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Results for "

heterobifunctional

" in MedChemExpress (MCE) Product Catalog:

46

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3

Biochemical Assay Reagents

2

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W041994
    GMBS

    		Biochemical Assay Reagents Others
    GMBS is a heterobifunctional cross-linker. GMBS can be used in chemical cross-linking of proteins coupled with mass spectrometry (CXMS) to study protein folding and to map the interfaces between interacting proteins .
    GMBS
  • HY-147099
    dTAG-47-NEG

    		PROTACs Cancer
    dTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN). dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47 .
    dTAG-47-NEG
  • HY-145514A
    dTAGV-1-NEG

    		PROTACs FKBP Cancer
    dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12 F36V-selective degrader .
    dTAGV-1-NEG
  • HY-134592
    Piperidine-GNE-049-N-Boc

    		Ligands for Target Protein for PROTAC Cancer
    Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1 (HY-134582). dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP .
    Piperidine-GNE-049-N-Boc
  • HY-134582
    dCBP-1
    3 Publications Verification

    		 PROTACs Epigenetic Reader Domain Cancer
    dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression .
    dCBP-1
  • HY-147098
    dTAG-47

    		PROTACs FKBP Cancer
    dTAG-47, heterobifunctional dTAG molecule, targets mutant FKBP12 (FKBP12 F36V). FKBP12 F36V serves as a degradation tag (dTAG) and is fused to a protein of interest. dTAG-47 can be used for the research of basal-like breast cancers (BBC) .
    dTAG-47
  • HY-129377
    Sulfo-SPP

    		ADC Linker Cancer
    Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-SPP
  • HY-145514B
    dTAGV-1-NEG TFA

    		PROTACs FKBP Cancer
    dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12 F36V-selective degrader .
    dTAGV-1-NEG TFA
  • HY-129377A
    Sulfo-SPP sodium

    		ADC Linker Cancer
    Sulfo-SPP sodium a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-SPP sodium
  • HY-126495
    Sulfo-LC-SPDP

    		ADC Linker Cancer
    Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-LC-SPDP
  • HY-128925
    AMAS
    1 Publications Verification

    		 ADC Linker Cancer
    AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.
    AMAS
  • HY-W012166
    N-Succinimidyl bromoacetate

    NHS-Bromoacetate

    		 Biochemical Assay Reagents Others
    N-Succinimidyl bromoacetate is a heterobifunctional cross-linking reagent can be used to prepare peptide-protein immunogens .
    N-Succinimidyl bromoacetate
  • HY-164785
    TCO-PEG5-C2-Mal

    		Others Others
    TCO-PEG5-C2-Mal is a heterobifunctional linker that can be used for tetrazine ligation and sulfhydryl conjugation .
    TCO-PEG5-C2-Mal
  • HY-78961
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester

    EMCS

    		 ADC Linker Cancer
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates .
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester
  • HY-D0975
    Sulfo-SMCC sodium
    4 Publications Verification

    		 ADC Linker Cancer
    Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
    Sulfo-SMCC sodium
  • HY-155788
    DSPE-PEG-DBCO ammonium

    		Biochemical Assay Reagents Others
    DSPE-PEG-DBCO ammonium is the ammonium salt form of DSPE-PEG-DBCO. DSPE-PEG-DBCO ammonium is utilized in copper-free click chemistry through SPAAC conjugation with an azido-functionalized peptide ligand. DSPE-PEG-DBCO ammonium is applied in drug-delivery and nanoparticle research .
    DSPE-PEG-DBCO ammonium
  • HY-129655
    Sulfo-SMPB sodium

    		ADC Linker Cancer
    Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules .
    Sulfo-SMPB sodium
  • HY-137251
    Sulfo-MBS sodium

    		Biochemical Assay Reagents Others
    Sulfo-MBS sodium is a heterobifunctional crosslinker with a maleimide group and an N-hydroxysuccinimide (NHS) ester group, which can react with cysteine residues and lysine residues on proteins. Sulfo-MBS sodium be used for protein cross-linking studies .
    Sulfo-MBS sodium
  • HY-161095
    iRGD-CPT

    		DNA/RNA Synthesis Integrin Topoisomerase Cancer
    iRGD-CPT is a conjugate of iRGD and camptothecin that is covalently coupled through a heterobifunctional linker. iRGD-CPT has anticancer activity in vitroandin vivo. iRGD-CPT can be used for the study of colon cancer .
    iRGD-CPT
  • HY-W615173
    NHS ester-C2-NHCO-C2-NHS

    		Biochemical Assay Reagents Others
    NHS ester-C2-NHCO-C2-NHS is a heterobifunctional PEG linker, featuring a terminal NHS ester that can be used to label amine compounds and maleimide group for reactions with thiol groups.
    NHS ester-C2-NHCO-C2-NHS
  • HY-W190796
    Mal-PEG3-NH2

    		Biochemical Assay Reagents Others
    Mal-PEG3-NH2 is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 is a useful crosslinking reagent with a PEG spacer .
    Mal-PEG3-NH2
  • HY-138539
    CBP/p300 ligand 2

    		Ligands for Target Protein for PROTAC Cancer
    CBP/p300 ligand 2 is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP .
    CBP/p300 ligand 2
  • HY-172719
    Fmoc-PEG9-alcohol

    		Biochemical Assay Reagents Others
    Fmoc-PEG9-alcohol is a heterobifunctional PEG linker featuring a Fmoc-protected primary amine and an alcohol group. The hydroxy group is a versatile functionality while the Fmoc protecting group can be removed with base to reveal a primary amine.
    Fmoc-PEG9-alcohol
  • HY-W190786
    Bromoacetamido-PEG2-azide

    		Biochemical Assay Reagents Others
    Bromoacetamido-PEG2-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide.The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.
    Bromoacetamido-PEG2-azide
  • HY-W190925
    APN-C3-biotin

    		Biochemical Assay Reagents Others
    APN-C3-biotin is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and Biotin. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.
    APN-C3-biotin
  • HY-W190796A
    Mal-PEG3-NH2 TFA

    		PROTAC Linkers Cancer
    Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG crosslinker with Maleimide (HY-W007324) and amine. Mal-PEG3-NH2 TFA is a non-degradable (non-cleavable) PROTAC linker .
    Mal-PEG3-NH2 TFA
  • HY-156301
    Methyltetrazine-amido-PEG8-amine Trifluoroacetate

    		Biochemical Assay Reagents Others
    Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker containing a terminal methyltetrazine, which can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures, and terminal amine, which reacts with NHS ester specifically and efficiently. The PEG spacer enhances water solubility.
    Methyltetrazine-amido-PEG8-amine Trifluoroacetate
  • HY-134591
    Thalidomide-NH-PEG4-COOH

    		E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP .
    Thalidomide-NH-PEG4-COOH
  • HY-161157
    dTAG-13-NEG

    		PROTACs Cancer
    dTAG-13-NEG is a negative control of dTAG-13. dTAG-13 (HY-114421), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest .
    dTAG-13-NEG
  • HY-168664
    CPD-39

    		PROTACs CDK Cancer
    CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-39 shows anti-proliferation. (Pink: ligand for target protein (HY-50767); black: linker (HY-20240); Blue: E3 ligase ligand (HY-168667)) .
    CPD-39
  • HY-W440951
    Stearic acid-PEG-Mal (MW 3400)

    		Biochemical Assay Reagents Others
    Azide-PEG-Silane, MW 5000 is a heterobifunctional polyPEG for surface grafting through reaction between hydroxyl and ethoxyl silane. The polymer through its azide moiety can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a covalent triazole bond. Reagent grade, for research use only.
    Stearic acid-PEG-Mal (MW 3400)
  • HY-156820
    HLDA-221

    		Epigenetic Reader Domain Cancer
    HLDA-221 is a heterobifunctional small molecules called Regulated Induced Proximity Targeting Chimeras (RIPTACs). HLDA-221 elicits a stable ternary complex between a target protein selectively expressed in cancer tissue and a pan-expressed protein essential for cell survival, thus leading to cell death selectively in cells expressing the target protein .
    HLDA-221
  • HY-158101
    BMS-986365

    CC-94676

    		 PROTACs Androgen Receptor Cancer
    BMS-986365 (CC-94676) is an orally active and selective targeted androgen receptor (AR) PROTAC degrader, capable of inducing cereblon (CRBN) E3 ligase-dependent ubiquitination and degradation of the androgen receptor (AR), as well as various AR mutants. BMS-986365 shows significant in vivo potency, degrading AR, inhibiting AR signaling, and restricting tumor growth in animal models of advanced prostate cancer. (Blue: HY-W247437; Black: linker (HY-W126831); Pink: HY-168697) .
    BMS-986365
  • HY-W440954
    Stearic acid-PEG-CH2CO2H, MW 2000

    		Liposome Others
    Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
    Stearic acid-PEG-CH2CO2H, MW 2000
  • HY-114421
    FKBP12 PROTAC dTAG-13
    3 Publications Verification

    dTAG-13

    		 PROTACs FKBP Cancer
    FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12 F36V and CRBN, thereby selectively degrading FKBP12 F36V .
    FKBP12 PROTAC dTAG-13
  • HY-145232
    PhosTAC7
    2 Publications Verification

    		 Phosphatase Tau Protein Neurological Disease Cancer
    PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, FOXO3a protein, and Tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases .
    PhosTAC7
  • HY-122653
    CCT367766

    		PROTACs Cancer
    CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein .
    CCT367766
  • HY-138642
    Vepdegestrant
    3 Publications Verification

    ARV-471

    		 PROTACs Estrogen Receptor/ERR Cancer
    Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
    Vepdegestrant
  • HY-138642A
    (Rac)-Vepdegestrant

    (Rac)-ARV-471

    		 Estrogen Receptor/ERR PROTACs Cancer
    (Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
    (Rac)-Vepdegestrant
  • HY-163677
    ARM165

    		PROTACs PI3K Akt Cancer
    ARM165 is a heterobifunctional molecule. ARM165 degrades the PIK3CG proteins, inhibits PI3Kγ-Akt signaling pathway, and thus exhibits antileukemia efficacy. ARM165 inhibits proliferations of AML cells, with IC50 <1 μM. (Pink: ligand for target protein PI3Kγ inhibitor AZ2 (HY-111570); Black: linker; Blue: ligand for E3 ligase Pomalidomide (HY-10984))
    ARM165
  • HY-W1005067
    EN171

    		Molecular Glues Hippo (MST) Estrogen Receptor/ERR Others
    EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .
    EN171
  • HY-122653A
    CCT367766 formic

    		PROTACs Cancer
    CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .
    CCT367766 formic
  • HY-123941
    FKBP12 PROTAC dTAG-7
    2 Publications Verification

    dTAG-7

    		 PROTACs FKBP Epigenetic Reader Domain Cancer
    FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12 F36V with expression of FKBP12 F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN .
    FKBP12 PROTAC dTAG-7
  • HY-134850
    QC-01–175

    		PROTACs Tau Protein Neurological Disease
    QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984)) .
    QC-01–175
  • HY-161769
    HL435

    		PROTACs Epigenetic Reader Domain Apoptosis Cancer
    HL435 is a heterobifunctional molecule that degrades BRD4 by linking to JQ1, with DC50 of 11.9 nM and 21.9 nM, in MDA-MB-231 and MCF-7 cells, respectively. HL435 inhibits the proliferation of MDA-MB-231, MCF-7, 22Rv1 and A549, arrests the cell cycle and induces apoptosis. HL435 exhibits antitumor activity in mouse model. (Pink: ligand for target protein JQ-1 (HY-78695); Black: linker (HY-W004640); blue: ligand for E3 ligase HL389 (HY-161770))
    HL435
  • HY-145925B
    CFT8634

    		PROTACs Epigenetic Reader Domain Cancer
    CFT8634 is an orally bioavailable PROTAC BRD9 targeted degrader based on the E3 ubiquitin ligase CRBN mechanism. CFT8634 can be used for the study of synovial sarcoma and SMARCB1-deficient solid tumors (Pink: BRD9 ligand (HY-169988); Blue: E3 ligase ligand (HY-169989); Black: linker (HY-169991). CFT8634 is a heterobifunctional molecule that binds to BRD9 at one end and recruits CRBN at the other end, which can inhibit the growth of tumor cells that depend on BRD9. CFT8634 can be used for the study of SMARCB1-related cancers (such as synovial sarcoma and malignant rhabdoid tumor) .
    CFT8634

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