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Results for "

opioid peptides

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Opioid Receptor (42) Amino Acid Derivatives (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (2) Caspase (2) CXCR (1) Dopamine Receptor (2) Endogenous Metabolite (6) ERK (2) MMP (2) Neprilysin (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Metabolic Disease (6) Neurological Disease (45)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Opioid Receptor Formyl Peptide Receptor (FPR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1481A

β-Casomorphin, human TFA Human β-casomorphin 7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor .

HY-P0179

β-Casomorphin, bovine β-Casomorphin-7 (bovine); Bovine β-casomorphin-7	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a *opioid* peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-P1481

β-Casomorphin, human Human β-casomorphin 7	Opioid Receptor	Metabolic Disease
is an opioid peptide, acts as an agonist of opioid receptor .

HY-P0179A

β-Casomorphin, bovine TFA β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a *opioid* peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-P3550

β-Lipotropin (60-65) β-LPH (60-65); [Arg0] Met-Enkephalin	Opioid Receptor	Neurological Disease
β-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent *opioid* agonist .

HY-P3632

[DAla2, DArg6] Dynorphin A, (1-13) (porcine) DADAD	Opioid Receptor	Neurological Disease Metabolic Disease
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an **opioid peptide** (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .

HY-W000665

2,6-Dimethyl-L-tyrosine Dmt	Opioid Receptor	Neurological Disease
2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of **opioid peptides** .

HY-P3555

D-Ala-Gly-Phe-Met-NH2	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3555A

D-Ala-Gly-Phe-Met-NH2 monoacetate	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2 monoacetate, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3548

[D-Ala2]-Met-Enkephalinamide	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalinamide, an opioid peptide, is a potent *opioid* agonist. [D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism. [D-Ala2]-Met-Enkephalinamide has analgesic properties .

HY-P3223

Biphalin TFA	Opioid Receptor	Neurological Disease
Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-P3625

Dynorphin (2-17), amide (porcine)	Endogenous Metabolite Opioid Receptor	Neurological Disease
Dynorphin (2-17), amide (porcine) is a dynorphin derivative with some analgesic effects. Dynorphin is a class of opioid peptides produced by the precursor protein dynorphinogen and is involved in pain, addiction and mood regulation .

HY-P1333

Dynorphin A	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease .

HY-P1333A

Dynorphin A TFA	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research of neurological disease .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-P3513A

β-Neo-Endorphin acetate	ERK MMP	Neurological Disease
β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-P1331

BAM-22P Bovine adrenal medulla-22P	Opioid Receptor	Neurological Disease
BAM-22P, a highly potent opioid peptide, is a potent *opioid* agonist.

HY-P1334

DPDPE	Opioid Receptor	Neurological Disease
DPDPE, an opioid peptide, is a selective *δ-opioid* receptor?(DOR)** agonist?with anticonvulsant effects .

HY-P0318

Hemorphin-7	Opioid Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

HY-P1334A

DPDPE TFA	Opioid Receptor	Neurological Disease
DPDPE TFA, an opioid peptide, is a selective *δ-opioid* receptor (DOR)** agonist with anticonvulsant effects .

HY-P1596

Gluten Exorphin C	Opioid Receptor	Neurological Disease
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC₅₀ values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

HY-P1013

Deltorphin 2 [D-Ala2]-Deltorphin II	Opioid Receptor	Neurological Disease
Deltorphin 2 is a selective peptide agonist for the *δ opioid* receptor**.

HY-P1742

Gluten Exorphin B5	Opioid Receptor	Metabolic Disease
Gluten Exorphin B5 is an exogenous opioid peptides derived from wheat gluten, acts on opioid receptor, increases postprandial plasma insulin level in rats .

HY-P1502

β-Endorphin, human 1 Publications Verification	Opioid Receptor	Neurological Disease
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for *μ-opioid* receptor and δ-opioid receptor**; β-Endorphin, human exhibits antinociception activity.

HY-P1866

β-Endorphin, equine	Opioid Receptor	Neurological Disease
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both *μ/δ opioid* receptors** . Analgesic properties .

HY-P1013A

Deltorphin 2 TFA 2 Publications Verification [D-Ala2]-Deltorphin II TFA	Opioid Receptor	Neurological Disease
Deltorphin 2 TFA is a selective peptide agonist for the *δ opioid* receptor** .

HY-P2669

Boc-YPGFL(O-tBu)	Opioid Receptor	Neurological Disease
Boc-YPGFL(O-tBu) is a selective *δ opioid* receptor (DOR)** peptide antagonist .

HY-P2626

[D-Ala2]-Met-Enkephalin	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent *opioid* agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release .

HY-P1866A

β-Endorphin, equine TFA	Opioid Receptor	Neurological Disease
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both *μ/δ opioid* receptors**. β-Endorphin, equine TFA has analgesic properties .

HY-129271

Deltorphin Deltorphin A; Dermenkephalin	Opioid Receptor	Others
Deltorphin (Deltorphin A; Dermenkephalin) is a biological active peptide. (Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor.)

HY-P1170

N-terminally acetylated Leu-enkephalin Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH	Opioid Receptor	Neurological Disease
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P0288

[Leu5]-Enkephalin 1 Publications Verification Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin	Opioid Receptor Endogenous Metabolite	Neurological Disease
[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-W013154

Fmoc-Tic-OH	Amino Acid Derivatives	Others
Fmoc-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as the biotinylated derivative of the opioid receptor antagonist TIPP .

HY-15536

Cebranopadol Maximum Cited Publications 7 Publications Verification GRT6005	Opioid Receptor	Neurological Disease Cancer
Cebranopadol is an analgesic NOP and opioid receptor agonist with K_is/EC₅₀s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.

HY-W019787

BAM-12P	Opioid Receptor CXCR	Neurological Disease
BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate *human κ-opioid* receptor (hKOR) with an EC₅₀ of 101 nM and a pEC₅₀ of 6.99. BAM-12P is a ligand for CXCR7 with an EC₅₀** of 175 nM .

HY-P0288A

[Leu5]-Enkephalin TFA	Opioid Receptor Endogenous Metabolite	Neurological Disease
[Leu5]-Enkephalin TFA is a pentapeptide with morphine like properties. [Leu5]-Enkephalin TFA is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P1332

DSLET [D-Ser2, Leu5, Thr6]-enkephalin	Opioid Receptor	Neurological Disease
DSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a highly specific agonist of the δ-receptor. DSLET is an enkephalin-related peptide selectively bound to the δ opioid receptor .

HY-P1626

Acetyl tetrapeptide-15	Opioid Receptor	Neurological Disease
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .

HY-P2046

β-Endorphin (rat)	Opioid Receptor	Neurological Disease
β-Endorphin (rat) is an endogenous opioid neuropeptide and peptide hormone. β-Endorphin (rat) has analgesic activity and also contributes to food intake in satiated rats. β-Endorphin (rat) can be used in the research of neurological diseases such as analgesia and drug addiction .

HY-P2159

Dynorphin A (1-8)	Opioid Receptor Endogenous Metabolite	Neurological Disease
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC₅₀=303 nM) .

HY-128865

BPR1M97	Opioid Receptor	Neurological Disease
BPR1M97 is a dual-acting *mu opioid* receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with K_i** values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects .

HY-P1299A

UFP-101 TFA	Opioid Receptor	Neurological Disease
UFP-101 TFA is a potent, selective, and competitive antagonist of the *N/OFQ peptide* (NOP) receptor, with a pK_i** of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect .

HY-107663

MIF-1 Pro-Leu-Gly-NH2; Melanostatin	Dopamine Receptor	Neurological Disease
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .

HY-107663A

MIF-1 TFA Pro-Leu-Gly-NH2 TFA; Melanostatin TFA	Dopamine Receptor	Neurological Disease
MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .

HY-101202A

(Rac)-SNC80 (Rac)-NIH 10815	Opioid Receptor	Neurological Disease
(Rac)-SNC80 is a racemate of SNC80 (HY-101202). SNC80 (NIH 10815) is a potent, highly selective and non-peptide *δ-opioid* receptor agonist with a K_i of 1.78 nM and an IC₅₀** of 2.73 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment .

HY-101202

SNC80 NIH 10815	Opioid Receptor	Neurological Disease
SNC80 (NIH 10815) is a potent, highly selective and non-peptide *δ-opioid* receptor agonist with a K_i of 1.78 nM and an IC₅₀ of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC₅₀** of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment .

HY-P10555

(D-Arg2, Sar 4)-Dermorphin (1-4)	Opioid Receptor	Neurological Disease
(D-Arg2, Sar 4)-Dermorphin (1-4) is a tetrapeptide derivative of the peptide Dermorphin (HY-P0244) found in amphibian skin. (D-Arg2, Sar 4)-Dermorphin (1-4) has significant analgesic effects by binding to the μ-opioid receptor (MOR) in the body. (D-Arg2, Sar 4)-Dermorphin (1-4) can be used in the development of analgesic drugs .

HY-138232

Lys-psi(CH2NH)-Trp(Nps)-OMe LTNAM	Others	Neurological Disease
Lys-psi(CH2NH)-Trp(Nps)-OMe is a lysine-tryptophan (Nps) pseudodipeptide analog. It is obtained by replacing the peptide bond in the Lys-Trp(Nps) molecule with an aminomethylene bond and has analgesic activity. Lys-psi(CH2NH)-Trp(Nps)-OMe induces a dose-dependent and naloxone-reversible analgesia after intracerebroventricular administration in mice, and its analgesic effect lasts longer than that of the original compound. It protects methionine enkephalin from degradation in rat striatal slices and binds to low-dose opioid peptides to produce analgesia. Lys-psi(CH2NH)-Trp(Nps)-OMe effectively inhibits brain aminopeptidase activity both in vitro and in vivo. The enhanced resistance of this pseudodipeptide to proteolysis may explain its prolonged analgesic activity.

Cat. No.	Product Name	Target	Research Area

HY-P1481A

β-Casomorphin, human TFA Human β-casomorphin 7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor .

HY-P0179

β-Casomorphin, bovine β-Casomorphin-7 (bovine); Bovine β-casomorphin-7	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a *opioid* peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-P1481

β-Casomorphin, human Human β-casomorphin 7	Opioid Receptor	Metabolic Disease
is an opioid peptide, acts as an agonist of opioid receptor .

HY-P0179A

β-Casomorphin, bovine TFA β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a *opioid* peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-P3550

β-Lipotropin (60-65) β-LPH (60-65); [Arg0] Met-Enkephalin	Opioid Receptor	Neurological Disease
β-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent *opioid* agonist .

HY-P3632

[DAla2, DArg6] Dynorphin A, (1-13) (porcine) DADAD	Opioid Receptor	Neurological Disease Metabolic Disease
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an **opioid peptide** (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .

HY-W000665

2,6-Dimethyl-L-tyrosine Dmt	Opioid Receptor	Neurological Disease
2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of **opioid peptides** .

HY-P3555

D-Ala-Gly-Phe-Met-NH2	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3555A

D-Ala-Gly-Phe-Met-NH2 monoacetate	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2 monoacetate, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3548

[D-Ala2]-Met-Enkephalinamide	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalinamide, an opioid peptide, is a potent *opioid* agonist. [D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism. [D-Ala2]-Met-Enkephalinamide has analgesic properties .

HY-P3223

Biphalin TFA	Opioid Receptor	Neurological Disease
Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-P3625

Dynorphin (2-17), amide (porcine)	Endogenous Metabolite Opioid Receptor	Neurological Disease
Dynorphin (2-17), amide (porcine) is a dynorphin derivative with some analgesic effects. Dynorphin is a class of opioid peptides produced by the precursor protein dynorphinogen and is involved in pain, addiction and mood regulation .

HY-P1333

Dynorphin A	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease .

HY-P1333A

Dynorphin A TFA	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research of neurological disease .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-P1331

BAM-22P Bovine adrenal medulla-22P	Opioid Receptor	Neurological Disease
BAM-22P, a highly potent opioid peptide, is a potent *opioid* agonist.

HY-P1334

DPDPE	Opioid Receptor	Neurological Disease
DPDPE, an opioid peptide, is a selective *δ-opioid* receptor?(DOR)** agonist?with anticonvulsant effects .

HY-P0318

Hemorphin-7	Opioid Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

HY-P1334A

DPDPE TFA	Opioid Receptor	Neurological Disease
DPDPE TFA, an opioid peptide, is a selective *δ-opioid* receptor (DOR)** agonist with anticonvulsant effects .

HY-P1596

Gluten Exorphin C	Opioid Receptor	Neurological Disease
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC₅₀ values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

HY-P1013

Deltorphin 2 [D-Ala2]-Deltorphin II	Opioid Receptor	Neurological Disease
Deltorphin 2 is a selective peptide agonist for the *δ opioid* receptor**.

HY-P1742

Gluten Exorphin B5	Opioid Receptor	Metabolic Disease
Gluten Exorphin B5 is an exogenous opioid peptides derived from wheat gluten, acts on opioid receptor, increases postprandial plasma insulin level in rats .

HY-P1502

β-Endorphin, human 1 Publications Verification	Opioid Receptor	Neurological Disease
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for *μ-opioid* receptor and δ-opioid receptor**; β-Endorphin, human exhibits antinociception activity.

HY-P1866

β-Endorphin, equine	Opioid Receptor	Neurological Disease
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both *μ/δ opioid* receptors** . Analgesic properties .

HY-P1013A

Deltorphin 2 TFA 2 Publications Verification [D-Ala2]-Deltorphin II TFA	Opioid Receptor	Neurological Disease
Deltorphin 2 TFA is a selective peptide agonist for the *δ opioid* receptor** .

HY-P5061

Dynorphin A (1-13) amide	Peptides	Neurological Disease
Dynorphin A (1-13) amide is an endogenous opioid peptide that antagonizes morphine-induced analgesia .

HY-P2669

Boc-YPGFL(O-tBu)	Opioid Receptor	Neurological Disease
Boc-YPGFL(O-tBu) is a selective *δ opioid* receptor (DOR)** peptide antagonist .

HY-P1863

α-Neoendorphin (1-8)	Peptides	Neurological Disease
α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide.

HY-P2626

[D-Ala2]-Met-Enkephalin	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent *opioid* agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release .

HY-P1866A

β-Endorphin, equine TFA	Opioid Receptor	Neurological Disease
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both *μ/δ opioid* receptors**. β-Endorphin, equine TFA has analgesic properties .

HY-P1819

N-Acetyl-α-Endorphin	Peptides	Neurological Disease
N-Acetyl-α-Endorphin is an acetylated α-Endorphin at N-terminal. α-Endorphin is an endogenous opioid peptide.

HY-129271

Deltorphin Deltorphin A; Dermenkephalin	Opioid Receptor	Others
Deltorphin (Deltorphin A; Dermenkephalin) is a biological active peptide. (Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor.)

HY-P3045

Bilaid B	Peptides	Others
Bilaid B (compound 2a) is a tetrapeptide. Bilaid B resembles opioid peptides albeit with a unique, alternating LDLD amino acid configuration. .

HY-P1170

N-terminally acetylated Leu-enkephalin Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH	Opioid Receptor	Neurological Disease
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P0288

[Leu5]-Enkephalin 1 Publications Verification Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin	Opioid Receptor Endogenous Metabolite	Neurological Disease
[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-W013154

Fmoc-Tic-OH	Amino Acid Derivatives	Others
Fmoc-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as the biotinylated derivative of the opioid receptor antagonist TIPP .

HY-W019787

BAM-12P	Opioid Receptor CXCR	Neurological Disease
BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate *human κ-opioid* receptor (hKOR) with an EC₅₀ of 101 nM and a pEC₅₀ of 6.99. BAM-12P is a ligand for CXCR7 with an EC₅₀** of 175 nM .

HY-P0288A

[Leu5]-Enkephalin TFA	Opioid Receptor Endogenous Metabolite	Neurological Disease
[Leu5]-Enkephalin TFA is a pentapeptide with morphine like properties. [Leu5]-Enkephalin TFA is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P1332

DSLET [D-Ser2, Leu5, Thr6]-enkephalin	Opioid Receptor	Neurological Disease
DSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a highly specific agonist of the δ-receptor. DSLET is an enkephalin-related peptide selectively bound to the δ opioid receptor .

HY-P10176

Acetalin-2	Peptides	Others
Acetalin-2 is an opioid peptide with a sequence of Ac-Arg-Phe-Met-Trp-Met-Arg-NH2. Acetalin-2 is selectively bound to [ ³H]DAMGO with a K ⁱ value of 93.3 nM .

HY-P1626

Acetyl tetrapeptide-15	Opioid Receptor	Neurological Disease
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .

HY-P2046

β-Endorphin (rat)	Opioid Receptor	Neurological Disease
β-Endorphin (rat) is an endogenous opioid neuropeptide and peptide hormone. β-Endorphin (rat) has analgesic activity and also contributes to food intake in satiated rats. β-Endorphin (rat) can be used in the research of neurological diseases such as analgesia and drug addiction .

HY-P2159

Dynorphin A (1-8)	Opioid Receptor Endogenous Metabolite	Neurological Disease
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC₅₀=303 nM) .

HY-P1299A

UFP-101 TFA	Opioid Receptor	Neurological Disease
UFP-101 TFA is a potent, selective, and competitive antagonist of the *N/OFQ peptide* (NOP) receptor, with a pK_i** of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect .

HY-107663

MIF-1 Pro-Leu-Gly-NH2; Melanostatin	Dopamine Receptor	Neurological Disease
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .

HY-107663A

MIF-1 TFA Pro-Leu-Gly-NH2 TFA; Melanostatin TFA	Dopamine Receptor	Neurological Disease
MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .

HY-P10555

(D-Arg2, Sar 4)-Dermorphin (1-4)	Opioid Receptor	Neurological Disease
(D-Arg2, Sar 4)-Dermorphin (1-4) is a tetrapeptide derivative of the peptide Dermorphin (HY-P0244) found in amphibian skin. (D-Arg2, Sar 4)-Dermorphin (1-4) has significant analgesic effects by binding to the μ-opioid receptor (MOR) in the body. (D-Arg2, Sar 4)-Dermorphin (1-4) can be used in the development of analgesic drugs .

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