Others
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Cancer
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N-Carbobenzoxy-D-homoserine (N-(Benzyloxycarbonyl)-D-homoserine) is D-homoserine with N-Carbobenzoxy protecting group, which can be used to synthesize Antibody-Drug Conjugates (ADCs).
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- HY-164272
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Microtubule/Tubulin
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Cancer
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2'-O-TBDMS-Paclitaxel is a paclitaxel (HY-B0015) derivative which 2'-OH group is protected as a tert-butyldimethylsilyl (TBDMS) ether .
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- HY-W025723
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N-(Benzyloxycarbonyl)-L-homoserine
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Others
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Cancer
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N-Carbobenzoxy-L-homoserine (N-(Benzyloxycarbonyl)-L-homoserine) is L-homoserine with N-Carbobenzoxy protecting group, which can be used as a linker (ADC Linker) for the synthesis of Antibody-Drug Conjugates (ADCs).
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- HY-W337644
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Amino Acid Derivatives
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Others
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Fmoc-L-Homoarg(Et)2-OH hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Dap(Boc,Me)-OH can be used for synthesis of homoarginine containing peptide .
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- HY-W004864
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Amino Acid Derivatives
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Others
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Fmoc-(S)-2-(4-pentenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active secretin analogs .
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- HY-W007056
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Amino Acid Derivatives
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Others
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Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa .
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- HY-151825
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ADC Linker
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Others
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Fmoc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in solid-phase peptide synthesis. Poc-group can be further modified using Click-chemistry .
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- HY-Y1636
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Amino Acid Derivatives
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Others
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Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
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- HY-164252
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5′-O-Trityl-2′-deoxy-2′-fluorouridine
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DNA/RNA Synthesis
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Others
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DMT-2'-FU (5'-O-Trityl-2'-deoxy-2'-fluorouridine)Is with DMTProtecting Group (Protect 5'end), FLabeled uridine ribonucleotide.
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- HY-W008024
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Amino Acid Derivatives
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Others
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Fmoc-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize somatostatin analogs that inhibit neointima formation induced by balloon injury in rats without altering growth hormone release .
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- HY-W006886
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Amino Acid Derivatives
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Others
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Fmoc-(R)-2-(7-octenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize inhibitor peptides that combinatorially inactivate ErbB1, ErbB2, and ErbB3 .
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- HY-151748
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ADC Linker
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Others
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N3-L-Orn(Fmoc)-OH is a Fmoc-protected ornithine derivative, can be used as a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-N7502
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Others
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Others
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2-(Hydroxymethyl)anthraquinone is used as a photoremovable protecting group (PRPG) to chemically cage sex pheromone (e.g. (Z)-11-hexadecen-1-ol (sex pheromone of Chilo infuscatellussnellen)) .
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- HY-79255
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ADC Cytotoxin
Microtubule/Tubulin
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Cancer
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Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor with an Fmoc protecting group. The active ingredient of Fmoc-MMAF-OMe, MMAF (HY-15579), is the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs) .
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- HY-W006937
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Boc-p-amino-D-Phe(Fmoc)-OH; Boc-D-phe(4-NH-fmoc)-OH
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Amino Acid Derivatives
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Others
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Boc-D-(4-fmoc)-aminophenylalanine (Boc-p-amino-D-Phe(Fmoc)-OH) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with gonadotropin-releasing hormone antagonist activity .
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- HY-157181
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Others
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Inflammation/Immunology
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Hal-HS, a happen, fully protects and highlights the main functional groups of the molecule, thereby completely exposing it to the immune system. Hal-HS can be covalently attached to BSA via the active ester method to obtain hapten–protein conjugates (Hal-BSA) as immunogen .
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- HY-151703
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ADC Linker
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Others
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Boc-D-Lys(N3)-OH is a Boc-protected amino acid derivative, can be used as a click chemistry reagent and an intermediate for synthesis of linkers . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-151824
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ADC Linker
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Others
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Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-151764
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ADC Linker
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Others
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N3-D-Orn(Boc)-OH is a Boc-protected pentanoic amino acid derivative, can be used as a click chemistry reagent and has been used to synthesis antibody-drug conjugates (ADC) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-151764A
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ADC Linker
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Others
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N3-D-Orn(Boc)-OH (CHA) is a Boc-protected pentanoic amino acid derivative, can be used as a click chemistry reagent and has been used to synthesis antibody-drug conjugates (ADC) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-B1142
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(±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide
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NO Synthase
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Others
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Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
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- HY-120501
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B022
Maximum Cited Publications
7 Publications Verification
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NF-κB
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Inflammation/Immunology
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B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki of 4.2 nM; IC50=15.1 nM). B022 protects liver from toxin-induced inflammation, oxidative stress, and injury . B022 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-151715
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ADC Linker
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Others
|
N3-D-Dap(Fmoc)-OH is a click chemistry reagent. N3-D-Dap(Fmoc)-OH can be used as a component for coupling by click reaction and as an orthogonally protected diaminocarboxylic acid derivative . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-151823
-
|
ADC Linker
|
Others
|
8-Azido-octanoyl-OSu is a click chemistry reagent containing an azide group. Used as a building block to introduce 8-azidooctanoic acid (CAS 217180-76-2) fragment. This fragment is used for further modifications using Click-chemistry (CuAAC), as a protected aminogroup or is used in physico-chemical investigations . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-18941C
-
LY354740 hydrochloride; Eglumetad hydrochloride
|
mGluR
|
Neurological Disease
|
Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad hydrochloride protects neurons from NMDA toxicity. Eglumegad hydrochloride has anxiolytic- and antipsychotic-like effects .
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-
- HY-151640
-
|
ADC Linker
|
Others
|
Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-Y1636S1
-
|
Isotope-Labeled Compounds
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Others
|
L-Arginine-N-FMOC PBF-OH- 13C6 is the 13C labeled Fmoc-Arg(Pbf)-OH[1]. Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis)[2].
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-
- HY-151687
-
|
ADC Linker
|
Others
|
Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Tyr(2-azidoethyl)-OH is unnatural Fmoc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. And azido-UAAs can be employed as IR reporters . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-W072147
-
Fmoc-L-Ser-OMe
|
Amino Acid Derivatives
|
Others
|
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor .
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-
- HY-138106
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-D-Cit-OH is citrulline with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as H-Dmt-D-Cit-Aba-b-Ala-NMe-30,50-(CF3)2-Bn and H-Dmt-D-Cit-Aba-b-Ala-NMe-Bn with neurokinin-1 antagonist activity .
|
-
- HY-Y1169S1
-
|
Isotope-Labeled Compounds
|
Others
|
Fmoc-Asp(OtBu)-OH- 13C4, 15N is the 13C and 15N labeled Fmoc-Asp(OtBu)-OH[1]. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis[2].
|
-
- HY-108578
-
|
Potassium Channel
|
Neurological Disease
|
RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .
|
-
- HY-155887
-
DSPE-PEG-NH2, MW 3400 ammonium
|
Liposome
|
Others
|
DSPE-PEG-Amine, MW 3400 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 3400 (ammonium) can be converted to aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-155908
-
DSPE-PEG-NH2, MW 10000 ammonium
|
Liposome
|
Others
|
DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 10000 (ammonium) can be converted into aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-155907
-
DSPE-PEG-NH2, MW 5000 ammonium
|
Liposome
|
Others
|
DSPE-PEG-Amine, MW 5000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. DSPE-PEG-Amine, MW 5000 (ammonium) amino group can be converted to aromatic aldehydes that react with acetone-protected aromatic hydrazides on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes produce liposome-Bah-BCA conjugates by forming diaryl hydrazone (BAH) with target enzyme molecules. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-W440823A
-
DSPE-PEG-NH2, MW 1000 ammonium
|
Liposome
|
Others
|
DSPE-PEG-Amine, MW 1000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 1000 (ammonium) can be converted to an aromatic aldehyde, which reacts with an acetone-protected aromatic hydrazine on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-W584513
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-118783
-
(±)-2-Hexyl-4-pentynoic acid
|
HDAC
HSP
|
Neurological Disease
|
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons . 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-15578
-
McMMAF
5 Publications Verification
Maleimidocaproyl monomethylauristatin F
|
Drug-Linker Conjugates for ADC
Apoptosis
|
Cancer
|
McMMAF (Maleimidocaproyl monomethylauristatin F) is a maleimido-caproyl linker, made by coupling the powerful microtubule inhibitor Monomethyl auristatin F (MMAF) with the protecting group maleimidocaproyl. McMMAF serves as an active molecule linker for ADC. McMMAF is non-cleavable and must be internalized and degraded within the cell to release cysteine-McMMAF as the active molecule. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth .
|
-
- HY-W584534
-
|
Ligands for E3 Ligase
|
Cancer
|
VH032-CH2-Boc is a Boc-modified VH032 (HY-120217) that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-CH2-Boc will remove the protecting group under acidic conditions and be directly used in PROTAC molecule synthesis. VH032-CH2-Boc is a key intermediate in the synthesis of PROTAC based on VHL ligand.
|
-
- HY-124086
-
|
Others
|
Neurological Disease
|
BHQ-O-5HT is a light-activated caged 5-HT protected by a BHQ group. When exposed to light at 365 or 740 nm, BHQ-O-5HT releases 5-HT through 1 or 2 photon excitation, respectively. BHQ-O-5HT can be manipulated in space and time to explore the role of 5-HT in regulating mood, appetite, memory, learning, and other cognitive functions .
|
-
- HY-151837
-
|
ADC Linker
|
Others
|
H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W145552
-
4-Methoxyphenyl 3-O-allyl-beta-D-galactopyranoside
|
Biochemical Assay Reagents
|
Others
|
4-Methoxyphenyl 3-O-Allyl-β-D-galactopyranoside is an organic compound belonging to the family of galactopyranosides. It is often used as a building block for the synthesis of more complex glycosides and glycoconjugates. 4-Methoxyphenyl 3-O-Allyl-β-D-galactopyranoside has various applications in biochemical research, especially in the study of carbohydrate metabolism and protein-carbohydrate interactions. This compound contains an allyl protecting group that can be selectively removed using palladium-catalyzed conditions to reveal hydroxyl functionality for further chemical modification.
|
-
- HY-W584515
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)3-NH-Boc is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules targeting 11β-substituted estradiol.
|
-
- HY-W584520
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-4-NH-PEG1-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-W584529
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
VH032-C2-NH-Boc is a Boc-modified VH032 (HY-120217) that acts as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-C2-NH-Boc will remove the protecting group under acidic conditions, and can be directly used for the synthesis of PROTAC molecules. VH032-C2-NH-Boc is a key intermediate for the synthesis of PROTACs based on VHL ligands.
|
-
- HY-W584530
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
VH032-C4-NH-Boc is a Boc-modified VH032 (HY-120217) that acts as a ligand for VHL to recruit von Hippel-Lindau (VHL) proteins. VH032-C4-NH-Boc will remove the protecting group under acidic conditions and be directly used in PROTAC molecule synthesis. VH032-C4-NH-Boc is a key intermediate in the synthesis of PROTAC based on VHL ligand.
|
-
- HY-W584531
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
VH032-C6-NH-Boc is a Boc-modified VH032 (HY-120217) that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-C6-NH-Boc will remove the protecting group under acidic conditions and be directly used in PROTAC molecule synthesis. VH032-C6-NH-Boc is a key intermediate in the synthesis of PROTAC based on VHL ligand.
|
-
- HY-W584533
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
VH032-PEG2-NH-BOC is a Boc-modified VH032 (HY-120217) that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-PEG2-NH-BOC will remove the protecting group under acidic conditions and be directly used for PROTAC molecule synthesis. VH032-PEG2-NH-BOC is a key intermediate in the synthesis of PROTAC based on VHL ligand.
|
-
- HY-W584516
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-W584517
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-W584522
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-4-NH-PEG1-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG1-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-W584524
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-4-NH-PEG2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-W584532
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
VH032-O-C2-NH-Boc is a Boc-modified VH032 (HY-120217) that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-O-C2-NH-Boc will remove the protecting group under acidic conditions and can be directly used in PROTAC molecule synthesis. VH032-O-C2-NH-Boc is a key intermediate in the synthesis of PROTAC based on VHL ligand.
|
-
- HY-44063
-
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
Thalidomide-NH-PEG3-NH-Boc is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-NH-PEG3-NH-Boc acts as a ligand for Cereblon to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-PEG3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-PEG3-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-42771
-
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
|
-
- HY-117074
-
|
Others
|
Infection
|
BMS-247243 is a β-lactam antibiotic against methicillin-resistant Staphylococcus aureus. This section introduces its synthesis method and biological properties. A practical synthetic method was developed to exchange iodide ions with chloride ions to form 4-thiopyridinol 6b with C-3 side chain, thereby effectively synthesizing methyl ester 12b with C-7 side chain. The reaction of 14 with methylthiolate lithium salt was catalyzed by Bu4NCl to form methyl ester 12b in high yield. Reaction with thiolate dianion gave the corresponding Michael addition byproduct, resulting in a decrease in the quality of thermodynamic product 12b. The diester 17 was synthesized by acid chlorination acylation of 16 with 12b in a two-phase system, avoiding the troublesome deprotection work such as using DCC or EDAC. During the TFA reaction to remove the protecting group 17, the bis acid 20 was unexpectedly obtained. The bis acid 19 reacted with 4-thiopyridinol 6b to form BMS-247243 in moderate yield. Alternatively, efficient coupling of diester 17 with 4-thiopyridinol 6b afforded crystalline diester 21 with little contamination from isomer 22. Double deprotection of diester 21 followed by crystallization afforded the bis-zwitterion BMS-247243 in high yield.
|
-
-
-
HY-L007
-
|
5,514 compounds
|
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.
MCE designs a unique collection of 5,514 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.
|
Cat. No. |
Product Name |
Type |
-
- HY-W009229
-
-
- HY-135233
-
SATA
|
Biochemical Assay Reagents
|
N-Succinimidyl S-acetylthioacetate (SATA), a protein modification agent, introduces thiol-groups into protein molecules. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form .
|
-
- HY-155887
-
DSPE-PEG-NH2, MW 3400 ammonium
|
Drug Delivery
|
DSPE-PEG-Amine, MW 3400 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 3400 (ammonium) can be converted to aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-155908
-
DSPE-PEG-NH2, MW 10000 ammonium
|
Drug Delivery
|
DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 10000 (ammonium) can be converted into aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-155907
-
DSPE-PEG-NH2, MW 5000 ammonium
|
Drug Delivery
|
DSPE-PEG-Amine, MW 5000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. DSPE-PEG-Amine, MW 5000 (ammonium) amino group can be converted to aromatic aldehydes that react with acetone-protected aromatic hydrazides on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes produce liposome-Bah-BCA conjugates by forming diaryl hydrazone (BAH) with target enzyme molecules. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-W440823A
-
DSPE-PEG-NH2, MW 1000 ammonium
|
Drug Delivery
|
DSPE-PEG-Amine, MW 1000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 1000 (ammonium) can be converted to an aromatic aldehyde, which reacts with an acetone-protected aromatic hydrazine on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-W145552
-
4-Methoxyphenyl 3-O-allyl-beta-D-galactopyranoside
|
Carbohydrates
|
4-Methoxyphenyl 3-O-Allyl-β-D-galactopyranoside is an organic compound belonging to the family of galactopyranosides. It is often used as a building block for the synthesis of more complex glycosides and glycoconjugates. 4-Methoxyphenyl 3-O-Allyl-β-D-galactopyranoside has various applications in biochemical research, especially in the study of carbohydrate metabolism and protein-carbohydrate interactions. This compound contains an allyl protecting group that can be selectively removed using palladium-catalyzed conditions to reveal hydroxyl functionality for further chemical modification.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-W046355
-
-
- HY-W048673
-
|
Amino Acid Derivatives
|
Others
|
Boc-Dap(Boc)-OH is an amino acid derivative with a Boc protecting group and can be used in the synthesis of primary amides .
|
-
- HY-W005561
-
|
Amino Acid Derivatives
|
Others
|
H-Dab(Boc)-OMe hydrochloride is an N-terminally protected diaminobutyric acid containing two protecting groups: methoxy (OMe) and tert-butyloxycarbonyl (Boc). H-Dab(Boc)-OMe hydrochloride can be used to synthesize the bifunctional chelator H3Dpaa that can rapidly complex 68Ga under physiological conditions .
|
-
- HY-W013154
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as the biotinylated derivative of the opioid receptor antagonist TIPP .
|
-
- HY-W048722
-
Fmoc-D-2-Thienylalanine
|
Amino Acid Derivatives
|
Others
|
Fmoc-D-Thi-OH (Fmoc-D-2-Thienylalanine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize AS-Z-P with thrombin inhibitory activity .
|
-
- HY-W047799
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Phe(4-CONH2)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a small-sized HTLV-I protease inhibitor with hydrophilicity .
|
-
- HY-W048730
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Phe(4-tBu)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize rOicPaPhe(p-Me)-NH(2) with platelet aggregation activation inhibitory activity .
|
-
- HY-W013153
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-D-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg 10]HOE 140, which has bradykinin B1 antagonist activity .
|
-
- HY-W048718
-
Fmoc-D-α-t-butylglycine
|
Amino Acid Derivatives
|
Others
|
Fmoc-D-Tle-OH (Fmoc-D-α-t-butylglycine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize chelating agents that can form a single stereoisomer-enriched form after coordination with metal centers .
|
-
- HY-W048739
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-α-Me-Leu-OH is a leucine derivative with an Fmoc protecting group, which can be used to synthesize peptides with oxytocin receptor agonist activity .
|
-
- HY-W008919
-
N-Alpha,N-epsilon-di-Boc-L-lysine 4-nitrophenyl ester
|
Amino Acid Derivatives
|
Others
|
Boc-Lys(Boc)-Onp (N-Alpha,N-epsilon-di-Boc-L-lysine 4-nitrophenyl ester) is a lysine with a Boc protecting group. Boc-Lys(Boc)-Onp was used as a substrate for a catalyst model to study its enzymatic hydrolysis reaction catalyzed by a copper(II) complex .
|
-
- HY-W097054
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-L-cysteic acid is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize triarylsulfonium compounds for radiolabeling of peptides .
|
-
- HY-W019032
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-D-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with antibacterial activity .
|
-
- HY-W011156
-
|
Amino Acid Derivatives
|
Others
|
Mpa(Trt) is a 3-mercaptopropionic acid derivative containing a trityl protecting group (Trt) and can be used to synthesize compounds with anti-leukemia activity .
|
-
- HY-78927
-
|
Amino Acid Derivatives
|
Others
|
N-Boc-L-Prolinal is a proline with a Boc protecting group, which can be used to synthesize biologically active peptide mimetics, such as the synthesis of Dolastatin 10 (HY-15580) analogs with anti-colon cancer activity .
|
-
- HY-W010922
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bicyclic peptide tachykinin NK2 antagonists .
|
-
- HY-W047788
-
|
Amino Acid Derivatives
|
Others
|
H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities .
|
-
- HY-W008876
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II .
|
-
- HY-W106325
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-N-Me-D-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize somatostatin-dopamine chimeric analogs .
|
-
- HY-W077219
-
Boc-Arg(Mtr)-OH
|
Amino Acid Derivatives
|
Others
|
Boc-L-Arg(Mtr)-OH (Boc-Arg(Mtr)-OH) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antithrombotic activity .
|
-
- HY-W548477
-
|
Amino Acid Derivatives
|
Others
|
H-Lys(Fmoc)-OH hydrochloride is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize diacylated GLP-1 derivatives with antidiabetic activity .
|
-
- HY-W101889
-
N-Boc-N'-xanthyl-L-glutamine
|
Amino Acid Derivatives
|
Others
|
Boc-Gln(Xan)-OH (N-Boc-N'-xanthyl-L-glutamine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antigenic activity .
|
-
- HY-W091365
-
N-Boc-N'-xanthyl-L-asparagine
|
Amino Acid Derivatives
|
Others
|
Boc-Asn(Xan)-OH (N-Boc-N'-xanthyl-L-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize locust fat growth hormone .
|
-
- HY-W101305
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Pen(Acm)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize chemically modified cyclic peptides containing cell adhesion recognition (CAR) sequences .
|
-
- HY-137002
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .
|
-
- HY-W008064
-
Fmoc-L-Citrulline
|
Amino Acid Derivatives
|
Cancer
|
Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif .
|
-
- HY-W015987
-
Fmoc-NH2
|
Peptides
|
Others
|
9-Fluorenylmethyl carbamate (Fmoc-NH2) is an amide compound with an Fmoc protecting group, which can be used as a photobase initiator to prepare organosilane-based proton exchange membranes .
|
-
- HY-W048697
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-D-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize analogs of cyclic lanthionine enkephalin, a δ-opioid receptor selective ligand .
|
-
- HY-W101935
-
N-Boc-D-arginine hydrochloride
|
Amino Acid Derivatives
|
Others
|
N-Boc-D-Arg hydrochloride (N-Boc-D-arginine hydrochloride) is an amino acid derivative with a Boc protecting group, which can be used to synthesize desmopressin with the effects of improving nocturia, urinary incontinence and enuresis .
|
-
- HY-W009118
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-5-Ava-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize fatty acid-based dimeric peptides with PSD-95 inhibitory activity .
|
-
- HY-W010835
-
Boc-S-trityl-D-cysteine
|
Amino Acid Derivatives
|
Others
|
Boc-D-Cys(Trt)-OH (Boc-S-trityl-D-cysteine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize the bicyclic depsipeptide histone deacetylase inhibitor spirocysteine .
|
-
- HY-W089230
-
N,N'-Di-tert-butoxycarbonyl-L-histidine
|
Amino Acid Derivatives
|
Others
|
Boc-His(Boc)-OH (N,N'-Di-tert-butoxycarbonyl-L-histidine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize the dodecapeptide α-mating factor of Saccharomyces cerevisiae .
|
-
- HY-W101495
-
N-Boc-L-leucine monohydrate
|
Amino Acid Derivatives
|
Others
|
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .
|
-
- HY-W041989
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Oic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg 10]HOE 140, which has bradykinin B1 antagonist activity .
|
-
- HY-34738
-
3-(Boc-amino)-1-propanol
|
Amino Acid Derivatives
|
Others
|
Boc-β-Ala-ol (3-(Boc-amino)-1-propanol) is an alanine derivative with a Boc protecting group at the N-terminus, which can be used to synthesize bioactive peptide mimics, such as Nα-Benzoyl-α-azaornithine phenyl ester, which has trypsin inhibitory activity .
|
-
- HY-W089233
-
N-Boc-D-glutaMic acid 1-tert-butyl ester
|
Amino Acid Derivatives
|
Others
|
Boc-D-Glu-OtBu (N-Boc-D-glutaMic acid 1-tert-butyl ester) is an amino acid derivative with a Boc protecting group, which can be used to synthesize Adamant-1-yl tripeptide with immunostimulatory activity .
|
-
- HY-W088100
-
N-Boc-N'-trityl-D-asparagine; Boc-D-Asn(Trt)-OH
|
Amino Acid Derivatives
|
Cancer
|
Boc-N-gamma-trityl-D-asparagin (N-Boc-N'-trityl-D-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize metastasis-inhibiting or tumor growth-inhibiting metastasis-inhibiting MS derivatives .
|
-
- HY-W014692
-
N-t-Boc-amino-D-alanine; Boc-D-Dap-OH
|
Amino Acid Derivatives
|
Others
|
Boc-D-2,3-diaminopropionic acid (N-t-Boc-amino-D-alanine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize a potent NMDA receptor glycine site agonist with GluN2 subunit-specific activity .
|
-
- HY-W044285
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity .
|
-
- HY-Y1169
-
4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate; Fmoc-L-Asp(OtBu)-OH
|
Amino Acid Derivatives
|
Others
|
Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
|
-
- HY-20841
-
(S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid; Boc-4-Pyranoyl-Gly-OH
|
Amino Acid Derivatives
|
Others
|
Boc-(2S)-Gly-4-pyranoyl ((S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid) is an amino-terminally protected glycine derivative that can be used to synthesize dipeptidyl peptidase IV with antidiabetic activity .
|
-
- HY-Y1080
-
-
- HY-W010712
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation .
|
-
- HY-PS0011
-
|
Peptides
|
Others
|
Fmoc-Gly-Wang resin is a resin containing a glycine protecting group and can be used for the synthesis of peptides .
|
-
- HY-W338516
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-L-Homoarginine hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Homoarginine hydrochloride can be used for synthesis of homoarginine containing peptide .
|
-
- HY-PS0002
-
|
Peptides
|
Others
|
Fmoc-Ala-Wang resin is a resin containing an alanine amino protecting group and can be used for peptide synthesis .
|
-
- HY-PS0005
-
|
Peptides
|
Others
|
Fmoc-Arg(Pbf)-Wang resin is a resin containing an arginine protecting group and can be used for the synthesis of peptides .
|
-
- HY-PS0015
-
|
Peptides
|
Others
|
Fmoc-Lys(Boc)-Wang resin is a resin containing a lysine protecting group and can be used for the synthesis of peptides .
|
-
- HY-W419374
-
|
Amino Acid Derivatives
|
Others
|
ivDde-Lys(Fmoc)-OH is a derivative of amino acid with protecting groups. ivDde-Lys(Fmoc)-OH can be used for peptide synthesis .
|
-
- HY-W109214
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-L-Dap(Boc,Me)-OH is a derivative of amino acid with protecting groups. Fmoc-L-Dap(Boc,Me)-OH can be used for synthesis of diaminopropionic acid containing peptide .
|
- HY-W337644
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-L-Homoarg(Et)2-OH hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Dap(Boc,Me)-OH can be used for synthesis of homoarginine containing peptide .
|
- HY-W004864
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-(S)-2-(4-pentenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active secretin analogs .
|
- HY-W007056
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa .
|
- HY-Y1636
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
|
- HY-W008024
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize somatostatin analogs that inhibit neointima formation induced by balloon injury in rats without altering growth hormone release .
|
- HY-W006886
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-(R)-2-(7-octenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize inhibitor peptides that combinatorially inactivate ErbB1, ErbB2, and ErbB3 .
|
- HY-W006937
-
Boc-p-amino-D-Phe(Fmoc)-OH; Boc-D-phe(4-NH-fmoc)-OH
|
Amino Acid Derivatives
|
Others
|
Boc-D-(4-fmoc)-aminophenylalanine (Boc-p-amino-D-Phe(Fmoc)-OH) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with gonadotropin-releasing hormone antagonist activity .
|
- HY-W072147
-
Fmoc-L-Ser-OMe
|
Amino Acid Derivatives
|
Others
|
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor .
|
- HY-138106
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-D-Cit-OH is citrulline with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as H-Dmt-D-Cit-Aba-b-Ala-NMe-30,50-(CF3)2-Bn and H-Dmt-D-Cit-Aba-b-Ala-NMe-Bn with neurokinin-1 antagonist activity .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W010712S1
-
|
Fmoc-His(Trt)-OH- 15N3 is the 15N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].
|
-
-
- HY-Y1636S1
-
|
L-Arginine-N-FMOC PBF-OH- 13C6 is the 13C labeled Fmoc-Arg(Pbf)-OH[1]. Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis)[2].
|
-
-
- HY-Y1169S1
-
|
Fmoc-Asp(OtBu)-OH- 13C4, 15N is the 13C and 15N labeled Fmoc-Asp(OtBu)-OH[1]. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis[2].
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-151715
-
|
|
Azide
|
N3-D-Dap(Fmoc)-OH is a click chemistry reagent. N3-D-Dap(Fmoc)-OH can be used as a component for coupling by click reaction and as an orthogonally protected diaminocarboxylic acid derivative . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-151825
-
|
|
Alkynes
|
Fmoc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in solid-phase peptide synthesis. Poc-group can be further modified using Click-chemistry .
|
-
- HY-151748
-
|
|
Azide
|
N3-L-Orn(Fmoc)-OH is a Fmoc-protected ornithine derivative, can be used as a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-151703
-
|
|
Azide
|
Boc-D-Lys(N3)-OH is a Boc-protected amino acid derivative, can be used as a click chemistry reagent and an intermediate for synthesis of linkers . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-151824
-
|
|
Alkynes
|
Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151764
-
|
|
ADC Synthesis
Azide
|
N3-D-Orn(Boc)-OH is a Boc-protected pentanoic amino acid derivative, can be used as a click chemistry reagent and has been used to synthesis antibody-drug conjugates (ADC) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-151764A
-
|
|
ADC Synthesis
Azide
|
N3-D-Orn(Boc)-OH (CHA) is a Boc-protected pentanoic amino acid derivative, can be used as a click chemistry reagent and has been used to synthesis antibody-drug conjugates (ADC) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-151823
-
|
|
Azide
|
8-Azido-octanoyl-OSu is a click chemistry reagent containing an azide group. Used as a building block to introduce 8-azidooctanoic acid (CAS 217180-76-2) fragment. This fragment is used for further modifications using Click-chemistry (CuAAC), as a protected aminogroup or is used in physico-chemical investigations . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-151640
-
|
|
Azide
|
Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-151687
-
|
|
Azide
|
Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Tyr(2-azidoethyl)-OH is unnatural Fmoc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. And azido-UAAs can be employed as IR reporters . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-118783
-
(±)-2-Hexyl-4-pentynoic acid
|
|
Alkynes
|
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons . 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151837
-
|
|
Alkynes
|
H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
Cat. No. |
Product Name |
|
Classification |
-
- HY-164253
-
-
- HY-164249
-
-
- HY-164252
-
5′-O-Trityl-2′-deoxy-2′-fluorouridine
|
|
Nucleosides and their Analogs
|
DMT-2'-FU (5'-O-Trityl-2'-deoxy-2'-fluorouridine)Is with DMTProtecting Group (Protect 5'end), FLabeled uridine ribonucleotide.
|
-
- HY-155887
-
DSPE-PEG-NH2, MW 3400 ammonium
|
|
Pegylated Lipids
|
DSPE-PEG-Amine, MW 3400 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 3400 (ammonium) can be converted to aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-155908
-
DSPE-PEG-NH2, MW 10000 ammonium
|
|
Pegylated Lipids
|
DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 10000 (ammonium) can be converted into aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
|
-
- HY-155907
-
DSPE-PEG-NH2, MW 5000 ammonium
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Pegylated Lipids
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DSPE-PEG-Amine, MW 5000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. DSPE-PEG-Amine, MW 5000 (ammonium) amino group can be converted to aromatic aldehydes that react with acetone-protected aromatic hydrazides on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes produce liposome-Bah-BCA conjugates by forming diaryl hydrazone (BAH) with target enzyme molecules. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
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- HY-W440823A
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DSPE-PEG-NH2, MW 1000 ammonium
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Pegylated Lipids
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DSPE-PEG-Amine, MW 1000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG-Amine, MW 1000 (ammonium) can be converted to an aromatic aldehyde, which reacts with an acetone-protected aromatic hydrazine on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.
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