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Results for "

Smo

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Smo (55) Apoptosis (4) Autophagy (1) Bacterial (1) c-Met/HGFR (2) DYRK (1) Endogenous Metabolite (4) Estrogen Receptor/ERR (1) Gli (2) Glucocorticoid Receptor (2) Hedgehog (16) iGluR (2) Isotope-Labeled Compounds (1) Organoid (1) Small Interfering RNA (siRNA) (3) TAM Receptor (2)
By Research Areas:	Cancer (54) Endocrinology (3) Infection (3) Inflammation/Immunology (4) Neurological Disease (4)
Oligonucleotides:	Pre-designed siRNA Sets (3) Antisense Oligonucleotides (2) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Smo

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150564

SMO-IN-2	Smo Hedgehog	Cancer
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC₅₀ value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity .

HY-12848C

SAG dihydrochloride 20+ Cited Publications	Smo	Cancer
SAG dihydrochloride is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-145918

MRT-14	Smo	Cancer
MRT-14 is a potent antagonist of *Smo. Smo* is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling .

HY-150567

SMO-IN-3	Smo Hedgehog	Cancer
SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC₅₀ value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity .

HY-147743

SMO-IN-1	Smo	Cancer
SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh) .

HY-153499

SMO-IN-4	Smo	Cancer
SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC₅₀: 24 nM). SMO-IN-4 has antitumor activity .

HY-RS13441

SMO Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMO Human Pre-designed siRNA Set A contains three designed siRNAs for SMO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMO Human Pre-designed siRNA Set A SMO Human Pre-designed siRNA Set A

HY-RS13442

Smo Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smo Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smo gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smo Mouse Pre-designed siRNA Set A Smo Mouse Pre-designed siRNA Set A

HY-RS13443

Smo Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smo Rat Pre-designed siRNA Set A contains three designed siRNAs for Smo gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smo Rat Pre-designed siRNA Set A Smo Rat Pre-designed siRNA Set A

HY-131016

IHR-Cy3	Smo	Cancer
IHR-Cy3 is a potent fluorescent *Smo* antagonist with an IC₅₀ of 100 nM .

HY-16391A

Glasdegib maleate PF-04449913 maleate	Smo	Cancer
Glasdegib maleate (PF-04449913 maleate) is a potent and orally bioavailable smoothened inhibitor. Glasdegib maleate binds to human SMO (amino acids 181-787) with IC₅₀value of 4 nM .

HY-18287A

MRT-83 hydrochloride	Smo	Cancer
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease .

HY-13459

PF-5274857	Smo	Cancer
PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of *Smo, with an IC₅₀* of 5.8 nM and K_i of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway .

HY-13459A

PF-5274857 hydrochloride	Smo	Cancer
PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of *Smo, with an IC₅₀* of 5.8 nM and K_i of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway .

HY-117903A

MRT-92	Smo Hedgehog	Cancer
MRT-92 is a Smoothened (Smo) antagonist (K_i=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC₅₀=0.4 nM). MRT-92 can be used in the study of cerebellar glioma .

HY-19642A

Glesatinib hydrochloride 2 Publications Verification MGCD265 hydrochloride	TAM Receptor c-Met/HGFR	Cancer
Glesatinib hydrochloride (MGCD265 hydrochloride) is an orally active, potent *MET/SMO* dual inhibitor. Glesatinib hydrochloride, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) .

HY-19642

Glesatinib MGCD265	TAM Receptor c-Met/HGFR	Cancer
Glesatinib (MGCD265) is an orally active, potent *MET/SMO* dual inhibitor. Glesatinib, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) .

HY-108508

SMANT hydrochloride	Smo Hedgehog	Cancer
SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo .

HY-137115

BODIPY-Cyclopamine	Smo	Cancer
BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened (SMO) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs .

HY-12317

GSA-10	Smo Hedgehog	Cancer
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development .

HY-16582A

Sonidegib 5 Publications Verification EriSmodegib; LDE225; NVP-LDE225	Smo	Cancer
Sonidegib (Erismodegib) is a potent and selective *Smo* antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-16582

Sonidegib diphosphate 5 Publications Verification EriSmodegib diphosphate; LDE225 diphosphate; NVP-LDE225 diphosphate	Smo	Cancer
Sonidegib diphosphate (Erismodegib diphosphate) is a potent and selective *Smo* antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-16582AS

Sonidegib-d4 EriSmodegib-d₄; LDE225-d₄; NVP-LDE225-d₄	Isotope-Labeled Compounds	Others
Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-13809

BMS-833923 XL-139	Smo Apoptosis	Cancer
BMS-833923 (XL-139) is an orally biocompatible Smoothened (Smo) inhibitor with anti-tumor activity. It can inhibit the binding of BODIPY cyclopamine to SMO in a dose-dependent manner with an IC₅₀ of 21 nM .

HY-12848

SAG 20+ Cited Publications	Smo	Cancer
SAG is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848B

SAG hydrochloride 20+ Cited Publications	Smo	Cancer
SAG hydrochloride is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-15108

Purmorphamine 10+ Cited Publications	Organoid Smo Autophagy	Neurological Disease Cancer
Purmorphamine is a *smoothened/Smo* receptor agonist with an EC₅₀** of 1 μM.

HY-110240

IHR-1	Smo	Others
IHR-1 is a cell membrane impermeable *Smo* antagonist .

HY-117407

ALLO-2	Smo	Cancer
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC₅₀ of 6 nM .

HY-12848R

SAG (Standard)	Smo	Cancer
SAG (Standard) is the analytical standard of SAG. SAG is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848A

(Rac)-SAG	Smo	Cancer
(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-15412

HhAntag	Smo	Cancer
HhAntag is a specific, potent and orally active small molecule *SMO* antagonist of the Hh pathway .

HY-108507

MRT-10	Smo	Cancer
MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC₅₀ of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer .

HY-16587

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened *(Smo)*, a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-16587A

Saridegib hydrochloride IPI 926 hydrochloride; Patidegib hydrochloride	Smo	Cancer
Saridegib hydrochloride is a potent and specific inhibitor of Smoothened *(Smo)*, a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-119607

DYRKi	DYRK	Cancer
DYRKi is an inhibitor of DYRK1 and DYRK1B with IC₅₀ values of 3.7 µM and 90 nM, respectively, which is used as a potent antagonist of Hh/Gli signaling. DYRKi impairs SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi is promising for research of HH/GLI-associated cancers .

HY-17024

Cyclopamine Maximum Cited Publications 39 Publications Verification 11-Deoxojervine	Hedgehog Smo Endogenous Metabolite	Cancer
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective *Smo* inhibitor.

HY-18636

LEQ506 NVP-LEQ506	Smo	Cancer
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

HY-100515

Robotnikinin 3 Publications Verification	Hedgehog	Inflammation/Immunology
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo .

HY-147744

AZD7254	Smo	Cancer
AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh) .

HY-18287

MRT-83	Smo	Cancer
MRT-83 is a potent antagonist of *Smo, with an IC₅₀* in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

HY-16391B

Glasdegib hydrochloride PF-04449913 hydrochloride	Smo	Cancer
Glasdegib hydrochloride is a potent and orally bioavailable smoothened inhibitor. Glasdegib hydrochloride (PF-04449913) binds to human *SMO* (amino acids 181-787) with an IC₅₀ of 4 nM .

HY-147670

TPB15	Hedgehog Smo Gli Apoptosis	Cancer
TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks *Smo* (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity .

HY-16391

Glasdegib 4 Publications Verification PF-04449913	Smo	Cancer
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human *SMO* (amino acids 181-787) with an IC₅₀ of 4 nM .

HY-12848S

SAG-d3	Smo	Cancer
SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

HY-120499

AZD8542	Hedgehog Smo	Cancer
AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is a? Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment .

HY-123752

MS-0022	Hedgehog Smo	Cancer
MS-0022 is a Smoothened (SMO) antagonist. MS-0022 can inhibit the Hedgehog (Hh) signaling pathway. MS-0022 can be used in anti-tumor research .

HY-B0603

Fluticasone	Smo Glucocorticoid Receptor	Infection Inflammation/Immunology Endocrinology
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a *Smo* agonist with an IC₅₀ value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells .

HY-17024R

Cyclopamine (Standard)	Hedgehog Smo Endogenous Metabolite	Cancer
Cyclopamine (Standard) is the analytical standard of Cyclopamine. This product is intended for research and analytical applications. Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-N0247

Saikosaponin B1	Smo	Cancer
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting *SMO* .

Cat. No.	Product Name

HY-L020

Wnt/Hedgehog/Notch Compound Library

390 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 390 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

Cat. No.	Product Name	Type

HY-15108G

Purmorphamine (GMP)	Biochemical Assay Reagents
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a *smoothened/Smo* receptor** agonist with an EC₅₀ of 1 μM .

HY-W414581

7-Keto-27-hydroxycholesterol 3ß,27-Dihydroxy-5-cholesten-7-one	Cell Assay Reagents
7-Keto-27-hydroxycholesterol (3?,27-Dihydroxy-5-cholesten-7-one) is an important bioactive compound that agonizes the activity of smoothened (SMO) protein in the Hedgehog (Hh) signaling pathway, which is essential for proper cell differentiation in embryonic tissues.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17024

Cyclopamine Maximum Cited Publications 39 Publications Verification 11-Deoxojervine	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Classification of Application Fields Source classification Pyridine Alkaloids Plants Endogenous metabolite Disease Research Fields Steroids Cancer	Hedgehog Smo Endogenous Metabolite
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective *Smo* inhibitor.

HY-N0247

Saikosaponin B1	Structural Classification Classification of Application Fields Source classification Umbelliferae Plants Disease Research Fields Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Cancer	Smo
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting *SMO* .

HY-12316

20(S)-Hydroxycholesterol 2 Publications Verification 20α-Hydroxycholesterol	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-17024R

Cyclopamine (Standard)	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Pyridine Alkaloids Plants Endogenous metabolite Steroids	Hedgehog Smo Endogenous Metabolite
Cyclopamine (Standard) is the analytical standard of Cyclopamine. This product is intended for research and analytical applications. Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-N0247R

Saikosaponin B1 (Standard)	Structural Classification Source classification Umbelliferae Plants Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Smo
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO .

HY-12316R

20(S)-Hydroxycholesterol (Standard) 20α-Hydroxycholesterol (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

Cat. No.	Compare	Product Name	Species	Source

HY-P703220

	SMO Protein, Human (Sf9, Flag, His) SmoH	Human	Sf9 insect cells
	SMO Protein, Human (Sf9, Flag, His) is the recombinant human-derived SMO, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

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