Search Result

Results for "

skin disease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (6) Apoptosis (10) Autophagy (2) Bacterial (13) Beta-lactamase (4) Biochemical Assay Reagents (1) c-Kit (1) Caspase (2) CDK (1) COX (4) Cytochrome P450 (1) DNA Alkylator/Crosslinker (2) DNA Methyltransferase (1) DNA/RNA Synthesis (3) Endogenous Metabolite (3) Eukaryotic Initiation Factor (eIF) (1) FAK (1) Ferroptosis (2) Filovirus (1) Free Fatty Acid Receptor (1) Fungal (4) Glucocorticoid Receptor (4) HCV (2) Histamine Receptor (8) HSP (1) Interleukin Related (2) IRAK (1) Isotope-Labeled Compounds (3) JAK (5) Keap1-Nrf2 (2) Leukotriene Receptor (1) Lipoxygenase (2) Mitochondrial Metabolism (1) MMP (1) NF-κB (3) p38 MAPK (2) Parasite (3) Phosphatase (3) Procollagen C Proteinase (1) Prostaglandin Receptor (1) RAR/RXR (1) Reactive Oxygen Species (2) ROR (1) SHP2 (1) SphK (1) Stearoyl-CoA Desaturase (SCD) (1) TRP Channel (2) Tyrosinase (5)
By Research Areas:	Cancer (18) Cardiovascular Disease (6) Endocrinology (6) Infection (20) Inflammation/Immunology (62) Metabolic Disease (6) Neurological Disease (10)

By Targets:

Antibiotic (6)

Apoptosis (10)

Autophagy (2)

Bacterial (13)

Beta-lactamase (4)

Biochemical Assay Reagents (1)

c-Kit (1)

Caspase (2)

CDK (1)

COX (4)

Cytochrome P450 (1)

DNA Alkylator/Crosslinker (2)

DNA Methyltransferase (1)

DNA/RNA Synthesis (3)

Endogenous Metabolite (3)

Eukaryotic Initiation Factor (eIF) (1)

FAK (1)

Ferroptosis (2)

Filovirus (1)

Free Fatty Acid Receptor (1)

Fungal (4)

Glucocorticoid Receptor (4)

HCV (2)

Histamine Receptor (8)

HSP (1)

Interleukin Related (2)

IRAK (1)

Isotope-Labeled Compounds (3)

JAK (5)

Keap1-Nrf2 (2)

Leukotriene Receptor (1)

Lipoxygenase (2)

Mitochondrial Metabolism (1)

MMP (1)

NF-κB (3)

p38 MAPK (2)

Parasite (3)

Phosphatase (3)

Procollagen C Proteinase (1)

Prostaglandin Receptor (1)

RAR/RXR (1)

Reactive Oxygen Species (2)

ROR (1)

SHP2 (1)

SphK (1)

Stearoyl-CoA Desaturase (SCD) (1)

TRP Channel (2)

Tyrosinase (5)

By Research Areas:

Cancer (18)

Cardiovascular Disease (6)

Endocrinology (6)

Infection (20)

Inflammation/Immunology (62)

Metabolic Disease (6)

Neurological Disease (10)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00058

Diflucortolone valerate	Fungal Bacterial	Infection Inflammation/Immunology
Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases .

HY-B1365

Prednicarbate	Glucocorticoid Receptor	Inflammation/Immunology
Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis .

HY-153224

GLPG2534	IRAK	Inflammation/Immunology
GLPG2534 is an orally active and selective IRAK4 inhibitor, with IC₅₀ values of 6.4 nM and 3.5 nM for human and mouse IRAK4. GLPG2534 can be used for the research of inflammatory skin diseases .

HY-108411

Emedastine 1 Publications Verification	Histamine Receptor	Inflammation/Immunology
Emedastine is an orally active, selective and high affinity histamine H₁ receptor antagonist with a K_i value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .

HY-169328

Tyrosinase-IN-39	Tyrosinase	Metabolic Disease
Tyrosinase-IN-39 (compound 5r) is a competitive tyrosinase inhibitor with the IC₅₀ of 6.4 μM and can be used for study of skin diseases .

HY-144058

JAK-IN-18	JAK	Inflammation/Immunology
JAK-IN-18 is a potent inhibitor of JAK. JAK-IN-18 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases (extracted from patent WO2018204238A1, compound 1) .

HY-144057

JAK-IN-17	JAK	Inflammation/Immunology
JAK-IN-17 is a potent inhibitor of JAK. JAK-IN-17 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases (extracted from patent WO2021185305A1, compound 9-1) .

HY-B1365R

Prednicarbate (Standard)	Glucocorticoid Receptor	Inflammation/Immunology
Prednicarbate (Standard) is the analytical standard of Prednicarbate. This product is intended for research and analytical applications. Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis .

HY-146155

TRPC4/5-IN-1	TRP Channel	Metabolic Disease Inflammation/Immunology
TRPC4/5-IN-1 is a potent TRP channel 4/5 (TRPC4/5) inhibitor with IC₅₀s of 2.06 μM and 0.54 μM, respectively. TRPC4/5-IN-1 can be used for proteinuric kidney diseases and skin inflammatory diseases research .

HY-B2178

Emedastine difumarate	Histamine Receptor	Inflammation/Immunology
Emedastine difumarate is an orally active, selective and high affinity histamine H₁ receptor antagonist with a K_i value of 1.3 nM. Emedastine difumarate is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .

HY-P3410

Trichomide A	SHP2 Phosphatase	Inflammation/Immunology
Trichomide A is a potent activator of SHP2. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases .

HY-A0158

Diflorasone 1 Publications Verification	Others	Inflammation/Immunology
Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis .

HY-B0226A

(E)-Nitrofurazone (E)-Nitrofural	Bacterial Parasite	Infection
(E)-Nitrofurazone ((E)-Nitrofural) is a topical broad-spectrum antibacterial agent effective against both Gram-negative and Gram-positive bacteria. (E)-Nitrofurazone also possesses antiprotozoal and antiparasitic activities. (E)-Nitrofurazone is commonly used in the research of superficial wounds, burns, skin infections, pyoderma, infectious skin diseases, trypanosomiasis, and acute bacillary dysentery .

HY-157783

CTPS1-IN-2	DNA/RNA Synthesis	Inflammation/Immunology Cancer
CTPS1-IN-2 (P115) is an inhibitor of Cytidine Triphosphate Synthase 1 (CTPS1) with an IC₅₀ value of ≤ 0.1 μM. CTPS1-IN-2 can be used for research on cancer (such as leukemia and lymphoma), inflammatory skin diseases (such as psoriasis), or multiple sclerosis .

HY-108411R

Emedastine (Standard)	Histamine Receptor	Inflammation/Immunology
Emedastine (Standard) is the analytical standard of Emedastine. This product is intended for research and analytical applications. Emedastine is an orally active, selective and high affinity histamine H₁ receptor antagonist with a K_i value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .

HY-107431

Diphenylpyraline	Histamine Receptor	Inflammation/Immunology
Diphenylpyraline is a potent histamine H₁ receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al .

HY-100009

Ufenamate Flufenamic acid butyl ester; Butyl flufenamate	COX Prostaglandin Receptor	Inflammation/Immunology
Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2 .

HY-B2178R

Emedastine difumarate (Standard)	Histamine Receptor	Inflammation/Immunology
Emedastine (difumarate) (Standard) is the analytical standard of Emedastine (difumarate). This product is intended for research and analytical applications. Emedastine difumarate is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine difumarate is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .

HY-A0158R

Diflorasone (Standard)	Others	Inflammation/Immunology
Diflorasone (Standard) is the analytical standard of Diflorasone. This product is intended for research and analytical applications. Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis .

HY-107431R

Diphenylpyraline (Standard)	Histamine Receptor	Inflammation/Immunology
Diphenylpyraline (Standard) is the analytical standard of Diphenylpyraline. This product is intended for research and analytical applications. Diphenylpyraline is a potent histamine H1?receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent?with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al .

HY-W011303

Phytosphingosine 1 Publications Verification 4-Hydroxysphinganine	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology Cancer
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-147240

Acloproxalap ADX-629	Others	Infection Cardiovascular Disease Inflammation/Immunology
Acloproxalap is a quinoline-based aldehyde scavenger that can be used in studies of diseases with toxic aldehyde accumulation, such as inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, organ diseases, and viral infection-related syndromes .

HY-B0900

Anethole 1 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Apoptosis Fungal Bacterial MMP NF-κB	Infection Neurological Disease Inflammation/Immunology Cancer
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-B0775

Betamethasone-17-butyrate-21-propionate	Others	Inflammation/Immunology
Betamethasone-17-butyrate-21-propionate is a topical corticosteroid with potential in the treatment of inflammatory skin diseases.

HY-N11874

Staphyloferrin A	Others	Infection
Staphyloferrin A is a siderophore protein that can be combined with antibiotics to study drug-resistant bacteria that cause skin diseases .

HY-19915A

Contezolid acefosamil MRX-4	Bacterial Antibiotic	Infection Inflammation/Immunology
Contezolid acefosamil (MRX-4) is the orally active proagent of the active antimicrobial metabolite Contezolid (MRX-I), an oxazolidinone which shows potent in vitro activity against various multidrug-resistant Gram-positive bacteria, including MRSA .

HY-156621

Lepzacitinib	JAK	Inflammation/Immunology
Lepzacitinib is a Janus kinase inhibitor targeting to JAK 1/3. Lepzacitinib exhibits anti-inflammatory effect and inhibits atopic dermatitis and other skin diseases .

HY-19023

L-651896	COX Lipoxygenase	Others Inflammation/Immunology
L-651896 is a compound with anti-inflammatory and antiproliferative activities that inhibits 5-lipoxygenase and cyclooxygenase, thereby reducing the production of leukotrienes and prostaglandins. L-651896 can be used in the study of skin diseases and other inflammatory diseases .

HY-B0485S

Fluocinonide-d6	Glucocorticoid Receptor Isotope-Labeled Compounds	Inflammation/Immunology
Fluocinonide-d₆ is deuterated labeled Fluocinonide (HY-B0485). Fluocinonide (Vanos) is a glucocorticoid steroid with anti-inflammatory activity that acts on skin diseases.

HY-139077

SCD1 inhibitor-3	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease Cancer
SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer .

HY-U00058R

Diflucortolone valerate (Standard)	Fungal Bacterial	Infection Inflammation/Immunology
Diflucortolone valerate (Standard) is the analytical standard of Diflucortolone valerate. This product is intended for research and analytical applications. Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases .

HY-123025

Schizozygine	Others	Inflammation/Immunology
Schizozygine is an alkaloid that can be isolated from Schizozygia caffaeoides. Schizozygia caffaeoides has been used as a traditional medicine for skin disease. The leaf extracts has high antifungal and antimicrobial activity .

HY-119358

Traumatic Acid 2 Publications Verification	Reactive Oxygen Species Apoptosis	Cardiovascular Disease Inflammation/Immunology
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis .

HY-156622

Leramistat HMC-C-01-A; MBS2320	Mitochondrial Metabolism	Cancer
Leramistat (HMC-C-01-A; MBS2320) is a mitochondrial complex 1 inhibitor, involving in cell metabolism immune metabolism regulation. Leramistat also inhibits ATP production in Thp1 human monocytes (IC₅₀: 0.63 μM). Leramistat inhibits atopic dermatitis and other skin diseases autoimmune diseases, inflammatory diseases, cancer; and also inhibits osteoclast mediated disease .

HY-17452

Cefditoren sodium ME 1206	Beta-lactamase Bacterial	Infection Inflammation/Immunology
Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-163731

EGR-1-IN-1	DNA Methyltransferase	Inflammation/Immunology
EGR-1-IN-1 (IT25) is an inhibitor targeting EGR-1, with IC₅₀ of 1.86 μM. EGR-1-IN-1 can be used in the research of inflammatory skin diseases .

HY-114071

BMS270394	RAR/RXR	Cancer
BMS270394 is a nuclear retinoic acid receptor (RAR-γ) agonist with the EC₅₀ values of 30 nM and 400 nM for humanRAR-γ and RAR-β, respectively .

HY-144397

LEO 134310	Glucocorticoid Receptor	Inflammation/Immunology
LEO 134310 is a selective, non-steroidal glucocorticoid receptor (GR) agonist optimized for topical research., LEO 134310 showed high affinity (EC₅₀ of 14 nM) in a GR binding assay. LEO 134310 can be used for skin diseases .

HY-P99462

Barzolvolimab CDX 0159	c-Kit	Inflammation/Immunology
Barzolvolimab (CDX 0159) is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria .

HY-117896

SC-50605	Leukotriene Receptor	Inflammation/Immunology
SC-50605 and SC-51146 are second-generation leukotriene B4 (LTB4) receptor antagonists that effectively inhibit LTB4-induced chemotaxis in guinea pigs. SC-50605 targets the LTB4 receptor and has the potential to inhibit inflammatory diseases such as asthma, rheumatoid arthritis, and skin diseases. .

HY-143271

RORγt inverse agonist 29	ROR	Inflammation/Immunology
RORγt inverse agonist 29 is a potent, orally active and selective RORγt inverse agonist (IC₅₀: 21 nM). RORγt inverse agonist 29 can be used in the research of skin inflammation and autoimmune diseases like psoriasis .

HY-N12040

γ-Isofagarine Iso-γ-fagarine	Others	Inflammation/Immunology
γ-Isofagarine (Iso-γ-fagarine) is an alkaloid that can be isolated from the root bark of Dictamnus angustifolius. Dictamnus angustifolius has been used in the research of rheumatism, bleeding, itching, jaundice, chronic hepatitis, skin diseases, etc .

HY-17452A

Cefditoren Pivoxil Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207	Beta-lactamase Bacterial Antibiotic	Infection Inflammation/Immunology
Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-17452B

Cefditoren Pivoxil hydrochloride Cefditoren pivoxyl hydrochloride; Cefditoren pivaloyloxymethyl ester hydrochloride; ME 1207 hydrochloride	Beta-lactamase Bacterial Antibiotic	Infection Inflammation/Immunology
Cefditoren Pivoxil (ME 1207) hydrochloride is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-149698

Tyrosinase-IN-17	Tyrosinase	Cancer
Tyrosinase-IN-17 (Compound 5b) is a lipophilic, skin-permeable, and non-cytotoxic Tyrosinase inhibitor (pIC₅₀=4.99). Tyrosinase-IN-17 can be used for research on melanin-related diseases, such as melanoma, melanogenesis, etc .

HY-13600S1

Clobetasol propionate-d5	Isotope-Labeled Compounds Cytochrome P450	Inflammation/Immunology
Clobetasol propionate-d₅ is a deuterium substitute of Clobetasol propionate. Clobetasol propionate is a potent, selective CYP3A5 inhibitor with a IC₅₀ of 0.206 μM and has potential for use in the study of psoriasis and other skin diseases .

HY-W127549

Petroselinic acid sodium cis-6-Octadecenoic acid	Biochemical Assay Reagents	Others
Petroselinic acid sodium is an organic compound belonging to the class of carboxylic acids. Petroselinic acid sodium has several applications in the cosmetic and personal care industries, especially as an emulsifier and conditioning agent in skin and hair care products. In addition, it has potential utility in inhibiting inflammation-related diseases and cancer.

HY-N0568

Madecassoside Asiaticoside A	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase	Cardiovascular Disease Others Neurological Disease Inflammation/Immunology Endocrinology Cancer
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-108342

PF-00956980	JAK	Inflammation/Immunology
PF-00956980 is a reversible pan-JAK inhibitor with IC₅₀ values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases .

HY-B0688S

Dapsone-d8 4,4′-Diaminodiphenyl sulfone-d₈; DDS-d₈	Antibiotic Parasite Bacterial Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

Cat. No.	Product Name

HY-L126

Nuclear Receptor Compound Library

674 compounds

Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes.

Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors.

MCE supplies a unique collection of 674 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

HY-L060

Cytoskeleton Compound Library

1,328 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1,328 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-W587468

all-trans-3,4-Didehydro retinoic acid

3,4-DHRA

Cell Assay Reagents

All-trans-3,4-Didehydro retinoic acid (3,4-DHRA) is a compound with gene-regulating activity that binds to retinoic acid receptors (RARs) and triggers receptor activation. All-trans-3,4-Didehydro retinoic acid plays an important role in skin development and differentiation and has potential anti-tumor and anti-inflammatory properties. All-trans-3,4-Didehydro retinoic acid is also being studied for the inhibition of a variety of diseases, including skin diseases and certain types of cancer.

HY-W127549

Petroselinic acid sodium cis-6-Octadecenoic acid	Drug Delivery
Petroselinic acid sodium is an organic compound belonging to the class of carboxylic acids. Petroselinic acid sodium has several applications in the cosmetic and personal care industries, especially as an emulsifier and conditioning agent in skin and hair care products. In addition, it has potential utility in inhibiting inflammation-related diseases and cancer.

Cat. No.	Product Name	Target	Research Area

HY-P1116A

PBP10 TFA 1 Publications Verification	Bacterial	Infection Inflammation/Immunology
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .

HY-P3410

Trichomide A	SHP2 Phosphatase	Inflammation/Immunology
Trichomide A is a potent activator of SHP2. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases .

HY-105174A

BPC 157 acetate	JAK FAK	Neurological Disease Metabolic Disease
BPC 157 acetate is the acetate salt form of BPC 157 (HY-105174). BPC 157 acetate is the 15-amino acide fragment of gastric peptide BPC. BPC 157 acetate exhibits wound healing promoting and neuroprotective activity. BPC 157 acetate maintains the integrity of the gastrointestinal mucosa without significant toxicity. BPC 157 acetate counteracts NSAIDs/insulin overdose/copper-induced toxicity. BPC 157 acetate ameliorates specific (over)stimulated/damaged neurotransmitter systems-induced behavioral disorders through serotonergic and dopaminergic systems .

Cat. No.	Product Name	Target	Research Area

HY-P99462

Barzolvolimab CDX 0159	c-Kit	Inflammation/Immunology
Barzolvolimab (CDX 0159) is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria .

HY-P99519

Vixarelimab 1 Publications Verification KPL-716	Interleukin Related	Inflammation/Immunology
Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash .

HY-P99659

Imsidolimab ANB 019	Interleukin Related	Inflammation/Immunology
Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti-IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011303

Phytosphingosine 1 Publications Verification 4-Hydroxysphinganine	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-B0900

Anethole 1 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Structural Classification Classification of Application Fields Source classification Plants Microorganisms Simple Phenylpropanols Leguminosae Phenylpropanoids Umbelliferae Vernonia Schreb. Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Apoptosis Fungal Bacterial MMP NF-κB
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-119358

Traumatic Acid 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Phaseolus vulgaris Linn. Cytokinin Agricultural Research Microorganisms Leguminosae Ketones, Aldehydes, Acids Phytohormone Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species Apoptosis
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis .

HY-N0568

Madecassoside Asiaticoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Tagetes lucida Cav. Umbelliferae Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-N3002

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Cosmetic Research Ericaceae Plants Disease Research Fields	Tyrosinase
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a tyrosinase inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes .

HY-19356

Rocaglamide Maximum Cited Publications 21 Publications Verification Roc-A; MG-002	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Plants Meliaceae Disease Research Fields Aglaia elliptifolia Cancer	NF-κB HSP Eukaryotic Initiation Factor (eIF)
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

HY-N11874

Staphyloferrin A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Staphyloferrin A is a siderophore protein that can be combined with antibiotics to study drug-resistant bacteria that cause skin diseases .

HY-123025

Schizozygine	Apocynaceae Structural Classification Alkaloids Schizozygia coffeoides Baill. Other Alkaloids Source classification Plants	Others
Schizozygine is an alkaloid that can be isolated from Schizozygia caffaeoides. Schizozygia caffaeoides has been used as a traditional medicine for skin disease. The leaf extracts has high antifungal and antimicrobial activity .

HY-N12040

γ-Isofagarine Iso-γ-fagarine	Structural Classification Alkaloids Other Alkaloids Source classification Rutaceae Dictamnus angustifolius G. Don ex Sweet Plants	Others
γ-Isofagarine (Iso-γ-fagarine) is an alkaloid that can be isolated from the root bark of Dictamnus angustifolius. Dictamnus angustifolius has been used in the research of rheumatism, bleeding, itching, jaundice, chronic hepatitis, skin diseases, etc .

HY-N0568R

Madecassoside (Standard)	Triterpenes Structural Classification Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants Endogenous metabolite	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase
Madecassoside (Standard) is the analytical standard of Madecassoside. This product is intended for research and analytical applications. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB , exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity[10]. Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-W011303A

(Rac)-Phytosphingosine (Rac)-4-Hydroxysphinganine	Structural Classification Natural Products other families Source classification Plants	Others
(Rac)-Phytosphingosine ((Rac)-4-Hydroxysphinganine) is the racemate of Phytosphingosine (HY-W011303). Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-W050154R

Kojic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Parasite Tyrosinase NF-κB CDK
Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields .

Cat. No.	Product Name	Chemical Structure

HY-B0688S

Dapsone-d8

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].