2. Gene
  3. Gh - growth hormone Gene

Gh - growth hormone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gh1; Ghb1

Gene ID: 14599 | Gene type: protein coding

About Gh

Summary

Enables growth hormone receptor binding activity. Acts upstream of or within cellular response to Insulin stimulus; regulation of growth; and response to food. Located in several cellular components, including extracellular space; secretory granule; and trans-Golgi network. Is expressed in brain; early conceptus; gut; hemolymphoid system; and male reproductive system. Used to study isolated growth hormone deficiency type II. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1). [provided by Alliance of Genome Resources, Apr 2022]

Gh Products(1)

mRNA Protein Name
NM_008117.3 NP_032143.1 somatotropin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables growth hormone receptor binding IPI
IPI: Inferred from physical interaction
10556780 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
16513828 MGI
acts upstream of or within positive regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
16467156 MGI
acts upstream of or within response to food IDA
IDA: Inferred from direct assay
16513828 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
7664670 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9144201 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9144201 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
1329576 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
9144201 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

somatotropin

growth hormone b1

Recombinant Gh Proteins

Cat. No. Product Name Accession Purity
HY-P70261 GH/Somatotropin Protein, Mouse P06880 (F27-F216) ≥95%

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16381A Pasireotide acetate Agonist 99.25% Yes
HY-16381 Pasireotide Agonist 99.88% Yes
HY-14820A Macimorelin acetate Agonist 98.96% Yes
HY-108905 Mecasermin / Unkown
HY-14820 Macimorelin Agonist / Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-109155 Paltusotine Agonist 99.52% Phase 3
HY-50844 Ibutamoren Mesylate Agonist 99.86% Phase 2
HY-P0024 Veldoreotide Activator / Phase 2
HY-153485 Cimdelirsen Inhibitor / Phase 2
HY-153485A Cimdelirsen sodium Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99900 Sevirumab Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (44)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13913 NS-398 Inhibitor 99.72% Unkown
HY-D1599 Rhodamine 6G hydrazide 98.05% Unkown
HY-P1155 GRF (1-29) amide (rat) Inducer 99.94% Unkown
HY-P0089A Human growth hormone-releasing factor TFA 99.66% Unkown
HY-101422 GAL-021 Inhibitor 99.93% Unkown
HY-10957 L-692429 Agonist 99.90% Unkown
HY-P5189A His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA 99.56% Unkown
HY-139431 NAG-thiazoline Inhibitor 98.08% Unkown
HY-149902 USP8-IN-3 Inhibitor 99.17% Unkown
HY-115661 Bisdionin C Inhibitor 98.97% Unkown
HY-50760 L-692585 Agonist 99.32% Unkown
HY-P0024A Veldoreotide TFA Agonist 98.37% Unkown
HY-P1777 IGF-I (24-41) 99.11% Unkown
HY-P4750 Acetyl-(D-Arg2)-GRF (1-29) amide (human) Antagonist 99.67% Unkown
HY-107678 SEN12333 Agonist 98.45% Unkown
HY-D1515 FM1-84 98.92% Unkown
HY-E70033 D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) / Unkown
HY-P0089 Human growth hormone-releasing factor / Unkown
HY-101422A GAL-021 sulfate Inhibitor / Unkown
HY-10199A Ibutamoren Agonist / Unkown
HY-103540 Tabimorelin hemifumarate Inhibitor / Unkown
HY-110161 sst2 Receptor agonist-1 Agonist / Unkown
HY-113906A (αR,8aS)-GSK1614343 Antagonist 99.40% Unkown
HY-117584 L-163255 free base / Unkown
HY-117931 NS004 Activator / Unkown
HY-121580 Tabimorelin Inhibitor / Unkown
HY-147666 α-Synuclein inhibitor 4 Inhibitor / Unkown
HY-E70105 α-Xylosidase / Unkown
HY-E70107 Cellobiohydrolase I / Unkown
HY-E70111 Endo-1,5-α-arabinanase / Unkown
HY-E70316 Chimax-O / Unkown
HY-P1139 Cortistatin-8 Antagonist / Unkown
HY-P1773A IGF-I (30-41) (TFA) / Unkown
HY-P1777A IGF-I (24-41) (TFA) / Unkown
HY-P3169 a-Helical Corticotropin Releasing Factor (9-41) Antagonist / Unkown
HY-P3595 GHRF, porcine / Unkown
HY-P3607 GHRF, bovine Activator / Unkown
HY-P4405 (D-Ala2)-GRF (1-29) amide (human) Agonist / Unkown
HY-RS05408 GH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05409 GH2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-109155A Paltusotine hydrochloride Agonist / Unkown
HY-10957A L-692429 hydrochloride Agonist / Unkown
HY-116959 SM-130686 / Unkown
HY-119997 Disulergine Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris Gh NCBI
Susscrofa domestica Gh NCBI
Leporidae Gh NCBI
Rattus norvegicus Gh NCBI
Macaca mulatta Gh NCBI