2. MAPK/ERK Pathway
  3. MAP3K p38 MAPK
  4. ASK1-IN-1

ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM).

For research use only. We do not sell to patients.

ASK1-IN-1 Chemical Structure

ASK1-IN-1 Chemical Structure

CAS No. : 2411382-24-4

Size Price Stock Quantity
1 mg USD 92 In-stock
5 mg USD 275 In-stock
10 mg USD 412 In-stock
25 mg USD 740 In-stock
50 mg USD 1110 In-stock
100 mg USD 1550 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

ASK1-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All MAP3K Isoform Specific Products:

View All Isoforms
MAP3K7/TAK1 MAP3K8 ASK2 MAP3K5/ASK1

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM)[1].

IC50 & Target

ASK1

 

In Vitro

ASK1-IN-1 (compound 21) has superior CYP inhibition profile and it is also inactive in a hERG assay. ASK1-IN-1 is selected for a kinase selectivity profile against a panel of 468 kinases and it is found to be moderately selective[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ASK1-IN-1 Related Antibodies
In Vivo

ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC50/IC70/IC90 at trough in the brain for 12 hours of 50/115/435 mg/kg respectively. ASK1-IN-1 has good biochemical and cellular potency, low clearance and good brain penetration in rodents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

405.41

Formula

C19H19N9O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=NN(C2=NC=CN=C2)C=C1C(NC3=NC(C4=NN=CN4C(C)C)=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMF : 4 mg/mL (9.87 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Ethanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4666 mL 12.3332 mL 24.6664 mL
5 mM 0.4933 mL 2.4666 mL 4.9333 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.4666 mL 12.3332 mL 24.6664 mL 61.6660 mL
5 mM 0.4933 mL 2.4666 mL 4.9333 mL 12.3332 mL
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ASK1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASK1-IN-12411382-24-4MAP3Kp38 MAPKMAP kinase kinase kinase, MEKK, MAPKKKCNSpenetrantASK1MAPKbrainInhibitorinhibitorinhibit

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