Hdac4 - histone deacetylase 4 Gene

Mus musculus

Also known as HD4; 4932408F19Rik

Gene ID: 208727 | Gene type: protein coding

About Hdac4

Chromosome 1: 91,856,501-92,123,421 reverse strand.GRCm39:CM000994.3

This gene has 12 transcripts (splice variants), 263 orthologues, 10 paralogues and is associated with 40 phenotypes. Ubiquitous expression in adrenal adult (RPKM 12.3), ovary adult (RPKM 1.9) and 28 other tissues.

Summary

Enables several functions, including chromatin binding activity; protein deacetylase activity; and transcription corepressor activity. Involved in regulation of nucleobase-containing compound metabolic process and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; osteoblast development; and regulation of cardiac muscle contraction by calcium ion signaling. Located in several cellular components, including actomyosin; cytosol; and neuromuscular junction. Is expressed in several structures, including alimentary system; early embryo; ganglia; hand; and telencephalon. Used to study eating disorder. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hdac4 Products(1)

mRNA	Protein	Name
NM_207225.2	NP_997108.1	histone deacetylase 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16260608	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10748098	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24768298	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14576337	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17468767	MGI
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	18250163	MGI
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	15990875	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	15537544	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15537544	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16260608	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14576337	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15537544	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15537544	MGI
involved in negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	19109424	MGI
involved in negative regulation of miRNA transcription	IGI IGI: Inferred from genetic interaction	24675724	MGI
involved in negative regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	24675724	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15990875	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17873280	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15537544	MGI
acts upstream of or within osteoblast development	IMP IMP: Inferred from mutant phenotype	15990875	MGI
acts upstream of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15990875	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19109424	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19109424	MGI
acts upstream of or within regulation of cardiac muscle contraction by calcium ion signaling	IMP IMP: Inferred from mutant phenotype	18250163	MGI
acts upstream of or within regulation of skeletal muscle fiber development	IGI IGI: Inferred from genetic interaction	17786239	MGI
acts upstream of or within regulation of skeletal muscle fiber differentiation	IGI IGI: Inferred from genetic interaction	17786239	MGI
involved in response to denervation involved in regulation of muscle adaptation	IMP IMP: Inferred from mutant phenotype	19109424	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	15537544	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actomyosin	IDA IDA: Inferred from direct assay	18250163	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	22318228	MGI
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	19109424	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17761942	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	17873280	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22318228	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	19109424	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac4 Protein Structure

ClassIIa_HDAC4_Gln-rich-N

HDAC4

0
200
400
600
800
1000
1076 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 4

Hdac4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Hdac4	Q6NZM9	Runx2	Mus musculus	Q08775	Anti Tag CoIP	15537544
Intra	Hdac4	Q6NZM9	Runx2	Mus musculus	Q08775	EMSA	15537544

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10528	Tasquinimod	Modulator	99.94%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.81%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18361	TMP195	Inhibitor	99.57%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-19350	BML-210	Inhibitor	98.06%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.94%	Unkown
HY-12954	PTACH	Inhibitor	99.65%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	/	Unkown
HY-163143	HDAC8-IN-6	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-151263	G4/HDAC-IN-1	Inhibitor	/	Unkown
HY-149372	HDAC6-IN-17	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-169400	HDACs/EZH2-IN-1	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-150503	KH-259	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hdac4	NCBI	NCBI:9759

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