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Biotin-Cel  (Synonyms: Celastrol-Biotin)

Cat. No.: HY-158099 Purity: 91.36%
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Biotin-Cel (Celastrol-Biotin) is a biotin-labeled Celastrol (HY-13067). Celastrol exhibits antitumor, anti-inflammatory, and anti-obesity activities. Biotin-Cel can be used in biotin-affinity pulldown assay to identify the molecular target of Celastrol in hepatocellular carcinoma cells.

For research use only. We do not sell to patients.

Biotin-Cel Chemical Structure

Biotin-Cel Chemical Structure

CAS No. : 2609685-71-2

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Based on 1 publication(s) in Google Scholar

Biotin-Cel Related Antibodies

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Description

Biotin-Cel (Celastrol-Biotin) is a biotin-labeled Celastrol (HY-13067). Celastrol exhibits antitumor, anti-inflammatory, and anti-obesity activities. Biotin-Cel can be used in biotin-affinity pulldown assay to identify the molecular target of Celastrol in hepatocellular carcinoma cells[1].

Molecular Weight

718.99

Formula

C41H58N4O5S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(NCCNC(CCCC[C@H]4[C@]5([H])[C@](NC(N5)=O)([H])CS4)=O)=O)C)(CC[C@@]6(C2=CC=C7C6=CC(C(O)=C7C)=O)C)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (139.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3908 mL 6.9542 mL 13.9084 mL
5 mM 0.2782 mL 1.3908 mL 2.7817 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3908 mL 6.9542 mL 13.9084 mL 34.7710 mL
5 mM 0.2782 mL 1.3908 mL 2.7817 mL 6.9542 mL
10 mM 0.1391 mL 0.6954 mL 1.3908 mL 3.4771 mL
15 mM 0.0927 mL 0.4636 mL 0.9272 mL 2.3181 mL
20 mM 0.0695 mL 0.3477 mL 0.6954 mL 1.7385 mL
25 mM 0.0556 mL 0.2782 mL 0.5563 mL 1.3908 mL
30 mM 0.0464 mL 0.2318 mL 0.4636 mL 1.1590 mL
40 mM 0.0348 mL 0.1739 mL 0.3477 mL 0.8693 mL
50 mM 0.0278 mL 0.1391 mL 0.2782 mL 0.6954 mL
60 mM 0.0232 mL 0.1159 mL 0.2318 mL 0.5795 mL
80 mM 0.0174 mL 0.0869 mL 0.1739 mL 0.4346 mL
100 mM 0.0139 mL 0.0695 mL 0.1391 mL 0.3477 mL
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Biotin-Cel Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-Cel2609685-71-2Celastrol-BiotinBiochemical Assay Reagentshepatocellular carcinomacelastrolpull-down assayInhibitorinhibitorinhibit

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