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poisoning

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62

Inhibitors & Agonists

1

Fluorescent Dye

5

Biochemical Assay Reagents

1

Peptides

16

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1738A
    Pralidoxime iodide

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning .
    Pralidoxime iodide
  • HY-B0567
    Dequalinium Chloride

    		Potassium Channel nAChR Apoptosis Bacterial Parasite Infection Cancer
    Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity .
    Dequalinium Chloride
  • HY-106662
    Chloroquinoxaline sulfonamide

    Chloroquinoxaline; NSC-339004

    		 Molecular Glues Topoisomerase Parasite Infection Cancer
    Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle . Antitumor activity .
    Chloroquinoxaline sulfonamide
  • HY-B1768
    Succimer

    Dimercaptosuccinic acid; DMSA

    		 Others Others Cancer
    Succimer is a widely used chelating agent for the treatment of Pb poisoning.
    Succimer
  • HY-B1285
    Dimercaprol

    2,3-Dimercapto-1-propanol; Dithioglycerol

    		 HIV Infection
    Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .
    Dimercaprol
  • HY-N2331
    Proscillaridin A

    		Topoisomerase Cancer
    Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively .
    Proscillaridin A
  • HY-B1542
    Benactyzine

    		Cholinesterase (ChE) Neurological Disease
    Benactyzine is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine is an anticholinergic drug. Benactyzine has the potential for organophosphate poisoning research .
    Benactyzine
  • HY-B0567R
    Dequalinium Chloride (Standard)

    		Potassium Channel nAChR Apoptosis Bacterial Parasite Infection Cancer
    Dequalinium (Chloride) (Standard) is the analytical standard of Dequalinium (Chloride). This product is intended for research and analytical applications. Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity .
    Dequalinium Chloride (Standard)
  • HY-161118
    MB327

    		Others Neurological Disease
    MB327 is a bipyridine nonoxime compound that restores neuromuscular function. MB327 restores the activity of nicotinamide acetylcholine receptors (nAChRs) for carbachol desensitization in a typical type II PAM manner. MB327 can neutralize nerve agent poisoning .
    MB327
  • HY-121229A
    (±)-Coniine

    2-Propylpiperidine

    		 Others Others
    (±)-Coniine, a piperidine alkaloid, is a toxin found in poison hemlock .
    (±)-Coniine
  • HY-N6608S
    Physostigmine-d3

    Eserine-d3

    		 Isotope-Labeled Compounds Cholinesterase (ChE) Neurological Disease
    Physostigmine-d3 is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].
    Physostigmine-d3
  • HY-B1285R
    Dimercaprol (Standard)

    		HIV Infection
    Dimercaprol (Standard) is the analytical standard of Dimercaprol. This product is intended for research and analytical applications. Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .
    Dimercaprol (Standard)
  • HY-16560B
    (R)-Camptothecin

    (R)-Campathecin; (R)-(+)-Camptothecin; (R)-CPT

    		 Others Others
    (R)-Camptothecin is an enantiomer of Camptothecin (CPT), is inactive as an inhibitor of the DNA religation reaction and consequently do not poison Top1 .
    (R)-Camptothecin
  • HY-B1326
    Bemegride

    3-Ethyl-3-methylglutarimide; Bemegrid

    		 GABA Receptor Neurological Disease
    Bemegride (3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning .
    Bemegride
  • HY-B1542A
    Benactyzine hydrochloride
    1 Publications Verification

    		 Cholinesterase (ChE) Neurological Disease
    Benactyzine hydrochloride is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine hydrochloride is an anticholinergic drug. Benactyzine hydrochloride has the potential for organophosphate poisoning research .
    Benactyzine hydrochloride
  • HY-W001117
    3,5-Dimethoxyphenol

    Phloroglucinol Dimethyl Ether

    		 Endogenous Metabolite Metabolic Disease
    3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .
    3,5-Dimethoxyphenol
  • HY-13745
    Sabarubicin

    MEN 10755

    		 Topoisomerase Cancer
    Sabarubicin is a doxorubicin disaccharide analogue with striking antitumor activity. Sabarubicin is more effective than doxorubicin as a topoisomerase II poison and stimulated DNA fragmentation at lower intracellular concentrations.
    Sabarubicin
  • HY-133219
    Guajadial C

    		Topoisomerase Cancer
    Guajadial C is a Top1 catalytic inhibitor that delays Top1 poison-mediated DNA damage. Guajadial C shows cytotoxicity against cancer cells .
    Guajadial C
  • HY-W016188
    1-Naphthyl acetate

    		Cholinesterase (ChE) Others
    1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate has the potential to detect organophosphorus pesticide (OP) poisoning .
    1-Naphthyl acetate
  • HY-111939
    Amiprofos methyl

    BAY-NTN 6867

    		 Microtubule/Tubulin Others
    Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells .
    Amiprofos methyl
  • HY-126931
    Dinophysistoxin 1

    DTX 1

    		 Others Cancer
    Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) is a causative agent of diarrhetic shellfish poisoning. Dinophysistoxin 1 exerts tumor-promoting activity, serves as a skin irritant as well .
    Dinophysistoxin 1
  • HY-N2331R
    Proscillaridin A (Standard)

    		Topoisomerase Cancer
    Proscillaridin A (Standard) is the analytical standard of Proscillaridin A. This product is intended for research and analytical applications. Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively .
    Proscillaridin A (Standard)
  • HY-B0373
    Tiopronin

    		Others Metabolic Disease
    Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders .
    Tiopronin
  • HY-105790
    Piperilate

    Pipethanate

    		 Cholinesterase (ChE) Cardiovascular Disease
    Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates .
    Piperilate
  • HY-105790A
    Piperilate hydrochloride

    		Cholinesterase (ChE) Cardiovascular Disease
    Piperilate (Pipethanate) hydrochloride is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate hydrochloride also causes hypotension and rescues mice poisoned by the organophosphates .
    Piperilate hydrochloride
  • HY-W011108
    Obidoxime dichloride

    		Cholinesterase (ChE) Neurological Disease
    Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated .
    Obidoxime dichloride
  • HY-19825
    Rebeccamycin

    		Topoisomerase ADC Cytotoxin Antibiotic Cancer
    Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .
    Rebeccamycin
  • HY-125559
    Jesaconitine

    		Others Cardiovascular Disease
    Jesaconitine is a toxic alkaloid. Jesaconitine can be derived from Aconitum. Jesaconitine is one of the major metabolites that can be detected in the blood of the right atrium after aconitum poisoning. Various types of arrhythimia are characteristic in aconitine intoxication .
    Jesaconitine
  • HY-B1200
    Pralidoxime chloride

    2-PAM chloride

    		 Cholinesterase (ChE) Neurological Disease
    Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .
    Pralidoxime chloride
  • HY-B1738
    Pralidoxime

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning .
    Pralidoxime
  • HY-122510
    Atropine oxide

    Atropine oxidation

    		 Others Neurological Disease
    Atropine Oxide (Atropine oxidation), a derivative of Atropine, acts as a competitive antagonist to the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5, and is utilized in the treatment of specific nerve agent and pesticide poisonings.
    Atropine oxide
  • HY-119419
    Pirimicarb

    		Cholinesterase (ChE) Parasite Neurological Disease
    Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an AChE inhibitor and an acaricide .
    Pirimicarb
  • HY-119419R
    Pirimicarb (Standard)

    		Cholinesterase (ChE) Parasite Neurological Disease
    Pirimicarb (Standard) is the analytical standard of Pirimicarb. This product is intended for research and analytical applications. Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an AChE inhibitor and an acaricide .
    Pirimicarb (Standard)
  • HY-118581
    Coralyne chloride

    		Topoisomerase Cancer
    Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes .
    Coralyne chloride
  • HY-N0584
    Anisodamine

    6-Hydroxyhyoscyamine

    		 mAChR Neurological Disease
    Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning .
    Anisodamine
  • HY-B1738B
    Pralidoxime methanesulfonate

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime methanesulfonate is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime methanesulfonate reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime methanesulfonate is an antidote for organophosphate poisoning .
    Pralidoxime methanesulfonate
  • HY-122330
    Dicobalt edetate

    Kelocyanor

    		 Others Others
    Dicobalt edetate (Kelocyanor) is a cobalt compound that is an antidote for hydrocyanic acid (cyanide) poisoning. Dicobalt edetate can form a stable complex with cyanide ions, thereby reducing the binding of cyanide ions to cytochrome oxidase, thereby preventing cyanide from inhibiting cellular respiration .
    Dicobalt edetate
  • HY-B0373S1
    Tiopronin-d3

    		Isotope-Labeled Compounds Metabolic Disease
    Tiopronin-d3 is the deuterium labeled Tiopronin. Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders[1][2].
    Tiopronin-d3
  • HY-N6608
    Physostigmine
    1 Publications Verification

    Eserine

    		 Cholinesterase (ChE) Neurological Disease
    Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .
    Physostigmine
  • HY-106594A
    Prussian blue insoluble

    Iron(III) ferrocyanide; Milori blue

    		 Bacterial Infection Cancer
    Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .
    Prussian blue insoluble
  • HY-106594B
    Prussian blue soluble

    Pigment blue 27

    		 Bacterial Infection Cancer
    Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .
    Prussian blue soluble
  • HY-B1229
    Isovaleramide

    3-Methylbutanamide

    		 Others Neurological Disease
    Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant that modulates central nervous system activity. Isovaleramide has anticonvulsant, anxiolytic, sedative, and sleep aid activities. Isovaleramide is promising for research of ethylene glycol (EG) poisoning-induced acute kidney injury and epilepsy .
    Isovaleramide
  • HY-N12016
    Fulvotomentoside B

    		Others Metabolic Disease
    Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl4, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .
    Fulvotomentoside B
  • HY-111939R
    Amiprofos methyl (Standard)

    		Microtubule/Tubulin Others
    Amiprofos methyl (Standard) is the analytical standard of Amiprofos methyl. This product is intended for research and analytical applications. Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells .
    Amiprofos methyl (Standard)
  • HY-163035
    EM-163

    		TNF Receptor IFNAR Inflammation/Immunology
    EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B) .
    EM-163
  • HY-B1266
    Physostigmine salicylate
    1 Publications Verification

    Eserine salicylate

    		 Cholinesterase (ChE) Neurological Disease
    Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning .
    Physostigmine salicylate
  • HY-B1200R
    Pralidoxime chloride (Standard)

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime (chloride) (Standard) is the analytical standard of Pralidoxime (chloride). This product is intended for research and analytical applications. Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .
    Pralidoxime chloride (Standard)
  • HY-B0876
    Fomepizole
    3 Publications Verification

    4-Methylpyrazole

    		 Cytochrome P450 Metabolic Disease
    Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning .
    Fomepizole
  • HY-N2320
    Physostigmine hemisulfate
    1 Publications Verification

    Eserine hemisulfate

    		 Cholinesterase (ChE) Neurological Disease
    Physostigmine hemisulfate (Eserine hemisulfate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning .
    Physostigmine hemisulfate
  • HY-B0876A
    Fomepizole hydrochloride

    4-Methylpyrazole hydrochloride

    		 Cytochrome P450 Metabolic Disease
    Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning .
    Fomepizole hydrochloride

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