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Results for "

aldose reductase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (57) Apoptosis (6) Autophagy (2) Carbonic Anhydrase (1) COX (1) DNA/RNA Synthesis (2) Endogenous Metabolite (2) Influenza Virus (2) Interleukin Related (2) Isotope-Labeled Compounds (1) Lipoxygenase (2) Mitochondrial Metabolism (1) Mitophagy (1) Opioid Receptor (2) Phosphatase (1) Reactive Oxygen Species (1) TNF Receptor (2) α-synuclein (2)
By Research Areas:	Cancer (13) Cardiovascular Disease (3) Endocrinology (5) Infection (4) Inflammation/Immunology (13) Metabolic Disease (44) Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Aldose Reductase Glutathione Reductase 5 alpha Reductase Dihydrofolate reductase (DHFR) HMG-CoA Reductase (HMGCR) TrxR GSNOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9898

Sinocrassoside C1	Others	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

HY-18967

Caficrestat aldose reductase-IN-1; AT-001	Aldose Reductase	Metabolic Disease
Caficrestat (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC₅₀ of 28.9 pM .

HY-W319094

4′-Hydroxyflavone	Aldose Reductase
4′-Hydroxyflavone (compound 50) can inhibit aldose reductase, with a log1/IC₅₀ of 4.92 .

HY-119842

ALO1567 AL1567	Aldose Reductase	Endocrinology
ALO1567 (AL1567) is an orally available aldose reductase inhibitor with an IC₅₀ of 27 nM for rat lens aldose reductase. ALO1567 can be used in the research of diabetes .

HY-116600

AL-4114	Aldose Reductase	Metabolic Disease
AL-4114 is an aldose reductase inhibitor which can be utilized in research related to the prevention of diabetic cataractogenesis .

HY-116508

MK 319	Aldose Reductase	Metabolic Disease
MK 319 is a selective aldose reductase (AR) inhibitor with an IC₅₀ of 0.3 μM. MK 319 can be utilized in diabetes research .

HY-122177

MK181	Aldose Reductase	Cancer
MK181 is an aldose reductase (AR) inhibitor with IC₅₀s of 0.71 μM and 4.5 μM for aldose reductase and AKR1B10, respectively. MK181 can bind into the external loop A subpocket of AKR1B10 .

HY-D0064

6,7-Dihydroxy-4-coumarinylacetic acid	Aldose Reductase	Metabolic Disease
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC₅₀s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation .

HY-115940

Aldose reductase-IN-2	Aldose Reductase	Metabolic Disease
Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR). Aldose reductase-IN-2 has antioxidation capacity. Aldose reductase-IN-2 is a promising anti-diabetic complications agent .

HY-115977

Aldose reductase-IN-3	Aldose Reductase	Inflammation/Immunology
Aldose reductase-IN-3 (Compound 5) is a potent and moderately selective inhibitor of aldose reductase (AR) with an IC₅₀ of 3.99 μM. Aldose reductase has recently emerged as a molecular target that is involved in various inflammatory diseases, including sepsis. Aldose reductase-IN-3 has the potential for the research of sepsis .

HY-147875

Aldose reductase-IN-6	Aldose Reductase	Metabolic Disease
Aldose reductase-IN-6 (Compound 3) is a competitive aldose reductase (AR) inhibitor with an IC₅₀ of 3.164 μM and a K_i of 0.018 μM. Aldose reductase-IN-6 exhibits no cytotoxicity against healthy cells .

HY-146661

Aldose reductase-IN-4	Aldose Reductase	Cancer
Aldose reductase-IN-4 (compund IIc) is an aldose reductase inhibitor with IC₅₀s of 11.70 μM and 0.98 μM for aldehyde reductase 1 (ALR1) and ALR2, respectively .

HY-16255

Imirestat 2 Publications Verification AL 1576; Alcon 1576; HOE 843	Aldose Reductase	Metabolic Disease
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

HY-16500

Tolrestat 1 Publications Verification AY-27773	Aldose Reductase	Cancer
Tolrestat is a potent, orally active aldose reductase inhibitor with IC₅₀ of 35 nM.

HY-100969

EBPC	Aldose Reductase	Metabolic Disease
EBPC is a potent and selective aldose reductase inhibitor with an IC₅₀ of 47 nM .

HY-120208

MK204	Aldose Reductase	Metabolic Disease
MK204 is an aldose reductase (AR) inhibitor that can be used in diabetes research .

HY-16433

Risarestat CT 112	Aldose Reductase	Metabolic Disease Inflammation/Immunology
Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.

HY-N2494

Hydroxyevodiamine Rhetsinine	Aldose Reductase	Inflammation/Immunology
Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC₅₀ value of 24.1 μM .

HY-66009

Epalrestat 3 Publications Verification ONO2235	Aldose Reductase	Metabolic Disease Inflammation/Immunology Cancer
Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy .

HY-B1202

Alrestatin 1 Publications Verification AY-22284	Aldose Reductase	Endocrinology
Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

HY-B1202A

Alrestatin sodium AY-22284A	Aldose Reductase	Endocrinology
Alrestatin sodium is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

HY-N0309

Soyasaponin Ba 1 Publications Verification	Aldose Reductase	Metabolic Disease
Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI) .

HY-105185

Fidarestat 2 Publications Verification SNK 860	Aldose Reductase	Metabolic Disease
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC₅₀s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

HY-N0310

Soyasaponin Bb 1 Publications Verification	Aldose Reductase	Endocrinology
soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris, acting as an aldose reductase differential inhibitor (ARDI) .

HY-106877

Minalrestat ARI-509; WAY-ARI 509	Aldose Reductase	Metabolic Disease
Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes .

HY-116239

Zenarestat	Aldose Reductase	Neurological Disease Metabolic Disease
Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats .

HY-146129

Aldose reductase-IN-5	Aldose Reductase	Metabolic Disease
As an aldose reductase (ALR2) inhibitor, the compound is used to enhance the combination of inhibitory excitability and antioxidant capacity to delay the progress of diabetes complications.

HY-N0075

(Rac)-Byakangelicin	Others	Metabolic Disease
(Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-16500R

Tolrestat (Standard)	Aldose Reductase	Cancer
Tolrestat (Standard) is the analytical standard of Tolrestat. This product is intended for research and analytical applications. Tolrestat is a potent, orally active aldose reductase inhibitor with IC₅₀ of 35 nM.

HY-19687

Zopolrestat 1 Publications Verification CP73850	Aldose Reductase	Metabolic Disease
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC₅₀ of 3.1 nM. Zopolrestat is used for the research of diabetic complications .

HY-W653944

Epalrestat-d5 ONO2235-d₅	Isotope-Labeled Compounds Aldose Reductase	Metabolic Disease
Epalrestat-d₅ is deuterium labeled Epalrestat. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy .

HY-50289

Sorbinil 2 Publications Verification	Aldose Reductase	Metabolic Disease
Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway .

HY-N0102

Isoliquiritigenin Maximum Cited Publications 18 Publications Verification GU17; ISL; Isoliquiritigen; SJ000286237	Aldose Reductase Influenza Virus Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

HY-66009R

Epalrestat (Standard)	Aldose Reductase	Metabolic Disease Inflammation/Immunology Cancer
Epalrestat (Standard) is the analytical standard of Epalrestat. This product is intended for research and analytical applications. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy .

HY-133708

β-Glucogallin 1-O-Galloyl-β-D-glucose	Aldose Reductase	Metabolic Disease
β-Glucogallin is a potent and selective aldose reductase (AKR1B1) inhibitor. β-Glucogallin can be isolated from the medicinal plant Emblica officinalis .

HY-121933

IDD388	Aldose Reductase	Metabolic Disease
IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC₅₀ of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC₅₀ of 14 μM) .

HY-N4089

Quercetin 3-gentiobioside	Aldose Reductase	Metabolic Disease
Quercetin 3-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs) .

HY-N11639

Ganoderic acid Df	Aldose Reductase	Metabolic Disease
Ganoderic acid Df is a lanostane-type triterpenoid, that can be isolated from the fruiting body of Ganoderma lucidum. Ganoderic acid Df potently inhibits aldose reductase, with an IC₅₀ of 22.8 ± 0.6 μM .

HY-N0309R

Soyasaponin Ba (Standard)	Aldose Reductase	Metabolic Disease
Soyasaponin Ba (Standard) is the analytical standard of Soyasaponin Ba. This product is intended for research and analytical applications. Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI) .

HY-131542

APPA	Aldose Reductase Apoptosis	Metabolic Disease
APPA is an aldose reductase inhibitor. APPA can effectively prevent apoptosis and the symptoms of Streptozotocin (HY-13753)-induced diabetes by inhibiting the polyol pathway in rats. APPA has the potential for diabetic nephropathy (DN) research .

HY-N0310R

Soyasaponin Bb (Standard)	Aldose Reductase	Endocrinology
Soyasaponin Bb (Standard) is the analytical standard of Soyasaponin Bb. This product is intended for research and analytical applications. soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris, acting as an aldose reductase differential inhibitor (ARDI) .

HY-129586

Govorestat AT-007	Aldose Reductase	Metabolic Disease
Govorestat (AT-007) is an orally active brain-penetrant aldose reductase inhibitor with an IC₅₀ value of 100 pM. Govorestat has the potential for galactose-1-phosphate uridyl transferase deficiency research .

HY-13633

Exisulind 2 Publications Verification	Aldose Reductase	Metabolic Disease Cancer
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac . Exisulind inhibits aldose reductase with an IC₅₀ of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications .

HY-N12871

Floramanoside D	Aldose Reductase	Others
Floramanoside D is a flavonol glycoside. Floramanoside D inhibits aldose reductase (IC₅₀ is 2.2 μM), scavenges the 2,2-diphenyl-1-picrylhydrazyl (DPPH) (SC₅₀ is 12.5 μM) .

HY-106198

Lidorestat IDD-676	Aldose Reductase	Metabolic Disease
Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC₅₀ of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation .

HY-162325

WJ-39	Aldose Reductase Mitochondrial Metabolism Apoptosis Mitophagy	Metabolic Disease
WJ-39 is an orally active aldose reductase (AR) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis .

HY-N0075R

(Rac)-Byakangelicin (Standard)	Others	Metabolic Disease
(Rac)-Byakangelicin (Standard) is the analytical standard of (Rac)-Byakangelicin. This product is intended for research and analytical applications. (Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-N0102R

Isoliquiritigenin (Standard)	Aldose Reductase Influenza Virus Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Isoliquiritigenin (Standard) is the analytical standard of Isoliquiritigenin. This product is intended for research and analytical applications. Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

HY-106697

Ponalrestat 1 Publications Verification ICI 128436	Aldose Reductase	Metabolic Disease
Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (K_i=7.7 nM) over ALR1 (K_i=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .

HY-151947

ALR2-IN-3	Aldose Reductase	Metabolic Disease
ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC₅₀s of 22 nM and 116 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications .

Cat. No.	Product Name	Type

HY-D0064

6,7-Dihydroxy-4-coumarinylacetic acid	Dyes
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC₅₀s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9898

Sinocrassoside C1	Structural Classification Sinocrassula indica (Decne.) Berger Flavonoids Flavones Source classification Crassulaceae Plants Saccharides Monosaccharides	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

HY-N0309

Soyasaponin Ba 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	Aldose Reductase
Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI) .

HY-N0310

Soyasaponin Bb 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants Disease Research Fields Endocrinology	Aldose Reductase
soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris, acting as an aldose reductase differential inhibitor (ARDI) .

HY-N0075

(Rac)-Byakangelicin	Classification of Application Fields Source classification Ruta graveolens Linn. Rutaceae Coumarins Metabolic Disease Phenylpropanoids Plants Disease Research Fields	Others
(Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-N0102

Isoliquiritigenin Maximum Cited Publications 18 Publications Verification GU17; ISL; Isoliquiritigen; SJ000286237	Structural Classification Classification of Application Fields Source classification Plants Infection Chalcones Flavonoids Microorganisms Leguminosae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Aldose Reductase Influenza Virus Autophagy Apoptosis
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

HY-133708

β-Glucogallin 1-O-Galloyl-β-D-glucose	Structural Classification Phyllanthaceae Source classification Phenols Polyphenols Phyllanthus emblica L. Plants	Aldose Reductase
β-Glucogallin is a potent and selective aldose reductase (AKR1B1) inhibitor. β-Glucogallin can be isolated from the medicinal plant Emblica officinalis .

HY-N4089

Quercetin 3-gentiobioside	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Aldose Reductase
Quercetin 3-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs) .

HY-N2494

Hydroxyevodiamine Rhetsinine	Alkaloids other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids	Aldose Reductase
Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC₅₀ value of 24.1 μM .

HY-N11639

Ganoderic acid Df	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Aldose Reductase
Ganoderic acid Df is a lanostane-type triterpenoid, that can be isolated from the fruiting body of Ganoderma lucidum. Ganoderic acid Df potently inhibits aldose reductase, with an IC₅₀ of 22.8 ± 0.6 μM .

HY-N0309R

Soyasaponin Ba (Standard)	Triterpenes Structural Classification Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants	Aldose Reductase
Soyasaponin Ba (Standard) is the analytical standard of Soyasaponin Ba. This product is intended for research and analytical applications. Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI) .

HY-N0310R

Soyasaponin Bb (Standard)	Triterpenes Structural Classification Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants	Aldose Reductase
Soyasaponin Bb (Standard) is the analytical standard of Soyasaponin Bb. This product is intended for research and analytical applications. soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris, acting as an aldose reductase differential inhibitor (ARDI) .

HY-N12871

Floramanoside D	Malvaceae Structural Classification Flavonoids Flavones Source classification Abelmoschus manihot (Linn.) Medicus Plants	Aldose Reductase
Floramanoside D is a flavonol glycoside. Floramanoside D inhibits aldose reductase (IC₅₀ is 2.2 μM), scavenges the 2,2-diphenyl-1-picrylhydrazyl (DPPH) (SC₅₀ is 12.5 μM) .

HY-N0075R

(Rac)-Byakangelicin (Standard)	Structural Classification Ruta graveolens Linn. Source classification Rutaceae Coumarins Phenylpropanoids Plants	Others
(Rac)-Byakangelicin (Standard) is the analytical standard of (Rac)-Byakangelicin. This product is intended for research and analytical applications. (Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-N0102R

Isoliquiritigenin (Standard)	Structural Classification Chalcones Flavonoids Microorganisms Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Aldose Reductase Influenza Virus Autophagy Apoptosis
Isoliquiritigenin (Standard) is the analytical standard of Isoliquiritigenin. This product is intended for research and analytical applications. Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

HY-122917

Danshenol A	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Aldose Reductase Reactive Oxygen Species
Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC₅₀ of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research .

HY-N4089R

Quercetin 3-gentiobioside (Standard)	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	Aldose Reductase
Quercetin 3-gentiobioside (Standard) is the analytical standard of Quercetin 3-gentiobioside. This product is intended for research and analytical applications. Quercetin 3-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs) .

HY-N0033

Poliumoside 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Callicarpa formosana Rolfe Plants Simple Phenylpropanols Verbenaceae Phenols Polyphenols Scrophulariaceae Phenylpropanoids Inflammation/Immunology Disease Research Fields Brandisia hancei Hook. f.	Aldose Reductase
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

HY-N6883

6-Methoxytricin	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Aldose Reductase
6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin (Compound 6) is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities with IC₅₀ values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin (Compound 6) has potential as an anti-diabetic complications agent .

HY-N3716

Dehydroglyasperin D	Structural Classification Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Aldose Reductase COX
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .

HY-N0033R

Poliumoside (Standard)	Structural Classification Simple Phenylpropanols Verbenaceae Source classification Phenols Polyphenols Scrophulariaceae Callicarpa formosana Rolfe Phenylpropanoids Plants Brandisia hancei Hook. f.	Aldose Reductase
Poliumoside (Standard) is the analytical standard of Poliumoside. This product is intended for research and analytical applications. Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

HY-Y0790

Cuminaldehyde p-Isopropylbenzaldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Rudbeckia laciniata L. Source classification Umbelliferae Plants Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis DNA/RNA Synthesis α-synuclein Lipoxygenase Opioid Receptor Interleukin Related TNF Receptor
Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL), α-glucosidase (IC₅₀=0.5 mg/mL) and lipoxygenase (IC₅₀=1370 μM). Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

HY-Y0790R

Cuminaldehyde (Standard)	Structural Classification Ketones, Aldehydes, Acids Rudbeckia laciniata L. Source classification Umbelliferae Plants Endogenous metabolite	Endogenous Metabolite Apoptosis DNA/RNA Synthesis α-synuclein Lipoxygenase Opioid Receptor Interleukin Related TNF Receptor
Cuminaldehyde (Standard) is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL) and α-glucosidase (IC₅₀=0.5 mg/mL). Cuminaldehyde can modulate α-synuclein fibrils. Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

Cat. No.	Product Name	Chemical Structure

HY-W653944

Epalrestat-d5
Epalrestat-d₅ is deuterium labeled Epalrestat. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy .

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aldose reductase inhibitor

Inhibitors & Agonists

Fluorescent Dye

NaturalProducts

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