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Gossypolone is an RNA-bindingproteinMusashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer .
KH-3 is a potent RNA-bindingproteinHu antigen R (HuR) inhibitor with an IC50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction .
Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-bindingprotein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo .
HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-bindingprotein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon, with an HTRF ratio < 0.02 .
Enoxacin hydrate (Enoxacin sesquihydrate), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin hydrate is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin hydrate has potent activities against gram-positive and -negative bacteria. Enoxacin hydrate is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bindingprotein 2 (TRBP)-mediated microRNA processing .
Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by bindingRNA-bindingprotein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression .
PSF-IN-1 (Compound No.10-3) is a RNA-bindingprotein (PSF) inhibitor and can effectively inhibit the PSF-RNA interaction (IC50: 2.2 pM). PSF-IN-1 can increase histone acetylation, inhibit tumor cell proliferation and induce apoptosis. PSF-IN-1 has antitumor activity .
Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bindingprotein 2 (TRBP)-mediated microRNA processing .
LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD). LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM) .
Enoxacin (Standard) is the analytical standard of Enoxacin. This product is intended for research and analytical applications. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bindingprotein 2 (TRBP)-mediated microRNA processing [4].
Enoxacin-d8 (hydrate) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bindingprotein 2 (TRBP)-mediated microRNA processing .
Enoxacin-d8 (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bindingprotein 2 (TRBP)-mediated microRNA processing[1][2][3][4].
Enoxacin (hydrate) (Standard) is the analytical standard of Enoxacin (hydrate). This product is intended for research and analytical applications. Enoxacin hydrate (Enoxacin sesquihydrate), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin hydrate is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin hydrate has potent activities against gram-positive and -negative bacteria. Enoxacin hydrate is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bindingprotein 2 (TRBP)-mediated microRNA processing [4].
Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation .
ASN03576800 could be a potent inhibitor for Ebola virus matrix proteinVP40 in process of viral assembly and budding process. ASN03576800 occupies the RNA binding region of VP40 .
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA bindingprotein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .
AMT-NHS is an RNA-protein crosslinker. AMT-NHS is composed of a psoralen derivative and an N-hydroxysuccinimide ester group which react with RNA bases and primary amines of protein, respectively. AMT-NHS can penetrate into living yeast cells and crosslink Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different crosslinking patterns and targets both single- and double-stranded regions of RNA. AMT-NHS can be used for capturing diverse RNA-protein interactions in cells .
SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element bindingprotein 1 (FUBP1) and KH-spliced RNA bindingProtein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research .
CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA bindingprotein, can regulate target mRNAs stability and translation .
(R)-SKBG-1 is a covalent inhibitor targeting the RNA bindingproteinNONO. (R)-SKBG-1 can reduce the expression of androgen receptor (AR) and its splice variants, inhibiting cancer cell proliferation. (R)-SKBG-1 inhibits androgen receptor expression with IC50 of 3.1 μM and 5.5 μM for AR-FL mRNA and AR-V7 mRNA, respectively. (R)-SKBG-1 interferes with the gene regulatory network of cancer cells and inhibits cancer cell growth by stabilizing the interaction between NONO and mRNA. (R)-SKBG-1 can be used in the study of cancers related to NONO dysfunction, such as prostate cancer .
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA bindingprotein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .
Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation .
CIRBP protein, a key player in cellular response to genotoxic stress, stabilizes survival-associated transcripts. It aids stress granule assembly, suppresses cell proliferation in the cold, and regulates translation. CIRBP interacts with EIF4G1, associates with ribosomes, and targets the 3'-UTRs of stress-responsive transcripts like RPA2 and TXN. It contributes to intricate molecular regulatory mechanisms. CIRBP Protein, Mouse (His) is the recombinant mouse-derived CIRBP protein, expressed by E. coli , with N-6*His labeled tag. The total length of CIRBP Protein, Mouse (His) is 172 a.a., with molecular weight of ~24 kDa.
CIRBP is a cold-induced mRNA-binding protein that plays a key role in cellular responses to genotoxic stress, exerting a protective effect by stabilizing transcripts of genes critical for cell survival. As a translation activator, CIRBP appears to be critical for cold-induced inhibition of cell proliferation. CIRBP Protein, Human (His) is the recombinant human-derived CIRBP protein, expressed by E. coli , with N-His labeled tag. The total length of CIRBP Protein, Human (His) is 172 a.a., with molecular weight of ~23 KDa.
The RBM14 protein has different isoforms with multiple functions. Isoform 1 enhances transcription as a nuclear receptor coactivator, interacting with NCOA6 and CITED1. RBM14 Protein, Human (His-SUMO) is the recombinant human-derived RBM14 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of RBM14 Protein, Human (His-SUMO) is 669 a.a., with molecular weight of ~85.5 kDa.
FUS Protein, Human (His, Myc) is the recombinant human-derived FUS, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of FUS Protein, Human (His, Myc) is 526 a.a.,
The acnB protein coordinates short-chain fatty acid catabolism through the TCA pathway and 2-methylcitric acid cycle I, demonstrating catalytic versatility. It is involved in the reversible isomerization of citric acid to isocitrate and the hydration of 2-methyl-cis-aconitic acid. acnB Protein, E. coli is the recombinant Virus-derived acnB protein, expressed by E. coli , with tag free. The total length of acnB Protein, E. coli is 865 a.a., with molecular weight of ~95 kDa.
The SARS-CoV-2 nucleocapsid protein plays a crucial role in assembling the virion, forming the helical ribonucleocapsid (RNP), and interacting with the viral genome and membrane protein M. In addition to its structural function, it also enhances subgenomic viral RNA transcription and overall replication. NCP N Protein, SARS-CoV-2 (Sf9, His, Flag) is the recombinant virus-derived NCP N, expressed by Sf9 insect cells , with His, Flag labeled tag. ,
The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP8 Protein, SARS-CoV-2 is the recombinant virus-derived NSP8, expressed by E. coli , with tag Free labeled tag. ,
The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (His) is the recombinant virus-derived NSP3, expressed by E. coli , with His labeled tag. ,
The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP9 Protein, SARS-CoV-2 (His) is the recombinant virus-derived NSP9, expressed by E. coli , with His labeled tag. ,
The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP8 Protein, SARS-CoV-2 (His, Flag) is the recombinant virus-derived NSP8, expressed by E. coli , with His, Flag labeled tag. ,
POLG proteins play multiple roles in the viral life cycle, contributing to viral RNA packaging, budding, and particle production. It exhibits RNA-binding and RNA chaperone activities, affecting translation initiation through interactions with viral IRES and ribosomal subunits. HCVNS5B Protein, HCV is the recombinant HCVNS5B, expressed by E. coli , with tag Free labeled tag. ,
ELAV like 3; ELAV like 4; ELAV like neuron specific RNAbindingprotein 3; ELAV like neuron specific RNAbindingprotein 4; ELAV like protein 3; ELAV like protein 4; ELAV-like protein 3; PLE21; PNEM
ELAVL3 protein is an RNA-binding protein that specifically binds to the ARE sequence in target mRNA, including VEGF. It may also interact with polyA tracts through its RRM3. ELAVL3 Protein, Human (P.pastoris, His) is the recombinant human-derived ELAVL3 protein, expressed by P. pastoris , with N-His labeled tag. The total length of ELAVL3 Protein, Human (P.pastoris, His) is 367 a.a., with molecular weight of ~41.5 kDa.
The EIF3G protein is an RNA-binding component of the eIF-3 complex that initiates protein synthesis by promoting the recruitment of factors to form the 43S PIC. EIF3G is critical in both mRNA recruitment and AUG recognition scanning. EIF3G Protein, Human (His-SUMO) is the recombinant human-derived EIF3G protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of EIF3G Protein, Human (His-SUMO) is 319 a.a., with molecular weight of 51.5 kDa.
Enoxacin-d8 (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bindingprotein 2 (TRBP)-mediated microRNA processing[1][2][3][4].
Enoxacin-d8 (hydrate) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bindingprotein 2 (TRBP)-mediated microRNA processing .
EWSR1; EWS; RNA-bindingprotein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein
WB, IHC-P, ICC/IF
Human, Mouse, Rat
EWSR1 Antibody (YA2270) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2270), targeting EWSR1, with a predicted molecular weight of 68 kDa (observed band size: 85 kDa). EWSR1 Antibody (YA2270) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.
RBMX; HNRPG; RBMXP1; RNA-binding motif protein; X chromosome; Glycoprotein p43; Heterogeneous nuclear ribonucleoprotein G; hnRNP G
WB, IHC-F, IHC-P, ICC/IF
Human
hnRNP G Antibody (YA3029) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3029), targeting hnRNP G, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). hnRNP G Antibody (YA3029) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.
Musashi 1 Antibody (YA2815) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2815), targeting Musashi 1, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Musashi 1 Antibody (YA2815) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.
Musashi 2 Antibody (YA3045) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3045), targeting Musashi 2, with a predicted molecular weight of 35 kDa (observed band size: 35 kDa). Musashi 2 Antibody (YA3045) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.
CELF1; BRUNOL2; CUGBP; CUGBP1; NAB50; CUGBP Elav-like family member 1; CELF-1; 50 kDa nuclear polyadenylated RNA-bindingprotein; Bruno-like protein 2; CUG triplet repeat RNA-bindingprotein 1; CUG-BP1; CUG-BP- and ETR-3-like factor 1; Dead
WB, IHC-P, ICC/IF, IP, FC
Human, Mouse, Rat
CUG BP1 Antibody (YA2806) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2806), targeting CUG BP1, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). CUG BP1 Antibody (YA2806) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
SYNCRIP; HNRPQ; NSAP1; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-bindingprotein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein
WB, IHC-P, ICC/IF
Human, Mouse, Rat
hnRNP Q Antibody (YA1838) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1838), targeting hnRNP Q, with a predicted molecular weight of 70 kDa (observed band size: 65-82 kDa). hnRNP Q Antibody (YA1838) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.
TAF15 Antibody (YA2134) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2134), targeting TAF15, with a predicted molecular weight of 62 kDa (observed band size: 77 kDa). TAF15 Antibody (YA2134) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.
ILF3; DRBF; MPHOSPH4; NF90; Interleukin enhancer-binding factor 3; Double-stranded RNA-bindingprotein 76; DRBP76; M-phase phosphoprotein 4; MPP4; Nuclear factor associated with dsRNA; NFAR; Nuclear factor of activated T-cells 90 kDa; NF-AT-90; Translational control protein 80; TCP80
WB, IHC-P, ICC/IF, IP, FC
Human, Mouse
ILF3 Antibody (YA1904) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1904), targeting ILF3, with a predicted molecular weight of 95 kDa (observed band size: 95 kDa). ILF3 Antibody (YA1904) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse background.
DAZ homolog; DAZ like autosomal; DAZH; DAZL; DAZL1; DAZLA; Deleted in azoospermia like 1; Germline specific RNAbindingprotein; SPGY like autosomal; SPGYLA; Tpx2
WB
Human
DAZL Antibody (YA3337) is a non-conjugated IgG antibody, targeting DAZL, with a predicted molecular weight of 33 kDa (observed band size: 33 kDa). DAZL Antibody (YA3337) can be used for WB experiment in human background.
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