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Results for "

Vasoconstriction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (19) Angiotensin Receptor (4) Arrestin (2) Calcium Channel (3) Endogenous Metabolite (3) Endothelin Receptor (8) Fluorescent Dye (1) Interleukin Related (5) Isotope-Labeled Compounds (1) Na+/Ca2+ Exchanger (2) Neuropeptide Y Receptor (1) P2X Receptor (2) p38 MAPK (1) Prostaglandin Receptor (4) Serotonin Transporter (1) Sodium Channel (2) TNF Receptor (5) TRP Channel (1) Vasopressin Receptor (3) VEGFR (5)
By Research Areas:	Cancer (4) Cardiovascular Disease (45) Endocrinology (16) Inflammation/Immunology (10) Metabolic Disease (2) Neurological Disease (9)

By Targets:

5-HT Receptor (2)

Adrenergic Receptor (19)

Angiotensin Receptor (4)

Arrestin (2)

Calcium Channel (3)

Endogenous Metabolite (3)

Endothelin Receptor (8)

Fluorescent Dye (1)

Interleukin Related (5)

Isotope-Labeled Compounds (1)

Na+/Ca2+ Exchanger (2)

Neuropeptide Y Receptor (1)

P2X Receptor (2)

p38 MAPK (1)

Prostaglandin Receptor (4)

Serotonin Transporter (1)

Sodium Channel (2)

TNF Receptor (5)

TRP Channel (1)

Vasopressin Receptor (3)

VEGFR (5)

By Research Areas:

Cancer (4)

Cardiovascular Disease (45)

Endocrinology (16)

Inflammation/Immunology (10)

Metabolic Disease (2)

Neurological Disease (9)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17352

Clazosentan Ro 61-1790; VML 588; AXV-034343	Endothelin Receptor	Cardiovascular Disease
Clazosentan (Ro 61-1790) is a selective endothelin A (ET_A) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction .

HY-B1298

Methoxamine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstriction and increased peripheral vascular resistance . Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery .

HY-B1546A

Benzamil hydrochloride Benzylamiloride hydrochloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca ²⁺-activated currents, with an IC₅₀ of 1.1 μM .

HY-17034

Medetomidine	Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine is an orally active α2-adrenoceptor agonist (K_i: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-17352A

Clazosentan disodium Ro 61-1790 disodium; VML 588 disodium; AXV-034343 disodium	Endothelin Receptor	Cardiovascular Disease
Clazosentan disodium (Ro 61-1790) is a selective endothelin A (ET_A) receptor antagonist. Clazosentan disodium inhibits ET-1-mediated vasoconstriction. Clazosentan disodium prevents cerebral vasospasm, vasospasm-related cerebral infarction .

HY-B1298A

Methoxamine	Adrenergic Receptor	Cardiovascular Disease
Methoxamine is a selective alpha1-adrenergic receptor agonist. Methoxamine causes vasoconstriction and increased peripheral vascular resistance . Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery .

HY-D1501

Fura PE-3 potassium	Fluorescent Dye	Others
Fura PE-3 potassium is a Ca ²⁺sensitive fluorophore. Fura PE-3 potassium loads in IPA (intrapulmonary arteries) and MA (mesenteric resistance arteries) for the research of vasoconstriction .

HY-134370

Ap4G	P2X Receptor	Cardiovascular Disease
Ap4G is a dinucleoside polyphosphate compound with vasoconstrictor activity. Ap4G regulates vasoconstriction through P2 receptors, especially P2X receptors, and is an important tool for studying vascular physiology and pathology .

HY-112824

L-162313	Angiotensin Receptor	Cardiovascular Disease
L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC₅₀ values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth .

HY-B1546

Benzamil Benzylamiloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca ²⁺-activated currents, with an IC₅₀ of 1.1 μM .

HY-17034B

Medetomidine hydrochloride MPV785	Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-106123

Pomisartan	Angiotensin Receptor	Cardiovascular Disease
Pomisartan is an orally active angiotensin II receptor type AT1 antagonist (IC₅₀=0.26 μM). Pomisartan works by inhibiting the binding of angiotensin II to the AT1 receptor, thereby blocking the vasoconstriction and aldosterone release caused by this interaction. Pomisartan results in a blood pressure-lowering effect .

HY-113654

AMG 7905	TRP Channel	Others
AMG 7905 is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin .

HY-111326

Naphazoline Naphthazoline	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline can be used for non-bacterial conjunctivitis research .

HY-111326A

Naphazoline nitrate Naphthazoline nitrate	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research .

HY-130304

8-Isoprostaglandin E2 iPE2-III	Prostaglandin Receptor	Cardiovascular Disease
8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway .

HY-116680

LY53857	5-HT Receptor	Cardiovascular Disease Neurological Disease
LY53857 is a potent antagonist of vasoconstriction and serotonin-mediated 5-HT₂ receptors. LY53857 did not reduce mean arterial blood pressure in spontaneously hypertensive rats (SHR) at doses that blocked the depressor response to serotonin and blocked central serotonin receptors. In addition, LY53857 was able to enhance neurotransmitter release in rat vas deferens and guinea pig ileal nerves .

HY-B0446

Naphazoline hydrochloride Naphthazoline hydrochloride	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research .

HY-111326AR

Naphazoline nitrate (Standard)	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (nitrate) (Standard) is the analytical standard of Naphazoline (nitrate). This product is intended for research and analytical applications. Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research .

HY-P1016

BQ-3020	Endothelin Receptor	Cardiovascular Disease
BQ-3020 is a selective endothelin receptor (ET_B receptor) agonist that displaces [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research ¹ ².

HY-B0446R

Naphazoline hydrochloride (Standard)	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (hydrochloride) (Standard) is the analytical standard of Naphazoline (hydrochloride). This product is intended for research and analytical applications. Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research .

HY-P1016B

BQ-3020 ammonium	Endothelin Receptor	Cardiovascular Disease
BQ-3020 ammonium is a selective endothelin receptor (ET_B receptor) agonist. BQ-3020 ammonium inhibits [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 ammonium elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 ammonium makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research . .

HY-113350

Thromboxane A2 TXA2	Prostaglandin Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses .

HY-B0556A

Tetrahydrozoline hydrochloride Tetryzoline hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion .

HY-B0556

Tetrahydrozoline Tetryzoline	Adrenergic Receptor	Cardiovascular Disease
Tetrahydrozoline (Tetryzoline), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion .

HY-B0556B

Tetrahydrozoline nitrate Tetryzoline nitrate	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
Tetrahydrozoline (Tetryzoline) nitrate , a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion .

HY-102029

Sarafotoxin S6c SRTX-c	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels .

HY-12749B

(R)-Midodrine hydrochloride	Others	Cardiovascular Disease
(R)-Midodrine hydrochloride is a vasopressor used as an antihypertensive agent for the treatment of symptomatic postural hypotension, exhibiting peripheral alpha(1)-adrenoreceptor agonistic activity that induces venous and arterial vasoconstriction.

HY-131545

Parogrelil NT-702 free base; NT-702 free base	Others	Others
Parogrelil (NT-702 free base) is a compound with intermittent claudication inhibitory activity that inhibits PDE3, inhibits platelet aggregation and vasoconstriction, and improves walking distance and plantar surface temperature in a rat experimental model.

HY-P10291

[Pro34]Neuropeptide Y, porcine	Neuropeptide Y Receptor	Neurological Disease
[Pro34]Neuropeptide Y, porcine is a selective NPY receptor (Y1 receptor) agonist. [Pro34]Neuropeptide Y, porcine evokes vasoconstrictions in the guinea pig caval vein .

HY-B0556AS

Tetrahydrozoline-d4 hydrochloride Tetryzoline-d₄ (hydrochloride)	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tetrahydrozoline-d₄ (hydrochloride) is the deuterium labeled Tetrahydrozoline hydrochloride. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion[1][2].

HY-B0556R

Tetrahydrozoline (Standard)	Adrenergic Receptor	Cardiovascular Disease
Tetrahydrozoline (Standard) is the analytical standard of Tetrahydrozoline. This product is intended for research and analytical applications. Tetrahydrozoline (Tetryzoline), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion .

HY-B0556AR

Tetrahydrozoline hydrochloride (Standard)	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tetrahydrozoline (hydrochloride) (Standard) is the analytical standard of Tetrahydrozoline (hydrochloride). This product is intended for research and analytical applications. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion .

HY-114666

Trimoxamine hydrochloride NDR-5523A	Others	Cardiovascular Disease
Trimoxamine hydrochloride (NDR-5523A) is an antihypertensive drug with hypotensive activity. Trimoxamine hydrochloride can be used to inhibit hypertension-related diseases. Trimoxamine hydrochloride lowers blood pressure by inhibiting vasoconstriction. Trimoxamine hydrochloride plays an important role in the management of cardiovascular diseases .

HY-113042

Prostaglandin B2	Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin B2 is a prostaglandin. Prostaglandin B2 is the main substance in cord blood mesenchymal stem cells, to inhibit DC-T Cell proliferation. Prostaglandin B2 also induces cutaneous vasoconstriction of the canine hind paw .

HY-N8251

Cyclocurcumin	p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities .

HY-124150

BM567	Prostaglandin Receptor	Cardiovascular Disease
BM567 is a sulfonylurea compound (compound 1), which exhibits antithrombogenic efficacy as thromboxane A₂ receptor (TXR) antagonists and thromboxane A₂ synthase (TXS) inhibitors, with IC₅₀s of 1.1 and 12 nM, respectively .

HY-131395

N-Acetyl-Leukotriene E4 N-Acetyl-LTE4	Endogenous Metabolite	Cardiovascular Disease
N-Acetyl-Leukotriene E4 (N-Acetyl-LTE4) is a metabolite of Leukotriene E4 (LTE4) (HY-113465), which is detected in bile and urine . N-Acetyl-Leukotriene E4 produces a vasoconstriction in the mesenteric vessels which led to reduction of blood flow to the gut .

HY-17034BS1

Medetomidine-13C,d3 hydrochloride MPV785-¹³C,d₃	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-160210

BAY-6096	Adrenergic Receptor	Cardiovascular Disease
BAY-6096 is a potent, selective, and highly water-soluble adrenergic receptor α_2B antagonist with an IC₅₀ of 14 nM. BAY-6096 can effectively reduceα _2B receptor agonist-induced rat vascular contraction .

HY-120535

RS 30026	Calcium Channel	Neurological Disease
RS 30026 is a potent calcium channel agonist with a pEC₅₀ value of 7.45 .

HY-P1019

[Ala1,3,11,15]-Endothelin (53-63)	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction

HY-P1019A

[Ala1,3,11,15]-Endothelin (53-63) (TFA)	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction .

HY-121311

Metrenperone	Serotonin Transporter Adrenergic Receptor	Cardiovascular Disease
Metrenperone is an inhibitor for 5-HT2 receptor. Metrenperone exhibits α1 and α2 antagonist activity as well as anti-H1 and anti-dopaminergic efficacy. Metrenperone can lower the blood pressure, enhances bradycardia in peripheral ischemia, inhibits serotonin-induced platelet aggregation, and antagonizes serotonin-mediated vasoconstriction. Metrenperone promotes the repair of acutely damaged collagen tissue .

HY-13527

LY310762 1 Publications Verification	5-HT Receptor	Cardiovascular Disease Neurological Disease
LY310762 is a selective 5-HT_1D receptor antagonist (K_i=249 nM) with a weak affinity for 5-HT_1B receptor. LY310762 effectively abolishes the renal vasodilatory effects of 5-HTSumatriptan (HY-B0121B)-induced decrease in excitatory postsynaptic potential (EPSC) amplitude .

HY-137606

Uridine adenosine tetraphosphate UP4A	P2X Receptor	Cardiovascular Disease
Uridine adenosine tetraphosphate (UP4A) is an endothelium-derived vasoconstrictor that primarily acts through the P2X1 receptor and possibly through the P2Y2 and P2Y4 receptors. Uridine adenosine tetraphosphate can be used in the study of cardiovascular diseases .

HY-101607A

KT-362 free acid	Calcium Channel	Cardiovascular Disease
KT-362 free acid is an intracellular calcium antagonist with antiarrhythmic and vasodilatory effects. KT-362 free acid shows an antagonistic effect against norepinephrine (NE) induced vasoconstriction response, achieved by reducing inositol phospholipid hydrolysis, thereby reducing intracellular calcium mobilization. KT-362 free acid can be used to study the contraction and relaxation mechanisms of vascular smooth muscle, especially in exploring the role of intracellular calcium mobilization and inositol phospholipid hydrolysis in vascular contraction .

HY-135283

ABT-546 A-216546	Endothelin Receptor	Cardiovascular Disease Endocrinology
ABT-546 (A-216546) is a potent, highly selective and active endothelin ET_A receptor antagonist with a K_i of 0.46 nM for [ ¹²⁵I]endothelin-1 binding to cloned human endothelin ET_A. ABT-546 is >25,000-fold more selective for the ET_A receptor than for the ET_B receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC₅₀ of 0.59 nM and 3 nM, respectively .

HY-101390

(+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride	Calcium Channel	Cardiovascular Disease
(+)-Niguldipine hydrochloride is an antagonist for calcium channel. (+)-Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+)-Niguldipine hydrochloride inhibits U-46619 (HY-108566)-induced coronary vasoconstriction in guinea pig Langendorff heart with pID₅₀ of 11.37, binds to calcium channel on guinea pig skeletal muscle membrane with K_i of 9.75, and lowers the blood pressure in spontaneously hypertensive rat with pED₃₀ of 7.1. (+)-Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension, angina pectoris and arrhythmias .

HY-137355

15(S)-15-methyl Prostaglandin D2 15(S)-15-Methyl PGD2	Prostaglandin Receptor	Cardiovascular Disease Metabolic Disease
15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2).

Cat. No.	Product Name	Target	Research Area

HY-P1016B

BQ-3020 ammonium	Endothelin Receptor	Cardiovascular Disease
BQ-3020 ammonium is a selective endothelin receptor (ET_B receptor) agonist. BQ-3020 ammonium inhibits [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 ammonium elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 ammonium makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research . .

HY-102029

Sarafotoxin S6c SRTX-c	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels .

HY-12554A

Terlipressin diacetate 1 Publications Verification	Vasopressin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology
Terlipressin diacetate is a vasopressin analogue with potent vasoactive properties. Terlipressin diacetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin diacetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin diacetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .

HY-P3765

Auriculin A	Peptides	Cardiovascular Disease
Auriculin A is a synthetic atrial natriuretic factor (ANF) with hemodynamic effect. Auriculin A antagonizes renal vasoconstriction in the dog, and influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits .

HY-P1016

BQ-3020	Endothelin Receptor	Cardiovascular Disease
BQ-3020 is a selective endothelin receptor (ET_B receptor) agonist that displaces [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research ¹ ².

HY-P10291

[Pro34]Neuropeptide Y, porcine	Neuropeptide Y Receptor	Neurological Disease
[Pro34]Neuropeptide Y, porcine is a selective NPY receptor (Y1 receptor) agonist. [Pro34]Neuropeptide Y, porcine evokes vasoconstrictions in the guinea pig caval vein .

HY-P1019

[Ala1,3,11,15]-Endothelin (53-63)	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction

HY-P1019A

[Ala1,3,11,15]-Endothelin (53-63) (TFA)	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction .

HY-P3565

Sarafotoxin S6d STX-b	Peptides	Cardiovascular Disease
Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases .

HY-12554B

Terlipressin acetate	Vasopressin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology
Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .

HY-P2141A

TRV-120027 TFA 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling . TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment .

HY-P2141

TRV-120027 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling . TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure