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  4. BEBT-908

BEBT-908  (Synonyms: PI3Kα inhibitor 1)

Cat. No.: HY-19763 Purity: 99.60%
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BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) .

For research use only. We do not sell to patients.

BEBT-908 Chemical Structure

BEBT-908 Chemical Structure

CAS No. : 1235449-52-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 357 In-stock
Solution
10 mM * 1 mL in DMSO USD 357 In-stock
Solid
5 mg USD 320 In-stock
10 mg USD 480 In-stock
50 mg USD 1380 In-stock
100 mg USD 1950 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

BEBT-908 Related Antibodies

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Description

BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) .

IC50 & Target[1]

PI3Kα

0.1 μM (IC50)

HDAC

0.1 μM (IC50)

Molecular Weight

507.57

Formula

C23H25N9O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(CC1=CC(N=C(C2=CN=C(NC)C=C2)N=C3N4CCOCC4)=C3S1)C5=NC=C(C(NO)=O)C=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (72.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9702 mL 9.8509 mL 19.7017 mL
5 mM 0.3940 mL 1.9702 mL 3.9403 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9702 mL 9.8509 mL 19.7017 mL 49.2543 mL
5 mM 0.3940 mL 1.9702 mL 3.9403 mL 9.8509 mL
10 mM 0.1970 mL 0.9851 mL 1.9702 mL 4.9254 mL
15 mM 0.1313 mL 0.6567 mL 1.3134 mL 3.2836 mL
20 mM 0.0985 mL 0.4925 mL 0.9851 mL 2.4627 mL
25 mM 0.0788 mL 0.3940 mL 0.7881 mL 1.9702 mL
30 mM 0.0657 mL 0.3284 mL 0.6567 mL 1.6418 mL
40 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2314 mL
50 mM 0.0394 mL 0.1970 mL 0.3940 mL 0.9851 mL
60 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8209 mL
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BEBT-908 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BEBT-9081235449-52-1PI3Kα inhibitor 1BEBT908BEBT 908PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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