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immunodeficiency

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (50) Antibiotic (3) Apoptosis (6) Bacterial (4) Bcl-2 Family (1) CCR (2) CMV (1) CXCR (3) DNA/RNA Synthesis (3) Drug Metabolite (3) Endogenous Metabolite (1) ERK (1) Fungal (1) HBV (3) HIV Integrase (4) HIV Protease (8) HPV (2) HSV (2) IFNAR (2) Interleukin Related (2) Isotope-Labeled Compounds (2) Microtubule/Tubulin (1) Nucleoside Antimetabolite/Analog (4) Parasite (1) PI3K (3) PKC (1) Platelet-activating Factor Receptor (PAFR) (1) Reverse Transcriptase (6) SARS-CoV (1) Toll-like Receptor (TLR) (1) VEGFR (1) VSV (1)
By Research Areas:	Cancer (11) Infection (63) Inflammation/Immunology (29) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	Azide (1)
Oligonucleotides:	Nucleotides and their Analogs (1) Nucleosides and their Analogs (2) CpG ODNs (2)

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Isotope-Labeled Compounds

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Oligonucleotides

Targets Recommended: HIV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158258

Antiviral agent 55	HIV	Infection
Antiviral agent 55 (Compound 95) is an inhibitor for human immunodeficiency virus 1 and 2 (HIV 1 and HIV 2), and exhibits antiviral activity .

HY-118870

γ-Globulins from human blood	Endogenous Metabolite	Inflammation/Immunology
γ-Globulins from human blood are a class of proteins in the blood. γ-Globulin is a protein fraction of blood serum containing many antibodies that protect against bacterial and viral infectious diseases. γ-Globulins from human blood is used for common variable immunodeficiency

HY-102026

Formycin A NSC 102811	HIV Nucleoside Antimetabolite/Analog Antibiotic	Infection Cancer
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent *human immunodeficiency* virus type 1 (HIV-1) inhibitor with an EC₅₀** of 10 μM. Formycin A shows antitumor and antiviral activities .

HY-19232

R-87366	HIV Protease	Inflammation/Immunology
R-87366 is a water-soluble *human immunodeficiency* virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a K_i** value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV) .

HY-131607

Carbovir triphosphate CBV-TP; (-)-Carbovir triphosphate; (-)-Carbovir 5′-triphosphate	HIV	Infection Inflammation/Immunology
Carbovir triphosphate (CBV-TP) is a phosphorylated metabolite. Carbovir triphosphate can be used for the research of human immunodeficiency virus (HIV) .

HY-100212

JE-2147 AG1776; KNI-764	HIV HIV Protease	Infection
JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a K_i of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro .

HY-P4018

HIV Protease Substrate IV	HIV Protease	Infection
HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease .

HY-P5643

Retrocyclin-2	Bacterial	Infection
Retrocyclin-2 is an antimicrobial peptide against human immunodeficiency virus, influenza A and herpes simplex virus .

HY-P5644

Retrocyclin-3	Bacterial	Infection
Retrocyclin-3 is an antimicrobial peptide against human immunodeficiency virus, influenza A and herpes simplex virus .

HY-P2379

His-Cys-Lys-Phe-Trp-Trp	HIV Integrase	Infection
His-Cys-Lys-Phe-Trp-Trp is an inhibitor for the human immunodeficiency virus (HIV) integrase with an IC₅₀ of 2 μM .

HY-P2251

T-peptide	HIV Microtubule/Tubulin	Infection Inflammation/Immunology Cancer
T-peptide, a Tuftsin analog, can be used for the research of *human immunodeficiency* virus (HIV)** infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection .

HY-150747

ODN 6016	IFNAR	Inflammation/Immunology
ODN 6016 is a CpG-A oligonucleotides. ODN 6016 can induce IFN-α production, can be used for researching immune disorders including immunodeficiency caused by HIV-1. ODN 6016 sequence: T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G .

HY-150747A

ODN 6016 sodium	IFNAR	Inflammation/Immunology
ODN 6016 sodium is a CpG-A oligonucleotides. ODN 6016 sodium can induce IFN-α production, and can be used for researching immune disorders including immunodeficiency caused by HIV-1. ODN 6016 sequence: T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G .

HY-116282C

Dextran sulfate sodium salt (MW 35000-50000) 2 Publications Verification DSS (MW 35000-50000); DXS (MW 35000-50000)	HIV Apoptosis	Infection Inflammation/Immunology
Dextran sulfate sodium salt (MW 35000-50000) is a polymer of anhydroglucose and is a potent inducer of colitis. Dextran sulfate sodium salt (MW 35000-50000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium. Dextran sulfate sodium salt (MW 35000-50000) also inhibits human immunodeficiency virus replication by preventing viral adsorption to host cells. Dextran sulfate sodium salt (MW 35000-50000) is also used to bind to insulin, encapsulate it in gold nanoparticles, and serve as an insulin carrier to bind to insulin receptors to achieve the purpose of slowly releasing insulin and prolonging insulin activity .

HY-P35433

Tifuvirtide T-1249	HIV	Inflammation/Immunology
Tifuvirtide (T-1249) is a peptide *human immunodeficiency* virus type-1 (HIV-1)** fusion inhibitor. Tifuvirtide is a synthetically designed hybrid retroviral envelope polypeptide. Tifuvirtide has antiretroviral activity. Tifuvirtide can be used for the research of HIV infection .

HY-144286

CXCR4 antagonist 3	CXCR	Infection
CXCR4 antagonist 3 (compound 12a) is a potent antagonist of CXCR4 with an IC₅₀ of 11 nM. CXCR4 antagonist 3 is a congener of TIQ15. CXCR4 antagonist 3 demonstrates the best overall properties including CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. CXCR4 antagonist 3 has the potential for the research of human immunodeficiency virus .

HY-13269

BMS-707035 1 Publications Verification	HIV HIV Integrase	Infection Inflammation/Immunology
BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC₅₀ value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) .

HY-150079

HIV-1 integrase inhibitor 10	HIV Integrase	Infection
HIV-1 integrase inhibitor 10 is an orally active HIV-1 allosteric integrase inhibitor (ALLINI). HIV-1 integrase inhibitor 10 can inhibit viral outgrowth of the NLRepRluc virus in MT-2 cells with EC₅₀ values of 3-5 nM. HIV-1 integrase inhibitor 10 can be used for the research of Human immunodeficiency virus-1 (HIV-1) .

HY-19194

A-80987	HIV Protease	Infection
A-80987 is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease .

HY-17635

Leniolisib 1 Publications Verification CDZ173	PI3K	Inflammation/Immunology
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

HY-B1834

Megestrol	Drug Metabolite	Inflammation/Immunology Cancer
Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis .

HY-17635A

Leniolisib phosphate 1 Publications Verification CDZ173 phosphate	PI3K	Inflammation/Immunology
Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.

HY-139794

SDZ283-910	HIV	Infection
SDZ283-910 is a potent *human immunodeficiency* virus type-1 (HIV-1)** protease inhibitor .

HY-W251687

2'-Deoxy-2'-fluoroarabinoadenosine	Nucleoside Antimetabolite/Analog HIV	Infection
2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue, which exhibits anticancer activity against human immunodeficiency virus (HIV) .

HY-105207

L 696229	HIV	Infection
L 696229 is a specific inhibitor ofhuman immunodeficiency virus type 1 (HIV-1)reverse transcriptase (RT) activity that possesses antiviral activity .

HY-125433

A-75925	HIV	Infection
A-75925 is a human immunodeficiency virus type 1 (HIV-1) proteinase inhibitor and can be utilized in HIV-1 rersearch .

HY-116252

(±)-trans-Lamivudine	Others	Infection
(±)-trans-Lamivudine is separated from the salt of (S)-(+) mandelic acid. (±)-trans-Lamivudine forms cocrystals with (S)-BINOL. (±)-trans-Lamivudine is promising for research of human immunodeficiency virus infection .

HY-129667

BM 21.1298	Reverse Transcriptase HIV	Infection
BM 21.1298 is a selective and high specific nonnucleoside immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) inhibitor with antiviral activity .

HY-14135

BMS 488043 BMS 043	HIV	Infection Inflammation/Immunology
BMS 488043 (BMS 043) is an orally active and well-tolerated inhibitor of the attachment of human immunodeficiency virus type 1 (HIV-1) to CD4+ lymphocytes .

HY-116282A

Dextran sulfate sodium salt (MW 4500-5500) DSS (MW 4500-5500); DXS (MW 4500-5500)	HIV Apoptosis	Infection Inflammation/Immunology
Dextran sulfate sodium salt (MW 4500-5500) is a polymer of anhydroglucose with a molecular weight of 4500-5500. Dextran sulfate sodium salt (MW 4500-5500) can be used to induce acute colitis and cause apoptosis of colonic epithelial cells in mice. The recommended molecular weight in the study is 5000 (HY-116282) and the use concentration is 5% (in feed, W/W). The sulfated polysaccharide dextran sulfate is also an effective inhibitor of HIV. Dextran sulfate sodium salt (MW 4500-5500) can significantly inhibit HIV-1 replication at concentrations that do not significantly inhibit the blood coagulation process. Dextran sulfate sodium salt (MW 4500-5500) protects MT-4 cells from HIV-1-induced cellular pathogenicity. Dextran sulfate-induced colitis can be inhibited by Puerarin (HY-N0145), Baicalein (HY-N0196), β-Caryophyllene (HY-N1415).

HY-116282

Dextran sulfate sodium salt (MW 5000) 1 Publications Verification DSS (MW 5000); DXS (MW 5000)	HIV Apoptosis	Infection Inflammation/Immunology
Dextran sulfate sodium salt (MW 5000) is a polymer of anhydroglucose with a molecular weight of 5000. Dextran sulfate sodium salt (MW 5000) can be used to induce acute colitis and cause apoptosis of colonic epithelial cells in mice. The concentration dose used in the study was 5% (in feed, w/w). The sulfated polysaccharide dextran sulfate is also an effective inhibitor of HIV. Dextran sulfate sodium salt (MW 5000) can significantly inhibit HIV-1 replication at a concentration that does not significantly inhibit the blood coagulation process. Dextran sulfate sodium salt (MW 5000) protects MT-4 cells from HIV-1-induced cellular pathogenicity. Dextran sulfate-induced colitis can be inhibited by Puerarin (HY-N0145), Baicalein (HY-N0196), β-Caryophyllene (HY-N1415).

HY-120331

U-89360E	HIV HIV Protease	Infection
U-89360E is an inhibitor for HIV-1 protease. U-89360E inhibits the protease of HIV-1 wildtype, V82D mutant and V82N mutant with K_i of 20 nM, 560 nM and 2100 nM, respectively .

HY-P0281A

TAT TFA	HIV	Infection
TAT TFA (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins .

HY-17635S

Leniolisib-d5 CDZ173-d₅	Isotope-Labeled Compounds PI3K	Inflammation/Immunology
Leniolisib-d5 is a deuterated labeled Leniolisib . Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

HY-105025B

Thymocartin acetate Thymopoietin II (32-35) acetate; TP 4 acetate	Apoptosis	Inflammation/Immunology
Thymocartin (TP 4) acetate is the 32-35 fragment of thymic factor (thymopoietin). Thymocartin acetate inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals. Thymocartin acetate is potential for immunodeficiency diseases research .

HY-116001

(+)-Carbovir NSC 614846	Others	Infection
(+)-Carbovir (NSC 614846) is an antiviral drug with activity against human immunodeficiency virus type 1. (+)-Carbovir is a nucleoside analog with enhanced chemical and metabolic stability. (+)-Carbovir can be used in AIDS research .

HY-P0281

TAT	HIV	Infection
TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins .

HY-100083

Dolutegravir intermediate-1	HIV	Others
Dolutegravir intermediate-1 is a synthetic intermediate of Dolutegravir extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-1 infection.

HY-B1834S1

Megestrol-d5	Isotope-Labeled Compounds Drug Metabolite	Inflammation/Immunology
Megestrol-d₅ is the deuterium labeled Megestrol. Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1][2].

HY-105025A

Thymocartin TFA Thymopoietin II (32-35) (TFA); TP 4 TFA	Apoptosis	Inflammation/Immunology
Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025). Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals. Thymocartin TFA is potential for immunodeficiency diseases research .

HY-122453

Palinavir	HIV Protease	Infection
Palinavir is a potent human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) protease inhibitor with an IC₅₀ of 0.5-30 nM . Palinavir has antiviral activity .

HY-122482

β-Rubromycin	HIV Reverse Transcriptase Antibiotic	Inflammation/Immunology
β-Rubromycin is a potent and selective inhibitor of human immunodeficiency virus-1 (HIV-1) RNA-directed DNA polymeras (reverse transcriptase). β-Rubromycin is a class of quinone antibacterials .

HY-B1834R

Megestrol (Standard)	Drug Metabolite	Inflammation/Immunology Cancer
Megestrol (Standard) is the analytical standard of Megestrol. This product is intended for research and analytical applications. Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis .

HY-106038

Acopafant Dacopafant; RP 55778	HIV Platelet-activating Factor Receptor (PAFR)	Infection Cancer
Acopafant (Dacopafant; RP 55778) is a potent platelet-activating factor antagonist. Acopafant inhibits the induction of human immunodeficiency virus (HIV) expression in chronically infected cells. Acopafant has the potential for the research of HIV infection .

HY-109137

Selgantolimod GS-9688	Toll-like Receptor (TLR) HBV	Infection
Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection .

HY-16907

GSK-364735 S/GSK-364735	HIV HIV Integrase	Infection
GSK-364735 is a potent antiretroviral agent against human immunodeficiency virus type 1 (HIV-1) and serves as an integrase inhibitor with an IC₅₀ of 8 ± 2 nM. GSK-364735 can be utilized in antiviral research .

HY-106395A

(Rac)-Telinavir (Rac)-SC-52151	Others	Infection
(Rac)-Telinavir ((Rac)-SC-52151) is a potent, selective, tight-binding human immunodeficiency virus (HIV) protease inhibitor that exhibits significant anti-HIV activity. (Rac)-Telinavir has a mean 50% effective concentration of 26 ng/ml (43 nM) against various strains of HIV, including HIV-1, HIV-2, and simian immunodeficiency virus. (Rac)-Telinavir, in combination with nucleoside reverse transcriptase inhibitors, demonstrates synergistic effects on inhibiting HIV-1 replication without additive toxicity. (Rac)-Telinavir is highly protein bound in human plasma and exhibits low partitioning into erythrocytes.

HY-118740

L-708906	HIV	Infection
L-708906 is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an IC₅₀ value of 12 μM. L-708906 inhibits HIV strains resistant to nonnucleoside or nucleoside reverse transcriptase inhibitors .

HY-106382

PMEDAP	HIV CMV	Infection Cancer
PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality .

HY-N1034

12-Oxocalanolide A (±)-12-Oxocalanolide A	HIV	Infection
12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC₅₀ and EC₅₀ of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-118870

γ-Globulins from human blood	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
γ-Globulins from human blood are a class of proteins in the blood. γ-Globulin is a protein fraction of blood serum containing many antibodies that protect against bacterial and viral infectious diseases. γ-Globulins from human blood is used for common variable immunodeficiency

HY-P99488

Briquilimab JSP-191	Classification of Application Fields Disease Research Fields Cancer	Others
Briquilimab (JSP-191) is a non-toxic humanized monoclonal antibody targeting CD117 (c-Kit) to deplete hematopoietic stem cell (HSC). Briquilimab has safety to clear host marrow niche space to enable sufficient donor HSC engraftment and immune reconstitution as primary method of severe combined immunodeficiency (SCID) .

HY-N2575

Hypocrellin A 1 Publications Verification	Infection Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	PKC Bacterial Parasite HIV VSV VEGFR Bcl-2 Family Apoptosis
Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC₅₀=0.27 μg/ml) .

HY-P0281

TAT	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	HIV
TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins .

HY-N12905

Celastramycin A (isomer)	Structural Classification Microorganisms Source classification Phenols Polyphenols	Antibiotic Bacterial
Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL .

HY-N11939

Kadsuralignan A	Schisandra lancifolia (Rehd. et Wils.) A. C. Smith Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae	HIV
Kadsuralignan A (compound 1) is a dibenzocyclooctadiene lignan isolated from the leaves and stems of Schisandra lancifolia. Kadsuralignan A has anti-HIV activity with EC₅₀=2.23 μg/mL .

Cat. No.	Product Name	Chemical Structure

HY-17635S

Leniolisib-d5
Leniolisib-d5 is a deuterated labeled Leniolisib . Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

HY-B1834S1

Megestrol-d5
Megestrol-d₅ is the deuterium labeled Megestrol. Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1][2].

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Species:	Virus (5) Human (1)
Tag:	His (5) Fc (1)
Source:	HEK293 (5) E. coli (1)


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immunodeficiency

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Natural
Products