Diquat dibromide

Name: Diquat dibromide
Brand: MedChemExpress
SKU: HY-122984
Rating: 4.5 (1 reviews)

Cat. No.: HY-122984 Purity: 99.86%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Diquat dibromide is a comprehensive herbicide. Diquat dibromide increases the production of ROS and triggers mitochondrial Autophagy. Diquat dibromide generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide is cytotoxic, reproductive, and neurotoxic. Diquat dibromide is used in cotton, soybean, and other crops to combat noxious weeds.

For research use only. We do not sell to patients.

Diquat dibromide Chemical Structure

CAS No. : 85-00-7

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in DMSO	USD 61	In-stock	Estimated Time of Arrival: May 20
Solid
25 mg	USD 56	In-stock	Estimated Time of Arrival: May 20
50 mg	USD 90	In-stock	Estimated Time of Arrival: May 20
100 mg	USD 150	In-stock	Estimated Time of Arrival: May 20
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Diquat dibromide:

Diquat-d₄ dibromide Get quote
Diquat dibromide hydrate Get quote
Diquat (dibromide hydrate) (Standard) Get quote
Diquat (dibromide) (Standard) Get quote

1 Publications Citing Use of MCE Diquat dibromide

•Biochem Biophys Res Commun. 2025 Jan 10.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Diquat (10-20 μM; 20 h) dibromide causes cell death in SH-SY5Y cells^[3].
Diquat (50 μM) dibromide induces axonal degeneration in cultured dorsal root ganglion (DRG) neurons^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Diquat (10 mg/kg bodyweight; i.p.) dibromide induces oxidative stress, increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets^[2].
Diquat dibromide (25 mg/L in drinking water; 10-week treatment) reduces beak red chroma and total plasma carotenoids, and increases lipophilic antioxidant capacity in adult male zebra finches^[4].
Diquat (8-12 mg/kg; i.p.; twice a week; 4 weeks) dibromide causes reproductive toxicity in female mice^[6].
Diquat (10 mg/kg; i.p.; twice a week; for 6 weeks) dibromide shows neurotoxic effects in male C57/BL-6 mice, inducing motor dysfunctions (such as bradykinesia, gait abnormalities, decreased swimming ability, etc.)^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Twelve male Duroc × Landrace × Yorkshire 35-d-old pigs (weaned at 21 d of age), with an average body weight of 9.6 kg, used as a model for studying the effect of Diquat-induced oxidative stress on intestinal barrier, mitochondrial function, and mitophagy^[2].
Dosage:	10 mg/kg BW (dissolved in 0.9% NaCl solution)
Administration:	Intraperitoneal injection
Result:	Significantly decreased ADFI and ADG. Impaired the intestinal barrier function, as indicated by a decrease in TER, an increase in FD4 flux, and a reduction in the protein abundance of claudin-1, occludin, and zonula occludens-1. Caused mitochondrial dysfunction, with increased ROS production, decreased membrane potential in intestinal mitochondria, and a decrease in the mRNA abundance of genes related to mitochondrial biogenesis and function. Triggered mitophagy, as shown by the increased expression of mitophagy-related proteins and the increased ratio of LC3-II to LC3-I.

Animal Model:	Female ICR mice^[6]
Dosage:	8 mg/kg or 12 mg/kg (dissolved in normal saline)
Administration:	Intraperitoneal injection, twice a week, for 4 weeks
Result:	Significantly reduced ovary weights compared with control mice. Decreased the percentage of normal GV oocytes and polar body extrusion. Significantly increased ROS production in follicular granulosa cells and oocytes. Decreased the activities of antioxidant enzymes (T-SOD, GPx and CAT) in the serum, and increased the MDA content. Reduced the average numbers of fetus and litter size on GD 7.5 d.

Molecular Weight

344.05

Formula

C₁₂H₁₂Br₂N₂

CAS No.

85-00-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

[N+]12=CC=CC=C1C3=[N+](CC2)C=CC=C3.[Br-].[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.86%

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Data Sheet (279 KB) SDS (791 KB)

COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Moreland D E. Mechanisms of action of herbicides. 1980.

[2]. Cao S, et al. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. J Anim Sci. 2018 May 4;96(5):1795-1805. [Content Brief]

[3]. Singh P, et al. Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Parkinsons Dis. 2017;2017:2643587. [Content Brief]

[4]. Tomášek O, et al. Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signalling. Sci Rep. 2016 Mar 22;6:23546. [Content Brief]

[5]. Nisar R, et al. Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. Arch Toxicol. 2015 Oct;89(10):1811-25. [Content Brief]

[6]. Zhang JQ, et al. Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice. PLoS One. 2016 Jan 19;11(1):e0147075. [Content Brief]

[7]. Karuppagounder SS, et al. Investigate the chronic neurotoxic effects of diquat. Neurochem Res. 2012 May;37(5):1102-11. [Content Brief]

[8]. Acar A. In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach. Environ Sci Pollut Res Int. 2021;28(34):47550-47561. [Content Brief]