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skeleton

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54

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Peptides

27

Natural
Products

5

Isotope-Labeled Compounds

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W013636
    2-Ketoglutaric acid
    4 Publications Verification

    Alpha-Ketoglutaric acid

    		 Tyrosinase Endogenous Metabolite Others
    2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
    2-Ketoglutaric acid
  • HY-W013636C
    2-Ketoglutaric acid potassium
    4 Publications Verification

    Alpha-Ketoglutaric acid potassium

    		 Tyrosinase Metabolic Disease
    2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium is a reversible inhibitor of tyrosinase with an IC50 value of 15 mM .
    2-Ketoglutaric acid potassium
  • HY-W013636A
    2-Ketoglutaric acid Sodium
    4 Publications Verification

    Alpha-Ketoglutaric acid Sodium

    		 Tyrosinase Endogenous Metabolite Metabolic Disease
    2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM) .
    2-Ketoglutaric acid Sodium
  • HY-W013636B
    Calcium 2-oxoglutarate
    4 Publications Verification

    		 Tyrosinase Endogenous Metabolite Metabolic Disease
    Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM) .
    Calcium 2-oxoglutarate
  • HY-W013636R
    2-Ketoglutaric acid (standard)
    4 Publications Verification

    		 Tyrosinase Endogenous Metabolite Others
    2-Ketoglutaric acid (Standard) is the analytical standard of 2-Ketoglutaric acid. This product is intended for research and analytical applications. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
    2-Ketoglutaric acid (standard)
  • HY-N0656
    Usnic acid
    1 Publications Verification

    		 Bacterial Infection Cancer
    Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1 .
    Usnic acid
  • HY-N11896
    10-Hydroxyaloin B

    		Others Inflammation/Immunology
    10-Hydroxyaloin B is a bioactive oxanthrone based on the aloin skeleton .
    10-Hydroxyaloin B
  • HY-N3411
    Labd-13(E)-ene-8α,15-diol

    13E-Labdene-8α,15-diol; Copal-8α,15-diol

    		 Others Others
    Labd-13(E)-ene-8α,15-diol is a diterpene with the labdane skeleton which can be extracted from Cistus symphytijbfolius .
    Labd-13(E)-ene-8α,15-diol
  • HY-W013636S3
    2-Ketoglutaric acid-13C

    Alpha-Ketoglutaric acid-13C

    		 Isotope-Labeled Compounds Endogenous Metabolite Tyrosinase Others
    2-Ketoglutaric acid- 13C (Alpha-Ketoglutaric acid- 13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
    2-Ketoglutaric acid-13C
  • HY-N2528
    Usnic acid sodium

    		Bacterial Infection Cancer
    Usnic acid sodium, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid sodium has excellent anticancer and antimicrobial properties. Usnic acid sodium significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1 .
    Usnic acid sodium
  • HY-136473
    CTX-0124143

    		Histone Acetyltransferase Cancer
    CTX-0124143 is a KAT6A inhibitor with a sulfonyl hydrazine skeleton .
    CTX-0124143
  • HY-133209
    Fischeria A

    		Others Cancer
    Fischeria A is a norditerpene lactone of a new carbon skeleton, can be isolated from Euphorbia fischeriana .
    Fischeria A
  • HY-N1303
    Shoreic acid

    Shoric acid

    		 Others Others
    Shoreic acid (compound 8a) is a dammarane skeleton compound isolated from Cabralea eichleriana DC .
    Shoreic acid
  • HY-135324
    4,4'-Iminodiphenol

    		Estrogen Receptor/ERR Endocrinology
    4-Propionamidophenol (compound 4a) is an inactive estrogen receptor ligand based on the diphenylamine skeleton .
    4,4'-Iminodiphenol
  • HY-126613
    Laurycolactone A

    		Others Others
    Laurycolactone A is a quassinoid with a C18 basic skeleton. Laurycolactone A can be isolated from Eurycoma longifolia .
    Laurycolactone A
  • HY-W007771
    Acridone

    		Bacterial Infection Cancer
    Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .
    Acridone
  • HY-N11663
    Dugesin C

    		Others Others
    Dugesin C is a diterpenoid isolated from the plant Salvia dugesii with a spiro carbocyclic ring system derived from the normal neocrotane skeleton .
    Dugesin C
  • HY-U00190
    Deprodone propionate

    RD20000

    		 Bacterial Inflammation/Immunology
    Deprodone propionate (RD20000) is a corticosteroid which is obtained by esterifying with propionic acid the 17-position of the prednisolone skeleton and deoxidating its 21-position.
    Deprodone propionate
  • HY-157779
    TPA-NAC

    		Reactive Oxygen Species Metabolic Disease
    TPA-NAC is a nonfluorogenic prodrug by introducing N-acetyl-L-cysteine (NAC) into a conjugated acceptor skeleton. TPA-NAC is capable of fluorogenic selective labeling of HSA .
    TPA-NAC
  • HY-W016349
    Chelidamic acid

    		Others Others
    Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
    Chelidamic acid
  • HY-N6849
    InteriotherinA

    		HIV Infection Metabolic Disease
    Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent .
    InteriotherinA
  • HY-N9345
    (2α,3β)-Olean-12-ene-2,3-diol

    		Others Others
    (2α,3β)-Olean-12-ene-2,3-diol (Compound 3) is a triterpenoid with lupane, oleanane, and ursane skeleton .
    (2α,3β)-Olean-12-ene-2,3-diol
  • HY-W007771R
    Acridone (Standard)

    		Bacterial Infection Cancer
    Acridone (Standard) is the analytical standard of Acridone. This product is intended for research and analytical applications. Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .
    Acridone (Standard)
  • HY-N6894
    Pseudocoptisine acetate

    Isocoptisine acetate

    		 Cholinesterase (ChE) Inflammation/Immunology
    Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects .
    Pseudocoptisine acetate
  • HY-N6894A
    Pseudocoptisine chloride

    Isocoptisine chloride

    		 Cholinesterase (ChE) Inflammation/Immunology
    Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects .
    Pseudocoptisine chloride
  • HY-138913
    2H-Cho-Arg TFA

    		Liposome Cancer
    2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
    2H-Cho-Arg TFA
  • HY-N11977
    Stenophyllol B

    		Others Others
    Stenophyllol B (compound 4) is a trimeric stilbene with bicyclic and bridged tricyclic skeletons. Stenophyllol B was first discovered in the dipterocarps plant and has been found in many species of Hopea, Neobalanocarpus, Shorea, Stemonoporus and Vateri .
    Stenophyllol B
  • HY-N11015
    Withaphysalin R

    		Others Infection Inflammation/Immunology Cancer
    Withaphysalin R (compound 5) is a Withanolide that can be isolated from the Solanaceae. Withanolide is a steroid ester with an ergosterol skeleton, and some of these compounds have some significant activities, including cytotoxic and immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant .
    Withaphysalin R
  • HY-121162
    Mesembrine

    (+)-Mesembrine

    		 5-HT Receptor Phosphodiesterase (PDE) Neurological Disease
    Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM .
    Mesembrine
  • HY-N11646
    Ganorbiformin B

    		Bacterial Infection
    Ganorbiformin B is a lanostane triterpenoid. Ganorbiformin B shares the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T exhibits potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra .
    Ganorbiformin B
  • HY-N7550
    Latrunculin M

    		Fluorescent Dye Others
    Latrunculin M is a highly selective actin-macrolide conjugate that can be isolated from marine products. Latrunculin M can be converted from Latrunculin B, which can effectively induce actin depolymerization and is a good probe for detecting the actin skeleton.
    Latrunculin M
  • HY-N0829
    Shionone

    		Others Inflammation/Immunology
    Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .
    Shionone
  • HY-N10697
    Angulatin G

    Celangulatin E

    		 Parasite Infection
    Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows LD50 against Mythimna separata of 1656.4 μg/mL .
    Angulatin G
  • HY-151109
    IR-990

    		Fluorescent Dye Others
    IR-990 is an activatable NIR-II fluorescent probe with an acceptor-π-acceptor (A-π-A) skeleton for real-time detection of H2O2 in vivo. IR-990 is a powerful diagnosis of agent-induced liver injury (DILI) .
    IR-990
  • HY-N2936
    Bi-linderone

    		Others Others
    Bi-linderone is isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. Bi-linderone has activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 μg/mL .
    Bi-linderone
  • HY-N2920
    β-Amyrenonol

    11-Oxo-β-amyrin

    		 Cytochrome P450 Inflammation/Immunology Cancer
    β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids .
    β-Amyrenonol
  • HY-P2733
    Glycerol-3-phosphate oxidase, E. coli

    GPO

    		 Endogenous Metabolite Metabolic Disease
    Glycerol-3-phosphate oxidase, E. coli (GPO) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also a substrate in the respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation .
    Glycerol-3-phosphate oxidase, E. coli
  • HY-163634
    YZK-C22

    		Fungal Infection
    YZK-C22, containing a 1,2,3-thiadiazol-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole skeleton, is a fungicide lead compound with broad-spectrum fungicidal activity .
    YZK-C22
  • HY-W006187
    2-Amino-2-(p-tolyl)acetic acid

    		Glutaminase Cancer
    2-Amino-2-(p-tolyl)acetic acid is used for optimizing azide skeleton, and is the intermediate in the synthesis of 1,3, 4-thiadiazole compounds. 1,3,4-thiadiazole compounds exhibit potential anti-cancer activity, and inhibit glutaminase (GLSI) .
    2-Amino-2-(p-tolyl)acetic acid
  • HY-P2733B
    Glycerol 3-phosphate Oxidase, Aerococcus viridans

    GPO, Aerococcus viridans

    		 Endogenous Metabolite Metabolic Disease
    Glycerol-3-phosphate oxidase, Aerococcus viridans (GPO, Aerococcus viridans) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also a substrate of respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation .
    Glycerol 3-phosphate Oxidase, Aerococcus viridans
  • HY-P2733A
    Glycerol 3-phosphate Oxidase, Pedio coccus sp.

    GPO, Pedio coccus sp.

    		 Endogenous Metabolite Metabolic Disease
    Glycerol-3-phosphate oxidase, Pedio coccus sp. (GPO, Pedio coccus sp.) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also a substrate in the respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation .
    Glycerol 3-phosphate Oxidase, Pedio coccus sp.
  • HY-138912
    Cho-Arg TFA

    		Liposome Others
    Cho-Arg TFA is a steroid-based cationic lipid with an L-Arginine headgroup. Cho-Arg TFA shows a remarkably high optimized plasmid DNA transfection efficacy .
    Cho-Arg TFA
  • HY-N0829R
    Shionone (Standard)

    		Others Inflammation/Immunology
    Shionone (Standard) is the analytical standard of Shionone. This product is intended for research and analytical applications. Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .
    Shionone (Standard)
  • HY-118242
    RU 45144

    		Estrogen Receptor/ERR Calmodulin Others
    RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.
    RU 45144
  • HY-161338
    Tubulin polymerization-IN-61

    		Microtubule/Tubulin Apoptosis Cancer
    Tubulin polymerization-IN-61 (Compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model .
    Tubulin polymerization-IN-61
  • HY-W013636S
    2-Ketoglutaric acid-13C5

    		Tyrosinase Endogenous Metabolite Others
    2-Ketoglutaric acid- 13C5 is the 13C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
    2-Ketoglutaric acid-13C5
  • HY-W013636S1
    2-Ketoglutaric acid-d4

    Alpha-Ketoglutaric acid-d4

    		 Tyrosinase Endogenous Metabolite Others
    2-Ketoglutaric acid-d4 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
    2-Ketoglutaric acid-d4
  • HY-W013636S2
    2-Ketoglutaric acid-d6

    		Tyrosinase Endogenous Metabolite Others
    2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
    2-Ketoglutaric acid-d6
  • HY-W013636S4
    2-Ketoglutaric acid-13C2

    Alpha-Ketoglutaric acid-13C2

    		 Isotope-Labeled Compounds Tyrosinase Endogenous Metabolite Others
    2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
    2-Ketoglutaric acid-13C2
  • HY-155705
    BMP agonist 1

    		TGF-β Receptor GSK-3 β-catenin Others
    BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research .
    BMP agonist 1

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