Cepharadione A

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Cepharadione A can be isolated from the roots of Piper betle Linn. Cepharadione A inhibits FMLP/CB induced elastase release by human neutrophils.

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Cepharadione A Chemical Structure

CAS No. : 55610-01-0

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Description

Cepharadione A can be isolated from the roots of Piper betle Linn. Cepharadione A inhibits FMLP/CB induced elastase release by human neutrophils^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	> 10 μg/mL Compound: 2	Growth inhibition of human BXPC3 cells after 48 hrs by SRB assay Growth inhibition of human BXPC3 cells after 48 hrs by SRB assay	[PMID: 17624787]
DU-145	GI₅₀	4.3 μg/mL Compound: 2	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 17624787]
KM-20L2	GI₅₀	17.3 μg/mL Compound: 2	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 17624787]
MCF7	GI₅₀	6.3 μg/mL Compound: 2	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 17624787]
NCI-H460	GI₅₀	2.5 μg/mL Compound: 2	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 17624787]
SF-268	GI₅₀	2.9 μg/mL Compound: 2	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 17624787]

Molecular Weight

305.28

Formula

C₁₈H₁₁NO₄

CAS No.

55610-01-0

SMILES

CN(C1=O)C2=C3C(C4=C(OCO4)C=C3C1=O)=C5C(C=CC=C5)=C2

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin CF, et al. A new hydroxychavicol dimer from the roots of Piper betle. Molecules. 2013 Feb 26;18(3):2563-70. [Content Brief]

Cepharadione A Related Classifications

Inflammation/Immunology

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cepharadione A55610-01-0Otherselastase releaseneutrophilsFMLP/CBInhibitorinhibitorinhibit

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