2. Autophagy Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Autophagy Apoptosis EGFR
  4. Corosolic acid

Corosolic acid  (Synonyms: Colosolic acid)

Cat. No.: HY-N0280 Purity: 99.23%
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Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis.

For research use only. We do not sell to patients.

Corosolic acid Chemical Structure

Corosolic acid Chemical Structure

CAS No. : 4547-24-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 55 In-stock
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10 mg USD 75 In-stock
25 mg USD 140 In-stock
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100 mg USD 310 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Corosolic acid:

Corosolic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Corosolic acid

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  • Biological Activity

  • Purity & Documentation

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Description

Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis[1][2][3].

In Vitro

Corosolic acid shows cytotoxicity for Hep G2, A549, SNU-C4, HeLa, K-562 cells, with ED50s of 0.4-5.0 μg/mL[1].
Corosolic acid (0-50 μg/mL) inhibits PKC activity in a dose-dependent way[1].
Corosolic acid (0-50 μM, 6-24 h) induces apoptosis and increases cells in the sub-G1 population in CT-26 cells[3].
Corosolic acid (20 μM, 0-24 h) inhibits HER2/HER3 heterodimerization and phosphorylation of HER2 and HER3 in HCT116 and SW480 cells[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Corosolic acid Related Antibodies

Apoptosis Analysis[3]

Cell Line: CT-26 cells
Concentration: 25 µM
Incubation Time: 12 and 24 h
Result: Increased cleaved caspase-3 level.
Increased cells in the sub-G1 population.
Increased fluorescin-dUTP labeling DNA strand breaks.

Western Blot Analysis[5]

Cell Line: HCT116 and SW480 cells
Concentration: 20 μM
Incubation Time: 0-24 h
Result: Decreased the formation of NRG1-induced HER2/HER3 heterodimer.
Inhibited the PI3K/Akt/PDE3B but not the ERK1/2 signaling pathway.
In Vivo

Corosolic acid (5, 25 mg/kg/day, peritumor injection, 12 days) inhibits tumor growth and shows anti-angiogenic effect in CT-26 allograft colon carcinoma mice model[3].
Corosolic acid (10 and 20 mg/kg, i.p., every 2 days) inhibits tumor growth in a murine PC-3 xenograft model by activating ER stress[4].
Corosolic acid (10 mg/kg/d, supplemented in diet, 8 weeks) inhibits adipose tissue inflammation, and improves insulin resistance via AMPK activation in high-fat fed mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT-26 allograft colon carcinoma mice model[3]
Dosage: 5, 25 mg/kg/day
Administration: Peritumor injection, 12 days
Result: Reduced the tumor weight to 76.2% and 53.8% of the control group.
Reduced blood and lymphatic vessel densities.
Animal Model: high-fat fed mice[6]
Dosage: 10 mg/kg/day
Administration: Supplemented in diet, 8 weeks
Result: Inhibited hyperlipidemia, Improved insulin sensitivity and glucose intolerance.
Inhibited inflammation in adipose tissues.
Inhibited macrophage infiltrations into adipose tissue.
Molecular Weight

472.70

Formula

C30H48O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (52.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1155 mL 10.5775 mL 21.1551 mL
5 mM 0.4231 mL 2.1155 mL 4.2310 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.75 mg/mL (5.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.23%

COA (252 KB) HNMR (303 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1155 mL 10.5775 mL 21.1551 mL 52.8877 mL
5 mM 0.4231 mL 2.1155 mL 4.2310 mL 10.5775 mL
10 mM 0.2116 mL 1.0578 mL 2.1155 mL 5.2888 mL
15 mM 0.1410 mL 0.7052 mL 1.4103 mL 3.5258 mL
20 mM 0.1058 mL 0.5289 mL 1.0578 mL 2.6444 mL
25 mM 0.0846 mL 0.4231 mL 0.8462 mL 2.1155 mL
30 mM 0.0705 mL 0.3526 mL 0.7052 mL 1.7629 mL
40 mM 0.0529 mL 0.2644 mL 0.5289 mL 1.3222 mL
50 mM 0.0423 mL 0.2116 mL 0.4231 mL 1.0578 mL
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Corosolic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Corosolic acid4547-24-4Colosolic acidAutophagyApoptosisEGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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