2. Gene
  3. Jun - Jun proto-oncogene, AP-1 transcription factor subunit Gene

Jun - Jun proto-oncogene, AP-1 transcription factor subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24516 | Gene type: protein coding

About Jun

Primary_assembly 5: 109,893,145-109,897,656 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 226 orthologues, 1 paralogue and is associated with 40 phenotypes.

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to potassium ion starvation; positive regulation of macromolecule biosynthetic process; and positive regulation of monocyte differentiation. Located in cytosol and nucleus. Part of protein-containing complex. Colocalizes with chromatin. Used to study hypertension. Biomarker of mental depression and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Jun Products(1)

mRNA Protein Name
NM_021835.3 NP_068607.1 transcription factor Jun

Jun Protein Structure

Jun

Jun: pfam03957 (5 - 242)

bZIP_Jun

bZIP_Jun: cd14696 (256 - 316)

bZIP_Jun

bZIP_Jun: cd14696 (257 - 308)

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  • 334 a.a.
Protein Preferred Names Protein Names

transcription factor Jun

AP1

Avian sarcoma virus 17 (v-jun) oncogene homolog

Jun oncogene

V-jun avian sarcoma virus 17 oncogene homolog

activator protein 1

proto-oncogene c-jun

transcription factor AP-1

transcription factor AP-1 subunit Jun

v-jun sarcoma virus 17 oncogene homolog

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-13241 Ralimetinib dimesylate 99.91% Phase 2
HY-138304 CC-90001 Inhibitor 99.75% Phase 2
HY-13241A Ralimetinib Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107598 JNK Inhibitor VIII Inhibitor 99.46% Unkown
HY-11010 AS601245 Inhibitor 98.83% Unkown
HY-W010983 SC-236 99.56% Unkown
HY-125838 J30-8 Inhibitor 99.90% Unkown
HY-148510 HKB99 Inhibitor 97.35% Unkown
HY-107599 AEG3482 Inhibitor 99.95% Unkown
HY-107600 IQ-3 Inhibitor 99.38% Unkown
HY-101287 MPT0B392 99.63% Unkown
HY-P1190 c-JUN peptide 99.25% Unkown
HY-113438 15(S)-HPETE ≥97.0% Unkown
HY-141582 Ceramide 3 ≥98.0% Unkown
HY-107621 U0124 ≥98.0% Unkown
HY-134975 NY2267 Inhibitor 98.53% Unkown
HY-157403 Jun12682 99.60% Unkown
HY-114250 Cantrixil Inducer 99.84% Yes
HY-152142 DN-1289 Inhibitor / Unkown
HY-118529 JUN-1111 Inhibitor 98.57% Unkown
HY-P10506 CMX-8933 Activator 99.82% Unkown
HY-151928 JNK3 inhibitor-3 Inhibitor / Unkown
HY-155593 JNK-1-IN-2 Inhibitor / Unkown
HY-162922 MAP4K4-IN-6 Inhibitor / Unkown
HY-169021 JNK-1-IN-3 Inhibitor / Unkown
HY-169177 JNK-1-IN-4 Inhibitor / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS07054 JUN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07055 Jun Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07056 Jun Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-11010A AS601245 TFA Inhibitor / Unkown
HY-157305 Jun11165 Inhibitor / Unkown
HY-158751 Jun9-72-2 Inhibitor / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jun NCBI NCBI:3725
Mus musculus Jun NCBI NCBI:16476