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Pathways Recommended: Membrane Transporter/Ion Channel
Results for "

cellular membranes

" in MedChemExpress (MCE) Product Catalog:

123

Inhibitors & Agonists

4

Screening Libraries

11

Fluorescent Dye

5

Biochemical Assay Reagents

5

Peptides

1

Inhibitory Antibodies

10

Natural
Products

61

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99853

    CR6261

    Influenza Virus Infection
    Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus .
    Diridavumab
  • HY-153725

    Liposome Cancer
    17:1 Lyso PC is a liposome to simulate biological phospholipid membrane. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble payloads can be trapped in the internal aqueous space of liposomes, while lipophilic payloads can partition into and become part of the lipid bilayer. Especially for delivering antisense oligonucleotides, it can overcome problems such as inefficient cellular uptake and rapid loss in the body .
    17:1 Lyso PC
  • HY-D1906

    Fluorescent Dye Others
    BDP R6G NHS ester is a borodipyrromethane fluorophore, which contains a NHS ester group that can react with amine groups (-NH2) in proteins or other molecules to form stable amide bonds (Ex/Em = 530/548 nm) .
    BDP R6G NHS ester
  • HY-145257

    GABA Receptor Neurological Disease
    GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability .
    GABAA receptor agent 5
  • HY-W591449

    Liposome Cancer
    DOPE-PEG-Azide, MW 2000 is a liposome to simulate biological phospholipid membrane. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble payloads can be trapped in the internal aqueous space of liposomes, while lipophilic payloads can partition into and become part of the lipid bilayer. Especially for delivering antisense oligonucleotides, it can overcome problems such as inefficient cellular uptake and rapid loss in the body .
    DOPE-PEG-Azide, MW 2000
  • HY-134939

    Drug Derivative Others
    thio-Miltefosine is a modulator of rafts in membrane tissue. Rafts are nanoscale aggregates of different lipids and proteins that profoundly affect cellular function. Thio-Miltefosine modulates membrane phase behavior on cell-derived giant plasma membrane vesicles .
    thio-Miltefosine
  • HY-130210

    Fluorescent Dye Others
    Oxonol V is a slow-response sensitive probe for measuring cellular membrane potential.
    Oxonol V
  • HY-117133

    SF0166

    Integrin Metabolic Disease
    Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model .
    Nesvategrast
  • HY-114346A

    Fluorescent Dye Others
    ODIPY FL EDA free base is an amine-based, green fluorescent probe. The R-NH2 of ODIPY FL EDA free base can be coupled with aldehydes or ketones to form reversible Schiff base products. Convert to stable amine derivatives using reducing agents such as sodium borohydride or sodium cyanoborohydride. ODIPY FL EDA free base can be used to detect modified or normal deoxynucleotides and demonstrate DNA damage and genomic DNA methylation.
    BODIPY FL EDA free base
  • HY-149182

    Fluorescent Dye Others
    Lucifer yellow iodoacetamide dipotassium is a thiol-reactive fluorescent tracer.
    Lucifer yellow iodoacetamide dipotassium
  • HY-D2012

    Fluorescent Dye Others
    ATTO 488 iodacetamid is a fluorescent dye suitable for single molecule detection applications and high-resolution microscopy for use in flow cytometry (FACS), fluorescence in situ hybridization (FISH) experiments. ATTO 488 iodacetamid has an effective excitation wavelength of 480-515 nm. When using an argon ion laser, the excitation wavelength is recommended to be 488 nm.
    ATTO 488 iodacetamid
  • HY-148129

    TRP Channel Cardiovascular Disease
    TRPC6-IN-3 (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. TRPC6-IN-3 modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. TRPC6-IN-3 can be used in research of respiratory system .
    TRPC6-IN-3
  • HY-136513

    Modown; MC-4379

    Herbicide Others
    Bifenox (Modown; MC-4379) is a potent herbicide. Bifenox increases the ROS production. Bifenox causes cellular membrane disruption, inhibition of photosynthesis .
    Bifenox
  • HY-N12158

    Apoptosis Cancer
    Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces apoptosis .
    Pipermethystine
  • HY-D0830

    Fluorexon tetraethyl ester

    Fluorescent Dye Others
    Calcein tetraethyl ester is a fluorescent dye, is used in biology as it can be transported through the cellular membrane into live cells, which makes it useful for testing of cell viability and for short-term labeling of cells.
    Calcein (tetraethyl ester)
  • HY-D1694

    Fluorescent Dye Others
    LysoTracker Yellow HCK 123 is a potent yellow membrane-permeable fluorescent probe. LysoTracker Yellow HCK 123 is a weakly basic amine that selectively accumulates in cellular compartments with low luminal pH .
    LysoTracker Yellow HCK 123
  • HY-D2316

    Fluorescent Dye Others
    Flipper-TR probe (Compound FliptR probe) is a fluorescent probe specifically designed to measure cell membrane tension. Flipper-TR probe reports changes in membrane tension through variations in its fluorescence lifetime. Flipper-TR probe is applicable to a wide range of organisms including bacteria, yeast, mammals, and plants .
    Flipper-TR probe
  • HY-P10362

    Bacterial Infection
    Temporin-GHd exhibits antibacterial activity against Streptococcus mutans (MIC=13.1 μM; MBC=26 μM). Temporin-GHd increases the permeability of the bacterial cell membrane, causing membrane damage and leakage of cellular contents. Temporin-GHd disrupts preformed biofilms at high concentrations. Temporin-GHd can bind to bacterial DNA, inhibiting DNA migration .
    Temporin-GHd
  • HY-126220

    Fluorescent Dye Others
    KMG-301AM is the acetoxy methyl esterified form of KMG-301. KMG-301AM successfully accumulates in mitochondria and then it is hydrolyzed to KMG-301. KMG-301 is an Mg 2+-selective fluorescent probe functional in mitochondria in intact cells. Since the mitochondrial membrane is impermeable to KMG-301, it is not released upon depolarization of the mitochondrial membrane potential. KMG-301 can indicate changes in mitochondrial Mg2+ concentration and shows Mg 2+ transport across the mitochondrial membrane in the early phases of a cellular model .
    KMG-301AM
  • HY-157922

    α-D-Glucopyranosyl-α-D-glucopyranoside monododecanoate

    Biochemical Assay Reagents Others
    Trehalose C12 (α-D-Glucopyranosyl-α-D-glucopyranoside monododecanoate) is a nonreducing disaccharide with amphiphilic property, which is used as emulsifier, surfactant, encapsulating materials, and in the biochemical researches of cellular processes and membrane interactions .
    Trehalose C12
  • HY-145258

    GABA Receptor Neurological Disease
    GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 µM. GABAA receptor agent 6 shows γ-GABAAR antagonist activity with low cellular membrane permeability .
    GABAA receptor agent 6
  • HY-145256

    GABA Receptor Neurological Disease
    GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 µM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential .
    GABAA receptor agent 4
  • HY-126220A

    Fluorescent Dye Others
    KMG-301AM TFA is the acetoxy methyl esterified form of KMG-301. KMG-301AM TFA successfully accumulates in mitochondria and then it is hydrolyzed to KMG-301. KMG-301 is an Mg 2+-selective fluorescent probe functional in mitochondria in intact cells. Since the mitochondrial membrane is impermeable to KMG-301, it is not released upon depolarization of the mitochondrial membrane potential. KMG-301 can indicate changes in mitochondrial Mg2+ concentration and shows Mg 2+ transport across the mitochondrial membrane in the early phases of a cellular model .
    KMG-301AM TFA
  • HY-145417

    Bacterial Infection
    G092 is a potent inhibitor of MsbA. MsbA is an ABC transporter. Transmembrane ATP-binding cassette (ABC) transporters are crucial cellular machines that move molecules small and large across membranes. G092 has the potential for the research of antimicrobial agents .
    G092
  • HY-D2376

    Fluorescent Dye Cancer
    BH-Vis is a two-photon fluorescent probe that inhibits cell plasma membrane (CPM). BH-Vis has great potential to accurately identify pyroptosis at the cellular level during AAA development in the mouse abdominal aortic aneurysm AAA model .
    BH-Vis
  • HY-13554

    Antibiotic Infection Cancer
    Annamycin is an antibiotic, that has high affinity for lipid membranes and can bypass the multidrug resistance protein-1 (MDR-1 ) mechanism of cellular drug resistance. Annamycin exhibits antitumor efficacy in multilamellar vesicles against solid tumor .
    Annamycin
  • HY-132178

    Endogenous Metabolite Metabolic Disease Cancer
    Cytochrome P450 is a family of monooxygenase enzymes that catalyzes the conversion of fatty acids to terminal alkenes using hydrogen peroxide as a cosubstrate. Cytochrome P450 as membrane-bound hemoproteins, plays important roles in the detoxification of drugs, cellular metabolism, and homeostasis .
    Cytochrome P450
  • HY-W777429

    Biochemical Assay Reagents
    Ceratamine B is a fluorescent substrate with significant biological activity and can be used for cell imaging and biolabeling. Ceratamine B can effectively penetrate cell membranes, facilitating the study of cellular processes. Ceratamine B also shows broad application potential in compound screening and biosensor development.
    Ceratamine B
  • HY-129308

    Herbicide Others
    LS 82-556 is a light and oxygen-dependent herbicide, which leads to degradation of fatty acids, deals structural damage at the cellular membrane level, and results in the bleaching, wilting, and desiccation of leaves and stems. LS 82-556 exhibits herbicidal activity with the presence of chloroplastic pigments .
    LS 82-556
  • HY-168066

    Fungal Infection
    Antifungal agent 117 is a bis-pyrazole carboxamide derivative with antifungal activity, exhibiting an EC50 value of 11.58 mg/L against Sclerotinia sclerotiorum. Antifungal agent 117 increases cell membrane permeability, causing an imbalance in osmotic pressure inside and outside the cell, and induces the accumulation of reactive oxygen species (ROS), leading to oxidative damage to the cell membrane, resulting in leakage of cellular contents and eventually cell death. RNA sequencing analysis reveals that Antifungal agent 117 downregulates catalase genes and upregulates neutral ceramidase genes, disrupting cell membrane structure, accelerating sphingolipid metabolism, and promoting cell death. Antifungal agent 117 shows great potential in the fields of plant protection and antifungal infection .
    Antifungal agent 117
  • HY-N8015

    Endogenous Metabolite Bacterial Fungal Infection Cancer
    Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL .
    Octanal
  • HY-P4135

    Fluorescent Dye Others
    FITC-LC-Antennapedia Peptide is a FITC labeled Antennapedia Peptide (HY-P0307). Antennapedia Peptide is a cellular-membrane permeable peptides (CPP). FITC-LC-Antennapedia Peptide has good penetration in 3T3 cell line, which was rapidly accumulated into nuclei .
    FITC-LC-Antennapedia Peptide
  • HY-D1672

    Fluorescent Dye Neurological Disease
    TMR Biocytin is a polar tracer used in the research of cell-cell and cell-liposome fusions, as well as membrane permeability and cellular uptake during pinocytosis. TMR Biocytin can be detected using streptavidin, and is an effective neuronal tracer in live tissue (Ex=544 nm, Em=571 nm) .
    TMR Biocytin
  • HY-139533

    Biochemical Assay Reagents Others
    Phosphatidylinositols, soya, sodium salts is a mixture of phosphatidylinositols. Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics .
    Phosphatidylinositols, soya, sodium salts
  • HY-W800798

    1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(cyanur)

    Liposome Cancer
    16:0 Cyanur PE is a cyanur-functionalized lipid attached to a phosphoethanolamine linked to two palmitic acid groups.
    16:0 Cyanur PE
  • HY-W440724

    Liposome Cancer
    Cholesterol-PEG-Thiol (MW 3400) is an amphiphatic PEG derivative which forms micelles in water and can be used to prepare liposomes or nanoparticles for drug delivery system. The thiol moiety is reactive with maleimide to form a stable thioether bond.
    Cholesterol-PEG-Thiol (MW 3400)
  • HY-W343736

    1,3-DPPE; 1,3-Dipalmitoyl-sn-glycero-2-PE

    Liposome Cancer
    1,3-Dipalmitoyl-glycero-2-phosphoethanolamine is a phospholipid containing the saturated long-chain (16:0) stearic acid inserted at the sn-1 and sn-3 positions and PE at the sn-2 site. It can be used in the generation of micelles, liposomes, and other types of artificial membranes.
    1,3-Dipalmitoyl-glycero-2-phosphoethanolamine
  • HY-W591461

    Liposome Cancer
    DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
    DSPE-PEG-COOH, MW 2000
  • HY-W440991

    Liposome Cancer
    DOPE-PEG-Amine (MW 2000) is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelle formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and is reactive with alkyne to form a triazole ring.
    DOPE-PEG-Amine (MW 2000)
  • HY-138913

    Liposome Cancer
    2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
    2H-Cho-Arg TFA
  • HY-W590535

    1,2-DNPC; 1,2-Dinonadecanoyl-sn-glycero-3-phosphocholine

    Liposome Cancer
    19:0 PC is a saturated phospholipid that has been used as a standard for the quantification of phosphatidylcholines in human synovial fluid. It has also been used to study dynamics of lipid bilayer phase transition.
    19:0 PC
  • HY-W440711

    Liposome Cancer
    Cholesterol-PEG-Biotin (MW 2000) is a pegylated lipids which has strong binding to avidin or streptavidin.
    Cholesterol-PEG-Biotin (MW 2000)
  • HY-W800777

    Liposome Cancer
    6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.
    6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate
  • HY-W440957

    PC(16:0/14:0); 1-palmitoyl-2-myristoyl-sn-glycero-3-phosphocholine

    Liposome Cancer
    PMPC is a phosphatidylcholine with asymmetrical fatty acid. Palmitic acid occupies sn-1 position while myristic acid is placed at the sn-2 position.
    PMPC
  • HY-W440690

    Liposome Cancer
    Cholesterol-PEG-Amine (MW 2000) is a pegylated lipids which can be used for preparation of liposome or nanoparticle. The lipophilic moiety can encapsulate hydrophobic drugs whereas the hydrophilic PEG chain helps the overal water solubility of the micelles.
    Cholesterol-PEG-Amine (MW 2000)
  • HY-W590555

    Liposome Cancer
    Thiol-PEG-DMG, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
    Thiol-PEG-DMG, MW 2000
  • HY-141615

    PDME; 16:0 Dimethyl PE

    Liposome Cancer
    1,2-Dipalmitoyl-sn-glycero-3-phospho-N,N-dimethylethanolamine has been used in the generation of liposomes and monolayers for use in the study of membrane permeability and monolayer viscosity, respectively.
    1,2-Dipalmitoyl-sn-glycero-3-phospho-N,N-dimethylethanolamine
  • HY-W800796

    1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(biotinyl)

    Liposome Cancer
    18:1 Biotinyl PE is a biotin-functionalized lipid attached to a phosphoethanolamine linked to two oleic acid groups.
    18:1 Biotinyl PE
  • HY-W800825

    Liposome Cancer
    Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
    Octadecanedioic acid mono-L-carnitine ester
  • HY-W800789

    Liposome Cancer
    16:0 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a phenyl maleimide group.
    16:0 MPB PE