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PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 µM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity .
Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM . A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection .
A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM . A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection .
N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a formyl peptide receptor 1 (FPR1) antagonist, which increases pain effects and inhibits antinociceptive activity of annexin .
Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively .
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .
Endosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm .
PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) .
Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a formyl peptide receptor 1 (FPR1) antagonist, which increases pain effects and inhibits antinociceptive activity of annexin .
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .
Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models .
Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .
Ac2-12 TFA, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 TFA has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models .
MCE Annexin V-FITC/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-), early apoptosis cells show green fluorescence(Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).
MCE Annexin V-iFluor 488/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-),, early apoptosis cells show green fluorescence (Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).
Annexin V-EGFP/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-), early apoptosis cells show green fluorescence(Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+). Compared with FITC, the fluorescence of EGFP is stronger and more stable.
Annexin V-mCherry Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells and necrosis cells show red fluorescence.
MCE Annexin V-PE Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells and necrosis cells show red fluorescence.
Annexin V-mCherry/SYTOX Green Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells show red fluorescence, necrosis cells show red and green fluorescence.
The Annexin A4/ANXA4 protein is a calcium/phospholipid-binding protein that plays a key role in membrane dynamics by promoting membrane fusion and exocytosis. This protein exhibits specific affinity for calcium ions and phospholipids, allowing it to participate in cellular processes involving membrane interactions. Annexin A4/ANXA4 Protein, Mouse (His-Myc) is the recombinant mouse-derived Annexin A4/ANXA4 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Annexin A4/ANXA4 Protein, Mouse (His-Myc) is 318 a.a., with molecular weight of ~40.8 kDa.
The annexin A8 (ANXA8) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex in the coagulation cascade. Its regulatory role underscores its importance in regulating key components of the coagulation pathway, highlighting its potential to influence the delicate balance between pro- and anticoagulant factors. Annexin A8/ANXA8 Protein, Human (His) is the recombinant human-derived Annexin A8/ANXA8 protein, expressed by E. coli , with N-6*His labeled tag.
The annexin A5 (ANXA5) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex, which is critical in the coagulation cascade. As a monomer, ANXA5 plays a key role in regulating the coagulation pathway, affecting the delicate balance between pro- and anti-coagulant factors. Annexin A5/ANXA5 Protein, Mouse (His, Myc) is the recombinant mouse-derived Annexin A5/ANXA5 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Annexin A5/ANXA5 Protein, Mouse (His, Myc) is 318 a.a., with molecular weight of 43.2 kDa.
Annexin A1 Protein, Human is an approximately 34.0 kDa Annexin A1 protein expressed by the E. coli system. Annexin A1 is a Ca2+-dependent phospholipid binding protein and has inhibitory effects on phospholipase A2 (PLA2).
Annexin A13 Protein, Human is a 35-kDa multifunctional protein which belongs to the annexin family. Annexin A13 is highly expressed in the digestive system and may plays a role in apoptotic cell-mediated immunosuppression, hypertension, and cell death recognition. Annexin A13 can be used as biomarker in CRC biomarker in colorectal cancer (CRC).
Annexin A2/ANXA2 Protein, Human is a 38kDa multifunctional protein which belongs to the annexin family. Annexin A2 is important for the regulation in the cellular growth and in signal transduction pathways. Annexin A2 also can be used as an autocrine factor that can heighten osteoclast formation and bone resorption.
Annexin A3 Protein, Human is a 37 kDa endogenous and secretory multifunctional protein which belongs to the annexin family. Annexin A13 is highly expressed in various carcinomas cells. Human Annexin A3 can promote aggressive cancer and stem cell-like properties and can be used as a useful predictive biomarker in HCC.
Annexin A13/ANXA13 protein has a high affinity for folic acid and can bind to reduced folic acid derivatives to promote the transport of 5-methyltetrahydrofolate and folic acid analogs into cells. After endocytosis, the FOLR1 protein undergoes conformational changes when exposed to slightly acidic pH, resulting in a significant reduction in its affinity for folate and subsequent release. Annexin A13/ANXA13 Protein, Dog (P.pastoris, His) is the recombinant dog-derived Annexin A13/ANXA13 protein, expressed by P. pastoris , with N-His labeled tag.
Annexin A1 (ANXA1) plays multifaceted roles in innate and adaptive immune responses. It acts as an effector of glucocorticoid-mediated responses, downregulating early inflammation. Annexin A1/ANXA1 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived Annexin A1/ANXA1 protein, expressed by E. coli , with C-His labeled tag.
Annexin A10/ANXA10 Protein, Human is a 28-35 kDa Annexin A10 protein expressed by E. coli system. Annexin A10 is a Ca2+-dependent phospholipid binding protein ad plays a role in the regulation of cellular growth and in signal transduction pathways.
Annexin A7 Protein, Human is a 51 kDa multifunctional protein which belongs to the the group A annexin family and contains an extraordinarily long amino terminus. Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion.
Annexin A6 Protein, Human (His) is a Annexin A6 protein fused to His-tag at N-terminus. Annexin A6 is an endogenous and secretory multifunctional protein and locates on the cell surface. Annexin A6 can be used for the study in mediating the endosome aggregation and vesicle fusion during exocytosis.
Annexin A1 (ANXA1) plays multifaceted roles in innate and adaptive immune responses.It acts as an effector of glucocorticoid-mediated responses, downregulating early inflammation.Annexin A1/ANXA1 Protein, Mouse (His) is the recombinant mouse-derived Annexin A1/ANXA1 protein, expressed by E.coli , with N-6*His labeled tag.
Annexin A1 (ANXA1) plays multifaceted roles in innate and adaptive immune responses.It acts as an effector of glucocorticoid-mediated responses, downregulating early inflammation.Annexin A1/ANXA1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Annexin A1/ANXA1 protein, expressed by P.pastoris , with N-His labeled tag.
Annexin A5 Protein, Human is a 35 kDa multifunctional protein which belongs to the annexin family. Annexin A5 induces in vitro fusion and aggregation of vesicles in a Ca2+- and acidic-pH-dependent manner.Annexin A5 is accepted as an early marker of apoptosis. Annexin A5 has anti-thrombotic and anti-microbial properties.
Annexin A5 Protein, Human is a 35 kDa multifunctional protein which belongs to the annexin family. Annexin A5 induces in vitro fusion and aggregation of vesicles in a Ca2+- and acidic-pH-dependent manner.Annexin A5 is accepted as an early marker of apoptosis. Annexin A5 has anti-thrombotic and anti-microbial properties.
Annexin A4 Protein, Human (His-SUMO, Myc) is the recombinant human-derived Annexin A4, expressed by E. coli Cell-free , with C-Myc, N-SUMO, N-10*His labeled tag. The total length of Annexin A4 Protein, Human (His-SUMO, Myc) is 318 a.a.,
Annexin A2 (ANXA2) is a calcium-regulated membrane-binding protein with heightened calcium affinity in the presence of anionic phospholipids. Known for its potential involvement in the heat-stress response, ANXA2 operates as a heterotetramer, comprising two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. It inhibits PCSK9-enhanced LDLR degradation, potentially through translational mechanisms, while also competing with LDLR for PCSK9 binding. ANXA2 interacts with various proteins, including ATP1B1, DYSF, COCH, and CEACAM1, with the latter interaction being regulated by CEACAM1 phosphorylation. Moreover, ANXA2 interacts with PCSK9, forming a complex that hinders LDLR degradation. Additionally, it associates with APPL2 and APPL1, facilitating the targeting of APPL2 to endosomes in parallel with RAB5A. The intricate network of ANXA2 interactions underscores its versatile role in cellular processes and regulatory pathways. Annexin A2/ANXA2 Protein, Mouse (His) is the recombinant mouse-derived Annexin A2/ANXA2 protein, expressed by E. coli , with N-His labeled tag. The total length of Annexin A2/ANXA2 Protein, Mouse (His) is 338 a.a., with molecular weight of ~39.6 kDa.
Annexin A5 (ANXA5) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex in the coagulation cascade. ANXA5 exists as a monomer and its role is not limited to coagulation regulation, but also has binding interactions involving ATRX and EIF5B, suggesting its involvement in a variety of cells. Animal-Free Annexin A5/ANXA5 Protein, Human (His) is the recombinant human-derived animal-FreeAnnexin A5/ANXA5 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free Annexin A5/ANXA5 Protein, Human (His) is 320 a.a., with molecular weight of ~36.75 kDa.
Annexin A1 Antibody (YA832) is a non-conjugated and Mouse origined monoclonal antibody about 39 kDa, targeting to Annexin A1 (5E4D8). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.
Annexin A10 Antibody (YA1134) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1134), targeting Annexin A10. Annexin A10 Antibody (YA1134) can be used for IHC-P experiment in human background.
Annexin A2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 39 kDa, targeting to Annexin A2. It can be used for WB,IHC-P,ICC/IF,FC assays with tag free, in the background of Human, Mouse.
ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; annexin A2; annexin II; annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
WB, IP
Human
Annexin 2 Antibody (YA2711) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2711), targeting Annexin 2, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Annexin 2 Antibody (YA2711) can be used for WB, IP experiment in human background.
Annexin VII Antibody (YA1138) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1138), targeting Annexin VII. Annexin VII Antibody (YA1138) can be used for IHC-P experiment in human background.
Annexin VI Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 76 kDa, targeting to Annexin A6 (ANXA6). It can be used for WB,IHC-P,IP assays in the background of Human, Mouse, Rat.
Annexin V Antibody (YA1829) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1829), targeting Annexin V, with a predicted molecular weight of 36 kDa (observed band size: 36 kDa). Annexin V Antibody (YA1829) can be used for WB, ICC/IF experiment in human, mouse, rat background.
Annexin 4 Antibody (YA2714) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2714), targeting Annexin 4, with a predicted molecular weight of 36 kDa (observed band size: 36 kDa). Annexin 4 Antibody (YA2714) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat, hamster background.
Annexin IV Antibody (YA1921) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1921), targeting Annexin IV, with a predicted molecular weight of 36 kDa (observed band size: 30 kDa). Annexin IV Antibody (YA1921) can be used for WB, ICC/IF, FC experiment in human background.
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