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Isoforms Recommended:	SIRT2

Results for "

SirT2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (12) Autophagy (6) c-Myc (1) CMV (1) Dihydroorotate Dehydrogenase (3) Endogenous Metabolite (3) HBV (3) HDAC (1) Histone Demethylase (1) HSP (3) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (3) Microtubule/Tubulin (1) Organoid (1) Parasite (3) Phosphatase (3) Phospholipase (1) PROTACs (1) Reverse Transcriptase (3) SARS-CoV (4) Sirtuin (66) Small Interfering RNA (siRNA) (3) Topoisomerase (3)
By Research Areas:	Cancer (48) Cardiovascular Disease (3) Infection (6) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (16)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

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Products

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107660

SIRT2-IN-8	Sirtuin	Neurological Disease
SIRT2-IN-8 is a potent *SIRT2* inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research .

HY-RS12940

SIRT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SIRT2 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIRT2 Human Pre-designed siRNA Set A SIRT2 Human Pre-designed siRNA Set A

HY-RS12941

Sirt2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sirt2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt2 Mouse Pre-designed siRNA Set A Sirt2 Mouse Pre-designed siRNA Set A

HY-RS12942

Sirt2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sirt2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt2 Rat Pre-designed siRNA Set A Sirt2 Rat Pre-designed siRNA Set A

HY-119857

AGK7 SirT2 Inhibitor,Inactive Control	Sirtuin	Neurological Disease
AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease .

HY-159126

SIRT2-IN-15	Sirtuin	Neurological Disease
SIRT2-IN-15 (compound 1) is a *SIRT2* deacetylase and deamyloacylase inhibitor with IC₅₀ 7 and 37 μM, respectively .

HY-162252

SIRT2-IN-12	Sirtuin	Others
SIRT2-IN-12 (Compound 3) is a *SIRT2* inhibitor with a IC₅₀ value of 50 μM .

HY-115979

Sirt2-IN-5	Sirtuin	Neurological Disease Cancer
Sirt2-IN-5 is a potent *SIRT2* inhibtor .

HY-151185

Sirt2-IN-7	Sirtuin	Cancer
Sirt2-IN-7 (compound 22) is a selective inhibitor of *SIRT2. Sirt2-IN-7 inhibits SIRT2* with an IC₅₀ value and a K_i value of 178.2 nM and 154.3 nM, respectively. Sirt2-IN-7 can be used for the research of cancer .

HY-145958

Sirt2-IN-6	Sirtuin	Cancer
Sirt2-IN-6 (compound 24a) potent and selective inhibitor of *SIRT2, with an IC₅₀* of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer .

HY-151522

SIRT2-IN-10	Sirtuin	Neurological Disease Cancer
SIRT2-IN-10 (Compound 12) is a potent *SIRT2* inhibitor with an IC₅₀ of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease .

HY-112427

Sirt2-IN-1	Sirtuin	Inflammation/Immunology Cancer
Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC₅₀ of 163 nM .

HY-161339

SIRT2-IN-13	Apoptosis Sirtuin	Cancer
SIRT2-IN-13 (compound 7c) is an inhibitor of SIRT2 and induces apoptosis. SIRT2-IN-13 selectively inhibits colon cancer and leukemia cells and arrests the cell cycle in the G2 phase .

HY-112428

Sirt2-IN-2	Sirtuin	Inflammation/Immunology
Sirt2-IN-2 (Compound 10) is a selective *Sirt2* inhibitor with an IC₅₀ of 0.118 μM .

HY-160617

SIRT2-IN-14	Sirtuin	Neurological Disease
SIRT2-IN-14 (Compound 78) is a selectve inhibitor for *SIRT2* with an IC₅₀ of 0.196 μM .

HY-148408

SIRT2-IN-11	Sirtuin	Cancer
SIRT2-IN-11 (AEM1) is a selective *SIRT2* inhibitor with an IC₅₀ value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers .

HY-151519

SIRT2-IN-9	Sirtuin	Cancer
SIRT2-IN-9 (compound 12) is a selective inhibitor of *SRIT2* with an IC₅₀ value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer .

HY-123194

SIRT2/6-IN-1	Histone Demethylase Sirtuin	Metabolic Disease
SIRT2/6-IN-1 (Compound 5) is a *SIRT6/SIRT2* inhibitor, with IC₅₀s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells .

HY-103636

*PROTAC Sirt2* Degrader-1**	Sirtuin PROTACs	Cancer
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a *Sirt2* degrader, composed of a highly potent and isotype-selective *Sirt2* inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC₅₀ of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC₅₀s>100 μM) .

HY-149637

*HSP70/SIRT2-IN-1*	Sirtuin HSP	Cancer
HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and HSP70, with IC₅₀ of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity .

HY-149638

*HSP70/SIRT2-IN-2*	Sirtuin HSP	Cancer
HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC₅₀ of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity .

HY-118343

AC-93253	Sirtuin	Cancer
AC-93253 is a selective, potent *SIRT2* inhibitor. AC93253 can inhibit SIRT2 with an IC₅₀ value of 6 μM. AC93253 can be used for the research of tumors .

HY-123994

Tenovin-D3 hydrochloride	Sirtuin	Cancer
Tenovin-D3 hydrochloride is a sirtuin SirT2 inhibitor that increases p21 (CDKN1A) expression in a p53 independent manner .

HY-147233

MIND4-19	Sirtuin	Neurological Disease
MIND4-19 is a potent *SIRT2* inhibitor with an IC₅₀ value of 7.0 μM. MIND4-19 can be used for researching Huntington's disease .

HY-139144

YM-08	Sirtuin HSP	Neurological Disease Cancer
YM-08 (Compounds 7a) is a brain-penetrant inhibitors of *SIRT2*,with the IC₅₀ of 19.9 μM. YM-08 also is inhibitor of Hsp70 .

HY-107453

SirReal1-O-propargyl PROTAC SirT2-binding moiety 1	Ligands for Target Protein for PROTAC	Cancer
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC₅₀ of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-155392

Mz325	HDAC Sirtuin	Cancer
Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC₅₀ of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration .

HY-W841840

SR94	Sirtuin	Neurological Disease Cancer
SR94, a SR17 derivative, is a *SIRT2* inhibitor that contains an arbitrary 6-member ring and different R2 groups. SR94 is promising for research of cancer, ischemia-reperfusion and neurodegenerative diseases .

HY-163698

SIRT-IN-4	Sirtuin	Cancer
SIRT-IN-4 is an inhibitor of the NAD+-dependent lysine deacetylase Sirtuin2 (Sirt2) (IC₅₀=0.35 μM). SIRT-IN-4 is a potent *Sirt2* deacetylase inhibitor that reduces cell survival and inhibits the migration of prostate cancer cells. SIRT-IN-4 can be used to study *Sirt2* in cell cycle regulation, gene expression regulation, etc .

HY-101278

Thiomyristoyl 5 Publications Verification	Sirtuin	Cancer
Thiomyristoyl is a potent and specific *SIRT2* inhibitor with an IC₅₀ of 28 nM.

HY-111522

RK-9123016	Sirtuin c-Myc	Cancer
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC₅₀ value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression .

HY-119889

A1B11	Sirtuin	Neurological Disease
A1B11 is a selective *SIRT* inhibitor (SIRT2:IC50=5.3 μM) that can be used in the study of neurodegenerative diseases .

HY-16691

AK-7 2 Publications Verification	Sirtuin	Neurological Disease
AK-7 is a selective cell- and brain-permeable *SIRT2* inhibitor, with an IC₅₀ of 15.5 μM.

HY-101073

Salermide 2 Publications Verification	Sirtuin Apoptosis	Cancer
Salermide is an inhibitor of *Sirt1* and *Sirt2*; can cause strong cancer-specific apoptotic cell death.

HY-101465

AK-1	Sirtuin	Neurological Disease
AK-1 is a potent, specific and cell-permeable *SIRT2* inhibitor, with an IC₅₀ of 12.5 μM.

HY-123653

SirReal-1	Sirtuin
SirReal-1 is a potent and selective *Sirt2* inhibitor（IC50 = 3.7 uM） .

HY-133998

SIRT-IN-3 1 Publications Verification	Sirtuin	Cancer
SIRT-IN-3 is a potent *SIRT* inhibitor, with an IC₅₀ of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC₅₀ of 74 μM and 235 μM for SIRT2 and SIRT3, respectively) .

HY-160944

hsa62	Sirtuin	Cancer
hsa62 is a dual inhibitor for SIRT1 and SIRT2, with IC₅₀ of 1.3 and 5.5 μM, respectively .

HY-117993

MIND4	Others	Neurological Disease
MIND4 is a novel thiozoline that was found to inhibit the deacetylase SIRT2 and to have neuroprotective activity in in vitro brain slices and Drosophila models of Huntington's disease (HD). A systems biology approach revealed another SIRT2-independent property of MIND4, namely as an inducer of nuclear factor erythroid 2 p45-derived factor 2 (NRF2) activity. Structure-activity relationship studies further identified a potent NRF2 activator (MIND4-17) that lacks SIRT2 inhibitory activity. MIND compounds induce NRF2 activation responses in both neuronal and non-neuronal cells and reduce the generation of reactive oxygen and nitrogen intermediates. These agent-like thiozolines offer exciting opportunities for the development of multi-target agents with potential synergistic therapeutic benefits for HD and related disorders.

HY-15145A

SRT 1720 dihydrochloride 35+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 dihydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .

HY-146013

Sirt1/2-IN-1	Sirtuin Microtubule/Tubulin	Cancer
Sirt1/2-IN-1 (Compound 7) is a *SIRT1* and *SIRT2* inhibitor with IC₅₀ values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and *SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC₅₀* of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity .

HY-15145

SRT 1720 monohydrochloride 35+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 monohydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .

HY-100578

AGK2 10+ Cited Publications	Sirtuin Apoptosis	Cancer
AGK2 is a selective *SIRT2* inhibitor with an IC₅₀ of 3.5 μM. AGK2 inhibits *SIRT1* and *SIRT3* with IC₅₀s of 30 and 91 μM, respectively.

HY-108986

JFD00244	Sirtuin SARS-CoV	Cancer
JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against *SARS-CoV-2* ^[2].

HY-100732

Cambinol 1 Publications Verification	Sirtuin Apoptosis Phospholipase	Cancer
Cambinol is a *SIRT1* and *SIRT2* inhibitor with IC₅₀ values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) ^[2].

HY-100591

SirReal2 2 Publications Verification	Sirtuin	Neurological Disease Inflammation/Immunology Cancer
SirReal2 is a potent, isotype-selective *Sirt2* inhibitor with an IC₅₀ value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration ^[2] .

HY-N1926

Dihydrocoumarin Hydrocoumarin; Chroman-2-one	Sirtuin	Cancer
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and *SIRT2* with IC₅₀s of 208 μM and 295 μM, respectively .

HY-10532

SRT 1720 35+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 is a selective activator of human *SIRT1* with an EC_1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC_1.5s of 37 μM and > 300 μM, respectively.

HY-N9892

Guttiferone G	Sirtuin	Others
Guttiferone G inhibits recombinant human *SIRT1* and *SIRT2* (IC₅₀: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC₅₀: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla ^[2].

HY-N1926R

Dihydrocoumarin (Standard)	Sirtuin	Cancer
Dihydrocoumarin (Standard) is the analytical standard of Dihydrocoumarin. This product is intended for research and analytical applications. Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively .

Species:	Human (2)
Tag:	His (1) GST (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P703015

	SIRT2 Protein, Human (GST) SIR2L; SIR2L2	Human	E. coli
	SIRT2 Protein, Human (GST) is the recombinant human-derived SIRT2, expressed by E. coli , with GST labeled tag. ,

HY-P702906

	SIRT2 Protein, Human (His) SIR2L; SIR2L2; SirTuin 2	Human	E. coli
	SIRT2 Protein, Human (His) is the recombinant human-derived SIRT2, expressed by E. coli , with C-6*His labeled tag. ,

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HY-P80320

	SIRT2 Antibody	WB, ICC/IF, IP, FC	Human, Rat
	SIRT2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to SIRT2. It can be used for WB,ICC/IF,IP,FC assays with tag free, in the background of Human, Rat.