Search Result
Results for "
esterases
" in MedChemExpress (MCE) Product Catalog:
10
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D2277
-
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Fluorescent Dye
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Others
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Fluorescein-CM2 is a fluorogenic molecule that can be used to rapidly screen esterase cut sites for protein-protein interaction-dependent (PPI-dependent) esterase activity in E. coli .
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- HY-100085
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21-desDFZ
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Drug Metabolite
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Inflammation/Immunology
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21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .
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- HY-E70100
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AXEs
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Biochemical Assay Reagents
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Others
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Acetylxylan esterases (AXEs) belongs to carbohydrate esterase family 4 (CE4). Acetylxylan esterases catalyzes the deacetylation of acetylated carbohydrates .
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- HY-124258
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- HY-E70409
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Endogenous Metabolite
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Metabolic Disease
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Diacetinase, Bacillus subtilis is a member of the esterase family and is responsible for catalyzing the hydrolysis of diacetin. This enzyme is used in the measurement of lipase activity .
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-
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- HY-156984
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- HY-131736
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-
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- HY-D1678
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Fluorescent Dye
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Others
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5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm) .
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- HY-143252
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Cholinesterase (ChE)
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Metabolic Disease
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CEase-IN-1 (Compound A1H3) is a potent and selective cholesterol esterase (CEase) inhibitor with an IC50 of 0.36 μM. CEase-IN-1 can be used for the research of hypercholesterolemia .
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- HY-123120
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Thrombin
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Others
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SA-152 is an organophosphorus inhibitor. SA-152 modulates the fibrinogen coagulation and TAME esterase activity of bovine α-thrombin .
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- HY-132409S
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-
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- HY-W275616
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Others
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Others
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4-Methylumbelliferyl nonanoate is a fluorogenic substrate of esterases. 4-Methylumbelliferyl nonanoate can be hydrolyzed to 4-methylumbelliferone with bright blue fluorescence .
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- HY-145127
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C3-CA-DTZ
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Fluorescent Dye
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Neurological Disease
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ETZ (C3-CA-DTZ) is a promising luciferase substrate (prosubstrate) activatable in vivo by nonspecific esterase to enhance the brain delivery of the luciferin .
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- HY-100085R
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Drug Metabolite
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Inflammation/Immunology
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21-Desacetyldeflazacort (Standard) is the analytical standard of 21-Desacetyldeflazacort. This product is intended for research and analytical applications. 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .
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- HY-107010A
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Adrenergic Receptor
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Cardiovascular Disease
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Esprolol hydrochloride is an orally active and potent β-adrenergic receptor antagonist. Esprolol hydrochloride undergoes rapid metabolism by blood and tissue esterases to form an active metabolite, amoxolol. Esprolol hydrochloride is promising for research of exertional angina .
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- HY-107010
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Adrenergic Receptor
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Cardiovascular Disease
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Esprolol is an orally active and potent β-adrenergic receptor antagonist. Esprolol is rapidly metabolized by blood and tissue esterases to form the active metabolite amoxolol. Esprolol holds potential for research in exercise-induced angina .
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- HY-126561
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CMFDA
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Fluorescent Dye
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Others
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Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope .
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- HY-131131
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Fluorescent Dye
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Others
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5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .
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- HY-131842
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N6-Benzyladenosine-3',5'-cyclic monophosphate
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PKA
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Cancer
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6-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinase (PKA) which does not activate Epac. 6-Bn-cAMP increases hydrolytic stability against PDE, esterases, amidases and considerably higher membrane permeability compared to cAMP .
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- HY-19651B
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TAK-147 fumarate
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Cholinesterase (ChE)
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Neurological Disease
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Zanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD) .
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- HY-19651A
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TAK-147
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Cholinesterase (ChE)
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Neurological Disease
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Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil can be used for the research of early stages of Alzheimer's disease (AD) .
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- HY-19651
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TAK-147 free base
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Cholinesterase (ChE)
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Neurological Disease
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Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD) .
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- HY-106429
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Reactive Oxygen Species
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Others
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OT-551 (free base) is a lipophilic, disubstituted hydroxylamine with antioxidant properties. OT-551 can be used as an eye drop and can be converted by intraocular esterases to its active metabolite, Tempol-H (TP-H). OT-551 can be utilized in geographic atrophy and macular degeneration research .
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- HY-135036
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Fluorescent Dye
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Others
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4-Methylumbelliferyl butyrate (4-MUB) is a coumarin-based fluorogenic substrate used for the identification of M. catarrhalis C4- esterase. 4-Methylumbelliferyl butyrate can converse to the blue-emissive 4-methylumbelliferone (4-MU; HY-N0187) .
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- HY-18522
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Phospholipase
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Metabolic Disease
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AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .
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- HY-116016
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L-DOPA ethyl ester; Levodopa ethyl ester
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Dopamine Receptor
Drug Metabolite
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Neurological Disease
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Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine .
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- HY-116016A
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L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride
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Dopamine Receptor
Drug Metabolite
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Neurological Disease
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Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine .
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- HY-W411215
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Fluorescent Dye
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Others
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1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH .
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- HY-E70361
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Unsonicated White Blood Cell Esterase, WBC Esterase
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Biochemical Assay Reagents
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Others
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Whole Leukocyte Esterase, Human (Unsonicated White Blood Cell Esterase, WBC Esterase) is a biological material or organic compound that can be used in life science research .
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- HY-E70124B
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- HY-E70124A
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- HY-E70124C
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- HY-52112
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5-bromo-4-chloroindoxyl acetate
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Fluorescent Dye
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Others
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BCDA (5-bromo-4-chloroindoxyl acetate) is a chromogenic substrate of esterase used to potently detect the activity of esterase .
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- HY-E70115
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Others
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Others
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Feruloyl esterase plays a major role in the degradation of plant biomass. Feruloyl esterase catalyzes the cleavage and formation of ester bonds between plant cell wall polysaccharide and phenolic acid .
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- HY-P2879C
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Endogenous Metabolite
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Metabolic Disease
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Cholesterol esterase, Schizophyllum commune is an enzyme that catalyzes the hydrolysis of cholesterol esters into free cholesterol and fatty acids, facilitating the absorption of cholesterol in the intestine.
Cholesterol esterase, Schizophyllum commune can be used in combination with cholesterol oxidase to measure cholesterol content .
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- HY-P2879A
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Endogenous Metabolite
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Metabolic Disease
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Cholesterol esterase, Porcine pancreas is an enzyme that hydrolyzes cholesterol ester to cholesterol and free fatty acid in the intestinal lumen. Cholesterol synthesized in the acinar cells and is stored in zymogen granules. Cholesterol esterase is also known as bile salt-stimulated lipase and carboxy ester lipasea, acts function for acceleration of cholesterol absorption.
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- HY-P2879
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Endogenous Metabolite
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Metabolic Disease
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Cholesterol esterase, Pseudomonas is an enzyme that hydrolyzes cholesterol ester to cholesterol and free fatty acid in the intestinal lumen. Cholesterol synthesized in the acinar cells and is stored in zymogen granules. Cholesterol esterase is also known as bile salt-stimulated lipase and carboxy ester lipasea, acts function for acceleration of cholesterol absorption .
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- HY-103610
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p-Anisil
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Cholinesterase (ChE)
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Cancer
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4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM.
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- HY-B1323
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Dipivefrine hydrochloride
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Endogenous Metabolite
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Neurological Disease
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Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea .
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- HY-19861
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- HY-P4772
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- HY-P2831
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CESs
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Endogenous Metabolite
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Metabolic Disease
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Esterase, pig liver (CESs), namely carboxylate hydrolases, are widely distributed in nature, commonly found in mammalian liver, and often used in biochemical research. Esterase catalyzes the hydrolysis of a variety of endogenous and exogenous substrates, including esters, thioesters, carbamates, and amides, hydrolyzing carboxylic acid esters to the corresponding alcohols and carboxylic acids .
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- HY-145235
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- HY-W638077
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- HY-D0719
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3,6-Diacetoxyfluoran; Di-O-acetylfluorescein
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Biochemical Assay Reagents
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Others
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Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
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- HY-167885
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iGluR
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Neurological Disease
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SN-35210 free base, an ester analogue, is designed for rapid offset via esterase-mediated hydrolysis .
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- HY-157797
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Others
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Cancer
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SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI)-dependent esterase to mediate cell death in MDA-MB-231 cells .
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- HY-102054
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FAAH
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Cardiovascular Disease
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Acetylhydrolase-IN-1 is a 1-Alkyl-2-acetylglycerophosphocholine esterase (Alkylacetyl-GPC: acetylhydrolase) inhibtor.
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- HY-163780
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Parasite
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Infection
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Nematicidal agent 1 is a potent nematicidal agent. Nematicidal agent 1 binds to the pocket of acetylcholine esterase (AChE) .
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- HY-P6079
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- HY-E70319
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Immobilized cephalosporin C or 7-ACA esterase
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Endogenous Metabolite
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Others
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AMK-EX (Immobilized cephalosporin C or 7-ACA esterase) is an immobilized enzyme, among which cephalosporin C C/7-ACA esterase is a type of enzyme that can hydrolyze the ester bond of cephalosporin C or 7-ACA. Immobilized enzyme is a technology that immobilizes enzymes on carriers, which can be easily separated and recovered, improving the stability, activity and reusability of enzymes .
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- HY-P6079A
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Biochemical Assay Reagents
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Others
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Ac-IHIHIYI-NH2 TFA is an amyloid self-assembling peptide variant that can be used as a bioactive nanomaterial with esterase activity .
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- HY-114336
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Phosphatase
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Inflammation/Immunology
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Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .
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- HY-D0158
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- HY-B1323S
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Dipivefrine-d6 hydrochloride
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Isotope-Labeled Compounds
Endogenous Metabolite
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Neurological Disease
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Dipivefrin-d6 (hydrochloride) is deuterium labeled Dipivefrin (hydrochloride). Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea[1][2].
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- HY-W142459
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Biochemical Assay Reagents
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Others
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Naphthol AS-D, in the form of its chloroacetate, can be used to demonstrate the esterase activity of human myeloid cells and contribute to research related to white blood cells .
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- HY-P2895
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Clostridiopeptidase B
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Endogenous Metabolite
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Others
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Clostripain (Clostridiopeptidase B) is a proteolytic enzyme isolated from Clostridium histolyticum with esterase, amidase and protease activities and is a highly specific carboxypeptide targeting arginine key protease .
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- HY-D1758
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Fluorescent Dye
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Others
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Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
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- HY-D1759
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Fluorescent Dye
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Others
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Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
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- HY-B1323R
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Endogenous Metabolite
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Neurological Disease
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Dipivefrin (hydrochloride) (Standard) is the analytical standard of Dipivefrin (hydrochloride). This product is intended for research and analytical applications. Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea .
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- HY-131474
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3-Hydroxy-2-naphthoic-o-toluidide chloroacetate,98% (TLC)
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Biochemical Assay Reagents
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Others
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Naphthol AS-D chloroacetate, 98% (TLC) (3-Hydroxy-2-naphthoic-o-toluidide chloroacetate, 98% (TLC)) is a substrate for esterase histochemical localization.
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- HY-P2424
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- HY-W099563
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Biochemical Assay Reagents
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Others
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4-Nitrophenyl stearate, which is an ester formed by the condensation of stearic acid and 4-nitrophenol, is commonly used as a substrate for enzymatic assays, where the hydrolysis of ester bonds by esterase and lipase can be measured by absorbance or ratio In addition, 4-Nitrophenyl stearate has been used as a model compound to study the enzymatic activity and selectivity of lipases and esterases from various sources. The long hydrophobic tail of the molecule makes it suitable for use in lipophilic Good solubility in the environment makes it a useful probe for studying lipid metabolism.
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- HY-B0305A
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HOE 760
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Histamine Receptor
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Metabolic Disease
Inflammation/Immunology
Cancer
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Roxatidine Acetate Hydrochloride is a potent, selective, competitive and orally active histamine H2-receptor antagonist. Roxatidine Acetate Hydrochloride has antisecretory potency against gastric acid secretion. Roxatidine Acetate Hydrochloride can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine Acetate Hydrochloride has antitumor activity .
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- HY-114879
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DDAO
1 Publications Verification
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Fluorescent Dye
Carboxylesterase (CES)
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Cancer
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DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .
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- HY-13538
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CP-4126; CO-101; Gemcitabine 5'-elaidate
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Nucleoside Antimetabolite/Analog
Autophagy
Apoptosis
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Cancer
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Gemcitabine elaidate (CP-4126) is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity .
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- HY-D0719R
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Biochemical Assay Reagents
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Others
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Fluorescein Diacetate (Standard) is the analytical standard of Fluorescein Diacetate. This product is intended for research and analytical applications. Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
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- HY-D1176
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Fluorescent Dye
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Others
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Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .
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- HY-13538A
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CP-4126 hydrochloride; CO-101 hydrochloride; Gemcitabine 5'-elaidate hydrochloride
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Nucleoside Antimetabolite/Analog
Autophagy
Apoptosis
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Cancer
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Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity .
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- HY-159860
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Liposome
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Others
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IR-117-17 is an ionizable cationic amino lipid, targeting the conducting airways. IR-117-17 could be degraded via esterase cleavage and thus be unlikely to accumulate upon repeated dosing .
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- HY-E70362
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BCHE, BuChE, PCHE, pseudocholinesterase, plasma cholinesterase, Acylcholine acyl-hydrolase, Choline esterase, butyryl
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Others
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Others
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Butyrylcholinesterase (BCHE), Horse Serum (BCHE, BuChE, PCHE, pseudocholinesterase, plasma cholinesterase, Acylcholine acyl-hydrolase, Choline esterase, butyryl) is a biological material or organic compound that can be used in life science research .
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- HY-W399193
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Prostaglandin F2α 1,9-lactone
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Prostaglandin Receptor
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Metabolic Disease
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PGF2α 1,9-lactone (Prostaglandin F2α 1,9-lactone) is a prostaglandin lactone. PGF2α 1,9-lactone shows resistant to hydrolysis by plasma esterases .
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- HY-134451
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DEUP
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Endogenous Metabolite
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Metabolic Disease
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Diethylumbelliferyl phosphate (DEUP), a selective and potent inhibitor of cholesterol esterase, does not inhibit protein kinase activity A in vitro, and it effectively disrupts steroidogenesis by blocking the transport of cholesterol into the mitochondria of steroidogenic cells, with an IC50 of 11.6 μM, potentially limiting dietary cholesterol absorption.
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- HY-D0717
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Diaminofluorescein-FM diacetate
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Fluorescent Dye
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Others
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DAF-FM DA (Diaminofluorescein-FM diacetate) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) .
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- HY-118222
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Cholinesterase (ChE)
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Neurological Disease
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KBR 2822 is an inhibitor of neurological target esterase (NTE) and has an inhibitory effect on AChE. KBR 2822 can aggravate neurological damage under certain conditions, but does not cause neurological disease when used alone in the absence of direct neurotoxicity or biochemical damage.
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- HY-106409
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CHR-2845
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HDAC
Apoptosis
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Cancer
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Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .
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- HY-19137
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KW 2189 free base
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Antibiotic
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Infection
Cancer
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Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC50 of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase .
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- HY-W127699
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N,N,N-Trimethyl-2-(propionyloxy)ethanaminium (p-toluenesulfonate)
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Biochemical Assay Reagents
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Others
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Propionylcholine (p-toluenesulfonate) is an organic compound commonly used in biochemical research and neuroscience research. It can be used to study cholinergic signal transduction and esterase activity, and is widely used in biomedical research and pharmacological research. In addition, this compound is also used as a substrate or catalyst in certain biochemical reactions.
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- HY-E70343
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Endogenous Metabolite
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Others
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Human leukocyte esterase (unsonicated) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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- HY-W039923
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Insulin Receptor
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Endocrinology
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β-D-Galactose pentaacetate is a negative regulator of insulin with plasma membrane penetrating ability and can be hydrolyzed by intracellular esterases. β-D-Galactose pentaacetate inhibits leucine-induced insulin release in Wistar rat islets, potentially preventing excessive insulin release in pathological conditions .
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- HY-W320032
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Fluorescent Dye
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Others
|
|
5-Bromo-1H-indol-3-yl octanoate is a chromogenic substrate for esterase with C8 activity. 5-Bromo-1H-indol-3-yl octanoate yields a blue precipitate when cleaved.
|
-
- HY-B0732
-
|
HSR803
|
Cholinesterase (ChE)
Dopamine Receptor
Bacterial
|
Neurological Disease
|
|
Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD) .
|
-
- HY-126564
-
|
|
Lipase
MetAP
|
Others
Inflammation/Immunology
|
|
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis .
|
-
- HY-D1643
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca 2+. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand .
|
-
- HY-161062
-
|
|
EAAT
|
Neurological Disease
|
|
TAOA AM Ester trimethyl lock is a high-affinity fluorescent prodrug-like inhibitor of the excitatory amino acid transporter (EAAT). It can penetrate the cell membrane and be activated by hydrolysis by endogenous cell esterases to form active EAAT inhibitors. TAOA AM Ester trimethyl lock can be used to study neurodegeneration and neuronal cell death .
|
-
- HY-P10765
-
|
|
Peptide-Drug Conjugates (PDCs)
Topoisomerase
|
Cancer
|
|
DTS-108 is a prodrug of SN38 (HY-13704) (a Topoisomerase I inhibitor). DTS-108 is a conjugate generated by linking SN38 to a human oligopeptide via an esterase sensitive cross-linker. DTS-108 exhibits anti-tumor activity against colorectal, lung, and mammary cancer .
|
-
- HY-D1739
-
|
|
Fluorescent Dye
Carboxylesterase (CES)
|
Others
|
|
DDAO phosphate diammonium is a fluorescent phosphatase substrate. DDAO phosphate diammonium has tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm). DDAO phosphate diammonium can be used to detect the activity of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.
|
-
- HY-B0577
-
|
PHXA41
|
Prostaglandin Receptor
|
Cardiovascular Disease
Others
|
|
Latanoprost (PHXA41) is a prostaglandin F2α analogue and can be used for glaucoma research. Latanoprost can effectively pass through cornea and be hydrolyzed by esterase to latanoprost acid. latanoprost acid is an F-prostaglandin (FP) receptor agonist, and can effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through uvea .
|
-
- HY-B0732A
-
|
HSR803 free base
|
Cholinesterase (ChE)
Dopamine Receptor
Bacterial
|
Others
|
|
Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD) .
|
-
- HY-15929
-
|
2,4,6-Tribromo-3-hydroxybenzoic acid
|
Biochemical Assay Reagents
|
Others
|
|
The Boehringer Mannheim cholesterol esterase/cholesterol oxidase/peroxidase/3,4-dichlorophenol kinetic reagent was modified by the inclusion of TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) which reacts with hydrogen peroxide and 4-aminophenazone to produce a quinone-imine dye with a greater molar absorptivity than that produced with phenol.
|
-
- HY-108751
-
|
|
Others
|
Neurological Disease
|
|
Aripiprazole lauroxil, an N-acyloxymethyl proagent of Aripiprazole (HY-14546), is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia and a ligand of dopamine receptor D2R/D4R. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.
|
-
- HY-130431
-
|
|
Parasite
|
Infection
|
|
Vinclozolin M2 is an active metabolite of vinclozolin. It is formed from vinclozolin by successive esterase activity and decarboxylation of vinclozolin in C. elegans and by decarboxylation in human liver microsomes. Vinclozolin M2 is an antagonist of the mineralocorticoid receptor (IC50=1,400 nM) and androgen receptor (IC50=0.17 nM) in reporter assays using MCF-7 cells.
|
-
- HY-76569B
-
|
PNU-200577 formic
|
mAChR
|
Neurological Disease
|
|
5-Hydroxymethyl tolterodine (formate) (PNU-200577 (formic)) is an active metabolite of the muscarinic acetylcholine receptor antagonists Tolterodine (HY-A0024) and Fesoterodine (HY-70053). 5-Hydroxymethyl tolterodine (formate) is formed from tolterodine by the cytochrome P450 (CYP) isoform CYP2D6 and from fesoterodine by plasma esterases.
|
-
- HY-130575
-
|
|
Fluorescent Dye
|
Others
|
|
Fura-FF AM is a cell-permeable acetoxymethyl ester of fura-FF, a dluorescent calcium indicator. Fura-FF AM is hydrolyzed by intracellular esterases to release fura-FF in cells. Fura-FF is a difluorinated derivative of the calcium indicator fura-2. Compared to fura-2, fura-FF has a low affinity for calcium and is suitable for studying compartments with high concentrations of calcium.
|
-
- HY-103370
-
|
BA 7602-06
|
Chloride Channel
|
Inflammation/Immunology
|
|
Talniflumate (BA 7602-06) is the proagent of Niflumic acid (HY-B0493), exerting its activity in the body through conversion to niflumic acid by esterase . Talniflumate is an orally active Ca 2+-activated Cl - channel (CaCC) blocker. Talniflumate can be used as an analgesic and anti-inflammatory agent in cystic fibrosis mouse model of distal intestinal obstructive syndrome .
|
-
- HY-D0716
-
|
Fluo-3-pentaacetoxymethyl ester
|
Fluorescent Dye
|
Others
|
|
Fluo-3 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-P2879B
-
|
|
Endogenous Metabolite
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Cholesterol esterase, Candida cylindracea is an enzyme located in the intestines that hydrolyzes cholesterol esters into cholesterol and free fatty acids. Also known as bile salt-stimulated lipase or carboxylester lipase, this enzyme facilitates cholesterol metabolism and absorption in the body. It can also be used as a biochemical reagent, and is employed in conjunction with cholesterol oxidase (HY-P2848) to measure cholesterol levels .
|
-
- HY-141749B
-
|
CLPM hydrochloride; SR 26334 hydrochloride
|
Drug Metabolite
|
Cardiovascular Disease
|
|
Clopidogrel carboxylic acid (CLPM) hydrochloride is an inactive metabolite of the widely used antiplatelet medication clopidogrel, which serves as a reference standard for quantitative analysis of clopidogrel metabolism. Clopidogrel carboxylic acid hydrochloride has been shown to represent approximately 85% of circulating clopidogrel, hydrolyzed from the active form by esterases. Clopidogrel carboxylic acid hydrochloride plays a crucial role in assessing the pharmacokinetics and bioavailability of clopidogrel in various clinical and research settings.
|
-
- HY-114584
-
|
|
Ser/Thr Protease
|
Neurological Disease
|
|
A-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain). A-953227 has enhanced selectivity for related cysteine proteases (cathepsins) and has shown good efficacy in cell experiments. A-953227 has shown broad efficacy in preclinical models for Alzheimer's disease, suggesting that it has potential benefits in inhibiting Alzheimer's disease .
|
-
- HY-B0732R
-
|
|
Cholinesterase (ChE)
Dopamine Receptor
Bacterial
|
Neurological Disease
|
|
Itopride (hydrochloride) (Standard) is the analytical standard of Itopride (hydrochloride). This product is intended for research and analytical applications. Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD) .
|
-
- HY-101902
-
|
Quin-2 acetoxymethyl ester
|
Fluorescent Dye
|
Others
|
|
Quin-2AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-155599
-
|
|
HIV
PKC
|
Infection
|
|
HIV-1 protease-IN-10 (Compound 2) has HIV-1 latency reversing activity (IC50: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC50: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis .
|
-
- HY-D1498
-
|
|
Fluorescent Dye
|
Others
|
|
Mag-Fluo-4 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-D0722
-
|
5-(6)-Carboxyfluorescein diacetate; CFDA
|
Fluorescent Dye
|
Others
|
|
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
|
-
- HY-D1746
-
|
EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
|
Biochemical Assay Reagents
|
Others
|
|
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
|
-
- HY-108204
-
|
THRX 918661
|
GABA Receptor
|
Others
|
|
AZD 3043 (THRX 918661) is a positive allosteric modulator of GABA(A) receptors with sedative and hypnotic activity. AZD 3043 can enhance GABA(A) receptor-mediated chloride currents in vitro and produce hypnotic and electroencephalographic inhibitory effects in vivo. Due to its esterase-dependent metabolic pathway, it has a short duration of action and can be quickly cleared even after long-term infusion, which may have clinical application potential.
|
-
- HY-134345
-
|
8-(4-Chlorophenylthio)-cGMP-AM
|
PKG
|
Neurological Disease
|
|
8-pCPT-cGMP-AM (8-(4-Chlorophenylthio)-cGMP-AM) is a highly membrane permeable prodrug of the PKG agonist 8-pCPT-cGMP, which increases the membrane permeability of cGMP and is converted to its active form by esterase hydrolysis within the cell, thereby activating PKG. 8-pCPT-cGMP-AM can be used to explore the role of cGMP signaling in neural plasticity and memory formation .
|
-
- HY-W013168
-
|
4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp
|
Bacterial
|
Infection
|
|
4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate) is a colorimetric lipase and esterase substrate. Upon enzymatic hydrolysis of 4-Nitrophenyl palmitate, 4-nitrophenol is released, which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipase.
|
-
- HY-D0041
-
Calcein-AM
Maximum Cited Publications
57 Publications Verification
Calcein acetoxymethyl ester
|
Fluorescent Dye
|
Cancer
|
|
Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .
|
-
- HY-P10053
-
|
|
Phospholipase
|
Metabolic Disease
|
|
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .
|
-
- HY-W423573
-
|
|
Amino Acid Derivatives
|
Others
Metabolic Disease
|
|
N,S-Diacetylcysteine methyl ester is a cysteine derivative that can increase the levels of intracellular cysteine and glutathione. N,S-Diacetylcysteine methyl ester is hydrolyzed by intracellular esterase to release cysteine, thereby promoting the synthesis of glutathione. Due to its acetylation properties, N,S-Diacetylcysteine methyl ester has better cell membrane permeability and can enter the cell more effectively. N,S-Diacetylcysteine methyl ester can be used to study the intracellular cysteine and glutathione (GSH) transport system .
|
-
- HY-W014449
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl butyrate consists of butyric acid chains esterified with 4-nitrophenol groups, thus giving it a yellow color. This compound is commonly used as a substrate in enzyme assays to measure esterase and lipase activity. When these enzymes cleave the ester bond, the nitrophenol group is released and the color changes from yellow to orange. Thus, the rate of color change can be used to determine enzyme activity. In addition, 4-Nitrophenyl butyrate can also be used as organic synthesis reagent and dye intermediate.
|
-
- HY-116016AR
-
-
- HY-116016R
-
|
|
Dopamine Receptor
Drug Metabolite
|
Neurological Disease
|
|
Chlorbenside (Standard) is the analytical standard of Chlorbenside. This product is intended for research and analytical applications. Chlorbenside is an organochlorine pesticide. Chlorbenside targets organism such as mites and ticks and possesses efficient ovicidal and larvicidal activities .
|
-
- HY-146678
-
|
|
HDAC
Amyloid-β
Cholinesterase (ChE)
|
Neurological Disease
|
|
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity .
|
-
- HY-146679
-
|
|
HDAC
Amyloid-β
Cholinesterase (ChE)
|
Neurological Disease
|
|
HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity .
|
-
- HY-D1701
-
|
|
Fluorescent Dye
|
Others
|
|
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.
MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
|
-
- HY-101898
-
|
Indo-1 Acetoxymethyl ester
|
Fluorescent Dye
|
Others
|
|
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.
MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
|
-
- HY-P2875
-
|
|
Endogenous Metabolite
|
Others
|
|
Hemicellulase is a hemicellulose-targeting hydrolase that breaks down the binding of glucose and polymers to water molecules present in plant fibers. Hemicellulase specifically degrades hemicellulose (such as xylan and mannan) in plant cell walls by hydrolyzing β-1,4-xylosidic bonds and ester bonds (such as acetyl and ferulic acid ester bonds) . Hemicellulase relies on the synergistic action of the glycoside hydrolase (GH) and carbohydrate esterase (CE) families to achieve efficient hydrolysis through acid-base catalysis (such as Glu/Asp residues) and substrate binding pockets. Hemicellulase can be used in the food industry (such as improving bread texture)， biofuel production (lignocellulose pretreatment) and paper industry (biobleaching) .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D2277
-
|
|
Fluorescent Dyes/Probes
|
|
Fluorescein-CM2 is a fluorogenic molecule that can be used to rapidly screen esterase cut sites for protein-protein interaction-dependent (PPI-dependent) esterase activity in E. coli .
|
-
- HY-126561
-
|
CMFDA
|
Fluorescent Dyes/Probes
|
|
Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope .
|
-
- HY-131131
-
|
|
Fluorescent Dyes/Probes
|
|
5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .
|
-
- HY-52112
-
|
5-bromo-4-chloroindoxyl acetate
|
Chromogenic Substrates
|
|
BCDA (5-bromo-4-chloroindoxyl acetate) is a chromogenic substrate of esterase used to potently detect the activity of esterase .
|
-
- HY-D0719
-
|
3,6-Diacetoxyfluoran; Di-O-acetylfluorescein
|
Dyes
Enzyme Substrates
|
|
Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
|
-
- HY-114879
-
DDAO
1 Publications Verification
|
Fluorescent Dyes/Probes
|
|
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .
|
-
- HY-D1678
-
|
|
Fluorescent Dyes/Probes
|
|
5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm) .
|
-
- HY-W411215
-
|
|
Fluorescent Dyes/Probes
|
|
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH .
|
-
- HY-D1758
-
|
|
Fluorescent Dyes/Probes
|
|
Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
|
-
- HY-D1759
-
|
|
Fluorescent Dyes/Probes
|
|
Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
|
-
- HY-D0719R
-
|
|
Dyes
Enzyme Substrates
|
|
Fluorescein Diacetate (Standard) is the analytical standard of Fluorescein Diacetate. This product is intended for research and analytical applications. Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
|
-
- HY-D1176
-
|
|
Fluorescent Dyes/Probes
|
|
Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .
|
-
- HY-D0717
-
|
Diaminofluorescein-FM diacetate
|
Chromogenic Assays
|
|
DAF-FM DA (Diaminofluorescein-FM diacetate) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) .
|
-
- HY-W320032
-
|
|
Chromogenic Substrates
|
|
5-Bromo-1H-indol-3-yl octanoate is a chromogenic substrate for esterase with C8 activity. 5-Bromo-1H-indol-3-yl octanoate yields a blue precipitate when cleaved.
|
-
- HY-D1739
-
|
|
Fluorescent Dyes/Probes
|
|
DDAO phosphate diammonium is a fluorescent phosphatase substrate. DDAO phosphate diammonium has tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm). DDAO phosphate diammonium can be used to detect the activity of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.
|
-
- HY-130575
-
|
|
Fluorescent Dyes/Probes
|
|
Fura-FF AM is a cell-permeable acetoxymethyl ester of fura-FF, a dluorescent calcium indicator. Fura-FF AM is hydrolyzed by intracellular esterases to release fura-FF in cells. Fura-FF is a difluorinated derivative of the calcium indicator fura-2. Compared to fura-2, fura-FF has a low affinity for calcium and is suitable for studying compartments with high concentrations of calcium.
|
-
- HY-D0716
-
|
Fluo-3-pentaacetoxymethyl ester
|
Fluorescent Dyes/Probes
|
|
Fluo-3 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-101902
-
|
Quin-2 acetoxymethyl ester
|
Fluorescent Dyes/Probes
|
|
Quin-2AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-D1498
-
|
|
Fluorescent Dyes/Probes
|
|
Mag-Fluo-4 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-D0722
-
|
5-(6)-Carboxyfluorescein diacetate; CFDA
|
Fluorescent Dyes/Probes
|
|
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
|
-
- HY-D1746
-
|
EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
|
Fluorescent Dyes/Probes
|
|
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
|
-
- HY-W013168
-
|
4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp
|
Dyes
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4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate) is a colorimetric lipase and esterase substrate. Upon enzymatic hydrolysis of 4-Nitrophenyl palmitate, 4-nitrophenol is released, which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipase.
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- HY-D0041
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Calcein-AM
Maximum Cited Publications
57 Publications Verification
Calcein acetoxymethyl ester
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Fluorescent Dyes/Probes
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Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .
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- HY-D1701
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Fluorescent Dyes/Probes
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Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.
MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
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- HY-101898
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Indo-1 Acetoxymethyl ester
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Fluorescent Dyes/Probes
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Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.
MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
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| Cat. No. |
Product Name |
Type |
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- HY-D0719
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3,6-Diacetoxyfluoran; Di-O-acetylfluorescein
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Dyes
Enzyme Substrates
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Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
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- HY-W099563
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Enzyme Substrates
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4-Nitrophenyl stearate, which is an ester formed by the condensation of stearic acid and 4-nitrophenol, is commonly used as a substrate for enzymatic assays, where the hydrolysis of ester bonds by esterase and lipase can be measured by absorbance or ratio In addition, 4-Nitrophenyl stearate has been used as a model compound to study the enzymatic activity and selectivity of lipases and esterases from various sources. The long hydrophobic tail of the molecule makes it suitable for use in lipophilic Good solubility in the environment makes it a useful probe for studying lipid metabolism.
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- HY-W127699
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N,N,N-Trimethyl-2-(propionyloxy)ethanaminium (p-toluenesulfonate)
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Cell Assay Reagents
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Propionylcholine (p-toluenesulfonate) is an organic compound commonly used in biochemical research and neuroscience research. It can be used to study cholinergic signal transduction and esterase activity, and is widely used in biomedical research and pharmacological research. In addition, this compound is also used as a substrate or catalyst in certain biochemical reactions.
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- HY-W039923
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Carbohydrates
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β-D-Galactose pentaacetate is a negative regulator of insulin with plasma membrane penetrating ability and can be hydrolyzed by intracellular esterases. β-D-Galactose pentaacetate inhibits leucine-induced insulin release in Wistar rat islets, potentially preventing excessive insulin release in pathological conditions .
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- HY-15929
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2,4,6-Tribromo-3-hydroxybenzoic acid
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Biochemical Assay Reagents
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The Boehringer Mannheim cholesterol esterase/cholesterol oxidase/peroxidase/3,4-dichlorophenol kinetic reagent was modified by the inclusion of TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) which reacts with hydrogen peroxide and 4-aminophenazone to produce a quinone-imine dye with a greater molar absorptivity than that produced with phenol.
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- HY-W014449
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Enzyme Substrates
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4-Nitrophenyl butyrate consists of butyric acid chains esterified with 4-nitrophenol groups, thus giving it a yellow color. This compound is commonly used as a substrate in enzyme assays to measure esterase and lipase activity. When these enzymes cleave the ester bond, the nitrophenol group is released and the color changes from yellow to orange. Thus, the rate of color change can be used to determine enzyme activity. In addition, 4-Nitrophenyl butyrate can also be used as organic synthesis reagent and dye intermediate.
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- HY-W638077
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Cell Assay Reagents
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6-Chloro-3-indoxyl caprylate is a chromogenic substrate with C8 activity for esterases.
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- HY-D0158
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- HY-131474
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3-Hydroxy-2-naphthoic-o-toluidide chloroacetate,98% (TLC)
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Enzyme Substrates
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Naphthol AS-D chloroacetate, 98% (TLC) (3-Hydroxy-2-naphthoic-o-toluidide chloroacetate, 98% (TLC)) is a substrate for esterase histochemical localization.
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- HY-D0719R
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Dyes
Enzyme Substrates
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Fluorescein Diacetate (Standard) is the analytical standard of Fluorescein Diacetate. This product is intended for research and analytical applications. Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P6079A
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Biochemical Assay Reagents
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Others
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Ac-IHIHIYI-NH2 TFA is an amyloid self-assembling peptide variant that can be used as a bioactive nanomaterial with esterase activity .
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- HY-P4772
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- HY-P6079
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- HY-P2424
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- HY-P10765
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Peptide-Drug Conjugates (PDCs)
Topoisomerase
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Cancer
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DTS-108 is a prodrug of SN38 (HY-13704) (a Topoisomerase I inhibitor). DTS-108 is a conjugate generated by linking SN38 to a human oligopeptide via an esterase sensitive cross-linker. DTS-108 exhibits anti-tumor activity against colorectal, lung, and mammary cancer .
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- HY-P10053
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Phospholipase
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Metabolic Disease
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sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-B1323S
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Dipivefrin-d6 (hydrochloride) is deuterium labeled Dipivefrin (hydrochloride). Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea[1][2].
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- HY-132409S
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Monocrotophos-d6 is the deuterium labeled Monocrotophos. Monocrotophos. Monocrotophos is an organophosphate insecticide with broad application in crops. Monocrotophos inhibits the activity of the acetylcholine esterase (AChE) enzyme and affects the neurotransmission between neurons[1].
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