2. Gene
  3. Jun - jun proto-oncogene Gene

Jun - jun proto-oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AP-1; Junc; c-jun

Gene ID: 16476 | Gene type: protein coding

About Jun

Chromosome 4: 94,937,271-94,940,459 reverse strand.GRCm39:CM000997.3

This gene has 1 transcript (splice variant), 226 orthologues, 2 paralogues and is associated with 63 phenotypes.

Summary

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to anisomycin and positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus. Acts upstream of or within several processes, including animal organ development; negative regulation of protein autophosphorylation; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; long bone; and sensory organ. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Jun Products(1)

mRNA Protein Name
NM_010591.2 NP_034721.1 transcription factor Jun
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
10076871 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
20442316 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
2138707 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19303854 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
16847049 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
10352021 MGI
acts upstream of or within axon regeneration IMP
IMP: Inferred from mutant phenotype
15233917 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16007074 MGI
involved in cellular response to anisomycin IDA
IDA: Inferred from direct assay
19584270 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
19303854 MGI
acts upstream of or within eyelid development in camera-type eye IMP
IMP: Inferred from mutant phenotype
25224220 MGI
acts upstream of or within leading edge cell differentiation IMP
IMP: Inferred from mutant phenotype
12791271 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
10352021 MGI
acts upstream of or within microglial cell activation IMP
IMP: Inferred from mutant phenotype
15233917 MGI
acts upstream of or within monocyte differentiation IMP
IMP: Inferred from mutant phenotype
18326819 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10352021 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
16007074 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15233917 MGI
acts upstream of or within negative regulation of protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
16916642 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
10352021 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
25224220 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16847049 MGI
acts upstream of or within positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
25224220 MGI
acts upstream of or within positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
17182846 MGI
acts upstream of or within positive regulation of fibroblast proliferation IGI
IGI: Inferred from genetic interaction
17182846 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12798298 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19584270 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19303854 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11818961 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
11818961 MGI
acts upstream of or within response to muscle stretch IDA
IDA: Inferred from direct assay
20442316 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
9098922 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
12050152 MGI
part of transcription factor AP-1 complex IPI
IPI: Inferred from physical interaction
1631061 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
12798298 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
17182846 MGI
part of transcription repressor complex IPI
IPI: Inferred from physical interaction
17182846 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Jun Protein Structure

Jun

Jun: pfam03957 (5 - 242)

bZIP_Jun

bZIP_Jun: cd14696 (256 - 316)

bZIP_Jun

bZIP_Jun: cd14696 (257 - 308)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

transcription factor Jun

AH119

AP1

Jun oncogene

V-jun avian sarcoma virus 17 oncogene homolog

activator protein 1

immediate early

jun A

proto-oncogene c-jun

transcription factor AP-1

transcription factor AP-1 subunit Jun

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1198 Piperonyl butoxide Inhibitor ≥98.0% Unkown
HY-B1198R Piperonyl butoxide (Standard) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-13241 Ralimetinib dimesylate 99.91% Phase 2
HY-138304 CC-90001 Inhibitor 99.75% Phase 2
HY-13241A Ralimetinib Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (48)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107598 JNK Inhibitor VIII Inhibitor 99.46% Unkown
HY-11010 AS601245 Inhibitor 98.83% Unkown
HY-148510 HKB99 Inhibitor 97.35% Unkown
HY-W010983 SC-236 99.56% Unkown
HY-113438 15(S)-HPETE 97.3% Unkown
HY-125838 J30-8 Inhibitor 99.90% Unkown
HY-107599 AEG3482 Inhibitor 99.95% Unkown
HY-P1190 c-JUN peptide 99.25% Unkown
HY-101287 MPT0B392 99.63% Unkown
HY-107600 IQ-3 Inhibitor 99.38% Unkown
HY-141582 Ceramide 3 ≥98.0% Unkown
HY-157403 Jun12682 99.60% Unkown
HY-107621 U0124 ≥98.0% Unkown
HY-P10506 CMX-8933 Activator 99.82% Unkown
HY-152142 DN-1289 Inhibitor 99.63% Unkown
HY-114250 Cantrixil Inducer 99.84% Yes
HY-134975 NY2267 Inhibitor 98.53% Unkown
HY-169021 JNK-1-IN-3 Inhibitor / Unkown
HY-118529 JUN-1111 Inhibitor 98.57% Unkown
HY-B1198S Piperonyl butoxide-d9 Inhibitor / Unkown
HY-113443 12(S)-HPETE Activator / Unkown
HY-151928 JNK3 inhibitor-3 Inhibitor / Unkown
HY-155593 JNK-1-IN-2 Inhibitor / Unkown
HY-162922 MAP4K4-IN-6 Inhibitor / Unkown
HY-168337 SET-171 Inhibitor / Unkown
HY-168859 JNK3 inhibitor-9 Inhibitor / Unkown
HY-168895 c-Fos-IN-1 / Unkown
HY-168916 Jun13296 Inhibitor / Unkown
HY-169177 JNK-1-IN-4 Inhibitor / Unkown
HY-169314 JNK-IN-19 Inhibitor / Unkown
HY-N1961 Ophiopogonin B / Unkown
HY-P10048 TAT-JIP Inhibitor / Unkown
HY-P4699 (Thr17)-c-Jun (11-23) / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS07054 JUN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07055 Jun Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07056 Jun Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-11010A AS601245 TFA Inhibitor / Unkown
HY-121683 (E)-2-Hexadecenal / Unkown
HY-138844 3-AP-Me Activator / Unkown
HY-141582S Ceramide 3-d3 / Unkown
HY-157305 Jun11165 Inhibitor / Unkown
HY-158751 Jun9-72-2 Inhibitor / Unkown
HY-159985 Jun13728 Inhibitor / Unkown
HY-171202 In vivo Jun Mouse Pre-designed siRNA-1 Pre-designed Sets / Unkown
HY-171203 In vivo Jun Mouse Pre-designed siRNA-2 Pre-designed Sets / Unkown
HY-171204 In vivo Jun Mouse Pre-designed siRNA-3 Pre-designed Sets / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jun NCBI NCBI:3725
Rattus norvegicus Jun NCBI NCBI:24516