2. Cell Cycle/DNA Damage Autophagy Anti-infection Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis PI3K/Akt/mTOR MAPK/ERK Pathway
  3. Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
  4. Berberine hemisulfate

Berberine hemisulfate  (Synonyms: Natural Yellow 18 hemisulfate)

Cat. No.: HY-N0716A Purity: 99.63%
SDS COA Handling Instructions

Molarity Calculator

Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity.

For research use only. We do not sell to patients.

Berberine hemisulfate Chemical Structure

Berberine hemisulfate Chemical Structure

CAS No. : 316-41-6

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
25 mg USD 50 In-stock
50 mg USD 65 In-stock
100 mg USD 85 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 48 publication(s) in Google Scholar

Other Forms of Berberine hemisulfate:

Berberine hemisulfate Related Antibodies

Top Publications Citing Use of Products

45 Publications Citing Use of MCE Berberine hemisulfate

WB
Proliferation Assay
Cell Viability Assay

    Berberine hemisulfate purchased from MedChemExpress. Usage Cited in: BMC Pharmacol Toxicol. 2023 May 11;24(1):29.  [Abstract]

    Berberine (BBR; 0.625, 1.25, 2.5, 5, 10 µM; 48 h) inhibits the viability of A431cells in a dose-dependent matter.

    Berberine hemisulfate purchased from MedChemExpress. Usage Cited in: BMC Pharmacol Toxicol. 2023 May 11;24(1):29.  [Abstract]

    Berberine (BBR; 2.5, 5, 10 µM; 48 h) inhibits EGFR phosphorylation in a dose-dependent matter in A431cells.

    Berberine hemisulfate purchased from MedChemExpress. Usage Cited in: BMC Pharmacol Toxicol. 2023 May 11;24(1):29.  [Abstract]

    Berberine (BBR; 2.5 µM; 10 days) significantly inhibits NCI-H441 colony formation.

    View All Antibiotic Isoform Specific Products:

    View All Isoforms
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    View All Topoisomerase Isoform Specific Products:

    View All Isoforms
    Topoisomerase Topo I Topo II

    View All PI3K Isoform Specific Products:

    View All Isoforms
    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

    View All Akt Isoform Specific Products:

    View All Isoforms
    Akt Akt1 Akt2 Akt3

    View All Caspase Isoform Specific Products:

    View All Isoforms
    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

    View All JNK Isoform Specific Products:

    View All Isoforms
    JNK1 JNK2 JNK3 JNK

    View All AP-1 Isoform Specific Products:

    View All Isoforms
    c-Fos c-Jun

    View All NF-κB Isoform Specific Products:

    View All Isoforms
    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity[1][2][3][4][5][6].

    In Vitro

    Berberine hemisulfate exhibits antimicrobial acitivity through inhibition of cell division protein FtsZ, or through DNA/RNA binding and deal thus DNA/RNAdamege[3].
    Berberine hemisulfate exhibts anti-inflammatory activity by inhibiting TNF-α and the activation of its downstream pathway AP-1 and NF-kB[4].
    Berberine hemisulfate exhibits neuroprotective efficacy by inhibiting the reactive oxygen species (ROS) production and caspase activation, and activatiing the PI3K/Akt signaling pathway, and heme oxygenase-1 (HO-1) expression[5].
    Berberine hemisulfate attenuates metabolic diseases through regulations of the lipids composition and inhibition of insulin resistance[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Berberine hemisulfate Related Antibodies
    Molecular Weight

    384.40

    Formula

    C20H18NO4.1/2O4S
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=S([O-])([O-])=O.COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C=C2C=C1.[0.5]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 200 mg/mL (520.29 mM; Need ultrasonic)

    DMSO : 2 mg/mL (5.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6015 mL 13.0073 mL 26.0146 mL
    5 mM 0.5203 mL 2.6015 mL 5.2029 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.63%

    SDS (480 KB)

    COA (257 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.6015 mL 13.0073 mL 26.0146 mL 65.0364 mL
    5 mM 0.5203 mL 2.6015 mL 5.2029 mL 13.0073 mL
    H2O 10 mM 0.2601 mL 1.3007 mL 2.6015 mL 6.5036 mL
    15 mM 0.1734 mL 0.8672 mL 1.7343 mL 4.3358 mL
    20 mM 0.1301 mL 0.6504 mL 1.3007 mL 3.2518 mL
    25 mM 0.1041 mL 0.5203 mL 1.0406 mL 2.6015 mL
    30 mM 0.0867 mL 0.4336 mL 0.8672 mL 2.1679 mL
    40 mM 0.0650 mL 0.3252 mL 0.6504 mL 1.6259 mL
    50 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
    60 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0839 mL
    80 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8130 mL
    100 mM 0.0260 mL 0.1301 mL 0.2601 mL 0.6504 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Berberine hemisulfate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Berberine hemisulfate316-41-6Natural Yellow 18 hemisulfateAntibioticTopoisomeraseAutophagyBacterialReactive Oxygen SpeciesApoptosisPI3KAktCaspaseJNKAP-1NF-κBPhosphoinositide 3-kinasePKBProtein kinase Bc-Jun N-terminal kinaseActivator Protein 1Nuclear factor-κBNuclear factor-kappaBdiabetes mellitustype II diabetesAlzheimer’s diseaseParkinson’s diseasearrhythmiaatherosclerosishyperlipidemiahypertensionmyocarditiscardiomyopathyheart failureRAW264.7dopamineInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Salutation

    Applicant Name *

    		 

    Email Address *

    Phone Number *

    		 

    Organization Name *

    Department *

    		 

    Requested quantity *

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Berberine hemisulfate
    Cat. No.:
    HY-N0716A
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (480 KB) Français - FR (480 KB) Deutsch - DE (480 KB) Norwegian - NO (480 KB) Español - ES (480 KB) Swedish - SV (480 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.