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Results for "

sting

" in MedChemExpress (MCE) Product Catalog:

By Targets:	STING (129) ADC Cytotoxin (1) Akt (1) AMPK (1) Apoptosis (1) Autophagy (2) Bacterial (3) Deubiquitinase (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (5) EGFR (1) Endogenous Metabolite (12) Ferroptosis (1) HBV (1) HSV (1) IFNAR (4) Influenza Virus (1) Keap1-Nrf2 (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (1) NF-κB (1) NO Synthase (1) PARP (2) Phosphodiesterase (PDE) (3) PPAR (1) PROTACs (6) Reactive Oxygen Species (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3) Virus Protease (1)
By Research Areas:	Cancer (92) Infection (23) Inflammation/Immunology (59) Metabolic Disease (3) Neurological Disease (1)
Click Chemistry:	Azide (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) CpG ODNs (1) siRNAs (3)

151

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: STING

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-143320

STING agonist-17	STING	Cancer
STING agonist-17 (compound 4a) is a potent *STING* agonist with an IC₅₀ value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization .

HY-143896

STING agonist-7	STING	Cancer
STING agonist-7 is a non-nucleotide *STING* agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly .

HY-103665

STING agonist-3 5+ Cited Publications	STING	Cancer
STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING* agonist* with a pEC₅₀ and pIC₅₀ of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer .

HY-131994

STING agonist-16	STING	Infection Cancer
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool .

HY-148068

STING agonist-20	STING	Inflammation/Immunology Cancer
STING agonist-20 (compound 95) is a potent *STING* agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases .

HY-149781

STING agonist-34	STING	Cancer
STING agonist-34 (Compound 12L) is a potent *STING* agonist with an IC₅₀ value of 1.15 μM and an EC₅₀ of 0.38 μM in THP1 cells. STING agonist-34 could be used in cancer research .

HY-162331

STING Degrader-1	STING	Inflammation/Immunology Cancer
STING Degrader-1 (compound 2) is a potent *STING* degrader that covalently binds to STING and E3 ligase. STING Degrader-1 induces STING degradation through a ubiquitin-proteasome system-dependent pathway .

HY-144329

STING agonist-11	STING	Inflammation/Immunology Cancer
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of *STING* with EC₅₀ of 18 nM. Activation of STING is a highly promising approach in immunotherapy .

HY-144328

STING agonist-10	STING	Inflammation/Immunology Cancer
STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of *STING* with the EC₅₀ of 2600 nM. Activation of STING is a highly promising approach in immunotherapy .

HY-148643

STING modulator-5	STING	Inflammation/Immunology
STING modulator-5 (compound 38) is a *STING* modulator with a pIC₅₀ value of 9.5. STING modulator-5 antagonizes peripheral blood mononuclear cells (PBMC) with a pIC₅₀ value of 8.1. STING modulator-5 is a antagonist of THP-1 cells, it can be used for immunological disease research .

HY-138682

STING-IN-2 4 Publications Verification	STING	Inflammation/Immunology
STING-IN-2 (C-170) is a potent and covalent *STING* inhibitor. STING-IN-2 efficiently inhibits both *mouse STING* (mmSTING) and human STING (hsSTING)*. STING*-IN-2 can be used for autoinflammatory disease research .

HY-153546

STING agonist-31	STING	Cancer
STING agonist-31 is a *STING* agonist, with EC₅₀ values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency .

HY-148346

STING agonist-20-Ala-amide-PEG2-C2-NH2	Drug-Linker Conjugates for ADC STING	Cancer
STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer .

HY-114399

STING ligand-1	STING	Inflammation/Immunology
STING ligand-1 is a lead *STING* ligand with an IC₅₀ of 68 nM for HAQ STING .

HY-147834

STING agonist-9	STING	Cancer
STING agonist-9 (Compound 45) is a potent *STING* agonist with an EC₅₀ of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity .

HY-151970

STING-IN-4	STING	Inflammation/Immunology
STING-IN-4 (Compound 1) is a *STING* inhibitor that inhibits STING expression and hence reducing activation of STING and nuclear factor-κB (NF-κB) signaling. STING-IN-4 shows anti-inflammatory activity and can be used for the research of sepsis .

HY-122568

STING agonist-15	STING	Cancer
STING agonist-15 (Compound STING agonist-C11) Is a *STING* agonist. STING agonist-15 can be used for research of cancer and immune response .

HY-160910

STING agonist-35	STING ADC Cytotoxin	Cancer
STING agonist-35 (Compoind 1a) is an agonist for stimulator of interferon genes (STING), which activates the wild type STING and mutated type STING (R232H), with a rate of 99% and 92%. STING agonist-35 is a potent payload for ADC .

HY-156449

STING-IN-7	STING	Cancer
STING-IN-7 (compound 21) is a potent *STING* inhibitor with an IC₅₀ of 11.5 nM. STING-IN-7 inhibits the phosphorylation of STING and interferon regulatory factor 3 (IRF3) .

HY-139179

STING agonist-14	STING	Infection Cancer
STING agonist-14 (compound 12b) is a potent *STING* agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections .

HY-152960

STING agonist-27	STING	Infection
STING agonist-27 (CF509) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains .

HY-152962

STING agonist-29	STING	Infection
STING agonist-29 (CF511) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains .

HY-143321

STING agonist-13	STING	Cancer
STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate *STING* downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .

HY-148606

STING modulator-3	STING	Cancer
STING modulator-3 is a *STING* inhibitor. STING modulator-3 inhibits R232 STING with an K_i value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells .

HY-152956

STING agonist-23	STING	Infection
STING agonist-23 (CF502) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152957

STING agonist-24	STING	Infection
STING agonist-24 (CF504) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152958

STING agonist-25	STING	Infection
STING agonist-25 (CF505) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152959

STING agonist-26	STING	Infection
STING agonist-26 (CF508) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152961

STING agonist-28	STING	Infection
STING agonist-28 (CF510) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-148346A

STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA	Drug-Linker Conjugates for ADC STING	Cancer
STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer .

HY-149267

STING agonist-30	STING SARS-CoV	Infection
STING agonist-30 is a potent *STING* agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) .

HY-138683

STING-IN-3 2 Publications Verification	STING	Inflammation/Immunology
STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING .

HY-148644

STING-IN-6	STING	Inflammation/Immunology
STING-IN-6 (compound 50) is a potent STING inhibitor with a pIC₅₀ of 8.9. STING-IN-6 has the potential for immunity research .

HY-148546

STING agonist-21	STING	Cancer
STING agonist-21 (compound 1) is a *STING* agonist, with an EC₅₀ of 592.8 nM. STING agonist-21 can be used for cancer research .

HY-163643

STING modulator-7	STING	Others
STING modulator-7 (compound 132) is a modulator of STING, .

HY-152034

STING-IN-5	STING	Inflammation/Immunology
STING-IN-5 is a potent *STING* inhibitor, inhibiting LPS-induced NO synthesis in macrophages with an IC₅₀ value of 1.15 μM. STING-IN-5 inhibits the inflammatory response. STING-IN-5 can be used to research anti-inflammatory diseases and sepsis .

HY-148645

STING modulator-4	STING	Inflammation/Immunology
STING modulator-4 (compound AIH05) is a competitive *STING* modulator with a K_i of 0.0933 μM for R232H STING. STING modulator-4 has an EC₅₀ of >10 μM for p-IRF3 in THP-1 cell .

HY-152955

STING agonist-22	STING	Infection Inflammation/Immunology
STING agonist-22 (CF501) is a potent non-nucleotide *STING* agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research .

HY-123943

STING agonist-4 5 Publications Verification	STING	Cancer
STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC₅₀) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function .

HY-158711

STING agonist-38	STING	Cancer
STING agonist-38 (compound 58) is a potent agonist of *STING, with the EC₅₀* of 0.05 μM in THP1 cells. STING agonist-38 has certain oral bioactivity .

HY-163749

STING-IN-8	STING	Inflammation/Immunology
STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC₅₀ value of 0.121 μM in human and an IC₅₀ value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated *STING* signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of *STING*-associated inflammatory and autoimmune diseases .

HY-147010

STING agonist-12	STING	Inflammation/Immunology
STING agonist-12 (Compound 53) is a potent, orally active human *STING* activator with an EC₅₀ of 185 nM .

HY-162664

STING antagonist 1	STING	Inflammation/Immunology
STING antagonist 1 (Compound 107) is the antagonist for *STING* with an IC₅₀ of 3.8 nM. STING antagonist 1 exhibits inhibitory efficacy in human whole blood, with IC₅₀ of 31 nM .

HY-103665A

STING agonist-3 trihydrochloride 5+ Cited Publications	STING	Cancer
STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING* agonist* with a pEC₅₀ and pEC₅₀ of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer .

HY-153987

STING agonist-33	Others	Cancer
STING agonist-33 (example 1) is an agonist of STING (stimulator of interferon genes) based on 4-ethyl-2-methylthiazole-5-carboxylic acid ^{[1] ^.}

HY-144168A

STING agonist-8 dihydrochloride	STING	Inflammation/Immunology
STING agonist-8 dihydrochloride (compound 5-AB) is a potent *STING* agonist with an EC₅₀ of 27 nM in THP1-Dual KI-hSTING-R232 cells .

HY-144168

STING agonist-8	STING	Inflammation/Immunology
STING agonist-8 is a potent *STING* agonist with an EC₅₀ of 27 nM in THP1-Dual KI-hSTING-R232 cells (WO2021239068A1, compound 5-AB) .

HY-163751

STING-IN-9	Mineralocorticoid Receptor	Metabolic Disease
STING-IN-9 (compound 2) is a potent inhibitor of human CYP11B2. STING-IN-9 showed more than 80 times higher selectivity over human CYP11B1 in vitro .

HY-150075

STING agonist-19	Others	Others
STING agonist-19 can be used to synthesize ISAC (immune-stimulating antibody conjugates) molecule.

HY-158615

STING18 Stimulator of interferon genes 18	Others	Others
STING18 (Stimulator of interferon genes 18) is a compound that inhibits STING protein by utilizing a small molecule active site dimer, with good oral exposure, slow binding kinetics, and functional inhibitory activity on STING-mediated cytokine release.

Cat. No.	Product Name

HY-L031

Small Molecule Immuno-Oncology Compound Library

535 compounds

Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines.

MCE Small Molecule Immuno-Oncology Compound Library offers 535 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

Cat. No.	Product Name	Target	Research Area

HY-P2299

Protein E7(43-62)	Peptides	Cancer
Protein E7(43-62) is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein) .

HY-P2299A

Protein E7(43-62) TFA	Peptides	Cancer
Protein E7(43-62) TFA is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein) .

HY-P4044

HBV Seq2 aa:28-39	HBV	Infection
HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .

Species:	Human (2)
Tag:	SUMO (2) His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70700

	TMEM173 Protein, Human (Sumo-His) Stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;	Human	E. coli
	The TMEM173 protein acts as a promoter of innate immune signaling, acting as a sensor of bacterial and viral cytoplasmic DNA, ultimately promoting the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to the delivery of non-CpG double-stranded DNA from viruses and bacteria into the cytoplasm. TMEM173 Protein, Human (Sumo-His) is the recombinant human-derived TMEM173 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of TMEM173 Protein, Human (Sumo-His) is 187 a.a., with molecular weight of 35-38 kDa.

HY-P70700A

	TMEM173 Protein, Human (N-Sumo-His) 2 Publications Verification Stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;	Human	E. coli
	The TMEM173 protein acts as a promoter of innate immune signaling, acting as a sensor of bacterial and viral cytoplasmic DNA, ultimately promoting the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to the delivery of non-CpG double-stranded DNA from viruses and bacteria into the cytoplasm. TMEM173 Protein, Human (N-Sumo-His) is the recombinant human-derived TMEM173 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of TMEM173 Protein, Human (N-Sumo-His) is 187 a.a., with molecular weight of ~35.19 kDa.

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HY-P80940

	STING Antibody ERIS; MITA; MPYS; SAVI; NET23; sting; hMITA; hsting; sting-beta; Transmembrane Protein 173	WB	Human, Mouse
	STING Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 42 kDa, targeting to STING. It can be used for WB assays with N-6*His-tag, in the background of Human, Mouse.

HY-P80350

	STING Antibody (YA048)	WB, FC	Human
	STING Antibody (YA048) is a non-conjugated and Rabbit origined monoclonal antibody about 42 kDa, targeting to STING. It can be used for WB,FC assays with tag free, in the background of Human.

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Cat. No.	Product Name		Classification

HY-153486

N3-VC-PAB-PNP		Azide
N3-VC-PAB-PNP is the intermediate of bicyclic peptide ligand STING conjugates . N3-VC-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-160225

ISD sodium 1 Publications Verification		CpG ODNs
ISD (interferon stimulatory DNA) sodium is a non-CpG oligomer from the Listeria monocytogenes genome. When transfected into cells, ISD sodium strongly enhances the expression of IFN-β. This ISD-induced response is mediated by the STING-TBK1-IRF3 signaling axis .

HY-RS13916

STING1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
STING1 Human Pre-designed siRNA Set A contains three designed siRNAs for STING1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13917

Sting1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Sting1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sting1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13918

Sting1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Sting1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sting1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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