Jun - Jun proto-oncogene, AP-1 transcription factor subunit Gene

Rattus norvegicus

Gene ID: 24516 | Gene type: protein coding

About Jun

Primary_assembly 5: 109,893,145-109,897,656 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 226 orthologues, 1 paralogue and is associated with 40 phenotypes.

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to potassium ion starvation; positive regulation of macromolecule biosynthetic process; and positive regulation of monocyte differentiation. Located in cytosol and nucleus. Part of protein-containing complex. Colocalizes with chromatin. Used to study hypertension. Biomarker of mental depression and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Jun Products(1)

mRNA	Protein	Name
NM_021835.3	NP_068607.1	transcription factor Jun

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	17428807	RGD
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	10830307	RGD
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	16582099	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	10830307	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9369238	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14610205	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9369238	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10830307	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated transcription	IDA IDA: Inferred from direct assay	16582099	RGD
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	15126605	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	8593588	RGD
involved in cellular response to potassium ion starvation	IMP IMP: Inferred from mutant phenotype	17428807	RGD
involved in cellular response to prolactin	IEP IEP: Inferred from expression pattern	8584023	RGD
involved in cellular response to zinc ion starvation	IEP IEP: Inferred from expression pattern	21893222	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	10987819	RGD
involved in learning	IMP IMP: Inferred from mutant phenotype	7948848	RGD
involved in membrane depolarization	IDA IDA: Inferred from direct assay	11571252	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	9487126	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16582099	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12441106	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15609298	RGD
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	18384814	RGD
involved in positive regulation of monocyte differentiation	IDA IDA: Inferred from direct assay	7947389	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12514131	RGD
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	11571252	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19255142	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17428807	RGD
involved in release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	11301023	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	18280640	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	18280640	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	22576626	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	11053775	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	20818503	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11389931	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15126239	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11113530	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	21948387	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12093589	RGD
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10830307	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	9300399	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19255142	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Jun Protein Structure

Jun

bZIP_Jun

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

transcription factor Jun

AP1	Avian sarcoma virus 17 (v-jun) oncogene homolog
Jun oncogene	V-jun avian sarcoma virus 17 oncogene homolog
activator protein 1	proto-oncogene c-jun
transcription factor AP-1	transcription factor AP-1 subunit Jun
v-jun sarcoma virus 17 oncogene homolog

Jun Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Jun	P17325	Mapk8	Rattus norvegicus	P49185	Pull Down	18046461
Intra	Jun	P17325	Fos	Rattus norvegicus	P12841	Anti Bait CoIP	32949970
Intra	Jun	P17325	Fos	Rattus norvegicus	P12841	Anti Bait CoIP	16876161

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1198	Piperonyl butoxide	Inhibitor	≥98.0%	Unkown
HY-B1198R	Piperonyl butoxide (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12270	T-5224	Inhibitor	99.59%	Phase 2
HY-13241	Ralimetinib dimesylate		99.91%	Phase 2
HY-138304	CC-90001	Inhibitor	99.75%	Phase 2
HY-13241A	Ralimetinib	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107598	JNK Inhibitor VIII	Inhibitor	99.46%	Unkown
HY-11010	AS601245	Inhibitor	98.83%	Unkown
HY-148510	HKB99	Inhibitor	97.35%	Unkown
HY-W010983	SC-236		99.56%	Unkown
HY-125838	J30-8	Inhibitor	99.90%	Unkown
HY-107599	AEG3482	Inhibitor	99.95%	Unkown
HY-107600	IQ-3	Inhibitor	99.38%	Unkown
HY-101287	MPT0B392		99.63%	Unkown
HY-113438	15(S)-HPETE		97.3%	Unkown
HY-P1190	c-JUN peptide		99.25%	Unkown
HY-141582	Ceramide 3		≥98.0%	Unkown
HY-157403	Jun12682		99.60%	Unkown
HY-107621	U0124		≥98.0%	Unkown
HY-134975	NY2267	Inhibitor	98.53%	Unkown
HY-114250	Cantrixil	Inducer	99.84%	Yes
HY-152142	DN-1289	Inhibitor	/	Unkown
HY-118529	JUN-1111	Inhibitor	98.57%	Unkown
HY-P10506	CMX-8933	Activator	99.82%	Unkown
HY-B1198S	Piperonyl butoxide-d9	Inhibitor	/	Unkown
HY-151928	JNK3 inhibitor-3	Inhibitor	/	Unkown
HY-155593	JNK-1-IN-2	Inhibitor	/	Unkown
HY-162922	MAP4K4-IN-6	Inhibitor	/	Unkown
HY-169021	JNK-1-IN-3	Inhibitor	/	Unkown
HY-169177	JNK-1-IN-4	Inhibitor	/	Unkown
HY-169314	JNK-IN-19	Inhibitor	/	Unkown
HY-P6177	SGP8	Inhibitor	/	Unkown
HY-RS07054	JUN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07055	Jun Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07056	Jun Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-11010A	AS601245 TFA	Inhibitor	/	Unkown
HY-157305	Jun11165	Inhibitor	/	Unkown
HY-158751	Jun9-72-2	Inhibitor	/	Unkown
HY-P10401	TAT-GluR6-9c	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jun	NCBI	NCBI:3725
Mus musculus	Jun	NCBI	NCBI:16476

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